CN110691846A - 合理的多倍体腺相关病毒载体及其制造和使用方法 - Google Patents

合理的多倍体腺相关病毒载体及其制造和使用方法 Download PDF

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CN110691846A
CN110691846A CN201880032343.2A CN201880032343A CN110691846A CN 110691846 A CN110691846 A CN 110691846A CN 201880032343 A CN201880032343 A CN 201880032343A CN 110691846 A CN110691846 A CN 110691846A
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aav
serotype
viral
capsid
nucleic acid
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C.李
R.J.萨马尔斯基
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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Priority to CN202311045266.3A priority Critical patent/CN117535247A/zh
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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CN201880032343.2A 2018-05-07 2018-07-31 合理的多倍体腺相关病毒载体及其制造和使用方法 Pending CN110691846A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311045266.3A CN117535247A (zh) 2018-05-07 2018-07-31 合理的多倍体腺相关病毒载体及其制造和使用方法

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US201862668056P 2018-05-07 2018-05-07
US62/668056 2018-05-07
US201862678675P 2018-05-31 2018-05-31
US62/678675 2018-05-31
PCT/US2018/044632 WO2019216932A1 (en) 2018-05-07 2018-07-31 Rational polyploid adeno-associated virus vectors and methods of making and using the same

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EP (1) EP3596203A4 (de)
JP (2) JP2021522775A (de)
CN (2) CN110691846A (de)
AU (1) AU2018422759A1 (de)
WO (1) WO2019216932A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110684800A (zh) * 2018-11-02 2020-01-14 深圳益世康宁生物科技有限公司 一种携带肿瘤-睾丸抗原10基因的重组腺相关病毒载体及其应用价值

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240189447A1 (en) * 2021-04-16 2024-06-13 Asklepios Biopharmaceutical, Inc. Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
WO2022253955A2 (en) * 2021-06-02 2022-12-08 Uniqure Biopharma B.V. Insect cell production of parvoviral vectors with modified capsid proteins

Citations (3)

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WO2004099423A1 (en) * 2003-05-01 2004-11-18 University Of Florida Research Foundation, Inc. Vp2-modified raav vectors and uses thereof
WO2012112578A2 (en) * 2011-02-14 2012-08-23 The Children's Hospital Of Philadelphia Improved aav8 vector with enhanced functional activity and methods of use thereof
US20150023924A1 (en) * 2013-07-22 2015-01-22 The Children's Hospital Of Philadelphia Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues

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SI1496944T1 (sl) * 2002-05-01 2009-02-28 Univ Florida Izboljšani sistemi ekspresije RAAV za genetsko modifikacijo specifičnih kapsidnih proteinov
JP5588586B2 (ja) * 2003-09-02 2014-09-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
WO2007149852A2 (en) * 2006-06-19 2007-12-27 Asklepios Biopharmaceutical, Inc. Modified factor viii and factor ix genes and vectors for gene therapy
US10415056B2 (en) * 2010-11-10 2019-09-17 Fred Hutchinson Cancer Research Center Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
GB201103062D0 (en) * 2011-02-22 2011-04-06 Isis Innovation Method
AU2018234695A1 (en) * 2017-03-15 2019-09-12 The University Of North Carolina At Chapel Hill Polyploid adeno-associated virus vectors and methods of making and using the same

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2004099423A1 (en) * 2003-05-01 2004-11-18 University Of Florida Research Foundation, Inc. Vp2-modified raav vectors and uses thereof
WO2012112578A2 (en) * 2011-02-14 2012-08-23 The Children's Hospital Of Philadelphia Improved aav8 vector with enhanced functional activity and methods of use thereof
US20150023924A1 (en) * 2013-07-22 2015-01-22 The Children's Hospital Of Philadelphia Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues

Non-Patent Citations (1)

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Title
S.P.BECERRA ET AL.: "Synthesis of Adeno-Associated Virus Structural Proteins Requires Both Alternative mRNA Splicing and Alternative Initiations from a Single Transcript", 《JOURNAL OF VIROLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110684800A (zh) * 2018-11-02 2020-01-14 深圳益世康宁生物科技有限公司 一种携带肿瘤-睾丸抗原10基因的重组腺相关病毒载体及其应用价值

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CN117535247A (zh) 2024-02-09
WO2019216932A1 (en) 2019-11-14
EP3596203A4 (de) 2021-12-01
JP2021522775A (ja) 2021-09-02
JP2023154428A (ja) 2023-10-19
AU2018422759A1 (en) 2020-01-02
EP3596203A1 (de) 2020-01-22

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