CN1106688A - Sugarless antipyretic granule for cold and preparing method thereof - Google Patents
Sugarless antipyretic granule for cold and preparing method thereof Download PDFInfo
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- CN1106688A CN1106688A CN 94117709 CN94117709A CN1106688A CN 1106688 A CN1106688 A CN 1106688A CN 94117709 CN94117709 CN 94117709 CN 94117709 A CN94117709 A CN 94117709A CN 1106688 A CN1106688 A CN 1106688A
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- herba
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Abstract
The sugarless antipyretic granule for cold features no sugar, total stevioside, correctant and dextrin as vehicle. Its prepn process is that medicine extract, dextrin and total Stevioside are passed through single step of mixing, pelletizing and drying in reflux type one-step pelletizer. The said medicine prepn is suitable for abstainer from sugar including diabetic.
Description
The invention provides a kind of Sugarless antipyretic granule for cold and preparation method thereof.This electuary does not contain sucrose, replaces dextrin and makes excipient, and Flos Chrysanthemi total glycosides is made correctives, is a kind of Chinese patent medicine that comprises the treatment flu that diabetics also can be taken.
Existing common cold antipyretic granule, all make excipient and orthopedic dose with sucrose, cane sugar content is up to 60～70%, promptly contain the sucrose of having an appointment about eight grams in the infusion for treating coryza of wind cold type of one bag of 12 gram, for patients, in the electuary contained sucrose to disease without any therapeutical effect, the part patient is arranged, should not take and contain sugar or contain the too much medicine of sugar, as diabetics, sugar can increase the weight of the burden of islets of langerhans, finally may cause islet function depletion, therefore diabetics is avoided clothes and is contained sugared medicine, hepatopath and for example is after a large amount of sugar enters blood, because liver function is undesired, sugar can not be utilized fully, often the form with fat is stored in liver and other tissue of body, contains the too much medicine of sugar if take for a long time, and hepatocyte is filled by significant quantities of fat, might develop into " fatty liver ", even also can cause the organic disease of some cardiovascular systeies.The research worker of countries in the world is through studies confirm that for many years, and excessive absorption sugar can cause damage to human body, the generation of many pathological changes such as the disease that causes fat, hypertension, heart disease, diabetes.China's Ministry of Public Health and State Pharmaceutical Administration issued jointly in 1988 " reducing the notice that the part medicine contains sugared ratio " about research promptly ((88) defend No. the 29, medicine word].Infusion for treating coryza of wind cold type is treatment flu a kind of Chinese patent medicine commonly used, and its function is expelling wind and cold, the heat clearing away of inducing sweat, and be used to have a headache and fever, disease such as the dry pharynx of cough, and sucrose is hot material, grows and is bored with, and can have a negative impact to its therapeutical effect.
Flos Chrysanthemi total glycosides is the general glycoside that extracts in the perennial herb Compositae feverwort Folium Stevlae Rebaudianae.The sweet taste of Flos Chrysanthemi total glycosides is near sucrose in natural sweetener, and its sugariness is 200～300 times of sucrose, because Flos Chrysanthemi total glycosides belongs to non-metabolic material, thereby produces heat hardly after taking in body.U.S. food drug abuse test office thinks that stevioside is harmless, the physician of in 1977 Paraguay in the 7th international diabetes association has reported its drug effect and safety, think that Flos Chrysanthemi total glycosides is a kind of sweeting agent of empty calory, and bring high blood pressure down, enhance metabolism, regulate effects such as gastric acid, Flos Chrysanthemi total glycosides has also been got permission flavoring agent as medicine and food in China.
Existing infusion for treating coryza of wind cold type is all made correctives with sucrose, because sugared content height, effectively the crude drug composition is low relatively, therefore dose is big, once need take 12 grams, the preparation method of this kind electuary comprises batching, pulverizes, boils operations such as carrying, make soft material and system granule, and concrete steps are as follows:
1, batching: take by weighing through the qualified medical material of pre-treatment by prescription
Prescription (unit: kilogram)
Herba Schizonepetae 50 Herba Menthaes 15 Radix Saposhnikoviaes 25
Radix Bupleuri 25 Folium Perillaes 15 Radix Puerariaes 25
The Radix Angelicae Dahuricae 15 Herba Corydalis Bungeanaes 50 Radix Platycodoniss 15
Semen Armeniacae Amarum 20 Rhizoma Phragmitiss 40
Annotate: the Chinese crude drug consumption in this prescription be that " 250 times of the 522nd page of " infusion for treating coryza of wind cold type " recipe quantity of 90 years versions of Chinese pharmacopoeia 11 are distinguished the flavor of altogether, weigh 295 kilograms.
2, pulverize: with sucrose and dextrin with 3: 1 mixed even after, be ground into 65 purpose fine powders.
3, boil and carry: get Folium Perillae, Herba Schizonepetae, Herba Menthae three flavor medical materials, oil is carried in distillation, and the aqueous solution after distillation device is in addition collected; Eight flavor medical materials such as medicinal residues and Radix Bupleuri, Radix Saposhnikoviae, Semen Armeniacae Amarum, Radix Puerariae, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae, Rhizoma Phragmitis, Radix Platycodonis decoct with water twice, each 1.5 hours, collecting decoction, filtration, filtrate and above-mentioned aqueous solution merge, and are concentrated into relative density and are 1.35～1.38/50～60 ℃ clear paste.
4, system soft material: 1 part of qinghuo reagent, 4 parts of Icing Sugar and dextrin mixed powders drop in the blender, make solid colour, no fine powder and cross the qualified soft material that glues phenomenon.
5, granulate: soft material drops in the oscillating granulator and makes wet granular, then with wet granular through boiled bed drying, sieve, quantitatively add the volatile oil mix homogeneously.
The preparation method step of above-mentioned existing GANMAO CHONGJI is more, semi-finished product transport between distinct device, not only production efficiency is low, and because system soft material and granulation all are to be exposed in the air to carry out, the production utensil of contact is a lot, and the contaminated probability of product increases, bacterial population is increased, because of being subjected to anthropic factor bigger, repeatability is relatively poor, and product quality is wayward.
The object of the present invention is to provide a kind of Sugarless antipyretic granule for cold and preparation method thereof.This electuary patient that is not only applicable to generally catch a cold takes, and is applicable to that also those that comprise diabetics should not take the flu patient who contains sugared medicine and take.Its preparation method is to collect mixing, granulation, drying in one procedure, has not only improved production efficiency, has also reduced the contaminated probability of finished product, owing to do not contain sucrose, has improved drug effect, and is not only applied widely, and dose is few.Its composition and preparation method are as follows:
One, prescriptions of Chinese medicine (unit: kilogram)
Herba Schizonepetae 50 Herba Menthaes 15 Radix Saposhnikoviaes 25
Radix Bupleuri 25 Folium Perillaes 15 Radix Puerariaes 25
Radix Platycodonis 15 Semen Armeniacae Amarums 20 Radixs Angelicae Dahuricae 15
Herba Corydalis Bungeanae 50 Rhizoma Phragmitiss 40
Annotate: the Chinese crude drug consumption in this prescription be that " 250 times of the 522nd page of " infusion for treating coryza of wind cold type " recipe quantity of 90 years versions of Chinese pharmacopoeia 11 are distinguished the flavor of altogether, weigh 295 kilograms.
Flos Chrysanthemi total glycosides 1～5%(is with the clear paste restatement)
1～2.5 times in dextrin is to clear paste (that is: clear paste/dextrin=1/1～2.5)
Two, preparation method
1, batching: take by weighing through the qualified medical material of pre-treatment by prescription.
2, boil and carry: get Folium Perillae, Herba Schizonepetae, Herba Menthae three flavor medical materials and amount to 80 kilograms of distillations and carry oil, the aqueous solution after distillation device is in addition collected; Eight flavor medical materials such as medicinal residues and Radix Bupleuri, Radix Saposhnikoviae, Semen Armeniacae Amarum, Radix Puerariae, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae, Rhizoma Phragmitis, Radix Platycodonis amount to 215 kilograms, decoct with water secondary, each 1.5 hours, merge twice decocting liquid, filtration, aqueous solution after filtrate and the above-mentioned distillation merges, and is concentrated into relative density and is 1.35～1.38/50～60 ℃ clear paste.
3, granulate: 1 part of qinghuo reagent, add the suitable quantity of water dilution, get 1～5% Flos Chrysanthemi total glycosides and be dissolved in the medicinal liquid, mix homogeneously, other gets 1～2.5 part in dextrin, itself and medicinal liquid are dropped into respectively in the reverse-flow type one-step palletizing drying machine, begin hydrojet after adjusting temperature and spouting liquid, after medicinal liquid has sprayed, continue to be heated to drying, finished product quantitatively adds the volatile oil mix homogeneously, packing after checking.
Sugarless antipyretic granule for cold is compared with existing infusion for treating coryza of wind cold type has following characteristics:
(1) do not contain sucrose in the prescription, make all that comprise diabetics should not take the people who contains sugared medicine and can take yet, enlarged its range of application;
(2) Flos Chrysanthemi total glycosides is better than sucrose to the stability of acid, alkali, heat, ℃ heating is one hour in PH=3～9,100, its content is no change almost, and sucrose is met heat fusing, easily coking, and the moisture absorption under wet environment itself is easy to fermentation generation carbon source again and is utilized by microorganism, thereby influence the stability of electuary, Sugarless antipyretic granule for cold is a correctives with the Flos Chrysanthemi total glycosides, has overcome above-mentioned shortcoming, is convenient to storage, transports and carry;
(3) the sweet taste residence time of Flos Chrysanthemi total glycosides long, compare with sucrose and can improve its bitterness residual, make things convenient for the patient to take, and cane sugar content height in the existing infusion for treating coryza of wind cold type, sucrose itself can increase product viscosity, and makes the bitterness residence time long;
(4) use Flos Chrysanthemi total glycosides that the drug effect of product is not fully exerted, because of the function of infusion for treating coryza of wind cold type is expelling wind and cold, the heat clearing away of inducing sweat, from tcm theory and point of practical use, generally when using this class Chinese patent medicine of heat-clearing and toxic substances removing removing dampness, should avoid using the additive of high heat as far as possible, because the pharmaceutical properties in its prescription of this class preparation, one all based on cold property, and sucrose is hot material, influences the performance of drug effect.
(5) Sugarless antipyretic granule for cold is owing to use Flos Chrysanthemi total glycosides to make correctives, and effective crude drug is relative raising in the prescription, compares with existing infusion for treating coryza of wind cold type, and dosage has reduced 30～50%.
(6) preparation method of Sugarless antipyretic granule for cold is compared with the preparation method of common cold antipyretic granule, collect mixing, granulation, dry in a step operation, reduced semi-finished product transporting between distinct device, not only improved production efficiency, and reduced product and be exposed to contaminated probability in the air.
With embodiment the present invention is described below:
Embodiment 1
One, prescription (unit: kilogram)
Herba Schizonepetae 50 Herba Menthaes 15 Radix Saposhnikoviaes 25
Radix Bupleuri 25 Folium Perillaes 15 Radix Puerariaes 25
Radix Platycodonis 15 Semen Armeniacae Amarums 20 Radixs Angelicae Dahuricae 15
Herba Corydalis Bungeanae 50 Rhizoma Phragmitiss 40
Chinese crude drug consumption in this prescription be " in one one of 90 years version of Chinese pharmacopoeia 250 times of this product recipe quantity, amount to 11 flavors, weigh 295 kilograms.
Two, preparation
1, batching: take by weighing through the qualified medical material of pre-treatment by prescription.
2, boil and carry: get Folium Perillae, Herba Schizonepetae, Herba Menthae three flavor medical materials (recipe quantity), put and extract in the pot distillation and carry oil, separate volatile oil, the aqueous solution after distillation device is in addition collected; Eight flavor medical materials such as medicinal residues and Radix Bupleuri, Radix Saposhnikoviae, Semen Armeniacae Amarum, Radix Puerariae, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae, Rhizoma Phragmitis, Radix Platycodonis add decocting twice, each 1.5 hours, merge decocting liquid twice, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the clear paste of 1.35～1.38/50～60 ℃ of relative densities.
3, granulate: 1 part of qinghuo reagent, add water and make medicinal liquid in right amount, get 5%(with the clear paste restatement) Flos Chrysanthemi total glycosides be dissolved in the medicinal liquid mix homogeneously.Other gets 2.5 parts in dextrin, and medicinal liquid and dextrin are dropped in the reverse-flow type one-step palletizing drying machine, begins hydrojet behind adjustment temperature and the spouting liquid.After medicinal liquid has sprayed, continue to be heated to drying, after granule was emitted, finished product quantitatively added volatile oil, packs behind the mix homogeneously.
Embodiment 2
One, prescription: with embodiment 1.
Two, preparation
1, batching: with embodiment 1.
2, boil and carry: with embodiment 1.
3, granulate: 1 part of qinghuo reagent, add water and make medicinal liquid in right amount, get 2%(with the clear paste restatement) Flos Chrysanthemi total glycosides be dissolved in the medicinal liquid mix homogeneously, other gets 1.4 parts in dextrin, medicinal liquid and dextrin are dropped in the reverse-flow type one-step palletizing drying machine, begin hydrojet behind adjustment temperature and the spouting liquid, after medicinal liquid has sprayed, continue to be heated to drying, after granule was emitted, finished product quantitatively added volatile oil, packs behind the mix homogeneously.
Embodiment 3
One, prescription: with embodiment 1.
Two, preparation
1, batching: with embodiment 1.
2, boil and carry: with embodiment 1.
3, granulate: 1 part of qinghuo reagent, add water and make medicinal liquid in right amount, the Flos Chrysanthemi total glycosides of qinghuo reagent weight 1% is dissolved in the medicinal liquid, mix homogeneously, other gets 1 part in dextrin, medicinal liquid and dextrin are dropped in the reverse-flow type one-step palletizing drying machine, begin hydrojet behind adjustment temperature and the spouting liquid, after medicinal liquid has sprayed, continue to be heated to drying, after granule was emitted, finished product quantitatively added volatilization, packs behind the mix homogeneously.
Claims (2)
1, a kind of Sugarless antipyretic granule for cold, it be by comprise at least Herba Schizonepetae, Radix Platycodonis, Radix Bupleuri, the Radix Angelicae Dahuricae, Semen Armeniacae Amarum, Herba Corydalis Bungeanae etc. ten simply Chinese crude drug be prepared from, it is characterized in that: this electuary does not contain sucrose, replaces Flos Chrysanthemi total glycosides and makes correctives, with the Hu Jingzuo excipient.
2, Sugarless antipyretic granule for cold as claimed in claim 1, its preparation method comprises the steps:
Batching: take by weighing the qualified Chinese crude drug of pre-treatment by charger sheet;
Boil and carry: get the three flavor medical materials distillations of Herba Schizonepetae, Folium Perillae, Herba Menthae and carry oil, the aqueous solution after distillation device is in addition collected.Eight flavor medical materials such as medicinal residues and Radix Bupleuri, Radix Saposhnikoviae, Semen Armeniacae Amarum, Radix Puerariae, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae, Rhizoma Phragmitis, Radix Platycodonis decoct with water secondary, each 1.5 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, and are concentrated into the clear paste of 1.35～1.38/50～60 ℃ of relative densities;
Granulate: 1 part of qinghuo reagent adds the suitable quantity of water dilution; With 1～5%(with the clear paste restatement) Flos Chrysanthemi total glycosides be dissolved in wherein, mix homogeneously, other gets 1～2.5 part in dextrin, itself and medicinal liquid are dropped into respectively in the reverse-flow type one-step palletizing drying machine, begin hydrojet after adjusting temperature and spouting liquid, after medicinal liquid has sprayed, continue to be heated to drying, finished product adds the volatile oil mix homogeneously in right amount, packing after checking.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94117709 CN1106688A (en) | 1994-11-07 | 1994-11-07 | Sugarless antipyretic granule for cold and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94117709 CN1106688A (en) | 1994-11-07 | 1994-11-07 | Sugarless antipyretic granule for cold and preparing method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1106688A true CN1106688A (en) | 1995-08-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94117709 Pending CN1106688A (en) | 1994-11-07 | 1994-11-07 | Sugarless antipyretic granule for cold and preparing method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052897C (en) * | 1995-11-23 | 2000-05-31 | 中国北京同仁堂集团公司北京同仁堂制药厂 | Chinese proprietary medicine for curing cold |
| CN108607047A (en) * | 2016-12-09 | 2018-10-02 | 内蒙古天奇中蒙制药股份有限公司 | A kind of preparation method of GANMAO QINGRE KELI |
-
1994
- 1994-11-07 CN CN 94117709 patent/CN1106688A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052897C (en) * | 1995-11-23 | 2000-05-31 | 中国北京同仁堂集团公司北京同仁堂制药厂 | Chinese proprietary medicine for curing cold |
| CN108607047A (en) * | 2016-12-09 | 2018-10-02 | 内蒙古天奇中蒙制药股份有限公司 | A kind of preparation method of GANMAO QINGRE KELI |
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