CN110656044A - Novel intelligent microbial fermentation device - Google Patents

Novel intelligent microbial fermentation device Download PDF

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Publication number
CN110656044A
CN110656044A CN201810693353.2A CN201810693353A CN110656044A CN 110656044 A CN110656044 A CN 110656044A CN 201810693353 A CN201810693353 A CN 201810693353A CN 110656044 A CN110656044 A CN 110656044A
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China
Prior art keywords
tank body
pipe
sensor
valve
microbial fermentation
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Pending
Application number
CN201810693353.2A
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Chinese (zh)
Inventor
荆弘明
陈莹
王晓丹
曾范啟
邹来阳
严婉静
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Deer Rock
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Deer Rock
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Priority to CN201810693353.2A priority Critical patent/CN110656044A/en
Publication of CN110656044A publication Critical patent/CN110656044A/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/48Holding appliances; Racks; Supports
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02Stirrer or mobile mixing elements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06Nozzles; Sprayers; Spargers; Diffusers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20Degassing; Venting; Bubble traps
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/02Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control

Abstract

The invention relates to the technical field of microbial fermentation, in particular to a novel intelligent microbial fermentation device which comprises a tank body, a heating pipe, a steel sleeve, a motor, a sterile shaft seal, a defoamer, a stirring shaft, a stirrer, an oxygen injection device, an oxygen generator, a water valve, a temperature sensor, a feeding hole, a pressure gauge, a pH sensor, a dissolved oxygen sensor, an automatic control valve, an exhaust pipe, a sampling pipe, a control switch valve, a cooling water inlet pipe, a discharging pipe valve, a discharging pipe, a cooling water outlet pipe, a fixing frame, a control device, a liquid crystal display screen, an electric heating switch, a temperature setting knob, an oxygen generator control knob and a motor rotating speed control knob. The invention realizes the rapid culture of aerobic bacteria, has good fermentation effect, safety and sanitation, convenient operation, accurate regulation and control and intelligent operation. Can be completely suitable for occasions with large treatment capacity and large volume of fermentation tanks, lays a good foundation for the scale production of microorganisms, and has wide market prospect and application prospect.

Description

Novel intelligent microbial fermentation device
Technical Field
The invention relates to the technical field of microbial fermentation, in particular to a novel intelligent microbial fermentation device.
Background
The fermentation device is widely applied to the industries of pharmacy, fine chemical engineering, bioengineering and the like, and is a device for the growth, propagation and material reaction of microorganisms in the fermentation process. Microbial fermentation refers to a process of converting raw materials into products required by human beings through a specific metabolic pathway by using microorganisms under appropriate conditions. In the fermentation process of the microbial strains, a proper and stable fermentation environment needs to be provided to meet the culture and multiplication of the strains, so that the fermentation efficiency and quality of the microbial strains can be ensured. In the prior art, in the process of fermenting microorganism strains, generally, the uniformity of strains and a fermentation substrate is poor, and the internal air permeability of a fermented product is poor, so that the fermentation efficiency is low, the fermentation period is long, the activity of the microorganism strains obtained by fermentation is low, the concentration requirement on oxygen is strict as most microorganisms are aerobic microorganisms, the survival rate of the culture of most microorganisms at present is low, and the control on the oxygen concentration is inaccurate. Microbial fermentation is an intricate process, especially large-scale industrial fermentation, and various process parameters in the fermentation process must be strictly and accurately controlled to achieve a predetermined target. The fermentation device adopted in the prior art has single function, cannot effectively detect and control technical indexes and technological parameters in the whole process of microbial fermentation, and cannot adapt to modern high-efficiency microbial strain fermentation, so that the prior art needs to be improved.
Based on the analysis, the existing microbial strain fermentation technology is improved, and how to design a novel intelligent microbial fermentation device matched with the new fermentation technology becomes the problem to be solved currently.
Disclosure of Invention
The invention aims to provide a novel intelligent microbial fermentation device to solve the problems in the background technology.
In order to achieve the purpose, the invention adopts the following technical scheme:
novel intelligence microbial fermentation device, a serial communication port, the device includes a jar body, the heating pipe, the steel bushing, a motor, aseptic bearing seal, the defoamer, (mixing) shaft, the agitator, oxygen injection apparatus, the oxygenerator, the water valve, a weighing sensor, the feed inlet, the manometer, the PH sensor, dissolved oxygen sensor, automatic control valve, the blast pipe, the sampling tube, the control switch valve, the cooling water advances the pipe, the blowing pipe valve, the blowing pipe, the cooling water exit tube, the mount, controlling means, liquid crystal display, the electrical heating switch, the temperature sets for the knob, oxygenerator control knob, motor speed control knob.
Compared with the prior art, the invention has the beneficial effects that: the invention realizes the quick culture of aerobic bacteria, good fermentation effect, safety, sanitation, accurate regulation and control and intelligent operation. Can be completely suitable for occasions with large treatment capacity and large volume of fermentation tanks, lays a good foundation for the scale production of microorganisms, and has wide market prospect and application prospect.
Drawings
The invention is further illustrated with reference to the figures and embodiments.
Fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is an overall sectional view of the present invention.
Detailed Description
Referring to fig. 1 and fig. 2, through the description of the embodiments, the embodiments of the present invention, such as the interrelation between the related parts, the function and working principle of the parts, and the operation and use method, will be further described in detail to help the engineers in the art to understand the concept of the present invention more completely, accurately, and deeply.
The invention discloses a novel intelligent microbial fermentation device, which comprises a tank body 1, a heating pipe 2, a steel sleeve 3, a motor 4, an aseptic shaft seal 5, a defoamer 6, a stirring shaft 7, a stirrer 8, an oxygen injection device 9, an oxygen generator 10, a water valve 11, a temperature sensor 12, a feed inlet 13, a pressure gauge 14, a pH sensor 15, a dissolved oxygen sensor 16, an automatic control valve 17, an exhaust pipe 18, a sampling pipe 19, a control switch valve 20, a cooling water inlet pipe 21, a discharge pipe valve 22, a discharge pipe 23, a cooling water outlet pipe 24, a fixing frame 25, a control device 26, a liquid crystal display screen 27, an electric heating switch 28, a temperature setting knob 29, an oxygen generator control knob 30 and a motor rotating speed control knob 31.
The tank body 1 is cylindrical, the surface of the inner tank body is subjected to mirror polishing, process openings of the inlet and outlet pipe orifices and welding positions of the inner tank body are in arc transition, the tank body is smooth and easy to clean, no dead angle exists, and reliability and stability of the production process are guaranteed.
The heating pipe 2 is rectangular in cross section and arranged on the outer wall of the tank body 1, the rectangular structure is adopted to heat the tank body 1, the heating speed is accelerated, the heat transfer is uniform, the temperature in the tank body 1 is relatively constant, the control and the mastering are easy, the sudden situation caused by insufficient heat energy supply is avoided, the consumption and the utilization of the heat energy are reasonably controlled, and the operation cost is effectively controlled.
The steel jacket 3 is arranged on the outer side of the heating pipe 2 and is a closed container, circulating cooling water is filled in the steel jacket, the cooling water enters the pipe 21 through the cooling water and enters the pipe through the water valve 11, the water valve 11 controls the flow of the inlet water, and the circulating water is heated and is conveyed out through the cooling water outlet pipe 24 during working.
The motor 4 is connected with the stirring shaft 7, the stirring shaft 7 is arranged in the tank body 1, the defoamer 6 is arranged at the upper end of the stirring shaft 7, and the plurality of stirrers 8 are arranged on the stirring shaft 7. The invention realizes the uniform mixing of the strains, improves the fermentation rate, improves the influence of temperature, pressure and the like on the fermentation process in the fermentation process, and ensures the stable operation of the fermentation process.
The aseptic shaft seal 5 is arranged in the gap of the joint part of the top of the tank body 1 and the stirring shaft 7. The sterile shaft seal 5 can effectively control the breeding condition of microorganisms and bacteria in the tank body 1, and is beneficial to improving the fermentation effect.
The oxygen injection device 9 is arranged at the inner bottom of the tank body 1, and a plurality of spray holes are arranged on the oxygen injection device 9 and communicated with an oxygen generator 10 outside the tank body 1 through a pipeline.
The temperature sensor 12, the PH sensor 15 and the dissolved oxygen sensor 16 are embedded on the side wall inside the tank body 1, the temperature sensor 12, the PH sensor 15, the dissolved oxygen sensor 16, the electric heating switch 28, the temperature setting knob 29, the oxygenerator control knob 30, the motor rotating speed control knob 31 and the connection control device 26 are connected, the control device 26 is connected with the liquid crystal display screen 27, the temperature setting knob 29 and the motor rotating speed control knob 31 are set to required temperature and rotating speed, the dissolved oxygen sensor 16, the temperature sensor 12 and the PH sensor 15 collect the information inside the tank body 1 in time, and then transferred to the intelligent information analysis control device 26 composed of microprocessor, memory and controller, after analysis and comparison with the set information, the control device 26 controls the rotation speed of the motor 4 and whether the heating tube 2 is heated, and the corresponding PH value and dissolved oxygen content value are displayed on the liquid crystal display 27.
The feed inlet 13 is arranged at the upper end of the tank body 1, and fermentation materials enter the tank body 1 from the feed inlet 13.
The pressure gauge 14 is arranged at the upper end of the tank body 1, the pressure gauge 14 observes the pressure in the tank body, the automatic control valve 17 automatically controls the pressure in the tank body, when the pressure in the tank body 1 increases and exceeds the specified working pressure, the automatic control valve 17 is opened, the air is discharged through the exhaust pipe 18, the pressure in the tank body 1 does not exceed the working pressure all the time, and meanwhile, the waste gas generated in the fermentation process is discharged through the exhaust pipe 18, so that the fermentation process is facilitated.
The sampling tube 19 locate jar body 1 side upper portion, and the lower extreme of sampling tube 19 is pegged graft in jar body 1, sets up control switch valve 20 on the sampling tube 19, the pipeline of sampling tube 19 in jar body 1 is the position that 1/2 jar body 1 should be surpassed to the lower extreme.
The discharging pipe valve 22 and the discharging pipe 23 are arranged at the lower end outside the tank body 1, the upper end of the discharging pipe valve 22 is connected with the lower end of the tank body 1 through a pipeline, and the lower end of the discharging pipe valve is connected with the discharging pipe 23.
The fixing frame 25 is arranged at the bottom of the tank body 1 and the steel sleeve 3.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical scope of the present invention, and equivalents and modifications of the technical solutions and inventive concepts thereof should be covered by the scope of the present invention.

Claims (7)

1. Novel intelligent microbial fermentation device, which is characterized by comprising a tank body (1), a heating pipe (2), a steel sleeve (3), a motor (4), a sterile shaft seal (5), a defoamer (6), a stirring shaft (7), a stirrer (8), an oxygen injection device (9), an oxygen generator (10), a water valve (11), a temperature sensor (12), a feeding hole (13), a pressure gauge (14), a PH sensor (15), a dissolved oxygen sensor (16), an automatic control valve (17), an exhaust pipe (18), a sampling pipe (19), a control switch valve (20), a cooling water inlet pipe (21), a discharging pipe valve (22), a discharging pipe (23), a cooling water outlet pipe (24), a fixing frame (25), a control device (26), a liquid crystal display screen (27), an electric heating switch (28), a temperature setting knob (29), an oxygen generator control knob (30), A motor rotation speed control knob (31).
2. The novel intelligent microbial fermentation device of claim 1, wherein: the fermentation tank body (1) is cylindrical, the surface of the inner tank body is subjected to mirror polishing, and the process openings of the inlet and outlet pipe orifices and the welding part of the inner tank body (1) are in circular arc transition, so that the fermentation tank body is smooth and easy to clean and has no dead angle.
3. The novel intelligent microbial fermentation device of claim 1, wherein: the cross section of the heating pipe (2) is rectangular, the heating pipe is arranged on the outer wall of the tank body (1), the tank body (1) is heated by adopting a rectangular structural form, the heating speed is accelerated, and the heat transfer is uniform.
4. The novel intelligent microbial fermentation device of claim 1, wherein: steel bushing (3) locate the outside of heating pipe (2), for closed container, the built-in recirculated cooling water that has, cooling water advances pipe (21) through cooling water to get into through water valve (11), the flow of intaking is controlled to water valve (11), the during operation circulating water is heated and is carried away through cooling water exit tube (24).
5. The novel intelligent microbial fermentation device of claim 1, wherein: the motor (4) is connected with the stirring shaft (7), the stirring shaft (7) is arranged in the tank body (1), the defoamer (6) is arranged at the upper end of the stirring shaft (7), and the plurality of stirrers (8) are arranged on the stirring shaft (7).
6. The novel intelligent microbial fermentation device of claim 1, wherein: the oxygen injection device (9) is arranged at the inner bottom of the tank body (1), and a plurality of spray holes are arranged on the oxygen injection device (9) and communicated with an oxygen generator (10) outside the tank body (1) through a pipeline.
7. The novel intelligent microbial fermentation device of claim 1, wherein: the temperature sensor (12), the PH sensor (15), the dissolved oxygen sensor (16) are embedded on the side wall inside the tank body (1), the temperature sensor (12), the PH sensor (15), the dissolved oxygen sensor (16), the electric heating switch (28), the temperature setting knob (29), the oxygenerator control knob (30), the motor rotating speed control knob (31) and the connection control device (26), the control device (26) is connected with the liquid crystal display screen (27), the temperature setting knob (29) and the motor rotating speed control knob (31) set required temperature and rotating speed, the dissolved oxygen sensor (16), the temperature sensor (12) and the PH sensor (15) timely collect information inside the tank body (1) and transmit the information to the microprocessor, the memory, the intelligent information analysis control device (26) formed by the controller is analyzed and compared with the set information, the control device (26) controls the rotation speed of the motor (4) and whether the heating pipe (2) is heated, and the corresponding PH value and the dissolved oxygen content value are displayed on the liquid crystal display screen (27).
CN201810693353.2A 2018-06-29 2018-06-29 Novel intelligent microbial fermentation device Pending CN110656044A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810693353.2A CN110656044A (en) 2018-06-29 2018-06-29 Novel intelligent microbial fermentation device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810693353.2A CN110656044A (en) 2018-06-29 2018-06-29 Novel intelligent microbial fermentation device

Publications (1)

Publication Number Publication Date
CN110656044A true CN110656044A (en) 2020-01-07

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CN201810693353.2A Pending CN110656044A (en) 2018-06-29 2018-06-29 Novel intelligent microbial fermentation device

Country Status (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022031452A1 (en) * 2020-08-06 2022-02-10 Sanofi Systems and methods for controlling oxygen levels

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022031452A1 (en) * 2020-08-06 2022-02-10 Sanofi Systems and methods for controlling oxygen levels

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