CN208414406U - A kind of bioreactor - Google Patents
A kind of bioreactor Download PDFInfo
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- CN208414406U CN208414406U CN201820566291.4U CN201820566291U CN208414406U CN 208414406 U CN208414406 U CN 208414406U CN 201820566291 U CN201820566291 U CN 201820566291U CN 208414406 U CN208414406 U CN 208414406U
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- Prior art keywords
- jet pipe
- tank body
- stirrer paddle
- agitating shaft
- bioreactor
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Abstract
The utility model discloses a kind of bioreactors, the bioreactor includes tank body, the feeder that the intracorporal stirrer paddle of the tank is arranged in, connect with the tank body, provides the power device of power to the stirrer paddle, and is arranged in the intracorporal air and liquid mixer of the tank；Wherein, the stirrer paddle interval is mounted on the agitating shaft among the tank body, and one end of the agitating shaft is stretched out the tank body and connect with the power device；The air and liquid mixer includes the steam line that ring is located at the tank body inner sidewall and connect with the feeder.The bioreactor of the utility model can mix to the greatest extent the oxygen in air with feed liquid, facilitate thallus or cell rapidly and uniformly dissolves and absorbs, improve the dissolved oxygen rate of feed liquid, increase substantially fermentation index, improve the amount of product.Meanwhile so that reaction dead angle is not present in entire reactor.
Description
Technical field
The utility model relates to a kind of bioreactors.
Background technique
At present during biology aerobic ferments, as amino acid, organic acid, antibiotic, enzyme preparation product, glycitols produce
Product etc. are all to belong to liquid deep layer aerobic fermentation.During aerobic fermentation production, in order to enable thallus to obtain sufficiently
Aerobic respiration, so that thallus is obtained sufficient oxygen and nutritional ingredient, to reach the speed of growth for improving thallus, obtain high quality
Biological product purpose.
In addition, in the use process of specific fermentor, for obtain concentration more evenly, preferably heat transfer, mass transfer and
Mixed effect is typically employed on reactor wall and baffle is arranged, to prevent Maelstrom and increase fluid sinuous flow degree.It passes
There is air to be unevenly distributed for the bioreactor of system, stirs dead angle so that oxygen and bacterium material cannot be fully absorbed and causes dissolved oxygen
Insufficient defect is also unfavorable for the progress of cleaning to influence product quality and production efficiency.
In conclusion traditional bioreactor in structure there are clearly disadvantageous, can only be given by a point
The oxygen in air, can not be evenly distributed in the fermentation liquid of fermentor by gas supply in bioreactor, and especially major diameter is sent out
Fermentation tank, there are stirring dead angles, prevent oxygen and thallus feed liquid thallus from sufficiently merging, cause the insufficient defect of dissolved oxygen.
Utility model content
It is molten to solve existing bioreactor the purpose of this utility model is to provide a kind of bioreactor
Oxygen amount is insufficient, haves the defects that react dead angle.
To achieve the above object, a kind of bioreactor of the utility model, the bioreactor include tank body, setting exist
The intracorporal stirrer paddle of the tank, the feeder connecting with the tank body, the power for providing power to the stirrer paddle fill
It sets, and is arranged in the intracorporal air and liquid mixer of the tank；
Wherein, the stirrer paddle interval is mounted on the agitating shaft among the tank body, and the one of the agitating shaft
End is stretched out the tank body and is connect with the power device；
The air and liquid mixer includes the steam line that ring is located at the tank body inner sidewall and connect with the feeder,
And multiple nozzles on the steam line are mounted on, the outlet of multiple nozzles and the stirrer paddle are on agitating shaft
Gap it is corresponding.
Preferably, the nozzle includes the first jet pipe, the second jet pipe, third jet pipe and the 4th jet pipe；
The import of 4th jet pipe is placed on the exit of the third jet pipe, the third jet pipe and the 4th spray
Annular gap is equipped between pipe；
The import of the third jet pipe is placed on the exit of second jet pipe, second jet pipe and third spray
Annular gap is equipped between pipe；
The import of second jet pipe is placed on the exit of first jet pipe, first jet pipe and second spray
Annular gap is equipped between pipe, and the import of first jet pipe is connected to the steam line.
Preferably, the stirrer paddle includes the first stirrer paddle, the second stirrer paddle and third stirrer paddle, described
Stirrer paddle includes wheel disc and ring is located at multiple paddle blades on the wheel disc, and the paddle blade is relative to the agitating shaft
The angular range of cross section is within the scope of 8 ° to 12 °.
Preferably, temperature sensor is also equipped on the inner sidewall of the tank body.
Preferably, the lateral wall of the tank body is equipped with liquid level charactron.
Preferably, the agitating shaft stretches out the perforation of the bottom of the tank body, sets between the agitating shaft and the perforation
It is equipped with mechanical seal.
Preferably, the driving device is set as driving motor, and the driving motor is stirred by retarder, shaft coupling with described
Mix axis connection.
Preferably, side wall and the bottom of the tank body is arranged in the steam line.
The utility model has the advantages that
The bioreactor of the utility model can mix to the greatest extent the oxygen in air with feed liquid, facilitate thallus or
Cell rapidly and uniformly dissolves and absorbs, and improves the dissolved oxygen rate of feed liquid, increases substantially fermentation index, improves the amount of product.Together
When, so that there is no reaction dead angles for entire reactor.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model bioreactor.
Fig. 2 is the air and liquid mixer structural schematic diagram of the utility model.
Fig. 3 is the structural schematic diagram of the nozzle of the utility model.
Fig. 4 is the structural schematic diagram of the stirrer paddle of the utility model.
Fig. 5 is the structural schematic diagram of the paddle blade of the utility model.
Specific embodiment
The following examples illustrate the utility model, but is not intended to limit the scope of the present invention.
Specific embodiment of the utility model is described in more detail below.These embodiments are provided to be to be able to more thoroughly
The utility model is understood thoroughly, and the scope of the utility model can be fully disclosed to those skilled in the art.
"comprising" or " comprising " as mentioned throughout the specification and claims are an open language, therefore are answered
It is construed to " including but not limited to ".Specification subsequent descriptions are preferred embodiment of the present invention, so described to retouch
State is being not intended to limit the scope of the utility model for the purpose of the rule of specification.The protection model of the utility model
It encloses as defined by the appended claims.
As depicted in figs. 1 and 2, the utility model provides a kind of bioreactor comprising tank body 100 is arranged in tank body
Stirrer paddle 200 in 100, the feeder 400 connecting with tank body 100 provide the power device of power to stirrer paddle 200
300, and the air and liquid mixer 500 being arranged in tank body 100；Wherein, the interval of stirrer paddle 200 is mounted on tank body 100
On intermediate agitating shaft 240, one end of agitating shaft 240 is stretched out tank body 100 and is connect with power device 300；Air and liquid mixer 500 wraps
The steam line 510 that ring is located at 100 inner sidewall of tank body and connect with feeder 400 is included, and is mounted on steam line 510
Multiple nozzles 520, the outlet of nozzle 520 is corresponding with stirrer paddle 200, specifically, the nozzle 520 of air and liquid mixer go out
It is mouthful opposite with gap of the stirrer paddle 200 between agitating shaft 240, it, just can be when air and liquid mixer 500 sprays feed liquid
It is futher stirred under the action of stirrer paddle 200, oxygen is adequately dissolved into feed liquid, reach molten in feed liquid
Oxygen is in optimum state.
Wherein, as shown in figure 3, the nozzle 520 of the utility model includes the first jet pipe 521, the second jet pipe 522, third spray
Pipe 523 and the 4th jet pipe 524；The import of 4th jet pipe 524 is placed on the exit of third jet pipe 523,523 He of third jet pipe
Annular gap is equipped between 4th jet pipe 524；The import of third jet pipe 523 is placed on the exit of the second jet pipe 522, the second spray
Annular gap is equipped between pipe 522 and third jet pipe 523；The import of second jet pipe 522 is placed on the outlet of the first jet pipe 521
Place is equipped with annular gap, and the import of the first jet pipe 521 and steam line 510 between the first jet pipe 521 and the second jet pipe 522
Connection.After there is air in steam line 510 certain speed to spray into the first jet pipe 521, in the first jet pipe 521 and second
Jet pipe forms negative pressure between 522 annular gap, so that the feed liquid around air and liquid mixer enters second by the annular gap
In jet pipe 522, similarly, between the second jet pipe 522 and third jet pipe 523 and third jet pipe 523 and the 4th jet pipe 524 it
Between form negative pressuren zone, further by the oxygen mix in feed liquid and air, so that the purpose that feed liquid and oxygen mix well, together
When but also feed liquid tank body there is no reaction dead angle, sufficiently feed liquid is operated in tank body.Keep thallus or cell feed liquid past
In multiple circulation, the oxygen in air is rapidly and uniformly dissolved and absorbed with the somatic cells in thallus feed liquid, improves dissolved oxygen rate, greatly
Amplitude improves fermentation index and effectively increases tinning coefficient, increases substantially yield.
As disposable embodiment, the first jet pipe 521, the second jet pipe 522, third jet pipe 523 and the 4th jet pipe
524 shape is bell mouth shape, and the jet pipe of the shape is more conducive to the mixing of gas-liquid.
Specifically, as shown in Figure 4 and Figure 5, the stirrer paddle of the utility model is stirred including the first stirrer paddle 210, second
Blade 220 and third stirrer paddle 230 are mixed, stirrer paddle 200 is located at multiple on 212 disks of wheel including wheel disc 212 and ring
Paddle blade 211, paddle blade 211 relative to the cross section of agitating shaft 240 angular range within the scope of 8 ° to 12 °.Paddle blade 211
In the angular range, optimal rolling severe degree can be obtained, so that the mixing of feed liquid is more uniform and abundant, to make
Reaction solution is obtained adequately to mix with oxygen.
It is also equipped with temperature sensor 600 on the inner sidewall of tank body 100, it is intracorporal bioreactor tank can be detected constantly
Temperature, by the temperature of monitoring, real-time control the temperature conditions of tank interior, facilitate extraneous staff to related in tank body
The control of temperature.In addition, the lateral wall of tank body 100 is equipped with liquid level charactron 120, exist for detecting the intracorporal reaction material liquid of tank
The intracorporal liquid level of tank.
The agitating shaft 240 of the utility model stretches out the perforation of the bottom of tank body 100, is arranged between agitating shaft 240 and perforation
There is mechanical seal.Power device 300 is set as driving motor, and driving motor passes through retarder, shaft coupling and stirring axis connection.In tank
Power device is arranged in 100 bottom of body, and the stable structure of bioreactor is reliable, is applicable to large-scale culture cell, and can be real
Existing good mixing and mass transfer effect.
Preferably, side wall and the bottom of tank body is arranged in steam line 500, air and liquid mixer 500 can be distributed in tank body
On 100 side walls and the steam line of bottom, in this way in the different depth of tank body, different location is provided with air mixer, fills
That divides mixes the oxygen of air with feed liquid, facilitates the growth of thallus or cell, improves dissolved oxygen amount, improves the production of culture
Amount.
Although above having made detailed description to the utility model with generality explanation and specific embodiment,
On the basis of the utility model, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements on the basis of without departing from the spirit of the present invention, belong to the utility model and want
Seek the range of protection.
Claims (8)
1. a kind of bioreactor, which is characterized in that the bioreactor includes tank body, is arranged in the intracorporal stirring of the tank
Blade the feeder connecting with the tank body, provides the power device of power to the stirrer paddle, and is arranged described
The intracorporal air and liquid mixer of tank；
Wherein, the stirrer paddle interval is mounted on the agitating shaft among the tank body, and one end of the agitating shaft is stretched
The tank body is connect with the power device out；
The air and liquid mixer includes the steam line that ring is located at the tank body inner sidewall and connect with the feeder, and
Between the multiple nozzles being mounted on the steam line, the outlet of multiple nozzles and the stirrer paddle are on agitating shaft
Gap is corresponding.
2. bioreactor according to claim 1, which is characterized in that
The nozzle includes the first jet pipe, the second jet pipe, third jet pipe and the 4th jet pipe；
The import of 4th jet pipe is placed on the exit of the third jet pipe, the third jet pipe and the 4th jet pipe it
Between be equipped with annular gap；
The import of the third jet pipe is placed on the exit of second jet pipe, second jet pipe and the third jet pipe it
Between be equipped with annular gap；
The import of second jet pipe is placed on the exit of first jet pipe, first jet pipe and second jet pipe it
Between be equipped with annular gap, and the import of first jet pipe is connected to the steam line.
3. bioreactor according to claim 1, which is characterized in that
The stirrer paddle includes the first stirrer paddle, the second stirrer paddle and third stirrer paddle, the stirrer paddle packet
It includes wheel disc and ring is located at multiple paddle blades on the wheel disc, folder of the paddle blade relative to the cross section of the agitating shaft
Angular region is within the scope of 8 ° to 12 °.
4. bioreactor according to claim 1, which is characterized in that
Temperature sensor is also equipped on the inner sidewall of the tank body.
5. bioreactor according to claim 1, which is characterized in that
The lateral wall of the tank body is equipped with liquid level charactron.
6. bioreactor according to claim 1, which is characterized in that
The agitating shaft stretches out the perforation of the bottom of the tank body, is provided between the agitating shaft and the perforation mechanical close
Envelope.
7. bioreactor according to claim 1, which is characterized in that
The power device is set as driving motor, and the driving motor passes through retarder, shaft coupling and the stirring axis connection.
8. bioreactor according to claim 1, which is characterized in that
Side wall and the bottom of the tank body is arranged in the steam line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820566291.4U CN208414406U (en) | 2018-04-19 | 2018-04-19 | A kind of bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820566291.4U CN208414406U (en) | 2018-04-19 | 2018-04-19 | A kind of bioreactor |
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| Publication Number | Publication Date |
|---|---|
| CN208414406U true CN208414406U (en) | 2019-01-22 |
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ID=65119933
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820566291.4U Active CN208414406U (en) | 2018-04-19 | 2018-04-19 | A kind of bioreactor |
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| CN (1) | CN208414406U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113201441A (en) * | 2021-06-10 | 2021-08-03 | 江苏丰泽生物工程设备制造有限公司 | Fermentation tank with air energy structure and capable of enhancing dissolved oxygen effect and use method of fermentation tank |
-
2018
- 2018-04-19 CN CN201820566291.4U patent/CN208414406U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113201441A (en) * | 2021-06-10 | 2021-08-03 | 江苏丰泽生物工程设备制造有限公司 | Fermentation tank with air energy structure and capable of enhancing dissolved oxygen effect and use method of fermentation tank |
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