CN217628345U - Microbial high-density fermentation metering feed supplement distribution system - Google Patents
Microbial high-density fermentation metering feed supplement distribution system Download PDFInfo
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- CN217628345U CN217628345U CN202221584192.1U CN202221584192U CN217628345U CN 217628345 U CN217628345 U CN 217628345U CN 202221584192 U CN202221584192 U CN 202221584192U CN 217628345 U CN217628345 U CN 217628345U
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Abstract
The utility model relates to a little high density fermentation measurement feed supplement distribution system, it includes feed supplement system, measurement system, fermentation cylinder, first steam supply system, air supply system and second steam supply system, the feed supplement system pass through the feed supplement pipeline with the measurement system is connected, the measurement system passes through feed supplement pipeline two and fermentation cylinder sub-unit connection, first steam supply system and air supply system pass through pipeline and fermentation cylinder sub-unit connection, the second steam supply system passes through pipeline and feed supplement pipeline connection; the utility model discloses be fit for the large-scale fermentation system of microorganism high density fermentation, the flexibility is high, is fit for different feed supplement feed liquids, satisfies control demands such as ration feed supplement, continuous measurement feed supplement, permanent PH control, simple structure, disposable small investment, and it is simple and convenient to maintain.
Description
Technical Field
The utility model belongs to the technical field of microorganism fermentation equipment technique and specifically relates to a microorganism high density fermentation measurement feed supplement distribution system.
Background
In recent years, recombinant DNA technology is widely applied, products originally produced by non-microorganisms can be produced by microorganisms through the recombinant DNA technology, the recombinant DNA technology is widely applied to the aspects of medicine, agriculture, industry and the like, the combination process of the recombinant DNA technology and large-scale culture is accelerated, and a lot of products which cannot be obtained in large quantity can be produced in large quantity, so that the recombinant DNA technology is applied to various products. The high-density culture technology is adopted to improve the fermentation density of microbial cells and finally improve the specific productivity of products, so that the culture volume can be reduced, the downstream separation and extraction can be enhanced, the production period can be shortened, the equipment investment can be reduced, the production cost can be reduced, and the competitiveness of products on the market can be greatly improved, thereby becoming an important direction for the development of the fermentation industry in recent years. The key technology of the high-density fermentation production of the microorganisms is a feed supplement system, and the substrate concentration is kept at a lower level by supplementing nutrient substances, so that the accumulation of byproducts is effectively inhibited, and the expression efficiency of the products is improved.
Most of the existing feed supplementing systems open pores at different positions of the top of the fermentation tank and supplement different feed supplementing liquid, wherein the feed supplementing systems are not suitable for high-density fermentation due to a plurality of designs, and if the feed supplementing liquid is supplemented, the supplemented feed liquid can be suspended on foam due to the phenomenon of foam generated in the fermentation process in the tank body, so that the effect cannot be timely generated, and the condition of foam overflow is generated; when some nutrient substances are supplemented, the nutrient substances cannot reach the fermentation tank in time and are uniformly distributed to provide nutrition for the microorganisms, and some byproducts or inhibitors are generated.
For example, chinese patent No. CN212316093U discloses a liquid deep fermentation feeding system, which adds a feed liquid distributor placed between two layers of stirring, and a pipeline and a valve in the fermentation tank to shorten the mixing time of the feeding liquid and the culture medium, but when the feeding liquid amount of the feeding system is small, the feeding liquid cannot pass through the openings of the distributor through a feed liquid distributor under the pressure of the liquid in the fermentation tank, the feeding liquid only flows out from the opening at the near end, and the opening at the far end cannot achieve the distribution effect, so it is urgently needed to provide a high-density fermentation metering feeding distribution system which can be rapidly and uniformly mixed, cannot generate an inhibitor affecting the cell growth and the product expression, and improves the expression level of the final product.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem that a microorganism high density fermentation measurement feed supplement distribution system is provided, makes the rapid misce bene of feed liquid, prevents to produce the inhibitor that influences cell growth and result expression.
In order to solve the above problems, the utility model adopts the following technical proposal:
a microbial high-density fermentation metering feed distribution system comprises a feed system, a metering system, a fermentation tank, a first steam supply system, an air supply system and a second steam supply system, wherein the feed system is connected with the metering system through a feed pipeline, the metering system is connected with the lower part of the fermentation tank through a feed pipeline II, the first steam supply system and the air supply system are connected with the lower part of the fermentation tank through pipelines, and the second steam supply system is connected with the feed pipeline through a pipeline;
the fermentation cylinder is including a jar body, set up at the internal bottom of jar air distributor subassembly, set up and be used for making feed liquid homodisperse's toper feed supplement distributor subassembly and set up the rabbling mechanism at jar internal on air distributor subassembly upper portion, the air distributor subassembly with first steam supply system and air supply system connect, toper feed supplement distributor subassembly with feed supplement headtotail.
As an embodiment of the present invention, the conical feeding distributor component comprises a feeding distributor connected to the feeding system and a plurality of first bellmouths obliquely arranged on the feeding distributor;
the air distributor assembly comprises an annular distributor connected with an air supply system and a plurality of horn mouths II which are obliquely arranged on the annular distributor upwards, wherein the number of the horn mouths I corresponds to the number of the horn mouths II and the horn mouths II face to the same direction.
As an embodiment of the utility model, it is a plurality of be provided with through-hole one on the horn mouth lateral wall, be provided with a plurality ofly on the feed liquid distributor through-hole two, through-hole one with through-hole two correspond fixed intercommunication.
As an embodiment of the utility model, the stirring mechanism includes vertical setting (mixing) shaft in the fermentation tank, set up at the stirring rake on (mixing) shaft upper portion, set up in the (mixing) shaft bottom and be located the disc stirring rake of toper distributing device top and drive its rotatory gear motor.
As an embodiment of the utility model, the feed supplement system includes the feed supplement jar more than 3 at least, be provided with corresponding first pneumatic diaphragm valve and ejection of compact valve on the feed supplement pipeline that feed supplement jar and measurement system are connected.
As an embodiment of the utility model, the measurement system include with the corresponding quantity's of feed supplement jar metering cup, still be provided with between metering cup and the fermentation cylinder and be used for making the unanimous balanced pipeline of interior external pressure.
As an embodiment of the utility model, the measuring cup top is provided with ultrasonic wave level sensor.
As an embodiment of the utility model, still be provided with the sight glass that is used for surveing the feed liquid feeding condition on the measuring cup.
As an implementation mode of the utility model, the first horn mouth is arranged on the feed liquid distributor to be 3-6.
As an implementation mode of the utility model, the first pneumatic diaphragm valve with ultrasonic wave level sensor is connected with the fermentation autonomous system for realize automatic control.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in: in the fermentation process, sterile air of the fermentation tank is blown into the conical feed supplement distributor component through the air distributor component, the air blows a fermentation culture medium around the conical feed supplement distributor component to enter the feed liquid distributor to be mixed with the feed supplement feed liquid, an opening at the bottom of the conical feed supplement distributor component is stirred towards the stirring mechanism, and the feed supplement feed liquid can be rapidly mixed with the fermentation culture medium under the stirring effect; the utility model discloses simultaneously for the microorganism provides required oxygen, nutrients, rapid misce bene such as defoaming agent, can not produce the inhibitor that influences cell growth and result expression because of lacking dissolved oxygen and feed supplement liquid, relatively original feed supplement system final products expression level improves 10-20% in actual production, reduces more than 20% defoaming agent use amount in feed supplement batch fermentation production, has reduced batch production cost, has high using value in large-scale microorganism high density fermentation.
The utility model discloses be fit for the large-scale fermentation system of microorganism high density fermentation, the flexibility is high, is fit for different feed supplement feed liquids, satisfies control demands such as ration feed supplement, continuous measurement feed supplement, permanent PH control, simple structure, disposable small investment, and it is simple and convenient to maintain.
Drawings
Fig. 1 is a process flow diagram of an embodiment of the invention.
FIG. 2 is a schematic view of a part of the interior of a fermentation tank according to an embodiment of the present invention.
Wherein: 1 fermentation tank, 1-1 tank body, 2 alkali feed supplement storage tank, 3 acid feed supplement storage tank, 4 carbon source feed supplement storage tank, 5 defoaming feed supplement storage tank, 6 defoaming measuring cup, 7 carbon source measuring cup, 8 acid supplement measuring cup, 9 alkali supplement measuring cup, 10 ultrasonic liquid level sensor, 14 first pneumatic diaphragm valve, 18 second pneumatic diaphragm valve, 22 horn mouth two, 23 horn mouth one, 24 disc stirring paddle, 25 stirring paddle, 26 manual diaphragm valve, 27 blowdown valve, 28 discharge valve, 29 steam valve, 30 observation mirror, 31 stirring shaft, 32 gear motor, 35 feed supplement pipeline two, 36 alkali feed supplement pipeline, 37 acid feed supplement pipeline, 38 carbon source feed supplement pipeline, 39 defoaming feed supplement pipeline, 40 feed liquid distributor, 41 annular distributor, 42 supply valve, 44 balance pipeline, 45 balance pipeline manual diaphragm valve.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the following description of the present invention with reference to specific embodiments is given for clarity and completeness.
As shown in fig. 1, the utility model provides a microbial high-density fermentation measurement feed supplement distribution system, it includes feed supplement system, measurement system, fermentation cylinder 1, first steam supply system, air supply system and second steam supply system, the feed supplement system passes through feed supplement pipeline and is connected with the measurement system, the measurement system passes through feed supplement pipeline two 35 and fermentation cylinder 1 lower part connection, first steam supply system and air supply system pass through pipeline and fermentation cylinder 1 lower part connection, the second steam supply system passes through pipeline and feed supplement pipeline connection; further, the material supplementing system comprises at least more than 3 material supplementing tanks, and corresponding first pneumatic diaphragm valves 14 and discharge valves 28 are arranged on material supplementing pipelines connected with the metering system.
In this embodiment, the feed supplement system includes 4 feed supplement jars, is alkali feed supplement storage tank 2, acid feed supplement storage tank 3, carbon source feed supplement storage tank 4, defoaming feed supplement storage tank 5 respectively, 2 bottoms of alkali feed supplement storage tank are connected with 9 tops of alkali feed supplement measuring cup through alkali feed supplement pipeline 36, acid feed supplement storage tank 3 is connected with 8 tops of acid supplement measuring cup through acid feed supplement pipeline 37, carbon source feed supplement storage tank 4 is connected with 7 tops of carbon source measuring cup through carbon source feed supplement pipeline 38, defoaming feed supplement storage tank 5 is connected with 6 tops of defoaming measuring cup through defoaming feed supplement pipeline 39.
As shown in FIG. 1, the metering system comprises a corresponding number of metering cups to the feed tank, and a balance pipeline 44 for making the internal and external pressures consistent is arranged between the metering cups and the fermentation tank 1. In this embodiment, the number of the measuring cups is 4, the measuring cups are a defoaming measuring cup 6, a carbon source measuring cup 7, an acid supplement measuring cup 8 and an alkali supplement measuring cup 9, a balancing pipeline manual diaphragm valve 45 is arranged on the balancing pipeline 44, one end of the balancing pipeline 44 is arranged at the top end of the fermentation tank 1, the other end of the balancing pipeline is connected with the 4 measuring cups, and a through hole is arranged on one section of the balancing pipeline in the measuring cups, so that the pressure in the measuring cups is consistent with the pressure in the fermentation tank 1, and the material liquid flows down smoothly; the bottom ends of the 4 metering cups are respectively connected with the upper end of the fermentation tank 1 through a second pneumatic diaphragm valve 18 and a second feeding pipeline 35, and a sewage discharge valve 27 is further arranged on the second feeding pipeline 35.
Furthermore, still be provided with the sight glass 30 that is used for surveing the feed liquid feeding condition on the measuring cup, can observe the feed liquid condition in the measuring cup at any time through setting up sight glass 30, convenient operation.
4 the measuring cup top is provided with ultrasonic wave level sensor 10, first pneumatic diaphragm valve 14 with ultrasonic wave level sensor 10 is connected with the fermentation autonomous system for realize automatic control, through set up the feed liquid level height in the ultrasonic wave level sensor 10 monitors the measuring cup on the top, when reaching certain height, can control opening and closing of first pneumatic diaphragm valve 14 through ultrasonic wave level sensor 10, be used for controlling the addition of feed liquid, thereby realize the automatic control fermentation system.
As shown in fig. 1 and 2, the fermentation tank 1 comprises a tank body 1-1, an air distributor assembly arranged at the bottom inside the tank body 1-1, a conical feed supplement distributor assembly arranged at the upper part of the air distributor assembly for uniformly dispersing feed liquid, and a stirring mechanism arranged inside the tank body 1-1, wherein the air distributor assembly is connected with the first steam supply system and the air supply system, and the conical feed supplement distributor assembly is connected with the feed supplement system. In the present embodiment, the air distributor assembly includes an annular distributor 41 connected to the air supply system, and a plurality of bell mouths two 22 obliquely arranged upward on the annular distributor 41; the conical feed supplement distributor assembly comprises a feed liquid distributor 40 connected with a feed supplement system and a plurality of first bellmouths 23 arranged on the feed liquid distributor 40 in a downward inclined mode, wherein the first bellmouths 23 and the second bellmouths 22 are corresponding in quantity and are arranged in the same direction. Specifically, the number of the first bell mouths 23 and the number of the second bell mouths 22 are 3-6, and are uniformly 4 in the embodiment, and the number of the first bell mouths 23 is 1-2 times larger than that of the second bell mouths 22. Of course, the end with the larger diameter of the second bell mouth 22 is communicated with the annular distributor 41, and the end with the smaller diameter of the first bell mouth 23 is communicated with the feed liquid distributor 40. The feed liquid distributor 40 and the ring distributor 41 are respectively supported in the fermentation tank 1 by supports with different heights.
Furthermore, it is a plurality of be provided with through-hole one on the bellmouth 23 lateral wall, be provided with a plurality ofly on the feed liquid distributor 40 through-hole two, through-hole one with through-hole two corresponds fixed intercommunication. The utility model discloses a set up through-hole one and through-hole two, can make even dispersion come out in feed liquid distributor 40 of feed liquid, and set up horn mouth one 23 then to make the feed liquid flow down through the dispersion of horn mouth one 23, air supply system is through blowing in the air to annular distributor 41, mutually support through horn mouth one 23 and horn mouth two 22, make the air blown in toper feed supplement distributor subassembly, the air blows the fermentation medium around the toper feed supplement distributor subassembly and advances into feed liquid distributor 40 and feed supplement feed liquid mixture.
As shown in fig. 2, the stirring mechanism comprises a stirring shaft 31 vertically arranged in the fermentation tank 1, a stirring paddle 25 arranged on the upper part of the stirring shaft 31, a disc stirring paddle 24 arranged at the bottom end of the stirring shaft 31 and positioned above the conical distributor assembly, and a speed reduction motor 32 for driving the stirring shaft to rotate. In the embodiment, the bottom opening of the conical feed supplement distributor component faces to the stirring mechanism, and feed supplement liquid can be rapidly mixed with the fermentation medium under the stirring action; through setting up disc stirring rake 24, enable feed supplement feed liquid and fermentation medium mixture more evenly.
The specific working principle is as follows: before carrying out high-density fermentation of microorganisms, sterilizing a fermentation tank 1 and pipelines thereof, otherwise seriously affecting the quality of products, closing an air supply system when the fermentation tank 1 sterilizes an air distributor component, starting a first steam supply system, opening a supply valve 42, sequentially checking and closing a discharge valve 28 and sequentially opening a steam valve 29 when the fermentation tank 1 and a supplementary material metering and distributing system are sterilized, opening a first pneumatic diaphragm valve 14 and a second pneumatic diaphragm valve 18 in the fermentation system, opening a drain valve 27 to discharge condensed water, closing the drain valve 27 to one third, opening a manual diaphragm valve 26 to sterilize the conical supplementary material distributor component in the fermentation tank 1, opening a balance pipeline manual diaphragm valve 45, sterilizing the material supplementing system for 30 minutes, closing 27,4 second pneumatic diaphragm valves 18, 4 first pneumatic diaphragm valves 14, a steam valve 29 and a first steam supply system in sequence after the sterilization is finished, opening the air supply system to introduce air into the fermentation tank 1, opening 4 discharge valves 28 to wait for material supplementing, controlling 4 first pneumatic diaphragm valves 14 to be opened by an ultrasonic liquid level sensor 10 when the fermentation tank 1 needs material supplementing, enabling each feed liquid to enter a corresponding metering cup, controlling 4 first pneumatic diaphragm valves 14 to be closed by the ultrasonic liquid level sensor 10 when a specified liquid level is reached, connecting 4 second pneumatic diaphragm valves 18 with the fermentation automatic control system, and opening the second pneumatic diaphragm valves 18 at intervals to supplement and meter when the material supplementing is needed.
When the feeding system needs to be sterilized independently, the 4 discharge valves 28 are closed, the corresponding steam valve 29 is opened, the corresponding first pneumatic diaphragm valve 14 and the corresponding second pneumatic diaphragm valve 18 are opened in the fermentation system, and after the drain valve 27 is opened to drain the condensed water, the drain valve 27 is not adjusted, and the feeding system is sterilized for 30 minutes.
In this embodiment, after sterilization, two thirds of the fermentation medium is introduced into the fermentation tank 1 in advance, then air is blown out through the second bell mouth 22 in the air distributor component, 4 kinds of feed liquid are uniformly blown out through the first bell mouth 23 on the conical feeder component after being mixed, the air blows the pre-stored fermentation medium into the feed liquid distributor to be mixed with the feed liquid, then the disc stirring paddle 24 works, and the feed liquid can be rapidly mixed with the fermentation medium under the stirring effect; the utility model discloses simultaneously for the microorganism provides required oxygen, nutrients, rapid misce bene such as defoaming agent, can not produce the inhibitor that influences cell growth and result expression because of lacking dissolved oxygen and feed supplement liquid, relatively original feed supplement system final products expression level improves 10-20% in actual production, reduces more than 20% defoaming agent use amount in feed supplement batch fermentation production, has reduced batch production cost, has high using value in large-scale microorganism high density fermentation.
Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art may still modify the technical solutions described in the foregoing embodiments, or may substitute some technical features of the foregoing embodiments; such modifications and substitutions do not depart from the spirit and scope of the embodiments of the present invention.
Claims (10)
1. A microbial high-density fermentation measurement feed supplement distribution system which characterized in that: the system comprises a feeding system, a metering system, a fermentation tank, a first steam supply system, an air supply system and a second steam supply system, wherein the feeding system is connected with the metering system through a feeding pipeline, the metering system is connected with the lower part of the fermentation tank through a feeding pipeline II, the first steam supply system and the air supply system are connected with the lower part of the fermentation tank through pipelines, and the second steam supply system is connected with the feeding pipeline through a pipeline;
the fermentation cylinder is including a jar body, set up at the internal bottom of jar air distributor subassembly, set up and be used for making feed liquid homodisperse's toper feed supplement distributor subassembly and set up the rabbling mechanism at jar internal on air distributor subassembly upper portion, the air distributor subassembly with first steam supply system and air supply system connect, toper feed supplement distributor subassembly with feed supplement headtotail.
2. The microbial high-density fermentation metering feeding and distributing system of claim 1, wherein: the conical feed supplement distributor assembly comprises a feed liquid distributor connected with a feed supplement system and a plurality of first horn mouths obliquely arranged on the feed liquid distributor;
the air distributor assembly comprises an annular distributor connected with an air supply system and a plurality of horn mouths II which are obliquely arranged on the annular distributor upwards, wherein the number of the horn mouths I corresponds to that of the horn mouths II and the horn mouths I and the horn mouths II are arranged in the same direction.
3. The metering and feeding system for the high-density fermentation of microorganisms as claimed in claim 2, wherein: a plurality of through holes I are formed in the side wall of the first horn mouth, a plurality of through holes II are formed in the feed liquid distributor, and the through holes I and the through holes II correspond to each other and are fixedly communicated.
4. The microbial high-density fermentation metering feeding and distributing system of claim 1, wherein: the stirring mechanism comprises a stirring shaft vertically arranged in the fermentation tank, a stirring paddle arranged on the upper part of the stirring shaft, a disc stirring paddle arranged at the bottom end of the stirring shaft and positioned above the conical distributing device, and a speed reduction motor driving the disc stirring paddle to rotate.
5. The microbial high-density fermentation metering feeding and distributing system of claim 1, wherein: the material supplementing system comprises at least more than 3 material supplementing tanks, and corresponding first pneumatic diaphragm valves and discharge valves are arranged on material supplementing pipelines connected with the metering system.
6. The microbial high-density fermentation metering feeding and distributing system of claim 5, wherein: the metering system comprises metering cups with the number corresponding to that of the feed supplementing tank, and a balance pipeline for enabling the internal and external pressures to be consistent is further arranged between the metering cups and the fermentation tank.
7. The metering and feeding system for the high-density fermentation of microorganisms, according to claim 6, wherein: and an ultrasonic liquid level sensor is arranged at the top end of the metering cup.
8. The microbial high-density fermentation metering feeding and distributing system of claim 7, wherein: and the measuring cup is also provided with an observation mirror for observing the feeding condition of the feed liquid.
9. The microbial high-density fermentation metering feed distribution system of claim 3, wherein: the number of the first bell mouths is 3-6 on the feed liquid distributor.
10. The microbial high-density fermentation metering feeding and distributing system of claim 7, wherein: the first pneumatic diaphragm valve and the ultrasonic liquid level sensor are connected with a fermentation automatic control system and used for realizing automatic control.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202221584192.1U CN217628345U (en) | 2022-06-23 | 2022-06-23 | Microbial high-density fermentation metering feed supplement distribution system |
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| CN202221584192.1U CN217628345U (en) | 2022-06-23 | 2022-06-23 | Microbial high-density fermentation metering feed supplement distribution system |
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| CN202221584192.1U Active CN217628345U (en) | 2022-06-23 | 2022-06-23 | Microbial high-density fermentation metering feed supplement distribution system |
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