CN206396227U - A kind of hyaluronic acid production fermentation tank - Google Patents
A kind of hyaluronic acid production fermentation tank Download PDFInfo
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- CN206396227U CN206396227U CN201720083284.4U CN201720083284U CN206396227U CN 206396227 U CN206396227 U CN 206396227U CN 201720083284 U CN201720083284 U CN 201720083284U CN 206396227 U CN206396227 U CN 206396227U
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- hyaluronic acid
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 29
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 29
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 29
- 238000000855 fermentation Methods 0.000 title claims abstract description 28
- 230000004151 fermentation Effects 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000001301 oxygen Substances 0.000 claims abstract description 48
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 48
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 239000002253 acid Substances 0.000 claims abstract description 6
- 238000003860 storage Methods 0.000 claims abstract description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 1
- 238000007599 discharging Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 41
- 238000009826 distribution Methods 0.000 abstract description 16
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract description 12
- 229910001882 dioxygen Inorganic materials 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 11
- 230000008569 process Effects 0.000 abstract description 8
- 239000003513 alkali Substances 0.000 abstract description 4
- 230000012010 growth Effects 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 230000004099 anaerobic respiration Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
本实用新型提供一种透明质酸生产用发酵罐，包括罐体、分别设于罐体顶部和底部的加料口和出料口、设于罐体中的搅拌轴和设于搅拌轴底端的搅拌桨，罐体内设有pH计和溶氧传感器，搅拌轴与搅拌桨均为空腔体，搅拌轴的空腔与搅拌桨的空腔连通，搅拌桨上设有与搅拌桨空腔相通的通孔，搅拌轴的顶端通过管路与酸碱液储罐连通，管路上设有进液泵，罐体内底部设有氧气布气盘，氧气布气盘通过进气管与罐体外的供氧装置连通，氧气布气盘上侧设有径向辐射排列的气孔。该发酵罐可精确、均匀、自动的调控生产透明质酸过程中发酵液的pH和溶氧含量，提高透明质酸的产量。
The utility model provides a fermentation tank for hyaluronic acid production, which comprises a tank body, a feed port and a discharge port respectively arranged on the top and bottom of the tank body, a stirring shaft arranged in the tank body, and a stirring shaft arranged at the bottom end of the stirring shaft. The tank is equipped with a pH meter and a dissolved oxygen sensor, the stirring shaft and the stirring paddle are both hollow bodies, the cavity of the stirring shaft is connected with the cavity of the stirring paddle, and the stirring paddle is provided with a communication hole with the cavity of the stirring paddle hole, the top of the stirring shaft is connected with the acid and alkali storage tank through the pipeline, the pipeline is equipped with a liquid inlet pump, and the bottom of the tank is equipped with an oxygen gas distribution plate, and the oxygen gas distribution plate is connected with the oxygen supply device outside the tank through the intake pipe , The upper side of the oxygen gas distribution plate is provided with air holes radially arranged. The fermenter can accurately, uniformly and automatically regulate the pH and dissolved oxygen content of the fermented liquid in the process of producing hyaluronic acid, and increase the yield of hyaluronic acid.
Description
技术领域technical field
本实用新型涉及微生物发酵设备领域，尤其是涉及一种透明质酸生产用发酵罐。The utility model relates to the field of microbial fermentation equipment, in particular to a fermenter for hyaluronic acid production.
背景技术Background technique
透明质酸广泛应用于化妆品、美容行业、保健食品、医药等很多领域。生产透明质酸的常用方法有动物组织提取法、微生物发酵法和化学合成法，其中动物组织提取法和化学合成法成本高，产量低，受原料资源限制，不能满足市场需求，而微生物发酵法生产透明质酸具有不受原料资源限制、成本低、产量高等优点，成为透明质酸生产的主要方法。Hyaluronic acid is widely used in cosmetics, beauty industry, health food, medicine and many other fields. Common methods for producing hyaluronic acid include animal tissue extraction, microbial fermentation, and chemical synthesis. Among them, animal tissue extraction and chemical synthesis have high costs and low yields, and are limited by raw material resources and cannot meet market demand. Microbial fermentation The production of hyaluronic acid has the advantages of not being limited by raw material resources, low cost, and high output, and has become the main method for hyaluronic acid production.
微生物发酵法生产透明质酸的过程中，溶氧含量和pH值是影响发酵效率的两个关键因素。发酵液中溶氧低于临界溶氧30％时，无氧呼吸造成发酵液中乙酸、乙醇含量增高，抑制细胞生长和产物表达，影响透明质酸产量。而细胞菌体在生长过程中产酸使pH迅速下降，改变菌体的生存环境，使细胞生物量增长迅速下降，在适当时间调节pH，使其利于菌体的繁殖，就可延长其对数生长期，从而提高透明质酸的产量。During the production of hyaluronic acid by microbial fermentation, the dissolved oxygen content and pH value are two key factors affecting the fermentation efficiency. When the dissolved oxygen in the fermentation broth is lower than 30% of the critical dissolved oxygen, anaerobic respiration will increase the content of acetic acid and ethanol in the fermentation broth, inhibit cell growth and product expression, and affect the production of hyaluronic acid. During the growth process, the cells produce acid to make the pH drop rapidly, change the living environment of the cells, and cause the cell biomass growth to drop rapidly. Adjusting the pH at an appropriate time to make it conducive to the reproduction of the cells can prolong its logarithmic growth. period, thereby increasing the production of hyaluronic acid.
微生物发酵法生产透明质酸常在发酵罐中进行，因此发酵罐如何更好的控制发酵过程中发酵液的溶氧含量和pH值是决定透明质酸的产量的直接因素。The production of hyaluronic acid by microbial fermentation is often carried out in a fermenter, so how to better control the dissolved oxygen content and pH value of the fermentation liquid in the fermenter is the direct factor that determines the yield of hyaluronic acid.
发明内容Contents of the invention
本实用新型要解决的问题是提供一种透明质酸生产用发酵罐，可以精确且均匀的控制发酵过程中发酵罐中发酵液的溶氧含量和pH值，提高透明质酸的产量。The problem to be solved by the utility model is to provide a fermenter for hyaluronic acid production, which can accurately and uniformly control the dissolved oxygen content and pH value of the fermentation liquid in the fermenter during the fermentation process, and increase the output of hyaluronic acid.
为解决上述技术问题，本实用新型采用的技术方案是：一种透明质酸生产用发酵罐，包括罐体、分别设于罐体顶部和底部的加料口和出料口、设于罐体中的搅拌轴和设于搅拌轴底端的搅拌桨，罐体内设有pH计和溶氧传感器，搅拌轴与搅拌桨均为空腔体，搅拌轴的空腔与搅拌桨的空腔连通，搅拌桨上设有与搅拌桨空腔相通的通孔，搅拌轴的顶端通过管路与酸碱液储罐连通，管路上设有进液泵，罐体内底部设有氧气布气盘，氧气布气盘通过进气管与罐体外的供氧装置连通，氧气布气盘上侧设有径向辐射排列的气孔。In order to solve the above technical problems, the technical solution adopted by the utility model is: a fermenter for hyaluronic acid production, including a tank body, a feed port and a discharge port respectively located at the top and bottom of the tank body, and a tank body The stirring shaft and the stirring paddle arranged at the bottom of the stirring shaft, the tank body is provided with a pH meter and a dissolved oxygen sensor, the stirring shaft and the stirring paddle are both hollow bodies, the cavity of the stirring shaft communicates with the cavity of the stirring paddle, There is a through hole communicating with the cavity of the stirring paddle, the top of the stirring shaft is connected with the acid and alkali liquid storage tank through the pipeline, the pipeline is equipped with a liquid inlet pump, the bottom of the tank is equipped with an oxygen gas distribution plate, and the oxygen gas distribution plate The air intake pipe is connected with the oxygen supply device outside the tank, and the upper side of the oxygen gas distribution plate is provided with air holes arranged radially.
技术方案中，优选的，管路上设有第一电磁阀，进气管上设有第二电磁阀。In the technical solution, preferably, a first solenoid valve is provided on the pipeline, and a second solenoid valve is provided on the intake pipe.
技术方案中，优选的，还设有控制器，控制器分别与pH计、溶氧传感器、第一电磁阀和第二电磁阀电连接。In the technical solution, preferably, a controller is further provided, and the controller is electrically connected to the pH meter, the dissolved oxygen sensor, the first solenoid valve and the second solenoid valve respectively.
技术方案中，优选的，氧气布气盘设于搅拌桨下方。In the technical solution, preferably, the oxygen distribution disc is arranged below the stirring paddle.
本实用新型具有的优点和积极效果是：可以更精确、均匀、自动的调控生产透明质酸过程中发酵液的pH和溶氧含量，从而精准的控制生产过程中的工艺条件，使其保持在生产透明质酸的最佳条件下，进而提高透明质酸的产量。The utility model has the advantages and positive effects that: the pH and dissolved oxygen content of the fermented liquid in the production of hyaluronic acid can be regulated more precisely, uniformly and automatically, so as to accurately control the process conditions in the production process and keep it at Optimum conditions for the production of hyaluronic acid, thereby increasing the production of hyaluronic acid.
附图说明Description of drawings
图1是本实用新型发酵罐的结构示意图Fig. 1 is the structural representation of the utility model fermentation tank
图中：In the picture:
1、罐体 2、加料口 3、出料口1. Tank body 2. Feeding port 3. Discharge port
4、搅拌轴 5、电机 6、搅拌桨4. Stirring shaft 5. Motor 6. Stirring paddle
7、pH计 8、溶氧传感器 9、通孔7. pH meter 8. Dissolved oxygen sensor 9. Through hole
10、管路 11、酸碱液储罐 12、进液泵10. Pipeline 11. Acid and alkali storage tank 12. Inlet pump
13、氧气布气盘 14、进气管 15、供氧装置13. Oxygen gas distribution plate 14. Intake pipe 15. Oxygen supply device
16、出气孔 17、电磁阀 18、电磁阀16. Air outlet 17. Solenoid valve 18. Solenoid valve
具体实施方式detailed description
下面结合附图对本实用新型实施例做进一步描述：Below in conjunction with accompanying drawing, the utility model embodiment is further described:
如图1所示，本实施例所述的一种透明质酸生产用发酵罐，包括罐体1，罐体1底部设有底座，罐体1外设有夹套，用于罐体1换热，为防止罐体1中发酵液在搅拌过程中发生湍流，在罐体1内侧壁上设有挡板，罐体1顶部设有加料口2，罐体1底部设有出料口3，罐体1中部设有pH计和溶氧传感器接口，其中插有pH计7和溶氧传感器8，pH计7和溶氧传感器8伸入罐体1的中部靠下位置，可以实时监测罐体中发酵液的pH和溶氧含量，反馈给操作人员，当发酵液的pH或溶氧含量偏离最适宜值时，操作人员对发酵液体系的环境进行调节，以提高透明质酸的产量。As shown in Figure 1, a fermenter for the production of hyaluronic acid described in this embodiment includes a tank body 1, a base is provided at the bottom of the tank body 1, and a jacket is provided outside the tank body 1 for changing the tank body 1. Heat, in order to prevent the turbulent flow of the fermented liquid in the tank body 1 during the stirring process, a baffle plate is provided on the inner wall of the tank body 1, a feeding port 2 is provided at the top of the tank body 1, and a discharge port 3 is provided at the bottom of the tank body 1, The middle part of the tank body 1 is provided with a pH meter and a dissolved oxygen sensor interface, in which a pH meter 7 and a dissolved oxygen sensor 8 are inserted, and the pH meter 7 and the dissolved oxygen sensor 8 extend into the lower part of the tank body 1 to monitor the tank body in real time The pH and dissolved oxygen content of the fermentation broth are fed back to the operator. When the pH or dissolved oxygen content of the fermentation broth deviates from the optimum value, the operator will adjust the environment of the fermentation broth system to increase the production of hyaluronic acid.
搅拌轴4由罐体1顶部伸入罐体1中，搅拌轴4顶端与电机5的输出轴连接，搅拌轴4的底部连接多个搅拌桨6，搅拌桨6至少有3个，搅拌轴4与搅拌桨6均为空腔体，且搅拌轴4的空腔体与搅拌桨6的空腔体连通，搅拌桨6上设有与搅拌桨6空腔相通的通孔9，搅拌轴4的顶端通过一管路10与发酵罐1外的酸碱液储罐11连通，管路10上设有进液泵12，在发酵生产透明质酸的过程中，操作人员由pH计显示的值得知罐体1中发酵液的pH，细胞菌体在生长过程中产酸使pH迅速下降，偏离了菌体生长的最适宜值时，操作人员使用酸碱液储罐11向发酵罐1中添加碱，以将其调至最佳值，而碱液经由管路10进入搅拌轴4的腔体，再经搅拌桨6上的通孔9释放至发酵罐中，随着搅拌轴的旋转，碱液进行离心运动，均匀分散的释放在发酵液中的各个部位，可以避免常规的单点添加碱液时产生的局部碱液过浓现象，均匀的调整发酵液中的pH，提高透明质酸的生产速率。The stirring shaft 4 extends into the tank body 1 from the top of the tank body 1, the top of the stirring shaft 4 is connected to the output shaft of the motor 5, the bottom of the stirring shaft 4 is connected to a plurality of stirring paddles 6, there are at least three stirring paddles 6, and the stirring shaft 4 It is hollow body with stirring paddle 6, and the hollow body of stirring shaft 4 is communicated with the cavity body of stirring paddle 6, and stirring paddle 6 is provided with the through hole 9 that communicates with stirring paddle 6 cavity, and the through hole 9 of stirring shaft 4 The top is communicated with the acid-base liquid storage tank 11 outside the fermenter 1 through a pipeline 10. The pipeline 10 is provided with a liquid inlet pump 12. During the process of fermenting and producing hyaluronic acid, the operator can know from the value displayed by the pH meter The pH of the fermented liquid in the tank body 1, when the cells produce acid during the growth process, the pH drops rapidly, and when it deviates from the optimum value for the growth of the bacteria, the operator uses the acid-base liquid storage tank 11 to add alkali to the fermenter 1, To adjust it to the optimum value, the lye enters the cavity of the stirring shaft 4 through the pipeline 10, and is released into the fermenter through the through hole 9 on the stirring paddle 6. With the rotation of the stirring shaft, the lye proceeds Centrifugal movement, evenly distributed in various parts of the fermentation liquid, can avoid the phenomenon of local over-concentration of lye caused by conventional single-point addition of lye, adjust the pH of the fermentation liquid evenly, and increase the production rate of hyaluronic acid .
罐体1底部设有氧气布气盘13，氧气布气盘13通过进气管14与罐体1外的供氧装置15连通，供氧装置15可以为氧气罐或者空压机，氧气布气盘13设置于搅拌桨6的下方，氧气布气盘13的上侧面设有若干出气孔16，多个出气孔16沿氧气布气盘13的径向辐射排列。当溶氧传感器8检测到发酵液中的溶氧含量低于最适宜值时，操作人员通过供氧装置15向罐体1中供氧，氧气由进气管14引入罐体1中，并由布气盘13上的均匀径向辐射排列的出气孔16释放进发酵液中，气泡由发酵罐罐体1底部逐渐上升，并被布气盘13上方的搅拌桨6打碎成大量细小的气泡，大大的提高了氧气与发酵液的接触面积，均匀的调节了整个发酵液的溶氧量。The bottom of the tank body 1 is provided with an oxygen gas distribution plate 13, and the oxygen gas distribution plate 13 communicates with the oxygen supply device 15 outside the tank body 1 through the intake pipe 14. The oxygen supply device 15 can be an oxygen tank or an air compressor, and the oxygen gas distribution plate 13 is arranged below the stirring paddle 6, and the upper side of the oxygen gas distribution plate 13 is provided with a plurality of air outlet holes 16, and the plurality of air outlet holes 16 are radially arranged along the radial direction of the oxygen gas distribution plate 13. When the dissolved oxygen sensor 8 detects that the dissolved oxygen content in the fermentation broth is lower than the optimum value, the operator supplies oxygen to the tank body 1 through the oxygen supply device 15, and the oxygen is introduced into the tank body 1 by the air inlet pipe 14, and is fed by the air distribution device 15. The air outlet holes 16 uniformly radially arranged on the disk 13 are released into the fermentation liquid, and the air bubbles gradually rise from the bottom of the fermenter body 1, and are broken into a large number of fine air bubbles by the stirring paddle 6 above the air distribution disk 13. The contact area between the oxygen and the fermented liquid is improved, and the dissolved oxygen of the whole fermented liquid is evenly adjusted.
与搅拌轴4连接的管路10和与布气盘13连接的进气管14上均设有电磁阀17、18，在罐体1外还设有控制器，控制器分别与电磁阀17、18，pH计7和溶氧传感器8电连接，pH计7和溶氧传感器8将实时监测到的发酵液的pH和溶氧含量信号传送给控制器，控制器将信号与设定的最佳值进行比较，pH偏低时，控制器输出指令控制电磁阀17打开，向发酵罐1中添加碱液，调节发酵液的pH，至pH达最佳值后关闭电磁阀17，溶氧含量偏低时，控制器输出指令控制电磁阀18打开，向发酵罐1中补充氧气，至溶氧量达最佳值后关闭电磁阀18。通过控制器与pH计7和溶氧传感器8之间传递信号，控制电磁阀，可以使发酵罐实时自动控制进碱液和供氧，从而不需人工调节，自动调节发酵罐中发酵液的pH和溶氧量，使发酵液pH和溶氧量调节更及时，提高透明质酸的产量。The pipeline 10 connected with the stirring shaft 4 and the inlet pipe 14 connected with the gas distribution plate 13 are all provided with electromagnetic valves 17, 18, and a controller is also provided outside the tank body 1, and the controller is connected with the electromagnetic valves 17, 18 respectively. , the pH meter 7 and the dissolved oxygen sensor 8 are electrically connected, and the pH meter 7 and the dissolved oxygen sensor 8 transmit the pH and dissolved oxygen content signals of the fermented liquid monitored in real time to the controller, and the controller sends the signal to the optimal value set For comparison, when the pH is low, the controller outputs an instruction to control the solenoid valve 17 to open, add lye to the fermenter 1, adjust the pH of the fermentation broth, and close the solenoid valve 17 after the pH reaches the optimum value, and the dissolved oxygen content is low. , the controller outputs an instruction to control the solenoid valve 18 to open, supplement oxygen to the fermenter 1, and close the solenoid valve 18 after the dissolved oxygen reaches the optimum value. By transmitting signals between the controller, the pH meter 7 and the dissolved oxygen sensor 8, and controlling the solenoid valve, the fermenter can automatically control the lye and oxygen supply in real time, so that manual adjustment is not required, and the pH of the fermentation liquid in the fermenter can be automatically adjusted. and dissolved oxygen, so that the pH and dissolved oxygen of the fermentation broth can be adjusted more timely, and the production of hyaluronic acid can be increased.
本实用新型的优点和有益效果是：可以更精确、均匀、自动的调控生产透明质酸过程中发酵液的pH和溶氧含量，从而精准的控制生产过程中的工艺条件，使其保持在生产透明质酸的最佳条件下，进而提高透明质酸的产量。The advantages and beneficial effects of the utility model are: the pH and dissolved oxygen content of the fermented liquid in the process of producing hyaluronic acid can be regulated more accurately, uniformly and automatically, so as to precisely control the process conditions in the production process and keep it in the production process. Optimum conditions for hyaluronic acid, thereby increasing the production of hyaluronic acid.
以上对本实用新型的一个实施例进行了详细说明，但所述内容仅为本实用新型的较佳实施例，不能被认为用于限定本实用新型的实施范围。凡依本实用新型申请范围所作的均等变化与改进等，均应仍归属于本实用新型的专利涵盖范围之内。An embodiment of the present utility model has been described in detail above, but the content described is only a preferred embodiment of the present utility model, and cannot be considered as limiting the implementation scope of the present utility model. All equal changes and improvements made according to the application scope of the utility model should still belong to the scope covered by the patent of the utility model.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720083284.4U CN206396227U (en) | 2017-01-22 | 2017-01-22 | A kind of hyaluronic acid production fermentation tank |
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| CN201720083284.4U CN206396227U (en) | 2017-01-22 | 2017-01-22 | A kind of hyaluronic acid production fermentation tank |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108707544A (en) * | 2018-08-21 | 2018-10-26 | 天津荣利生物科技发展有限公司 | A kind of chlorella concentrate sirring and separating equipment |
| CN108893252A (en) * | 2018-07-23 | 2018-11-27 | 安徽合众智信科技咨询有限公司 | A kind of Zymolysis Equipment producing citric acid |
| CN109971614A (en) * | 2019-04-16 | 2019-07-05 | 北京航空航天大学 | An energy-saving method for a biological fermenter |
| CN112063518A (en) * | 2020-09-21 | 2020-12-11 | 安徽天凯生物科技有限公司 | Device and method for improving yield of docosahexaenoic acid by using liquid ammonia |
| CN113999755A (en) * | 2021-11-02 | 2022-02-01 | 湖北真福医药有限公司 | Aerobic microorganism liquid fermentation device |
| CN116254172A (en) * | 2023-03-20 | 2023-06-13 | 枣庄市杰诺生物酶有限公司 | Novel arginine purifying and preparing equipment and method |
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2017
- 2017-01-22 CN CN201720083284.4U patent/CN206396227U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108893252A (en) * | 2018-07-23 | 2018-11-27 | 安徽合众智信科技咨询有限公司 | A kind of Zymolysis Equipment producing citric acid |
| CN108707544A (en) * | 2018-08-21 | 2018-10-26 | 天津荣利生物科技发展有限公司 | A kind of chlorella concentrate sirring and separating equipment |
| CN108707544B (en) * | 2018-08-21 | 2023-09-19 | 天津荣利生物科技发展有限公司 | Chlorella concentrate stirring splitter |
| CN109971614A (en) * | 2019-04-16 | 2019-07-05 | 北京航空航天大学 | An energy-saving method for a biological fermenter |
| CN109971614B (en) * | 2019-04-16 | 2020-08-25 | 北京航空航天大学 | An energy-saving method for a biological fermenter |
| CN112063518A (en) * | 2020-09-21 | 2020-12-11 | 安徽天凯生物科技有限公司 | Device and method for improving yield of docosahexaenoic acid by using liquid ammonia |
| CN113999755A (en) * | 2021-11-02 | 2022-02-01 | 湖北真福医药有限公司 | Aerobic microorganism liquid fermentation device |
| CN116254172A (en) * | 2023-03-20 | 2023-06-13 | 枣庄市杰诺生物酶有限公司 | Novel arginine purifying and preparing equipment and method |
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