CN110624103B - 用于治疗皮肤异常的生物材料装置和局部组合物 - Google Patents
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| US16/123,986 US10758594B2 (en) | 2018-06-26 | 2018-09-06 | Biomaterial devices and topical compositions for treatment of skin abnormalities |
| US16/123986 | 2018-09-06 |
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| CN113293626A (zh) * | 2021-04-08 | 2021-08-24 | 南雄阳普医疗科技有限公司 | 一种创面敷料及其制备方法和应用 |
| CN113248633B (zh) * | 2021-06-25 | 2022-06-21 | 时垠(上海)生物科技有限公司 | 一种低分子壳聚糖的制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07196520A (ja) * | 1993-12-28 | 1995-08-01 | Nobushige Enomoto | 変性キトサン組成物 |
| CN101143155A (zh) * | 2006-09-15 | 2008-03-19 | 中国科学院大连化学物理研究所 | 一种双参组合物及其应用 |
| WO2012091636A2 (ru) * | 2010-12-30 | 2012-07-05 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Университет Имени Н.Г. Чернышевского" | Биополимерное волокно, состав формовочного раствора для его получения, способ приготовления формовочного раствора, полотно биомедицинского назначения, способ его модификации, биологическая повязка и способ лечения ран |
| CN104474572A (zh) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | 一种医用止血封堵敷料及其制备方法 |
| CN104546532A (zh) * | 2015-01-28 | 2015-04-29 | 广州丽丰化妆品制造有限公司 | 含有低聚壳聚糖和水母胶原蛋白的精华液及其制成的面膜 |
| CN104874014A (zh) * | 2015-05-22 | 2015-09-02 | 苏州市贝克生物科技有限公司 | 一种医用止血封堵敷料的制备方法 |
| CN105533710A (zh) * | 2015-12-30 | 2016-05-04 | 威海力元海洋生物科技有限公司 | 一种海参壳寡糖硒制剂及制备工艺 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6337076B1 (en) * | 1999-11-17 | 2002-01-08 | Sg Licensing Corporation | Method and composition for the treatment of scars |
| US6565960B2 (en) * | 2000-06-01 | 2003-05-20 | Shriners Hospital Of Children | Polymer composite compositions |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07196520A (ja) * | 1993-12-28 | 1995-08-01 | Nobushige Enomoto | 変性キトサン組成物 |
| CN101143155A (zh) * | 2006-09-15 | 2008-03-19 | 中国科学院大连化学物理研究所 | 一种双参组合物及其应用 |
| WO2012091636A2 (ru) * | 2010-12-30 | 2012-07-05 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Университет Имени Н.Г. Чернышевского" | Биополимерное волокно, состав формовочного раствора для его получения, способ приготовления формовочного раствора, полотно биомедицинского назначения, способ его модификации, биологическая повязка и способ лечения ран |
| CN104474572A (zh) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | 一种医用止血封堵敷料及其制备方法 |
| CN104546532A (zh) * | 2015-01-28 | 2015-04-29 | 广州丽丰化妆品制造有限公司 | 含有低聚壳聚糖和水母胶原蛋白的精华液及其制成的面膜 |
| CN104874014A (zh) * | 2015-05-22 | 2015-09-02 | 苏州市贝克生物科技有限公司 | 一种医用止血封堵敷料的制备方法 |
| CN105533710A (zh) * | 2015-12-30 | 2016-05-04 | 威海力元海洋生物科技有限公司 | 一种海参壳寡糖硒制剂及制备工艺 |
Non-Patent Citations (4)
| Title |
|---|
| ANA R. RIBEIRO ET AL.New Insights into Mutable Collagenous Tissue: Correlations between the Microstructure and Mechanical State of a SeaUrchin Ligament.《PLOS ONE》.2011,e24822. * |
| K. SILVIPRIYA ET AL.Collagen: Animal Sources and Biomedical Application.《JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE》.2015,123-127. * |
| Ravichandran Mahalingam.Semisolid Dosages: Ointments, Creams, and Gels.《Pharmaceutical Manufacturing: Production and Processes》.2010,全文. * |
| 马建标等.壳聚糖与胶原或海藻酸复合物海绵的制备以及人胎儿皮肤成纤维细胞在其中的生长.《自然科学进展》.2000,第第10卷卷(第第10卷期),第896-903页. * |
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| CN110624103A (zh) | 2019-12-31 |
| KR20200029363A (ko) | 2020-03-18 |
| JP6933393B2 (ja) | 2021-09-08 |
| KR102232371B1 (ko) | 2021-03-30 |
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