CN110596408B - Full-automatic dry-type immunoassay equipment - Google Patents
Full-automatic dry-type immunoassay equipment Download PDFInfo
- Publication number
- CN110596408B CN110596408B CN201910893591.2A CN201910893591A CN110596408B CN 110596408 B CN110596408 B CN 110596408B CN 201910893591 A CN201910893591 A CN 201910893591A CN 110596408 B CN110596408 B CN 110596408B
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- 238000003018 immunoassay Methods 0.000 title claims abstract description 44
- 230000007246 mechanism Effects 0.000 claims abstract description 95
- 239000007788 liquid Substances 0.000 claims abstract description 58
- 238000012360 testing method Methods 0.000 claims abstract description 49
- 238000001514 detection method Methods 0.000 claims abstract description 29
- 230000008878 coupling Effects 0.000 claims description 16
- 238000010168 coupling process Methods 0.000 claims description 16
- 238000005859 coupling reaction Methods 0.000 claims description 16
- 238000011084 recovery Methods 0.000 claims description 11
- 230000006835 compression Effects 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 12
- 230000008569 process Effects 0.000 abstract description 12
- 239000002699 waste material Substances 0.000 abstract description 5
- 239000008280 blood Substances 0.000 description 26
- 210000004369 blood Anatomy 0.000 description 26
- 238000010241 blood sampling Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a full-automatic dry immunoassay device, comprising: a base; the detection mechanism is fixedly connected to the base; the feeding mechanism is arranged at a distance from the detection mechanism; and the liquid taking mechanism is positioned right above the side of the feeding mechanism and moves back and forth between the detecting mechanism and the feeding mechanism, wherein the detecting mechanism is provided with a rotary table, a surrounding baffle plate extends upwards along the periphery of the rotary table in a circle, and at least two peak platforms are arranged on the surrounding baffle plate at intervals. According to the invention, the feeding mechanism and the detecting mechanism are arranged in a rotary mode and provided with a plurality of accommodating grooves, so that the number of disposable test samples is increased, the working efficiency of the test is improved, the whole processes of feeding, liquid taking, detecting and waste treatment are all full-automatic processes, the working efficiency is further improved, test tubes with all specifications can be placed in the feeding mechanism, and the applicability of the equipment is higher.
Description
Technical Field
The invention relates to the field of immunoassay instrument equipment, in particular to full-automatic dry immunoassay equipment.
Background
The full-automatic luminous immunoassay instrument is an instrument capable of performing immunological quantitative analysis on a body fluid sample of a patient, and can be used for detecting anemia, cardiovascular diseases, congenital diseases, sex hormones, infectious diseases, metabolic functions, tumor markers, thyroid gland and the like and monitoring therapeutic drugs.
Currently, when performing immune item detection in inspection departments such as outpatient service and emergency, a single device is used to collect blood from a nurse and then put the blood collection tube into a table centrifuge. Generally, a medical staff always waits for at least one small batch of samples, then puts the samples into a centrifugal machine manually for centrifugation, then takes the samples out of the centrifugal machine, removes a test tube cap, and puts the samples into full-automatic luminescence for testing in an immunoassay analyzer, wherein various implemented steps are all manually operated.
However, the existing immunoassay analyzer has a certain problem that, firstly, the part related to manual operation is more in the whole set of detection process, so that the efficiency of detection work is low in the daily detection process. Secondly, a turntable type structure is adopted for the process of assay detection and feeding, and a plurality of accommodating grooves are additionally arranged, so that the process and the efficiency of one-time detection and analysis can be greatly improved, but the quantity of samples which can be detected and analyzed by most of the devices of the analyzers is small, and the time consumption is long. Thirdly, the general immunoassay device is only suitable for detecting the blood sampling tube with the size which is used conventionally,
In view of the foregoing, there is a need for developing a fully automatic dry immunoassay device to solve the above-mentioned problems.
Disclosure of Invention
In order to solve the above-mentioned problems, the present invention provides a full-automatic dry immunoassay device, wherein a feeding mechanism and a detecting mechanism are rotated and provided with a plurality of accommodating grooves, so as to increase the number of disposable test samples, increase the working efficiency of the test, and the whole processes of feeding, liquid taking, detecting and waste treatment are all full-automatic, so that the working efficiency is further improved, and the feeding mechanism can be used for placing test tubes of all specifications, so that the applicability of the device is higher, and in order to achieve the above-mentioned objects and other advantages, the full-automatic dry immunoassay device is provided, comprising:
A base;
The detection mechanism is fixedly connected to the base;
the feeding mechanism is arranged at a distance from the detection mechanism; and
The liquid taking mechanism is positioned right above the side of the feeding mechanism and moves back and forth between the detecting mechanism and the feeding mechanism,
The detecting mechanism is provided with a rotary table, a surrounding baffle plate extends upwards along the periphery of the rotary table in a circle, and at least two peak platforms are arranged on the surrounding baffle plate at intervals.
Preferably, the detection mechanism further includes:
A fixed cylinder;
a first-stage rotary drum sleeved on the periphery of the cylinder; and
A second-stage rotary drum sleeved on the periphery of the first-stage rotary drum,
The end surfaces of the cylinder, the first-stage rotary drum and the second-stage rotary drum are stepped and sequentially recursively downwards from top to bottom, a rotary table is fixedly connected to the upper end surface of the second-stage rotary drum, and a horizontal pushing mechanism is fixedly connected to the upper end surface of the first-stage rotary drum.
Preferably, the transverse pushing mechanism comprises a gear shaft motor, a fixed disc and a push rod, wherein a through groove is formed in the middle of the gear shaft motor, the middle of the fixed disc and the push rod in the length direction, the width of the through groove is slightly larger than the diameter of the gear shaft motor, tooth-shaped strips and I-shaped track strips are fixedly connected to the edges of two side surfaces of the through groove respectively, a sliding rail block is arranged on a device corresponding to the I-shaped track strips, a compression block is fixedly connected with the sliding rail block, and the compression block is fixed on the fixed disc.
Preferably, the feeding mechanism comprises a rotary table, a supporting frame and a recovery mechanism, wherein the rotary table is provided with a feeding station, a uncapping station, a liquid pumping station and a recovery station which are sequentially arranged along the rotation direction of the rotary table.
Preferably, at least two test tube holding grooves which are arranged along the circumference of the turntable are formed in the periphery of the turntable, an adapter is arranged in each test tube holding groove, each test tube holding groove is surrounded by a side wall to form a holding cavity, a positioning block which is vertically placed is fixedly connected on the inner wall of each holding cavity, a positioning hole is formed in each positioning block, a fixing block is arranged at the bottom of each holding cavity, and the upper surface of each fixing block downwards penetrates through the corresponding fixing hole.
Preferably, the support frame rigid coupling has retrieve the mechanism, the rigid coupling has the rifle head tray on the support frame, the rigid coupling has rifle head tray support frame on the rifle head tray, the rifle head tray is L type and divides into the part of keeping flat and vertical part, keep flat the part rigid coupling in the support frame, just square hole has been seted up to the part middle part of keeping flat, square hole below is equipped with automatic bullet ware, automatic bullet ware rigid coupling in on the support frame, the rigid coupling has on the vertical part inner wall drawer adjustment piece.
Preferably, the liquid taking mechanism comprises a liquid taking pipe structure and a driving structure, and the driving structure drives the liquid taking pipe structure to do linear motion along the horizontal direction.
Preferably, the liquid taking pipe structure is provided with a liquid taking pipe part, a liquid taking pipe fixing block is fixedly connected with the liquid taking pipe part, a bearing fixing block is fixedly connected with the liquid taking pipe fixing block, a vertical sliding block is fixedly connected with the bearing fixing block, and a vertical bar-shaped connecting block is fixedly connected with the vertical sliding block.
Preferably, the bottom rigid coupling of bar connecting block has the loading base that the level was placed, loading base left end face rigid coupling has gear motor, gear motor runs through loading base downwardly extending, loading base right-hand member face rigid coupling has the rotation, the one end of axis of rotation is the rotation gear, the rotation gear upwards runs through the bearing connects the piece admittedly.
Preferably, the driving structure is provided with a transverse connection plate, one end of the transverse connection plate is fixedly connected with a first gear motor, the other end of the transverse connection plate is provided with a gear shaft, the transverse connection plate is provided with a transverse fixing block in a manner of being opposite to the first gear motor, the upper side and the lower side of the transverse connection plate are provided with a first sliding rail and a second sliding rail, the first sliding rail and the second sliding rail are respectively provided with a first sliding block and a second sliding block which are opposite to each other, and the transverse fixing block is fixed on the first sliding block and the second sliding block.
Compared with the prior art, the invention has the beneficial effects that: through establishing feed mechanism and detection mechanism into rotation type and be equipped with a plurality of holding tanks, the quantity of disposable inspection sample is improved, improves the work efficiency of inspection, and holistic material loading, liquid taking, detection and waste material processing's process are full-automatic process, further improvement work's efficiency, and the test tube of all specifications can be placed to feed mechanism equipment moreover, and the suitability of equipment is higher.
Drawings
Fig. 1 is a three-dimensional view of an external appearance structure of an immunoassay analyzer device according to the present invention;
fig. 2 is a three-dimensional schematic view of the internal structure of the immunoassay analyzer apparatus according to the present invention;
FIG. 3 is a three-dimensional schematic of an epicyclic loading mechanism of an immunoassay analyzer apparatus according to the present invention;
FIG. 4 is a three-dimensional exploded view of a rotating gripping member of an epicyclic loading mechanism of an immunoassay analyzer apparatus according to the present invention;
FIG. 5 is a three-dimensional exploded schematic view of a clamping member driving structure of an immunoassay analyzer device according to the present invention;
fig. 6 is a three-dimensional schematic view of a support mechanism of a rotary gripping member of an immunoassay analyzer apparatus according to the present invention.
FIG. 7 is a three-dimensional exploded schematic view of an epicyclic loading mechanism of an immunoassay analyzer apparatus according to the present invention;
FIG. 8 is a three-dimensional schematic view of a turntable of a epicyclic loading device of an immunoassay analyzer apparatus according to the present invention;
FIG. 9 is a top view of a carousel of the epicyclic loading device of an immunoassay analyzer apparatus according to the present invention;
FIG. 10 is a three-dimensional schematic view of a support frame of a epicyclic loading device of an immunoassay analyzer apparatus according to the present invention;
FIG. 11 is a three-dimensional schematic view of a detection disc for an immunoassay test paper sheet of an immunoassay analyzer apparatus according to the present invention;
FIG. 12 is a three-dimensional exploded schematic view of a detection disc for immunoassay test paper sheets of an immunoassay analyzer apparatus according to the present invention;
FIG. 13 is a schematic three-dimensional view of a traverse mechanism of a detection disc for immunoassay test paper sheets of an immunoassay analyzer device according to the present invention;
FIG. 14 is a three-dimensional schematic view of a turntable of a detection disk for immunoassay test paper sheets of an immunoassay analyzer apparatus according to the present invention;
FIG. 15 is a left side view of the liquid handling structure and the epicyclic loader of the immunoassay analyzer apparatus according to the present invention;
FIG. 16 is a schematic view showing a three-dimensional structure of a liquid-taking mechanism of an immunoassay analyzer apparatus according to the present invention;
FIG. 17 is a three-dimensional schematic view of a liquid-handling tube component of an immunoassay analyzer apparatus according to the present invention;
FIG. 18 is a three-dimensional schematic view of the exterior of a liquid extraction drive structure of an immunoassay analyzer apparatus according to the present invention;
fig. 19 is a three-dimensional schematic view of the interior of the liquid extraction driving structure of the immunoassay analyzer apparatus according to the present invention.
Detailed Description
The foregoing and other objects, features, aspects and advantages of the present invention will become more apparent to those skilled in the art from the following detailed description, which, taken in conjunction with the annexed drawings, discloses a device for practicing the invention. In the drawings, the shape and size may be exaggerated for clarity, and the same reference numerals will be used throughout the drawings to designate the same or similar components. In the following description, terms such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, lower, etc. are based on the orientation or positional relationship shown in the drawings. In particular, "height" corresponds to the top-to-bottom dimension, "width" corresponds to the left-to-right dimension, and "depth" corresponds to the front-to-back dimension. These relative terms are for convenience of description and are not generally intended to require a particular orientation. Terms (e.g., "connected" and "attached") referring to an attachment, coupling, etc., refer to a relationship wherein these structures are directly or indirectly secured or attached to one another through intervening structures, as well as both movable or rigid attachments or relationships, unless expressly described otherwise.
Referring to fig. 1 to 19, the immunoassay analyzer apparatus includes:
A base 7;
the detection mechanism 4 is fixedly connected to the base 7;
The feeding mechanism 1 is arranged at a distance from the detection mechanism 4; and
The liquid taking mechanism 6 is positioned right above the side of the feeding mechanism 1, and the liquid taking mechanism 6 moves back and forth between the detecting mechanism 4 and the feeding mechanism 1,
Referring to fig. 14, the detecting mechanism 4 is provided with a turntable 44, a circle of surrounding baffle plate extends upwards along the periphery of the turntable 44, at least two peak platforms 441 are spaced apart on the surrounding baffle plate, a test paper piece is placed between every two adjacent peak platforms 41, a placement position 412 adapting to one end of the test paper piece is provided on one side of the upper surface of each peak platform 41, a placement position 411 adapting to the other end of the test paper piece is provided on the other side of each peak platform, thus the test paper piece can be stably installed on the rotating disc 44, the test paper piece cannot fall easily in the rotating process of the rotating disc 44, the placement positions 412 and the placement positions 411 are provided on one side of the two sides of the upper end surface of each peak platform 441 according to the size of the two ends of the test paper piece, so that the two adjacent peak platforms 441 can be well embedded with each other, the embedding tightness is moderate, and the transverse pushing mechanism 41 can be conveniently pushed to test paper pieces after the test paper piece detection is completed.
Referring to fig. 4-6, a cap removing mechanism 2 is further disposed directly above the feeding mechanism 1, the cap removing mechanism 2 is divided into a rotary clamping component 21 and a clamping component 22, wherein the rotary clamping component 21 includes a jaw seat 211, a jaw 212, a rotating shaft 215 and a jaw opening and closing device 213, the cylinder Ding Xingtao is sleeved on the periphery of the lower end portion of the rotating shaft 215, the connecting top plate 217 is fixedly connected to the lower end of the cylinder Ding Xingtao, the jaw opening and closing device 213 is fixedly connected to the lower surface of the connecting top plate 217, the jaw opening and closing device 213 is used for controlling opening and closing of the jaw 212, when the rotary clamping component 21 descends to the upper side of a blood collection tube, the jaw opening and closing device 213 controls the jaw 212 to open and contain the cap of the blood collection tube, then the jaw 212 performs a merging operation to grasp the cap of the blood collection tube, when the cap is completely detected, the jaw 212 descends to the upper side of the blood collection tube with the cap, and when the cap is opened, the jaw opening and closing device 213 controls the jaw 212 again.
Further, the rotating shaft 215 sequentially penetrates through the motor bottom plate 58 and the connection push plate 53, the left end of the motor bottom plate 58 is provided with the first motor 57, the first motor 57 is provided with the motor screw 54, one end of the motor screw 54 penetrates through the motor bottom plate 58 to extend downwards, the other end of the motor screw 54 is fixed on the lower surface of the connection push plate 53, when the clamping part 4 clamps and fixes the blood collection tube, the rotating clamping part 21 needs to descend to a blood collection tube cap to perform uncapping action, at the moment, the first motor 57 rotates to drive the motor screw 5 to rotate, the motor screw 5 drives the connection push plate 53 to perform ascending and descending rectilinear motion, the rotating shaft 215 passes through the rotating shaft 2151 to enable the rotating shaft 215 to rotate, and finally the rotating shaft 215 enables the clamping jaw 212 to spiral when clamping the cap, so that the clamping jaw 212 can spirally rotate the cap.
Further, the clamping member 4 is provided with the second motor 221, the second motor 221 is provided with the motor base 222, a rotation shaft of the second motor 221 penetrates through the motor base 222, the driving gear 223 is sleeved at the upper end of the rotation shaft, and the first driven gear 225 and the second driven gear 224 meshed with the first driven gear 225 are meshed with the driving gear 223.
Further, the upper ends of the first driven gear 225 and the second driven gear 224 are respectively connected with the first annular seat 228 and the second annular seat 2210 in a rotating manner, the clamping finger seat 2282 is fixedly connected to the outer periphery of the first annular seat 228, the clamping finger seat 2282 is fixedly connected with the clamping jaw head 2283, the clamping jaw head 2283 is sleeved with the silica gel finger pad 227, when the blood collection tube reaches the uncapping station, the clamping part 4 clamps and fixes the blood collection tube, the second motor 221 rotates at the moment, so that the first driven gear 225 and the second driven gear 224 move in opposite directions, the clamping jaw heads on the first annular seat 228 and the second annular seat 2210 are combined to clamp the blood collection tube, at the moment, the rotating clamping part 21 can uncap the blood collection tube, and at the moment, the second motor 221 reversely operates to separate the clamping jaw heads to release the clamping of the blood collection tube when the detection is completed.
Further, at least two clamping finger seats 22101 are fixedly connected to the outer periphery of the second annular seat 2210, and the clamping finger seats 22101 are fixedly connected with the clamping jaw 22103 and the guiding jaw 22102 respectively.
Further, the first ring-shaped seat 228 is fixedly connected with the limiting finger seat 2281, the motor seat 222 adjacent to the limiting finger seat 2281 is provided with the limiter 229, and the first ring-shaped seat 228 is provided with the clamping light blocking piece between the finger seat 2282 and the limiting finger seat 2281.
Further, the detecting mechanism 4 further includes:
A fixed cylinder 47;
A first-stage drum 48 fitted around the outer periphery of the cylinder 47; and
A second stage drum 46, which is fitted around the first stage drum 48,
Wherein, the end surfaces of the cylinder 47, the first-stage rotary drum 48 and the second-stage rotary drum 46 are stepped and sequentially stepped downwards, the upper end surface of the second-stage rotary drum 46 is fixedly connected with a rotary table 44, and the upper end surface of the first-stage rotary drum 48 is fixedly connected with a horizontal pushing mechanism 41.
Referring to fig. 13, the horizontal pushing mechanism 41 includes a gear shaft motor 411, a fixed disc 417 and a push rod 414, a through slot is formed in the middle of the push rod 144 along the length direction, the width of the through slot is slightly larger than the diameter of the gear shaft motor 411, tooth-shaped strips 415 and h-shaped track strips 416 are fixedly connected to two side edges of the through slot respectively, a sliding rail block 413 is arranged corresponding to the h-shaped track strips 416, a compressing block 412 is fixedly connected to the sliding rail block 413, the compressing block 412 is fixed on the fixed disc 417, the horizontal pushing mechanism 41 includes the gear shaft motor 411, the fixed disc 417 and the push rod 414, the through slot is formed in the middle of the push rod 414 along the length direction, the width of the through slot is slightly larger than the diameter of the gear shaft motor 411, the upper surface of the push rod 414 is far higher than the fixed disc 417, and the push rod 414 is consistent with the central height line of a test paper, because the thickness of the test paper is not too thick, the center of the height of the push rod 414 can be aligned with the height center of the test paper, and the test paper can be accurately and effectively pushed in the pushing process.
Further, a paper sheet recovery box is disposed beside the detection mechanism 4 in the direction of the lateral pushing mechanism 41, and after the test paper sheet is detected, the lateral pushing mechanism 41 pushes the paper sheet into the paper sheet recovery box.
Tooth-shaped strips 145 and I-shaped track strips 146 are fixedly connected to the edges of two side surfaces of the through groove respectively, a sliding rail block 413 is arranged on the device corresponding to the I-shaped track strips 416, a compression block 412 is fixedly connected to the sliding rail block 413, the compression block 412 is fixed to a fixed disc 417, and because the use frequency of the step of pushing the rod is high, the tooth-shaped strips and the I-shaped track strips are consumed highly under the condition of relatively long time, and abrasion is easy to be caused, so that only the tooth-shaped strips and the I-shaped track strips are replaced respectively under the condition of later replacement, the transverse pushing rod 414 is not required to be detached in a troublesome mode, and the replacement is convenient, the cost and the work efficiency are saved.
Further, the feeding mechanism 1 comprises a rotary table 11, a supporting frame 12 and a recovery mechanism 15, and the rotary table 11 is provided with a feeding station, a uncapping station, a liquid pumping station and a recovery station which are sequentially arranged along the rotation direction of the rotary table 11.
Referring to fig. 8-9, at least two test tube holding grooves which are arranged along the circumference of the turntable 11 are formed in the periphery of the turntable 11, an adapter 3 is arranged in the test tube holding grooves, the test tube holding grooves are surrounded by a side wall 112 to form a holding cavity, a positioning block 111 which is vertically arranged is fixedly connected on the inner wall of the holding cavity, a positioning hole 1111 is formed in the positioning block 111, a fixing block 113 is arranged at the bottom of the holding cavity, a fixing hole 1131 is formed in the upper surface of the fixing block 113 in a downward penetrating manner, the adapter is arranged in the test tube holding grooves, the test tube holding grooves are surrounded by the side wall to form a holding cavity, a positioning block which is vertically arranged is fixedly connected on the inner wall of the holding cavity, the positioning hole is formed in the positioning block, the fixing block is arranged at the bottom of the holding cavity, and the fixing hole is formed in the lower surface of the fixing block in a penetrating manner. The test tube accommodating position of the turntable can be used for accommodating a common blood sampling test tube, a test tube can be provided, the adapter can be used for accommodating an irregular blood sampling test tube, the adapter for the irregular test tube can be fixedly arranged in the turntable, the positioning hole 1111 can be used for fixing the arrangement direction of the adapter, and the adapter can be prevented from being reversely arranged.
Further, the support frame 12 is fixedly connected with the recovery mechanism 15, a gun head tray 151 is fixedly connected to the support frame, a gun head tray support frame 152 is fixedly connected to the gun head tray 151, the gun head tray 151 is divided into a horizontal component and a vertical component in an L shape, the horizontal component is fixedly connected to the support frame, a square hole is formed in the middle of the horizontal component, an automatic bullet 155 is arranged below the square hole, the automatic bullet 155 is fixedly connected to the support frame, and a drawer adjusting sheet 153 is fixedly connected to the inner wall of the vertical component.
Referring to fig. 16, the liquid taking mechanism 6 includes a liquid taking tube structure 61 and a driving structure 62, the driving structure 62 drives the liquid taking tube structure 61 to do a linear motion along a horizontal direction, mainly, the liquid taking tube structure 61 is fixed on the driving structure 62, the driving structure 62 drives the liquid taking tube structure 61 to do a transverse motion through a motor, so that the liquid taking tube structure 61 moves from a starting station to a position above the turnover feeding mechanism 1, and at this time, the liquid taking tube structure 61 moves downward to take liquid.
Further, the liquid taking pipe structure 61 is provided with a liquid taking pipe component 611, a liquid taking pipe fixing block 618 is fixedly connected with the liquid taking pipe component 611, a bearing fixing block 619 is fixedly connected with the liquid taking pipe fixing block 618, a vertical sliding block 6110 is fixedly connected with the bearing fixing block 619, and a vertical bar-shaped connecting block 614 is fixedly connected with the vertical sliding block 6110.
Referring to fig. 17, a horizontally placed loading base 613 is fixedly connected to the bottom end of the bar-shaped connection block 614, a gear motor 612 is fixedly connected to the left end surface of the loading base 613, the gear motor 612 may rotate forward or backward, the gear motor 612 extends downward through the loading base 613, a rotation shaft 617 is fixedly connected to the right end surface of the loading base 613, one end of the rotation shaft 617 is a rotation gear 615, the rotation gear 615 penetrates upward through the bearing fixing block 619, when the gear motor 612 rotates, the rotation gear 615 drives the bearing fixing block 619 to move downward or upward, because the liquid taking pipe member 611 is fixedly connected to the bearing fixing block 619, and the liquid taking pipe member 611 moves upward or downward along with the bearing fixing block 619.
Referring to fig. 19, the driving structure 62 is provided with a transverse connection plate 622, one end of the transverse connection plate 622 is fixedly connected with a first gear motor 621, the other end of the transverse connection plate 622 is provided with a gear shaft 626, the transverse connection plate 622 is provided with a transverse fixing block 624 opposite to the first gear motor 621, the upper and lower sides of the transverse connection plate 622 are provided with a first sliding rail 6212 and a second sliding rail 6211, the first sliding rail 6212 and the second sliding rail 6211 are respectively provided with a first sliding block 6210 and a second sliding block 628 opposite to each other, the transverse fixing block 624 is fixed on the first sliding block 6210 and the second sliding block 628, the first gear motor 621 is connected with the gear shaft 626 through a belt, and the transverse fixing block 624 is fixedly connected with a belt driving block 629.
Further, a first connecting plate 623 and a second connecting plate 627 are arranged on the upper side and the lower side of the transverse connecting plate 622, a third connecting plate is arranged at the upper end of the second connecting plate 627, an X-axis moving chain is fixedly connected to the first connecting plate 623 and the second connecting plate 627, a Y-axis moving chain is fixedly connected to the third connecting plate, a top plate is fixedly arranged at the other end of the Y-axis moving chain, two Y-axis sliding rails are fixedly connected to the top plate, Y-axis sliding blocks are fixedly connected to the Y-axis sliding rails, one Y-axis sliding block is fixedly connected to the transverse connecting plate 622, the other Y-axis sliding block is fixedly connected to the transverse connecting plate 622 through an intermediate block, the intermediate block is fixedly connected to the transverse connecting plate 622, a motor rotating seat is fixedly connected to the motor rotating seat, and a Y-axis motor is fixedly connected to the motor rotating seat.
In operation, firstly, a test tube to be detected is manually placed in the rotary table 11, at the moment, when a loading sensor 16 on the supporting frame 12 senses that the blood collection tube is placed on the rotary table 11, then the driving mechanism 14 starts to drive the rotary table 11 to rotate to the uncapping station, when the uncapping sensor 17 senses that the rotary table 11 rotates to the uncapping station, the driving mechanism 14 stops rotating, the blood collection tube performs uncapping operation, when the uncapping operation is finished, the driving mechanism 14 drives the rotary table 11 to rotate to the next detection station, at the moment, when the sensor on the liquid collection mechanism senses the test tube, at the moment, a liquid collection tube part in the liquid collection mechanism moves to the position above the test tube in the X axial direction, at the moment, the liquid collection tube part starts to move downwards to collect liquid, and when the liquid collection mechanism 6 finishes liquid collection, the detected blood collection tube is recovered to the recovery device 15, when the turntable rotates to the uncapping station, a test tube sensor senses that a blood collection tube arrives at the uncapping station, at the moment, the clamping jaw 22102 guides the blood collection tube to the uncapping station, the second motor 221 is started to drive the driving gear 223 to rotate when the blood collection tube arrives at the station, so that the first driven gear 225 and the second driven gear 224 rotate, at the moment, the clamping jaw 2283 with the silica gel finger pad 227 clamps the blood collection tube, at the moment, the first motor 57 rotates to drive the motor screw 54 to rotate downwards to drive the sliding block 52 to slide downwards along the I-shaped sliding rail 55, when the sliding block slides to the upper side of the blood collection tube, the rotating clamping component 21 opens the jaw 212 through the lower part of the uncapping opening and closing device 213, then the uncapping device 213 clamps the cap of the blood collection tube, at this time, the first motor 417 drives the motor screw 414 to spiral up, drives the rotary gripping member 21 to spiral up, that is, to rotate, to remove the cap of the blood collection tube, so that the required cap removing force is reduced, and when the rotary gripping member 21 finishes the cap removing action, the second motor 221 rotates reversely, so that the gripper jaw 2283 loosens the blood collection tube, and the gripper finger seat 2281 on the first driven gear 225 moves to the position of the limiter 229, the gripper jaw 2283 and the gripper jaw 22103 are stopped to rotate, the whole cap removing process is finished, the blood collection tube is also detected, the turntable 11 is driven by the turntable driving mechanism 14 to rotate to the waste tube recycling mechanism 15, the detected blood collection tube is placed in the waste tube recycling mechanism 15, and at this time, the whole feeding mechanism finishes all the working steps.
When the liquid taking mechanism 6 obtains an object to be detected, the Y-axis motor starts to rotate at the moment, the liquid taking mechanism 6 is driven to move in the Y-axis direction, when the sensor senses that the liquid taking mechanism 6 moves to the upper side of the test paper sheet, the Y-axis motor stops rotating, after that, the liquid taking mechanism 6 starts to move downwards, the object to be detected is dripped on the test paper sheet, then moves upwards, and then the Y-axis motor rotates reversely, the liquid taking mechanism 6 is driven to return to the original position, at the moment, the motor 421 rotates to drive the turntable 44 to rotate, the test paper sheet to be detected is rotated to a detection area for detection, after the test paper sheet is detected, the motor 421 rotates reversely to drive the test paper sheet to rotate to the position of the transverse pushing mechanism 41, at the moment, the motor 411 rotates, the gear shaft of the gear shaft 411 drives the tooth-shaped strip 415 to move linearly forwards, the push rod 414 moves forwards along the sliding rail block 413, the test paper sheet is pushed out of the peak table 41, at the moment, the limit piece on the tooth-shaped strip 415 reaches the limit block, the push rod 418 cannot move forwards again, the push rod 414 can be guaranteed to be separated from the test paper sheet to be easily pushed out of the original position, and the limit piece is driven to rotate reversely, and the limit piece 418 can not move reversely.
Although embodiments of the present invention have been disclosed above, it is not limited to the details and embodiments shown and described, it is well suited to various fields of use for which the invention would be readily apparent to those skilled in the art, and accordingly, the invention is not limited to the specific details and illustrations shown and described herein, without departing from the general concepts defined in the claims and their equivalents.
Claims (8)
1. A fully automated dry immunoassay device comprising:
A base (7);
The detection mechanism (4) is fixedly connected to the base (7);
the feeding mechanism (1) is arranged at a distance from the detection mechanism (4); and
The liquid taking mechanism (6) is positioned right above the side of the feeding mechanism (1), the liquid taking mechanism (6) moves back and forth between the detecting mechanism (4) and the feeding mechanism (1),
The detection mechanism (4) is provided with a first rotary table (44), a surrounding baffle plate extends upwards along the periphery of the first rotary table (44), and at least two peak platforms (441) are arranged on the surrounding baffle plate at intervals;
The feeding mechanism (1) comprises a second rotary table (11), a supporting frame (12) and a recovery mechanism (15), wherein the second rotary table (11) is provided with a feeding station, a uncapping station, a liquid pumping station and a recovery station which are sequentially arranged along the rotation direction of the second rotary table;
The utility model discloses a gun head device, including support frame (12), automatic bullet ware (155), support frame (12) rigid coupling has recovery mechanism (15), the rigid coupling has rifle head tray (151) on the support frame, the rigid coupling has rifle head tray support frame (152) on rifle head tray (151), rifle head tray (151) are L type and divide into horizontal component and vertical part, horizontal component rigid coupling in the support frame, just square hole has been seted up to horizontal component middle part, square hole below is equipped with automatic bullet ware (155), automatic bullet ware (155) rigid coupling in on the support frame, the rigid coupling has drawer adjustment piece (153) on the vertical part inner wall.
2. The fully automated dry immunoassay apparatus of claim 1, wherein the detection mechanism (4) further comprises:
A fixed cylinder (47);
a first-stage drum (48) which is fitted around the outer periphery of the cylinder (47); and
A second stage drum (46) which is sleeved on the periphery of the first stage drum (48),
The end surfaces of the cylinder (47), the first-stage rotary drum (48) and the second-stage rotary drum (46) are stepped and sequentially and downwards recursively from top to bottom, a first rotary table (44) is fixedly connected to the upper end surface of the second-stage rotary drum (46), and a transverse pushing mechanism (41) is fixedly connected to the upper end surface of the first-stage rotary drum (48).
3. The full-automatic dry immunoassay equipment according to claim 2, wherein the transverse pushing mechanism (41) comprises a gear shaft motor (411), a fixed disc (417) and a push rod (414), a through groove is formed in the middle of the push rod (414) along the length direction, the width of the through groove is slightly larger than the diameter of the gear shaft motor (411), tooth-shaped strips (415) and I-shaped track strips (416) are fixedly connected to two side edges of the through groove respectively, a sliding rail block (413) is arranged on a device corresponding to the I-shaped track strips (416), a compression block (412) is fixedly connected to the sliding rail block (413), and the compression block (412) is fixed on the fixed disc (417).
4. The full-automatic dry immunoassay device according to claim 1, wherein at least two test tube accommodating grooves are formed in the periphery of the second turntable (11), the adapter (3) is arranged in the test tube accommodating grooves, an accommodating cavity is formed by surrounding the side wall (112) of the test tube accommodating grooves, a positioning block (111) which is vertically arranged is fixedly connected to the inner wall of the accommodating cavity, a positioning hole (1111) is formed in the positioning block (111), a fixing block (113) is arranged at the bottom of the accommodating cavity, and a fixing hole (1131) is formed in the upper surface of the fixing block (113) in a penetrating mode.
5. The full-automatic dry immunoassay device according to claim 1, wherein the liquid taking mechanism (6) comprises a liquid taking tube structure (61) and a driving structure (62), and the driving structure (62) drives the liquid taking tube structure (61) to do linear motion along the horizontal direction.
6. The full-automatic dry immunoassay device according to claim 5, wherein the liquid taking tube structure (61) is provided with a liquid taking tube component (611), a liquid taking tube fixing block (618) is fixedly connected with the liquid taking tube component (611), a bearing fixing block (619) is fixedly connected with the liquid taking tube fixing block (618), a vertical sliding block (6110) is fixedly connected with the bearing fixing block (619), and a vertical bar-shaped connecting block (614) is fixedly connected with the vertical sliding block (6110).
7. The full-automatic dry immunoassay device of claim 6, wherein a loading base (613) horizontally placed is fixedly connected to the bottom end of the bar-shaped connecting block (614), a gear motor (612) is fixedly connected to the left end face of the loading base (613), the gear motor (612) extends downwards through the loading base (613), a rotating shaft (617) is fixedly connected to the right end face of the loading base (613), one end of the rotating shaft (617) is a rotating gear (615), and the rotating gear (615) upwards penetrates through the bearing fixing block (619).
8. The full-automatic dry immunoassay device according to claim 5, wherein the driving structure (62) is provided with a transverse connection plate (622), one end of the transverse connection plate (622) is fixedly connected with a first gear motor (621), the other end of the transverse connection plate (622) is provided with a gear shaft (626), a transverse fixing block (624) is arranged on the transverse connection plate (622) opposite to the first gear motor (621), the upper side and the lower side of the transverse connection plate (622) are provided with a first sliding rail (6212) and a second sliding rail (6211), the first sliding rail (6212) and the second sliding rail (6211) are respectively provided with a first sliding block (6210) and a second sliding block (628) opposite to each other, and the transverse fixing block (624) is fixed on the first sliding block (6210) and the second sliding block (628).
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| CN201910893591.2A CN110596408B (en) | 2019-09-20 | 2019-09-20 | Full-automatic dry-type immunoassay equipment |
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| CN201910893591.2A CN110596408B (en) | 2019-09-20 | 2019-09-20 | Full-automatic dry-type immunoassay equipment |
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| CN110596408B true CN110596408B (en) | 2024-05-17 |
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| CN114196516B (en) * | 2020-09-02 | 2023-09-26 | 浙江康是医疗器械有限公司 | Full-automatic portable virus sampling pipe rapid analysis equipment |
| WO2022217397A1 (en) * | 2021-04-12 | 2022-10-20 | 苏州鼎实医疗科技有限公司 | Fully automated immunoassay analyzer convenient for feeding and discharging |
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| CN211505576U (en) * | 2019-09-20 | 2020-09-15 | 苏州鼎实医疗科技有限公司 | Full-automatic dry immunoassay equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104634984A (en) * | 2015-02-10 | 2015-05-20 | 中国科学院苏州生物医学工程技术研究所 | Fully-automatic fluorescence immunoassay system |
| CN105548132A (en) * | 2015-11-23 | 2016-05-04 | 王治才 | Automatic rotary-disc type fluorescence detector |
| CN106198480A (en) * | 2016-08-30 | 2016-12-07 | 广州蓝勃生物科技有限公司 | A kind of dry type fluorescence detector automatically |
| CN211505576U (en) * | 2019-09-20 | 2020-09-15 | 苏州鼎实医疗科技有限公司 | Full-automatic dry immunoassay equipment |
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