CN110585381A - Medicinal and edible composition for expelling toxoplasma gondii and preparation method thereof - Google Patents

Medicinal and edible composition for expelling toxoplasma gondii and preparation method thereof Download PDF

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CN110585381A
CN110585381A CN201910922023.0A CN201910922023A CN110585381A CN 110585381 A CN110585381 A CN 110585381A CN 201910922023 A CN201910922023 A CN 201910922023A CN 110585381 A CN110585381 A CN 110585381A
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toxoplasma gondii
edible composition
selenium
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方连明
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Shandong Jiaseliya Biological Co Ltd
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K2236/30Extraction of the material
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    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention relates to the technical field of medicinal and edible compositions, in particular to a medicinal and edible composition for expelling toxoplasma gondii and a preparation method thereof. The medicinal and edible composition for expelling toxoplasma gondii mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 10-15 parts of brucea javanica, 10-20 parts of astragalus membranaceus, 5-18 parts of radix stemonae, 6-10 parts of liquorice, 3-8 parts of Chinese torreya, 2-8 parts of fructus cannabis, 1-3 parts of semen euryales and 0.5-1.5 parts of schizophyllum commune. The medicinal and edible composition for expelling toxoplasma gondii and the preparation method thereof have reasonable compatibility and synergistic effect among the components, solve the toxoplasma gondii infection in most human bodies through the medicinal and edible composition, have no toxic or side effect, and are suitable for use in life.

Description

Medicinal and edible composition for expelling toxoplasma gondii and preparation method thereof
Technical Field
The invention relates to the technical field of medicinal and edible compositions, in particular to a medicinal and edible composition for expelling toxoplasma gondii and a preparation method thereof.
Background
Toxoplasma Gondii (Toxoplasma Gondii), also called a three-corpse worm, is an intracellular parasite. Parasitizing in cells, flowing with blood, reaching all parts of the body, damaging the brain, heart and fundus oculi, causing the immunity of people to be reduced and various diseases to be suffered. It is an obligate intracellular parasite of the order coccidioideae, isosporozoa, genus toxoplasma.
At present, a plurality of hospitals in China already carry out the detection of toxoplasma gondii antibodies. However, the quality of the examination is not high, the quality of the reagent and the screening method need to be standardized, and many clinicians are not familiar with the significance and the correct judgment of the result of the serological examination. False positive results and wrong interpretation by doctors caused by low inspection quality not only waste money and wealth of the sick families, but also cause unnecessary anxiety of the sick and the family members and bring great mental burden. The traditional toxoplasma resisting medicines are sulfadiazine and pyrimethamine, and the medicines such as spiramycin, clindamycin, azithromycin and the like can be adopted for treatment at present, but the medicines have certain toxic and side effects, are required to be treated according to the advice, are not suitable in life, and cannot solve toxoplasma infection in most human bodies.
Disclosure of Invention
The invention aims to provide a medicinal and edible composition for expelling toxoplasma gondii and a preparation method thereof, overcomes the defects of the prior art, solves toxoplasma gondii infection in most human bodies through the medicinal and edible composition, has no toxic or side effect, and is suitable for use in life.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a medicinal and edible composition for expelling Toxoplasma gondii comprises: the material mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 10-15 parts of brucea javanica, 10-20 parts of astragalus membranaceus, 5-18 parts of radix stemonae, 6-10 parts of liquorice, 3-8 parts of Chinese torreya, 2-8 parts of fructus cannabis, 1-3 parts of semen euryales and 0.5-1.5 parts of schizophyllum commune.
Preferably, the material mainly comprises the following raw materials in parts by weight: 4 parts of selenium malt, 13 parts of brucea javanica, 16 parts of astragalus mongholicus, 10 parts of radix stemonae, 8 parts of liquorice, 5 parts of Chinese torreya, 7 parts of fructus cannabis, 2 parts of semen euryales and 1 part of schizophyllum commune.
Preferably, the material mainly comprises the following raw materials in parts by weight: 2 parts of selenium malt, 10 parts of brucea javanica, 10 parts of astragalus membranaceus, 5 parts of radix stemonae, 6 parts of liquorice, 3 parts of Chinese torreya, 2 parts of fructus cannabis, 1 part of semen euryales and 0.5 part of schizophyllum commune.
Preferably, the material mainly comprises the following raw materials in parts by weight: 5 parts of selenium malt, 15 parts of brucea javanica, 20 parts of astragalus membranaceus, 18 parts of radix stemonae, 10 parts of liquorice, 8 parts of Chinese torreya, 8 parts of fructus cannabis, 3 parts of semen euryales and 1.5 parts of schizophyllum commune.
A preparation method of a medicinal and edible composition for expelling toxoplasma gondii comprises the following steps:
(1) distilling brucea javanica, astragalus membranaceus, radix stemonae and liquorice in specified weight parts for 1-2 times by using steam, wherein each time lasts for 2-10 hours, collecting volatile oil and distilled residual liquid, decocting the decoction dregs for 1-3 times to obtain an extracting solution, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain a clear paste A, wherein the relative density of the clear paste A at 55-60 ℃ is 1.35-1.44;
(2) decocting the residue after extracting volatile oil in step (1), Chinese torreya, fructus cannabis, semen euryales and schizophyllum commune with water for 1-3 times, each time for 1-3h, filtering, collecting filtrate, and concentrating to obtain fluid extract B, wherein the relative density of the fluid extract B at 55-60 ℃ is 1.35-1.44;
(3) mixing the clear paste A obtained in the step (1) with the clear paste B obtained in the step (2) to obtain an extract, and adding the malt selenium in a specified weight part into the extract;
(4) and (3) uniformly mixing the extract added with the selenium malted tea in the step (3) with the volatile oil in the step (1) to obtain the selenium malted tea.
Preferably, the ratio of g: and the mass volume ratio of the decoction dregs to the water is 1:6-8 by mL.
Preferably, in step (2) of step (2), the ratio of g: and the mass volume ratio of the decoction dregs to the water is 1: 6-8.
The invention has the beneficial effects that: compared with the prior art, the medicinal and edible composition for expelling toxoplasma gondii and the preparation method thereof have the advantages that the compatibility is reasonable, the components have synergistic effect, the toxoplasma gondii infection in most human bodies is solved through the medicinal and edible composition, no toxic or side effect is caused, and the medicinal and edible composition is suitable for use in life.
Detailed Description
Example 1
A medicinal and edible composition for expelling toxoplasma gondii mainly comprises the following raw materials in parts by weight: 4 parts of selenium malt, 13 parts of brucea javanica, 16 parts of astragalus mongholicus, 10 parts of radix stemonae, 8 parts of liquorice, 5 parts of Chinese torreya, 7 parts of fructus cannabis, 2 parts of semen euryales and 1 part of schizophyllum commune.
A preparation method of a medicinal and edible composition for expelling toxoplasma gondii comprises the following steps:
(1) distilling brucea javanica, astragalus membranaceus, radix stemonae and liquorice in specified weight parts for 2 times by using water vapor, collecting volatile oil and distilled residual liquid, decocting the residues for 2 times to obtain extracting solution, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain clear paste A, wherein the relative density of the clear paste A at 58 ℃ is 1.4;
(2) decocting the residue after extracting volatile oil in step (1), Chinese torreya, fructus cannabis, semen euryales and schizophyllum commune with water for 2 times, each time for 2h, filtering, collecting filtrate, and concentrating to obtain fluid extract B, wherein the relative density of the fluid extract B at 58 ℃ is 1.4;
(3) mixing the clear paste A obtained in the step (1) with the clear paste B obtained in the step (2) to obtain an extract, and adding the malt selenium in a specified weight part into the extract;
(4) and (3) uniformly mixing the extract added with the selenium malted tea in the step (3) with the volatile oil in the step (1) to obtain the selenium malted tea.
Example 2
A medicinal and edible composition for expelling toxoplasma gondii is characterized in that: the material mainly comprises the following raw materials in parts by weight: 2 parts of selenium malt, 10 parts of brucea javanica, 10 parts of astragalus membranaceus, 5 parts of radix stemonae, 6 parts of liquorice, 3 parts of Chinese torreya, 2 parts of fructus cannabis, 1 part of semen euryales and 0.5 part of schizophyllum commune.
A preparation method of a medicinal and edible composition for expelling toxoplasma gondii comprises the following steps:
(1) distilling brucea javanica, astragalus membranaceus, radix stemonae and liquorice in specified weight parts for 1 time by using steam, collecting volatile oil and distilled residual liquid for 2 hours each time, decocting the dregs of a decoction for 1 time to obtain extracting solution, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain clear paste A, wherein the relative density of the clear paste A at 55 ℃ is 1.35;
(2) decocting the residue after extracting volatile oil in step (1), Chinese torreya, fructus cannabis, semen euryales and schizophyllum commune with water for 1 time, each time for 1h, filtering, collecting filtrate, and concentrating to obtain fluid extract B, wherein the relative density of the fluid extract B at 55 ℃ is 1.35;
(3) mixing the clear paste A obtained in the step (1) with the clear paste B obtained in the step (2) to obtain an extract, and adding the malt selenium in a specified weight part into the extract;
(4) and (3) uniformly mixing the extract added with the selenium malted tea in the step (3) with the volatile oil in the step (1) to obtain the selenium malted tea.
Example 3
A medicinal and edible composition for expelling toxoplasma gondii mainly comprises the following raw materials in parts by weight: 5 parts of selenium malt, 15 parts of brucea javanica, 20 parts of astragalus membranaceus, 18 parts of radix stemonae, 10 parts of liquorice, 8 parts of Chinese torreya, 8 parts of fructus cannabis, 3 parts of semen euryales and 1.5 parts of schizophyllum commune.
A preparation method of a medicinal and edible composition for expelling toxoplasma gondii comprises the following steps:
(1) distilling brucea javanica, astragalus membranaceus, radix stemonae and liquorice in specified weight parts for 2 times by using water vapor, 10 hours each time, collecting volatile oil and distilled residual liquid, decocting the dregs of a decoction for 3 times to obtain an extracting solution, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain a clear paste A, wherein the relative density of the clear paste A at 60 ℃ is 1.44;
(2) decocting the residue after extracting volatile oil in step (1), Chinese torreya, fructus cannabis, semen euryales and schizophyllum commune with water for 3 times, each time for 3h, filtering, collecting filtrate, and concentrating to obtain fluid extract B, wherein the relative density of the fluid extract B at 60 ℃ is 1.44;
(3) mixing the clear paste A obtained in the step (1) with the clear paste B obtained in the step (2) to obtain an extract, and adding the malt selenium in a specified weight part into the extract;
(4) and (3) uniformly mixing the extract added with the selenium malted tea in the step (3) with the volatile oil in the step (1) to obtain the selenium malted tea.
Experimental example 1
The clinical practice test of 300 patients with toxoplasma in vivo is selected, one group is formed for every 100 patients, one dose is taken for each group, and 15 days are a course of treatment.
The therapeutic criteria are as follows:
and (3) healing: the symptoms and physical signs return to normal;
the effect is shown: the symptoms and physical symptoms are obviously improved;
the method has the following advantages: the symptoms and the physical symptoms are improved;
and (4) invalidation: the symptoms and physical symptoms are not obviously improved, and the symptoms are as before.
The total effective rate is the cure rate + significant efficiency + effective rate.
The results of the experiment are shown in table 1:
TABLE 1
The above embodiments are only specific examples of the present invention, and the protection scope of the present invention includes but is not limited to the product forms and styles of the above embodiments, and any suitable changes or modifications made by those skilled in the art according to the claims of the present invention shall fall within the protection scope of the present invention.

Claims (7)

1. A medicinal and edible composition for expelling toxoplasma gondii is characterized in that: the material mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 10-15 parts of brucea javanica, 10-20 parts of astragalus membranaceus, 5-18 parts of radix stemonae, 6-10 parts of liquorice, 3-8 parts of Chinese torreya, 2-8 parts of fructus cannabis, 1-3 parts of semen euryales and 0.5-1.5 parts of schizophyllum commune.
2. The medicinal and edible composition for repelling toxoplasma gondii as claimed in claim 1, wherein: the material mainly comprises the following raw materials in parts by weight: 4 parts of selenium malt, 13 parts of brucea javanica, 16 parts of astragalus mongholicus, 10 parts of radix stemonae, 8 parts of liquorice, 5 parts of Chinese torreya, 7 parts of fructus cannabis, 2 parts of semen euryales and 1 part of schizophyllum commune.
3. The medicinal and edible composition for repelling toxoplasma gondii as claimed in claim 1, wherein: the material mainly comprises the following raw materials in parts by weight: 2 parts of selenium malt, 10 parts of brucea javanica, 10 parts of astragalus membranaceus, 5 parts of radix stemonae, 6 parts of liquorice, 3 parts of Chinese torreya, 2 parts of fructus cannabis, 1 part of semen euryales and 0.5 part of schizophyllum commune.
4. The medicinal and edible composition for repelling toxoplasma gondii as claimed in claim 1, wherein: the material mainly comprises the following raw materials in parts by weight: 5 parts of selenium malt, 15 parts of brucea javanica, 20 parts of astragalus membranaceus, 18 parts of radix stemonae, 10 parts of liquorice, 8 parts of Chinese torreya, 8 parts of fructus cannabis, 3 parts of semen euryales and 1.5 parts of schizophyllum commune.
5. The preparation method of the medicinal and edible composition for repelling toxoplasma gondii as claimed in claim 1, is characterized in that:
the method comprises the following steps:
(1) distilling brucea javanica, astragalus membranaceus, radix stemonae and liquorice in specified weight parts for 1-2 times by using steam, wherein each time lasts for 2-10 hours, collecting volatile oil and distilled residual liquid, decocting the decoction dregs for 1-3 times to obtain an extracting solution, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain a clear paste A, wherein the relative density of the clear paste A at 55-60 ℃ is 1.35-1.44;
(2) decocting the residue after extracting volatile oil in step (1), Chinese torreya, fructus cannabis, semen euryales and schizophyllum commune with water for 1-3 times, each time for 1-3h, filtering, collecting filtrate, and concentrating to obtain fluid extract B, wherein the relative density of the fluid extract B at 55-60 ℃ is 1.35-1.44;
(3) mixing the clear paste A obtained in the step (1) with the clear paste B obtained in the step (2) to obtain an extract, and adding the malt selenium in a specified weight part into the extract;
(4) and (3) uniformly mixing the extract added with the selenium malted tea in the step (3) with the volatile oil in the step (1) to obtain the selenium malted tea.
6. The preparation method of the medicinal and edible composition for repelling toxoplasma gondii as claimed in claim 5, wherein: in the step (1), the ratio of g: and the mass volume ratio of the decoction dregs to the water is 1:6-8 by mL.
7. The preparation method of the medicinal and edible composition for repelling toxoplasma gondii as claimed in claim 5, wherein: in the step (2), the ratio of g: and the mass volume ratio of the decoction dregs to the water is 1: 6-8.
CN201910922023.0A 2019-09-27 2019-09-27 Medicinal and edible composition for expelling toxoplasma gondii and preparation method thereof Pending CN110585381A (en)

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Publication number Priority date Publication date Assignee Title
CN111135253A (en) * 2020-01-16 2020-05-12 珠海汉唐生物科技工程有限公司 Formula for eliminating toxoplasma gondii parasitism and preparation method of capsules thereof
CN116688022A (en) * 2023-04-28 2023-09-05 河北锦坤动物药业有限公司 Traditional Chinese medicine composition for treating toxoplasmosis and preparation method thereof

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CN103083500A (en) * 2011-11-03 2013-05-08 青岛康地恩药业股份有限公司 Chinese medicinal composition treating toxoplasmosis
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111135253A (en) * 2020-01-16 2020-05-12 珠海汉唐生物科技工程有限公司 Formula for eliminating toxoplasma gondii parasitism and preparation method of capsules thereof
CN116688022A (en) * 2023-04-28 2023-09-05 河北锦坤动物药业有限公司 Traditional Chinese medicine composition for treating toxoplasmosis and preparation method thereof
CN116688022B (en) * 2023-04-28 2024-06-04 河北锦坤动物药业有限公司 Traditional Chinese medicine composition for treating toxoplasmosis and preparation method thereof

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Application publication date: 20191220