CN101062326A - Chinese traditional combination having anti-fatigue function - Google Patents
Chinese traditional combination having anti-fatigue function Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation having fatigue-resisting function, which comprises the following Chinese medicinal herbs (by weight portion): acanthopanax root 2-6 parts, epimedium 1-4 parts, cyathula root 1-5 parts, doddor seed 1-4 parts, astragalus root 1-5 part, malt 2-6 parts. The medicament can be prepared into various oral dose forms including particles and capsules.
Description
One, technical field
What the present invention relates to is a kind of Chinese medicine composition with antifatigue effect.
Two, background technology
With the increase of social pressure, in developed country and city, except the patient that a part is made a definite diagnosis, the healthy person in ordinary person's eye has about half " subhealth state " state that is in the quickening pace of modern life.Subhealth state is the category concept between health fatigue and disease fatigue, and the tired mechanism that produces is fuzzyyer, the factor complexity.The typical case shows as fatigue among " subhealth state " crowd, the body discomfort.Fatigue is a comprehensive physiological process that relates to many physiology factors, is that body is crossed the state that the function of using and causing reduces and occur the body discomfort.Cross with causing that function reduces or the body discomfort refers to that not only muscle power also refers to mental and psychology, refers to that not only integral body also refers to the part.The body discomfort mainly shows as tired sleepy, also has some tired simultaneous phenomenons, as degradation under dizzy, forgetful, the sleep quality.Data shows according to statistics, also has people more than half to be in this state at present in that China is domestic.Therefore, tired and subhealth state not still medical problem and becoming day by day need the social problem that pays close attention to, seriously influencing people's quality of life, therefore control has become the task of top priority because of the tired subhealth state that causes.
Three, summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition with antifatigue effect; Another object of the present invention is that Chinese medicine composition is made medicinal preparation for oral administration, and taking convenience is used to regulate body function, stimulating appetite, brain-nourishing refreshing, improvement sleep.
Of the present invention is to adopt following technical proposals to be achieved, and a kind of Chinese medicine composition with antifatigue effect is made by the raw material of following parts by weight: Radix Et Caulis Acanthopanacis Senticosi 2-6 part, Herba Epimedii 1-4 part, Radix Cyathulae 1-5 part, Semen Cuscutae 1-4 part, Radix Astragali 1-5 part, Fructus Hordei Germinatus 2-6 part.
Tired institute's insufficiency of primordial QI that is at most or daily life imbalance or transition fatigue, brain overwork, body and mind consume and the organ function that arrives is low.Theory of Chinese medical science is thought: fatigue belongs to QI and blood consumption and hinders the deficient syndrome that causes, the speak sarcastically QI and blood of body of excessive fatigue energy consumption, outer disfigurement body, interior and internal organs; Excessive thinking and anxiety can secretly consume the menses of human body, and interior impairment of ZANG FU-organs is therefore tired relevant with the five internal organs, and mainly and spleen, liver, kidney be closely related.Have in the Chinese medicine composition component of antifatigue effect, the hot warm little hardship of Radix Et Caulis Acanthopanacis Senticosi is returned kidney channel, and contained different plain skin is the Rapid Expansion blood vessel surely, strengthens blood flow, improves blood supply, and the energy endocrine regulation, and the spleen invigorating QI invigorating is promoted the production of body fluid with fixed attention; The Radix Astragali can promote temper lung benefiting consolidating superficial resistance again, diuresis; Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali are principal agent altogether, the two mutually 5, tonifying Qi and lifting yang, hold up the spleen nourishing the stomach, make the QI and blood intercommunication, strengthening by means of tonics, allaying tiredness tiredness.Be aided with the key medicine that the Herba Epimedii kidney invigorating and YANG supporting is temperature compensation.Semen Cuscutae Xin Ganping returns liver, kidney channel, has the effect of beneficial marrow, and hypothalamus hypophysis, gonad function are had excitation, but the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the two treating YANG within YIN that matches, then positive cloudy helping and biochemically do not have.The Radix Cyathulae promoting blood circulation to restore menstrual flow, Liver and kidney is augmented in the Shu Li joint, the power of bone and muscle strengthening.Assistant with the Fructus Hordei Germinatus (parched) removing stagnancy of indigested food and making QI downward, transfer burnt in smooth, refresh oneself that it is tired to disappear.Above-mentioned prescription is started with from adjusting mechanism of qi, tonification vigour, strengthening the body resistance, reach stimulating appetite, the mind calming and mentality promoting, brain-nourishing refreshing and improve sleep, strengthen the purpose of disease-resistant, cold-resistant, the anti-fatigue ability of human body, prescription has the function of replenishing QI to invigorate the spleen, kidney-tonifying health-care, allaying tiredness.
The medicinal preparation for oral administration dosage form that above-mentioned Chinese medicine composition is made is granule, capsule.
Taboo: avoid eating anything raw or cold and greasy food, diseases caused by exogenous pathogenic factor person should not take.
Effect of the present invention and advantage:
1, the present invention has the function of replenishing QI to invigorate the spleen, kidney-tonifying health-care, allaying tiredness.
2, the medicinal preparation for oral administration made of the present invention, through taking tracing observation, the family of having office hours, vehicle driver to brain worker, few motion at ordinary times take under the state that feels fatigue, and have tangible brain-strengthening, an effect of refreshing oneself; At appetite strengthening, allaying tiredness, improvement aspect such as sleep, regain one's strength effect is preferably arranged; The prescription raw material is easy to get, and has no side effect.
Four, the specific embodiment
(1) embodiment
Embodiment 1:
1, amounts of components: 4 parts of Radix Et Caulis Acanthopanacis Senticosis, 2 parts of Herba Epimedii, 3 parts of Radix Cyathulaes, 2 parts of Semen Cuscutae, 3 parts of the Radixs Astragali, 4 parts in Fructus Hordei Germinatus.
2, the processing of component raw material
Radix Et Caulis Acanthopanacis Senticosi: the Radix Et Caulis Acanthopanacis Senticosi that will take by weighing by recipe quantity, pulverize the back and cross aperture 0.9mm sieve, be soaked in the petroleum ether (b.p.60-90 ℃), after room temperature was placed 3h, the lixiviating solution that inclines added petroleum ether again and soaks, and repeated multiple times is colourless to lixiviating solution, removes chlorophyll fully.The lixiviating solution that inclines, sample place the ventilation to be dried to no petroleum ether flavor, the reuse baking oven in 60 ℃ dry to constant weight extract, be positioned over preserve in the exsiccator stand-by.
The Radix Astragali: the Radix Astragali that will take by weighing by recipe quantity, after the pulverizing, with 8,8,6 times of amount 50% alcohol reflux 3 times, each 3h is evaporated to the extractum shape, and drying is pulverized stand-by
Herba Epimedii: the Herba Epimedii that will take by weighing by recipe quantity, 70% alcohol solvent that adds 10 times of amounts, soak 2h, reflux, extract, 1.5h, extracting solution concentrate the back and use the petroleum ether continuous extraction to closely colourless (defat), static, filter standardize solution in measuring bottle, the reuse methanol eddy extracts, and concentrates and makes extractum, drying is pulverized stand-by.
Radix Cyathulae: the Radix Cyathulae that will take by weighing by recipe quantity is in beaker, and (180ml soaks 20min first to add water, the 2nd 160ml), be positioned on the far infrared electric furnace, be heated to and boil, 30min is fried boiling at every turn, be fried boiling altogether 2 times, filter filtering residue 50ml water washing, merging filtrate then, water-solublely be concentrated into driedly, place (± 80 ℃) oven dry in the calorstat again, pulverize stand-by.
Semen Cuscutae: will place apparatus,Soxhlet's by the Semen Cuscutae that recipe quantity takes by weighing, with petroleum ether (60-90 ℃) water-bath backflow defat 2 times, the Semen Cuscutae after the defat is with 80% alcohol reflux 3h, after 2 times extracting solution, concentratedly make extractum, drying is pulverized stand-by.
Fructus Hordei Germinatus: will press Fructus Hordei Germinatus that recipe quantity takes by weighing and be tiled in and place in the enamel tray in the electrically heated drying cabinet, 140 ℃ of temperature heating 20min take out, and cool, and pulverize stand-by.
The processing of each component raw material is the conventional processing method of extracting.
3, make dissolved granule: after above-mentioned each component extract mixes, add adjuvant, make granule by the conventional method of Chinese medicine preparation, packed, every bag of 10g.
Embodiment 2:
1, constituent content: 6 parts of Radix Et Caulis Acanthopanacis Senticosis, 4 parts of Herba Epimedii, 5 parts of Radix Cyathulaes, 4 parts of Semen Cuscutae, 5 parts of the Radixs Astragali, 6 parts in Fructus Hordei Germinatus.
2, the processing method of component raw material is the same.
3, the conventional method of Chinese medicine preparation is made capsule, every dress Dissolve things inside 500mg.
(2) resisting fatigue of dissolved granule, toxicity test and clinical observation record
1 anti-fatigue test
A, experimental animal: select the healthy cleaning of 18-22g Kunming kind white mice for use, male and female half and half.
B, be subjected to the reagent thing: the resisting fatigue dissolved granule that above-mentioned prescription is made.
C, used instrument: high performance liquid chromatograph, 755 ultraviolet-uisible spectrophotometers, YSI1500 lactic acid analyzer, electronic balance, stopwatch, centrifuge, DS electric heating three usefulness waters, swimming case.
D, dosage design: mice is divided into 4 groups at random by body weight, 12 every group, establish blank group, resisting fatigue granule 200,400700mg/kgbw group, survey every index behind the continuous irrigation stomach 15d.The mouse stomach volume is heavy for the 0.1ml/10g Mus.
E, test method are the swimming with a load attached to the body test: after last is tried thing 30min to mice, place the swimming case to swim the load mice of 5% body weight galvanized wire of root of the tail portion, 25.0 ± 1.0 ℃ of depth of water 30cm, water temperatures, the record mice is from the extremely dead time of swimming beginning, as the mice swimming with a load attached to the body time.
H, detection index: 1. hepatic glycogen is measured, and after last is tried thing 30min to mice, puts to death immediately, get liver and after the normal saline rinsing, blot, accurately take by weighing liver 100mg, add 8mlTCA with filter paper, even oar 1min, to spare oar to going into centrifuge tube,, remove supernatant 1ml with the centrifugal 15min of 3000r/min, add 95% ethanol 4ml, fully do not leave the interface between mixing to two kind of liquid, with clean stopper beyond the Great Wall, erect under the room temperature to place and spend the night.Next day is with the centrifugal 15min of 3000r/min.Carefully outwell supernatant and test tube is stood upside down and place 10min, with 2ml dissolved in distilled water glycogen.Reagent blank pipe: inhale the 2ml distilled water to clean centrifuge tube standard pipe; Inhale 0.5ml glucose titer (100mg/dl) and 1.5ml distilled water and put into same pipe.
The 10ml anthrone reagent is firmly added each pipe, boil 15min, move on to ice-water bath then, absorbance is measured with reagent blank pipe zeroing back in the cooling back under the 620nm wavelength, be calculated as follows hepatic glycogen content:
DU is the sample absorbance; V is an extracting liquid volume; DS is the standard pipe absorbance; 0.5 be the glucose in the 0.5ml glucose titer; G is hepatic tissue weight (g); 0.9 for glucose being converted into the coefficient of glycogen.
2. blood lactic acid is measured: after last was tried thing 30min to mice, the 20 μ l that take a blood sample added the even smudge cells of vibration in the 40 μ l rupture of membranes liquid.Making mice then is to stop behind the swimming 10min in 30 ℃ the water in temperature, and the 20 μ l that take a blood sample immediately add in the 40 μ l rupture of membranes liquid, and vibration evenly.Behind the rest 20min, the 20 μ l that take a blood sample again add in the 40 μ l rupture of membranes liquid, and vibration is evenly measured with blood lactic acid analyzer, and gained is measured on duty 3 and is lactic acid value (mol/l).Be calculated as follows blood lactic acid rising ratio and eliminate ratio.
Blood before blood lactic acid rising ratio=(blood lactic acid value before blood lactic acid value-swimming of swimming back 0min)/swimming
The lactic acid value
Blood lactic acid is eliminated ratio=(blood lactic acid of the blood lactic acid value of swimming back 0min-swimming back rest 20min
Value)/the blood lactic acid value of 0min after swimming
Result of the test: resisting fatigue granule 400,700mgbw group can significantly improve the hepatic glycogen content (P＜0.01) of male mice; 700mgbw group blood lactic acid is eliminated ratio and is higher than matched group (P＜0.01), illustrates that being tried thing can strengthen male mice elimination lactic acid ability, and the result shows that the 700mgbw group can significantly improve the persistent period of male mice swimming with a load attached to the body.Antifatigue effect indexs such as mouse movement ability, hepatic glycogen content and elimination lactic acid ability are to strengthen along with the increase of total glycosides amount, illustrate that being tried the thing total glycosides has antifatigue effect and have tangible dose-effect relationship.
2, toxicity test carries out preliminary toxicology safety test according to People's Republic of China's " toxicological evaluation of food safety procedure and method " to it.
A, medicine and administering mode: medicine is the resisting fatigue dissolved granule that above-mentioned prescription is made.Administering mode is that chmice acute per os toxicity test is with the administration by gavage administration; Mice 30d feeding trial is with the method for breeding administration.
B, select 18-22g Kunming kind white mice, male and female half and half for use.
C, key instrument: BecmanCX4 type automatic clinical chemistry analyzer, TGL-16g type high speed tabletop centrifuge, JEM-1200EX type transmission electron microscope, LKB-V type ultramicrotome, LRIPZ-LC027 histotome.
D, test method: 1. chmice acute per os toxicity test, 24 mices are divided into two groups, 12 every group, male and female six, matched group is normally fed, and irritates stomach behind the hungry 12h of test group, medication amount be 0.3ml/ only.Observe a week after irritating stomach, situations such as the sleep of record mice, diet, activity, death are calculated LD
502. mice 30d feeding trial adds anti-fatigue medicament in the Mus material to, makes in every kg Mus material to contain medicine 100g.40 mice male and female half and half are divided into two groups, 20 every group.Matched group is normally fed, and experimental group is fed the feedstuff 30d that adds medicine.
E, ordinary circumstance and constructed observation: 1. Mus acute oral toxicity test movable minimizing in the 4h after irritating stomach, prolong the length of one's sleep, recovers normal behind the 4h.The viewing duration experimental mice mental status is good, and diet is normal, and the phenomena of mortality do not take place.2. in the mice 30d feeding trial process, mice diet, active situation are normal, and the mental status is good.The color of tissue such as the clinical visible heart, liver,kidney,spleen, lung, stomach, intestinal, form, big or small normal, pathological changes such as no swelling, necrosis.Displaing microstructure observing shows, experimental group liver, kidney, small intestinal, five kinds of organizational structuries of harmonization of the stomach brain are clear, do not find pathological changes such as hyperemia, congestion, cellular atrophy, degeneration, necrosis, inflammatory cell infiltration and proliferation of fibrous tissue, Ultrastructural observation shows, hepatocyte, renal cortical cell form are normal, and the organelle structure is normal.Structure of mitochondria is complete, film, ridge, basal granule are high-visible, and substrate is even, and electron density is moderate; Cell membrane is complete, and rough endoplasmic reticulum is wire, has a large amount of line grains to adhere on it; The Cytoplasm uniform coloring; The nucleus size is even, kernel nuclear membrane complete display.The organ index of liver, two kinds of main organs of kidney between two groups, no significant difference; No significant difference between two groups of routine blood test and biochemical indicators.
Experimental result: according to the chemicals acute toxicity grading criteria in " toxicological evaluation of food safety procedure and method ", the medicine that this prescription is made belongs to nontoxic level.The subchronic toxicity 30d of prescription feeds, and the mice ordinary circumstance is good; After feeding 30d, its anatomy and mainly organize microstructure normal; Liver, kidney cortex ultrastructure are normal; About biochemical indicator and matched group no significant difference, show that liver, renal function are normal.Match with the intact of its structure.
3, the effect tracing observation of taking of dissolved granule is noted down, and takes dosage form: granule, warm boiled water, each one bag, every bag of 10g, every day 3 times.
A, take personnel 80 people, wherein: male 50 people, women 30 people.
Taximan 30 people among 50 male, all the other 20 philtrums, 15 people are the break tour personnel, 5 financial staff by name.Clinical table disease is not for there be appetite, poor sleeping quality, tired fatigue.
Among 30 women, break tour 20 people, 10 nurse two people by name in addition, financial staff 5 people, 3 people's microcomputer cashiers, clinical table disease is bad for sleep, panesthesia out of spirits, do not have appetite, tired unable, work weak.
B, take the back effect, after above-noted persons take, 2 days produce effects of 76 people, sleep quality has clear improvement after 5 days, after especially human pilot is taken, to stimulating appetite, improve sleep, the effect that banishes the feeling of languor is obvious, total effective rate is 95%.
Claims (3)
1, a kind of Chinese medicine composition with antifatigue effect, it is characterized in that: Chinese medicine composition is made by the raw material of following parts by weight: Radix Et Caulis Acanthopanacis Senticosi 2-6 part, Herba Epimedii 1-4 part, Radix Cyathulae 1-5 part, Semen Cuscutae 1-4 part, Radix Astragali 1-5 part, Fructus Hordei Germinatus 2-6 part.
2, the Chinese medicine composition with antifatigue effect according to claim 1, it is characterized in that: Chinese medicine composition is made by the raw material of following parts by weight: 4 parts of Radix Et Caulis Acanthopanacis Senticosis, 2 parts of Herba Epimedii, 3 parts of Radix Cyathulaes, 2 parts of Semen Cuscutae, 3 parts of the Radixs Astragali, 4 parts in Fructus Hordei Germinatus.
3, the Chinese medicine composition with antifatigue effect according to claim 1 and 2 is characterized in that the oral medicine dosage form that Chinese medicine composition is made is granule, capsule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101983703A (en) * | 2010-11-19 | 2011-03-09 | 齐东华 | Traditional Chinese medicine composition and traditional Chinese medicine preparation |
| CN101632806B (en) * | 2008-07-25 | 2011-11-16 | 孙立辉 | Medicinal composition, pill and preparation method thereof |
| CN105106665A (en) * | 2015-09-20 | 2015-12-02 | 安徽联喆玉竹有限公司 | Anti-fatigue care capsule and preparation method |
| CN105832878A (en) * | 2016-06-19 | 2016-08-10 | 李�杰 | Anti-fatigue buccal tablet |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108669566A (en) * | 2018-03-13 | 2018-10-19 | 王羚郦 | A kind of functional composition and its application |
-
2007
- 2007-05-31 CN CNB2007100723138A patent/CN100493584C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632806B (en) * | 2008-07-25 | 2011-11-16 | 孙立辉 | Medicinal composition, pill and preparation method thereof |
| CN101983703A (en) * | 2010-11-19 | 2011-03-09 | 齐东华 | Traditional Chinese medicine composition and traditional Chinese medicine preparation |
| CN101983703B (en) * | 2010-11-19 | 2012-10-31 | 齐东华 | Traditional Chinese medicine composition and traditional Chinese medicine preparation |
| CN105106665A (en) * | 2015-09-20 | 2015-12-02 | 安徽联喆玉竹有限公司 | Anti-fatigue care capsule and preparation method |
| CN105832878A (en) * | 2016-06-19 | 2016-08-10 | 李�杰 | Anti-fatigue buccal tablet |
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