CN110585364A - Skin and mucous membrane disinfectant - Google Patents
Skin and mucous membrane disinfectant Download PDFInfo
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- CN110585364A CN110585364A CN201911026599.5A CN201911026599A CN110585364A CN 110585364 A CN110585364 A CN 110585364A CN 201911026599 A CN201911026599 A CN 201911026599A CN 110585364 A CN110585364 A CN 110585364A
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- 210000004400 mucous membrane Anatomy 0.000 title claims description 10
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- 238000002360 preparation method Methods 0.000 claims abstract description 16
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Classifications
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/234—Cnidium (snowparsley)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a skin mucosa disinfectant, which belongs to the technical field of disinfectants, and is prepared from the following raw materials in parts by weight: 20-40 parts of fructus cnidii, 20-40 parts of astragalus membranaceus, 10-40 parts of coptis chinensis, 10-30 parts of golden cypress, 10-25 parts of rhizoma atractylodis, 10-20 parts of purslane, 10-20 parts of ixeris sonchifolia, 10-20 parts of verbena, 10-20 parts of cogongrass rhizome and 10-30 parts of bighead atractylodes rhizome; the disinfectant prepared by the preparation method of the invention not only ensures that the disinfectant is nontoxic and harmless to the skin mucosa, but also has excellent disinfection and sterilization effects, and the synergistic effect of the traditional Chinese medicines can effectively resist and sterilize the skin mucosa, improve the disinfection and sterilization effects, ensure the good performance of the disinfectant and have wide application prospects.
Description
Technical Field
The invention relates to the technical field of disinfectants, and particularly relates to a skin mucosa disinfectant.
Background
The skin and the mucous membrane are the first defense line of human body infection resistance and have important protection effect on the human body, the skin and the mucous membrane separate the human body from the external environment, so that the human body forms a closed system, and when harmful substances are about to invade the human body, the skin and the mucous membrane can block external bacteria, viruses and the like outside the body. The existing common pathogenic microorganisms comprise staphylococcus aureus, escherichia coli, candida albicans, propionibacterium acnes and the like, and can cause various skin and mucous membrane diseases. In the prior art, the disinfectant for the skin mucosa has more chemical component content, residues exist after a large amount of disinfectant is used, the residual substances are harmful, most of disinfectants for the skin mucosa contain iodine preparations and the like, and the iodine preparations have strong irritation to human bodies and are not beneficial to human health. In order to prevent the invasion of pathogenic microorganisms to the skin mucosa of a human body and reduce the stimulation and harm of the skin mucosa disinfectant to the human body, the invention needs to invent a green, healthy and efficient skin mucosa disinfectant.
Disclosure of Invention
Aiming at the problems, the invention provides a skin mucosa disinfectant.
In order to achieve the above object, the present invention adopts the following technical solutions:
the skin and mucous membrane disinfectant is characterized by being prepared from the following raw materials in parts by weight: 20-40 parts of common cnidium fruit, 20-40 parts of astragalus membranaceus, 10-40 parts of coptis chinensis, 10-30 parts of golden cypress, 10-25 parts of rhizoma atractylodis, 10-20 parts of purslane, 10-20 parts of ixeris sonchifolia, 10-20 parts of verbena, 10-20 parts of lalang grass rhizome and 10-30 parts of bighead atractylodes rhizome.
Preferably, the disinfectant is prepared from the following raw materials in parts by weight: 25-35 parts of fructus cnidii, 25-35 parts of astragalus membranaceus, 20-35 parts of coptis chinensis, 15-25 parts of golden cypress, 15-20 parts of rhizoma atractylodis, 12-18 parts of purslane, 12-18 parts of ixeris sonchifolia, 12-18 parts of verbena, 12-18 parts of cogongrass rhizome and 15-25 parts of bighead atractylodes rhizome.
Preferably, the disinfectant is prepared from the following raw materials in parts by weight: 30 parts of common cnidium fruit, 30 parts of astragalus, 25 parts of coptis root, 20 parts of phellodendron, 18 parts of rhizoma atractylodis, 15 parts of purslane, 15 parts of ixeris sonchifolia hance, 15 parts of verbena, 15 parts of lalang grass rhizome and 20 parts of bighead atractylodes rhizome.
Preferably, the preparation method of the disinfectant comprises the following preparation steps:
s1: weighing the traditional Chinese medicine raw materials according to the parts by weight, grinding and crushing the common cnidium fruit, the astragalus root, the coptis root and the amur corktree bark, sieving the ground mixture with a 100-mesh and 150-mesh sieve to obtain mixed traditional Chinese medicine raw material powder, and extracting the effective components of the mixed traditional Chinese medicine raw material powder by two times; extracting for the first time: adding the mixed traditional Chinese medicine raw material powder into an extraction container, adding 45-55% by mass of ethanol for extraction, and filtering after extraction to obtain an extracting solution A and filter residue A; and (3) second extraction: putting the filter residue A into the extraction container again, simultaneously adding 55-65% by mass of ethanol for extraction, filtering after extraction to obtain an extract B, and mixing the extract A and the extract B according to the volume ratio of 5:1-2 to obtain a mixed extract;
s2: crushing and mixing rhizoma atractylodis, purslane, ixeris sonchifolia, verbena, lalang grass rhizome and bighead atractylodes rhizome, wrapping the mixed traditional Chinese medicine raw materials by three layers of filter cloth, putting the mixture into a frying pan, adding deionized water with the mass of 8-12 times of that of the mixture, soaking for 2-5h, boiling the mixture with strong fire, then slowly boiling the mixture with slow fire for 1.5-2h, filtering to obtain a decoction A and dregs, adding deionized water with the mass of half of that of the first decoction into the dregs, boiling the mixture with strong fire, then slowly boiling the mixture with slow fire for 1-1.5h, filtering to obtain a decoction B, mixing the decoction A and the decoction B, concentrating the mixture until the volume is 1/4-1/7 of the mixed volume, and obtaining a concentrated solution;
s3: mixing the mixed extract and the concentrated solution according to the volume ratio of 3-1:1-3, and adding additives to obtain the skin mucosa disinfectant.
Preferably, the cnidium fruit, the astragalus, the coptis and the phellodendron bark which are ground and crushed in the S1 are put into a refrigerating chamber at the temperature of minus 30 ℃ to 40 ℃ for freezing for 1 to 2 hours, taken out and heated to the room temperature for extraction.
The traditional Chinese medicine has the following effects:
fructus cnidii: bitter taste and warm nature, and has the effects of clearing heat, eliminating dampness, killing parasites, relieving itching, removing toxic substance, relieving pain, preventing corrosion and relieving swelling.
Astragalus root: sweet in taste, slightly warm, and has antibacterial effect.
Coptis chinensis: bitter taste and mild nature, has the efficacies of clearing heat and drying dampness, purging fire and removing toxicity, and has the antibacterial effect.
Phellodendron bark: is bitter in taste; is cold in nature, and has the effects of heat-clearing and toxicity-removing herbs and heat-clearing and dampness-drying herbs.
Rhizoma atractylodis: pungent and bitter with warm nature, and has repercussive and analgesic effects.
Purslane: has sweet and sour taste and cold property, and has the functions of clearing heat and promoting diuresis, detoxifying and reducing swelling and diminishing inflammation.
Herba Ixeritis Denticulatae: the traditional Chinese medicine is pungent and bitter in taste and slightly cold in nature, has the effects of clearing heat and removing toxicity, eliminating carbuncle and pus, removing blood stasis and relieving pain, and has the effects of eliminating local inflammation, improving microcirculation of a pathological part and promoting ulcer repair.
Verbena: has slightly cool nature, and has effects of cooling blood, removing blood stasis, dredging channels, clearing heat away, removing toxic substances, relieving itching, expelling intestinal parasites, and relieving flatulence.
Cogongrass rhizome: sweet taste and cold nature, and has the effects of cooling blood, stopping bleeding, clearing away heat and toxic materials.
White atractylodes rhizome: sweet and slightly bitter in taste, warm in nature, and has the effects of eliminating dampness, eliminating turbid pathogen and relieving pain.
Due to the adoption of the technical scheme, the invention has the beneficial effects that: the added fructus cnidii has the effects of preventing corrosion, reducing swelling and detoxifying, and can effectively remove bacteria and viruses on the surface of skin mucosa when being used together with the astragalus and the coptis, and the astragalus and the phellodendron are excellent antibacterial traditional Chinese medicines, so that the disinfectant disclosed by the invention is not only nontoxic and harmless to the skin mucosa, but also has excellent disinfection and sterilization effects; according to the invention, cell walls of Chinese herbal medicines such as purslane, veronica denticulata, vervain and the like are damaged through low-temperature freezing, so that effective components in cells are extracted, the purslane has the functions of detoxifying, detumescence and inflammation diminishing, the veronica denticulata can eliminate local inflammation and improve microcirculation of pathological change parts, and the skin mucous membrane is effectively subjected to antibiosis and sterilization under the synergistic effect of the traditional Chinese medicines, so that the disinfection and sterilization effects are improved, and the good disinfection and sterilization performance of the disinfectant is ensured; the preparation method is simple, the raw materials are simple and easy to obtain, the preparation method is simple and easy to operate, the raw materials are green and harmless, and the prepared skin mucosa disinfectant has wide application prospects.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention.
Example 1: the skin mucosa disinfectant is prepared, and comprises the following components:
30g of common cnidium fruit, 30g of astragalus, 25g of coptis root, 20g of phellodendron, 18g of rhizoma atractylodis, 15g of purslane, 15g of ixeris sonchifolia hance, 15g of verbena, 15g of cogongrass rhizome and 20g of bighead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicine raw materials, grinding and crushing fructus cnidii, astragalus membranaceus, coptis chinensis and golden cypress, sieving the ground powder with a 150-mesh sieve to obtain mixed traditional Chinese medicine raw material powder, putting the mixed traditional Chinese medicine raw material powder into a refrigerating chamber at the temperature of 35 ℃ below zero for freezing for 2 hours, taking out the powder, heating the powder to room temperature, extracting active ingredients of the mixed traditional Chinese medicine raw material powder, and extracting the active ingredients twice; extracting for the first time: adding the mixed traditional Chinese medicine raw material powder into an extraction container, adding 50% ethanol by mass for extraction, and filtering after extraction to obtain an extracting solution A and filter residue A; and (3) second extraction: putting the filter residue A into the extraction container again, simultaneously adding 60% ethanol by mass for extraction, filtering after the extraction is finished to obtain an extract B, and mixing the extract A and the extract B according to the volume ratio of 5:1 to obtain a mixed extract; crushing and mixing rhizoma atractylodis, purslane, ixeris sonchifolia, verbena, lalang grass rhizome and bighead atractylodes rhizome, wrapping the mixed traditional Chinese medicine raw materials by three layers of filter cloth, putting the mixture into a frying pan, adding deionized water with the mass being 10 times of that of the mixture, soaking the mixture for 4 hours, boiling the mixture with strong fire, then slowly boiling the mixture for 2 hours with slow fire, filtering the mixture to obtain decoction A and decoction dregs, adding deionized water with the mass being half that of the decoction in the first time into the decoction dregs, boiling the decoction with strong fire, then slowly boiling the decoction for 1 hour with slow fire, filtering the decoction B to obtain decoction B, mixing the decoction A and the decoction B, concentrating the mixture to 1/5 of the volume when the mixture is mixed to obtain concentrated solution; and finally, mixing the prepared mixed extracting solution and the concentrated solution according to the volume ratio of 3:1, and adding an additive to obtain the skin mucosa disinfectant.
Example 2: the skin mucosa disinfectant is prepared, and comprises the following components:
40g of common cnidium fruit, 40g of astragalus, 40g of coptis root, 30g of phellodendron, 25g of rhizoma atractylodis, 20g of purslane, 20g of ixeris sonchifolia hance, 20g of verbena, 20g of lalang grass rhizome and 30g of bighead atractylodes rhizome.
The preparation method is the same as example 1.
Example 3: the skin mucosa disinfectant is prepared, and comprises the following components:
20g of common cnidium fruit, 20g of astragalus, 10g of coptis root, 10g of phellodendron, 10g of rhizoma atractylodis, 10g of purslane, 10g of ixeris sonchifolia hance, 10g of verbena, 10g of cogongrass rhizome and 10g of bighead atractylodes rhizome.
The preparation method is the same as example 1.
Example 4: the skin mucosa disinfectant is prepared, and comprises the following components:
25g of common cnidium fruit, 25g of astragalus, 20g of coptis root, 15g of phellodendron, 15g of rhizoma atractylodis, 12g of purslane, 12g of ixeris sonchifolia hance, 12g of verbena, 12g of lalang grass rhizome and 15g of bighead atractylodes rhizome.
The preparation method is the same as example 1.
Example 5: the skin mucosa disinfectant is prepared, and comprises the following components:
35g of common cnidium fruit, 35g of astragalus, 35g of coptis root, 25g of phellodendron, 20g of rhizoma atractylodis, 18g of purslane, 18g of ixeris sonchifolia hance, 18g of verbena, 18g of cogongrass rhizome and 25g of bighead atractylodes rhizome.
The preparation method is the same as example 1.
And (3) sterilization experiment:
the skin mucosa disinfectant prepared in the above example 1 was subjected to a sterilization experiment.
Quantitative sterilization test of suspension: inoculating Staphylococcus aureus, Escherichia coli, and Candida albicans in culture medium, and culturing for 20 hr. Washing lawn in the culture medium with sterile normal saline, adding 0.5mL of experimental bacterial suspension into a sterile sterilized test tube with 30g/L bovine serum albumin bacterial suspension, uniformly mixing, carrying out water bath, keeping the temperature to 20 +/-1 ℃, sucking 2mL of disinfectant (0.2mL of the disinfectant of the invention +1.8mL of sterile hard water) and adding into the test tube, uniformly mixing and timing. Sucking 0.5mL of mixed liquid of the bacterial suspension and the disinfectant prepared in the embodiment 1 of the invention, mixing the mixed liquid with 4.5mL of neutralizing agent TSB for 5-10min, sucking 1mL of mixed liquid, measuring the number of viable bacteria according to a viable bacteria culture counting method, inoculating 3 plates in each tube, counting the number of viable bacteria, and calculating the killing rate.
The disinfectant has the advantages that the killing rate of the disinfectant on staphylococcus aureus is still 96.36% at 24h, the killing rate on candida albicans starts to take effect from 20min, the killing rate is reduced in a period of 12h to 24h, but the content of the candida albicans is only 2.55% at 24h, so that the disinfectant has good durability, the killing rate on escherichia coli is kept to be over 99.99% from 2min to 6h, and the high efficiency of the disinfectant on escherichia coli is realized.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (5)
1. The skin and mucous membrane disinfectant is characterized by being prepared from the following raw materials in parts by weight: 20-40 parts of common cnidium fruit, 20-40 parts of astragalus membranaceus, 10-40 parts of coptis chinensis, 10-30 parts of golden cypress, 10-25 parts of rhizoma atractylodis, 10-20 parts of purslane, 10-20 parts of ixeris sonchifolia, 10-20 parts of verbena, 10-20 parts of lalang grass rhizome and 10-30 parts of bighead atractylodes rhizome.
2. The skin and mucosa disinfectant as claimed in claim 1, wherein the disinfectant is prepared from the following raw materials in parts by weight: 25-35 parts of fructus cnidii, 25-35 parts of astragalus membranaceus, 20-35 parts of coptis chinensis, 15-25 parts of golden cypress, 15-20 parts of rhizoma atractylodis, 12-18 parts of purslane, 12-18 parts of ixeris sonchifolia, 12-18 parts of verbena, 12-18 parts of cogongrass rhizome and 15-25 parts of bighead atractylodes rhizome.
3. The skin and mucosa disinfectant as claimed in claim 1, wherein the disinfectant is prepared from the following raw materials in parts by weight: 30 parts of common cnidium fruit, 30 parts of astragalus, 25 parts of coptis root, 20 parts of phellodendron, 18 parts of rhizoma atractylodis, 15 parts of purslane, 15 parts of ixeris sonchifolia hance, 15 parts of verbena, 15 parts of lalang grass rhizome and 20 parts of bighead atractylodes rhizome.
4. The preparation method of the disinfectant for skin and mucous membrane according to any one of claims 1 to 3, characterized in that the preparation method comprises the following preparation steps:
s1: weighing the traditional Chinese medicine raw materials according to the parts by weight, grinding and crushing the common cnidium fruit, the astragalus root, the coptis root and the amur corktree bark, sieving the ground mixture with a 100-mesh and 150-mesh sieve to obtain mixed traditional Chinese medicine raw material powder, and extracting the effective components of the mixed traditional Chinese medicine raw material powder by two times; extracting for the first time: adding the mixed traditional Chinese medicine raw material powder into an extraction container, adding 45-55% by mass of ethanol for extraction, and filtering after extraction to obtain an extracting solution A and filter residue A; and (3) second extraction: putting the filter residue A into the extraction container again, simultaneously adding 55-65% by mass of ethanol for extraction, filtering after extraction to obtain an extract B, and mixing the extract A and the extract B according to the volume ratio of 5:1-2 to obtain a mixed extract;
s2: crushing and mixing rhizoma atractylodis, purslane, ixeris sonchifolia, verbena, lalang grass rhizome and bighead atractylodes rhizome, wrapping the mixed traditional Chinese medicine raw materials by three layers of filter cloth, putting the mixture into a frying pan, adding deionized water with the mass of 8-12 times of that of the mixture, soaking for 2-5h, boiling the mixture with strong fire, then slowly boiling the mixture with slow fire for 1.5-2h, filtering to obtain a decoction A and dregs, adding deionized water with the mass of half of that of the first decoction into the dregs, boiling the mixture with strong fire, then slowly boiling the mixture with slow fire for 1-1.5h, filtering to obtain a decoction B, mixing the decoction A and the decoction B, concentrating the mixture until the volume is 1/4-1/7 of the mixed volume, and obtaining a concentrated solution;
s3: mixing the mixed extract and the concentrated solution according to the volume ratio of 3-1:1-3, and adding additives to obtain the skin mucosa disinfectant.
5. The preparation method of the disinfectant for skin and mucous membrane according to claim 4, characterized in that the cnidium fruit, the astragalus root, the coptis root and the phellodendron bark which are ground and crushed in S1 are put into a refrigerating chamber at the temperature of minus 30 ℃ to 40 ℃ for freezing for 1 to 2 hours, and after being taken out, the temperature is raised to room temperature for extraction.
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Application publication date: 20191220 |