CN110545796A - 用于活性化合物的局部递送系统 - Google Patents

用于活性化合物的局部递送系统 Download PDF

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Publication number
CN110545796A
CN110545796A CN201880017253.6A CN201880017253A CN110545796A CN 110545796 A CN110545796 A CN 110545796A CN 201880017253 A CN201880017253 A CN 201880017253A CN 110545796 A CN110545796 A CN 110545796A
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CN
China
Prior art keywords
oil
formulation
oily
active
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880017253.6A
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English (en)
Chinese (zh)
Inventor
尼斯姆·伽迪
莎伦·伽迪列维
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solution Delivery Systems
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Solution Delivery Systems
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solution Delivery Systems, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Solution Delivery Systems
Publication of CN110545796A publication Critical patent/CN110545796A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/723—Xanthans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880017253.6A 2017-03-07 2018-03-07 用于活性化合物的局部递送系统 Pending CN110545796A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762467863P 2017-03-07 2017-03-07
US62/467,863 2017-03-07
PCT/IL2018/050265 WO2018163176A1 (en) 2017-03-07 2018-03-07 Topical delivery systems for active compounds

Publications (1)

Publication Number Publication Date
CN110545796A true CN110545796A (zh) 2019-12-06

Family

ID=61692208

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880017253.6A Pending CN110545796A (zh) 2017-03-07 2018-03-07 用于活性化合物的局部递送系统

Country Status (8)

Country Link
US (2) US20210137829A1 (https=)
EP (1) EP3592336A1 (https=)
JP (1) JP7250689B2 (https=)
CN (1) CN110545796A (https=)
AU (1) AU2018231842B2 (https=)
CA (1) CA3055159A1 (https=)
IL (1) IL268773B2 (https=)
WO (1) WO2018163176A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110960682A (zh) * 2019-12-13 2020-04-07 厦门大学 一种pH调控凝胶高压后融化态时长增强药物负载的方法
CN111632191A (zh) * 2020-05-11 2020-09-08 西安理工大学 一种释药磷酸钙基骨水泥的制备方法
CN113786382A (zh) * 2021-11-04 2021-12-14 浙江得恩德制药股份有限公司 一种盐酸特比萘酚凝胶及制备方法

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FR3076555B1 (fr) * 2018-01-11 2020-01-24 Jafer Enterprises R&D Sl Materiau polymerique solide impregne d'une substance organique volatile et d'un ester particulier et ses utilisations
WO2020123306A1 (en) 2018-12-14 2020-06-18 Mary Kay Inc. Cosmetic compositions
EP3986383A4 (en) * 2019-06-20 2023-07-19 Lyotropic Delivery Systems Ltd. POLYMERIC FLEXIBLE FILMS INCLUDING NANODOMAINS AND/OR A BIOACTIVE AGENT AND METHODS FOR PRODUCING THEM
CN114401770A (zh) * 2019-09-29 2022-04-26 莱雅公司 用于护理角蛋白材料的化妆品组合物
US20230113554A1 (en) * 2019-12-16 2023-04-13 Ao Technology Ag Non-stick antibiotic gels
US12109290B2 (en) 2020-12-29 2024-10-08 Kao Usa Inc. Hair shine compositions
EP4112043A1 (en) * 2021-06-30 2023-01-04 GSK Consumer Healthcare SARL Nano-complex composition comprising diclofenac
EP4342450A1 (en) * 2022-09-21 2024-03-27 Haleon CH SARL Hydroalcoholic topical diclofenac formulations
EP4342449A1 (en) * 2022-09-21 2024-03-27 Haleon CH SARL Hydroalcoholic single phase gel compositions for topical delivery of diclofenac
WO2025062440A1 (en) * 2023-09-20 2025-03-27 Pulse Pharmaceuticals Pvt. Ltd Topical nano-dispersion compositions and their preparation thereof
US20250099369A1 (en) * 2023-09-27 2025-03-27 Andros Pharmaceuticals Co., Ltd. Topical delivery compositions comprising non-steroidal anti-inflammatory drugs
WO2025153330A1 (en) * 2024-01-15 2025-07-24 JeNaCell GmbH Microemulsion systems for the incorporation of poorly-water soluble compounds into bacterial cellulose
WO2025193822A1 (en) * 2024-03-13 2025-09-18 Menning Mark Michael Aqueous compositions of poorly water-soluble compounds

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CN101583339A (zh) * 2006-11-29 2009-11-18 莫尔文药用化妆品有限公司 包含脂质和表面活性剂的大分子组装体的组合物
CN102151268A (zh) * 2011-03-28 2011-08-17 王义明 一种治疗阿尔茨海默症的复方制剂及其制备方法
CN102186470A (zh) * 2008-10-16 2011-09-14 诺瓦提斯公司 具有感觉组分的局部用nsaid组合物
CN103655459A (zh) * 2013-12-19 2014-03-26 中国药科大学 一种多功能微乳凝胶制剂及其制备工艺
WO2016038553A1 (en) * 2014-09-10 2016-03-17 Novartis Consumer Health S.A. Topical diclofenac sodium compositions

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JPH06509099A (ja) 1991-07-03 1994-10-13 サノ・コーポレーシヨン ジクロフエナツクの経皮デリバリーに対する組成物及び方法
AU2953497A (en) 1996-05-13 1997-12-05 Novartis Consumer Health S.A. Topical composition
US7182950B2 (en) 2002-06-12 2007-02-27 Nutralease Ltd. Nano-sized self-assembled liquid dilutable vehicles
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CN102186470A (zh) * 2008-10-16 2011-09-14 诺瓦提斯公司 具有感觉组分的局部用nsaid组合物
CN102151268A (zh) * 2011-03-28 2011-08-17 王义明 一种治疗阿尔茨海默症的复方制剂及其制备方法
CN103655459A (zh) * 2013-12-19 2014-03-26 中国药科大学 一种多功能微乳凝胶制剂及其制备工艺
WO2016038553A1 (en) * 2014-09-10 2016-03-17 Novartis Consumer Health S.A. Topical diclofenac sodium compositions

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110960682A (zh) * 2019-12-13 2020-04-07 厦门大学 一种pH调控凝胶高压后融化态时长增强药物负载的方法
CN111632191A (zh) * 2020-05-11 2020-09-08 西安理工大学 一种释药磷酸钙基骨水泥的制备方法
CN113786382A (zh) * 2021-11-04 2021-12-14 浙江得恩德制药股份有限公司 一种盐酸特比萘酚凝胶及制备方法
CN113786382B (zh) * 2021-11-04 2024-05-28 浙江得恩德制药股份有限公司 一种盐酸特比萘芬凝胶及制备方法

Also Published As

Publication number Publication date
CA3055159A1 (en) 2018-09-13
US20240350401A1 (en) 2024-10-24
JP7250689B2 (ja) 2023-04-03
RU2019129711A3 (https=) 2021-06-17
AU2018231842B2 (en) 2024-03-21
AU2018231842A1 (en) 2019-09-19
IL268773B1 (en) 2023-01-01
JP2020514342A (ja) 2020-05-21
IL268773B2 (en) 2023-05-01
WO2018163176A1 (en) 2018-09-13
IL268773A (en) 2019-10-31
US20210137829A1 (en) 2021-05-13
RU2019129711A (ru) 2021-04-07
EP3592336A1 (en) 2020-01-15

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