CN110538304B - Chinese medicinal preparation and its preparation method - Google Patents

Chinese medicinal preparation and its preparation method Download PDF

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Publication number
CN110538304B
CN110538304B CN201911017781.4A CN201911017781A CN110538304B CN 110538304 B CN110538304 B CN 110538304B CN 201911017781 A CN201911017781 A CN 201911017781A CN 110538304 B CN110538304 B CN 110538304B
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parts
azone
solvent
chinese medicinal
borneol
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CN110538304A (en
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崔公让
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Molecular Biology (AREA)
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Abstract

The invention discloses a Chinese medicinal preparation and a preparation method thereof, belonging to the technical field of pain treatment, the Chinese medicinal preparation is prepared by soaking tinospora root, coptis root, nux vomica, cattail pollen and turmeric in a solvent to obtain a soaking solution, and then adding borneol and azone into the soaking solution; the radix tinosporae and the coptis chinensis are cold and have the guiding effect of cold, the turmeric is an adjuvant drug to prevent the radix tinosporae and the coptis chinensis which are used as monarch drugs from being too cold, and can also increase the effects of dispersing blood stasis, dredging collaterals and relieving pain of the nux vomica and the cattail pollen which are used as ministerial drugs, and the borneol is used for dispersing the stagnation and relieving swelling and has stronger effect of walking and fleeing, so that the effects of the medicines can be adjusted, and the effects of the adjuvant drug and the ministerial drug can be realized; as the azone is a good penetrating agent, the active ingredients dissolved in the azone can be brought into the skin of a human body, so that the effect of the medicine is good, and the effect of radical cure without relapse is achieved.

Description

Chinese medicinal preparation and its preparation method
Technical Field
The invention belongs to the technical field of pain treatment, and particularly relates to a traditional Chinese medicine preparation and a preparation method thereof.
Background
Acute stage of traumatic injury and red swelling and pain due to tissue injury caused by toxic heat, such as herpes zoster, gouty arthritis, nodular phlebitis, erythema nodosum, rheumatic arthritis, rheumatoid arthritis, and burn; the existing medicines have no good treatment effect.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine preparation.
The technical scheme adopted by the invention is as follows: a Chinese medicinal preparation is prepared by soaking radix tinosporae, Coptidis rhizoma, semen Strychni, pollen Typhae and Curcuma rhizome in solvent to obtain soaking solution, and adding Borneolum and azone into the soaking solution.
The working principle/beneficial effects of the invention are as follows: radix tinosporae and rhizoma coptidis with effects of clearing heat, removing toxicity and cooling blood are used as monarch drugs, semen strychni and pollen typhae with effects of removing blood stasis, dredging collaterals and relieving pain are used as ministerial drugs, rhizoma curcumae longae with effects of warming, dredging and resolving masses is used as adjuvant drugs, and borneol with effects of warming, dispersing, relieving pain, regulating menstruation and activating collaterals is used as messenger drugs;
the radix tinosporae and the coptis chinensis are cold and have the guiding effect of cold, the turmeric is an adjuvant drug to prevent the radix tinosporae and the coptis chinensis which are used as monarch drugs from being too cold, and can also increase the effects of dispersing blood stasis, dredging collaterals and relieving pain of the nux vomica and the cattail pollen which are used as ministerial drugs, and the borneol is used for dispersing the stagnation and relieving swelling and has stronger effect of walking and fleeing, so that the effects of the medicines can be adjusted, and the effects of the adjuvant drug and the ministerial drug can; as the azone is a good penetrating agent, the active ingredients dissolved in the azone can be brought into the skin of a human body, so that the effect of the medicine is good, and the effect of clearing heat and relieving pain is achieved.
The Chinese medicinal preparation is suitable for acute stage of traumatic injury and red swelling and pain caused by tissue injury due to toxic heat, such as herpes zoster, gouty arthritis, nodular phlebitis, erythema nodosum, rheumarthritis, rheumatoid arthritis, burn, etc., and can achieve immediate analgesic effect.
Further limited, the mass parts of the components are as follows: 15-30 parts of radix tinosporae, 20-32 parts of coptis chinensis, 10-18 parts of nux vomica, 12-17 parts of cattail pollen, 3-5 parts of turmeric, 110-160 parts of solvent, 2-5 parts of borneol and 10-15 parts of azone.
Further limited, the solvent is alcohol solution with the mass fraction of ethanol of 65-82%.
Further limited, the mass parts of the components are as follows: 18 parts of radix tinosporae, 26 parts of coptis chinensis, 16 parts of nux vomica, 15 parts of cattail pollen, 4 parts of turmeric, 137 parts of solvent, 4 parts of borneol and 10 parts of azone.
Further limited, the solvent is an alcohol solution with the mass fraction of ethanol of 75%.
The invention also provides a preparation method of the traditional Chinese medicine preparation, which comprises the following steps:
s1: preparing raw materials: weighing the raw materials according to the mass parts, crushing the tinospora root, the coptis root, the nux vomica, the cattail pollen and the turmeric into powder, putting the powder into a breathable container, then soaking the powder into a solvent, stirring the powder once every 7 to 8 hours, taking the breathable container out of the solvent after soaking the powder for 6 to 8 days, and filtering the liquid to obtain a solution A;
s2: adding borneol and azone into the solution A, and fully dissolving to obtain the traditional Chinese medicine preparation.
The working principle/beneficial effects of the invention are as follows: the effective components in the traditional Chinese medicines are soaked out in a solvent soaking mode, and the effective components can be uniformly dispersed in the solvent, so that the effective components are not subjected to quality change, and the efficacy of the traditional Chinese medicine preparation is ensured; the reason for adding the borneol and the azone into the solution A obtained by soaking is to save the use amount of the borneol and the azone and reduce the cost, and the azone and the borneol have certain toxicity, so the azone and the azone are not suitable for being remained in the traditional Chinese medicine residues.
Further limited, the breathable container is a breathable cloth bag.
Further limiting, the particle size of the powder crushed in the step S1 is 10-20 meshes.
Detailed Description
Example 1
1. Preparation of the instruments
1 stirring rod, 2 500ml beakers, 1 breathable cloth bag, 1 250ml spraying kettle, one pulverizer and 1 piece of gauze.
2. Preparation of Chinese medicinal preparation
S1: weighing 15 g of radix tinosporae, 20 g of coptis chinensis, 10 g of nux vomica, 12 g of pollen typhae, 3 g of turmeric, 110 g of ethanol solution with the mass fraction of 65%, 2 g of borneol and 10 g of azone;
s2: adding radix tinosporae, rhizoma coptidis, semen strychni, pollen typhae and rhizoma curcumae longae into a pulverizer, pulverizing into 10-mesh fine powder, placing the pulverized powder into a breathable cloth bag, sealing the opening of a traditional Chinese medicine bag, then placing the bag into a beaker filled with an alcohol solution, soaking the bag for 6 days continuously, taking out the breathable cloth bag, and filtering the remaining solution to obtain a solution A;
s3: adding borneol and azone into the solution A, stirring uniformly and then putting into a spray kettle.
3. Using and using amount
The Chinese medicinal preparation is sprayed on affected part, alcohol is evaporated for about 1 min, and the spraying is continued for 3-5 times to obtain a group of treatments, 3-4 groups of treatments per day.
4. Storage method
The product can be stored at normal temperature or in a cold storage mode, and has the following quality guarantee period: and 24 months.
5. Medicine contraindication
The traditional Chinese medicine preparation is only suitable for red swelling and hot pain caused by tissue injury due to heat toxin and acute stage of traumatic injury, and the traditional Chinese medicine preparation is used with cautions in other cases; it should be used with cautions for children and pregnant women. It is forbidden for people allergic to alcohol. It is forbidden to treat ulcer. Before use, the user should be careful to spray a small amount of the liquid medicine on the inner skin of the forearm of the upper limb, and after about 30 minutes, the user can use the liquid medicine without obvious allergy.
6. Matters of attention
1) The traditional Chinese medicine preparation is not suitable for ulcer wound surfaces, so that the skin with ulcer surfaces is forbidden.
2) The liquid medicine is sprayed into glasses, nasal cavity and ear canal.
3) The traditional Chinese medicine preparation has little toxicity and is forbidden to be taken orally.
Example 2
The difference from embodiment 1 is that:
2. preparation of Chinese medicinal preparation
S1: weighing 18 g of radix tinosporae, 26 g of coptis chinensis, 16 g of nux vomica, 15 g of cattail pollen, 4 g of turmeric, 137 g of alcohol solution with the mass fraction of 75 percent of ethanol, 4 g of borneol and 10 g of azone;
s2: adding radix tinosporae, rhizoma coptidis, semen strychni, pollen typhae and rhizoma curcumae longae into a pulverizer, pulverizing into 10-mesh fine powder, placing the pulverized powder into a breathable cloth bag, sealing the opening of a traditional Chinese medicine bag, then placing the bag into a beaker filled with an alcohol solution, soaking the bag for 7 days continuously, taking out the breathable cloth bag, and filtering the remaining solution to obtain a solution B;
s3: adding borneol and azone into the solution B, stirring uniformly and then putting into a spray kettle.
Example 3
The difference from embodiment 1 is that:
2. preparation of Chinese medicinal preparation
S1: weighing 30 g of radix tinosporae, 32 g of coptis chinensis, 18 g of nux vomica, 17 g of pollen typhae, 5 g of turmeric, 160 g of ethanol solution with the mass fraction of 82%, 5 g of borneol and 35 g of azone;
s2: adding radix tinosporae, rhizoma coptidis, semen strychni, pollen typhae and rhizoma curcumae longae into a pulverizer, pulverizing into fine powder of 20 meshes, placing the pulverized powder into a breathable cloth bag, sealing the opening of a traditional Chinese medicine bag, then placing the bag into a beaker filled with an alcohol solution, soaking the bag for 8 days continuously, taking out the breathable cloth bag, and filtering the remaining solution to obtain a solution C;
s3: adding borneol and azone into the solution C, stirring uniformly and then putting into a spray kettle.
Clinical cases
Case 1
For a regular male, 38 years old, Pinsu prefers to eat thick paste and wine, and also prefers to sleep 12 o' clock in the evening, which results in hyperactivity of fire due to yin deficiency and interior accumulation of heat-toxin, and red swelling and pain of metatarsophalangeal joints of the 1 st of both feet. Rolling over during acute attack, insomnia, holding feet with both hands, profuse sweating, groan, and diagnosis: after the acute attack of the gouty arthritis, the solution is locally sprayed, the solution is repeatedly sprayed to the affected part after the skin medicine is evaporated after about 1 minute, so that the pain is immediately relieved after 5 times, and meanwhile, the traditional Chinese medicines are adopted to clear away heat and toxic materials, sooth the liver and relieve depression, and the disease is not relapsed after 3 years of observation.
Case 2
Yaoji, male, 24 years old, prefers to smoke, drink and drink as well as to eat spicy and pungent food, and has interior accumulation of heat-toxin. The prominent skin on the 5 th to 10 th ribs on the left side before 3 days is scattered on the red papules, and the red papules are combined into pieces after 2 days of attack, so the pain is severe, and the people cannot wear clothes and feel. The pain of the patient disappears immediately after the patient has come to a clinic and has outbreak for 3 days, namely the pain of the patient disappears after the patient is continuously sprayed for 5 times by adopting the traditional Chinese medicine spray, so the pain disappears 3-5 times a day, the lesion is scabbed after 3 days, and no pain sequelae are left after 1 week of recovery.
Case 3
When a woman is 28 years old, legs of the woman are injured due to careless tumbling in the off duty process, the woman is represented as dark green ball, after the traditional Chinese medicine preparation prepared by the invention is sprayed, the spraying is carried out 3-4 times a day for 2 days continuously, the swelling is reduced, the dark green color is lightened, and after the spraying is carried out for 5 days, the dark green ball completely disappears and the pain completely disappears.
Case 4
Some of the woods, women, 43 years old, have abnormal soma and are aversive to cold. Before 3 months, swelling and pain of joints of the 2 nd, 3 rd and 4 th fingers of hands are accompanied by unfavorable flexion and extension, tripterygium glycosides are used for treatment, but the joint pain is still not relieved, the traditional Chinese medicine spray is sprayed 5 times each time for 3-4 times every day, the pain is obviously relieved after 2 days, the movement is free, the swelling is gradually relieved after 1 week, the treatment is recovered to be normal after 1 month, and the disease is not relapsed after 4 months of observation.
Case 5
Liao, male, 56 years old, left leg varicose vein history 5 years old. The inflammation and pain of the skin on the inner side of the middle section of the left lower leg are found to be red, swollen and painful before 1 month, the cord-shaped induration can be touched, nodular phlebitis is diagnosed, the oral inflammation diminishing and pain easing medicine is not obviously relieved, the pain is obviously relieved after the medicine preparation is sprayed for 5 times, 4 times are carried out every day, 5 times are sprayed each time, the red and swollen of the skin at the affected part is obviously relieved after the medicine preparation is repeatedly diagnosed for 7 days, the pain is slight, the skin at the affected part is still red and dark, and the medicine preparation is externally used for 3-4 times in the day, the skin is continuously treated for 3 weeks, the skin color is normal, the vein is also seen to be restored, and the disease is not relapsed after 1 year observation.
The invention is not limited to the above alternative embodiments, and any other various forms of products can be obtained by anyone in the light of the present invention, but any changes in shape or structure thereof, which fall within the scope of the present invention as defined in the claims, fall within the scope of the present invention.

Claims (7)

1. A Chinese medicinal preparation is characterized in that tinospora root, coptis root, nux vomica, cattail pollen and turmeric are soaked in a solvent to obtain a soaking solution, and then borneol and azone are added into the soaking solution to finally obtain the Chinese medicinal preparation; the weight portions of the components are as follows: 15-30 parts of radix tinosporae, 20-32 parts of coptis chinensis, 10-18 parts of nux vomica, 12-17 parts of cattail pollen, 3-5 parts of turmeric, 110-160 parts of solvent, 2-5 parts of borneol and 10-15 parts of azone.
2. The traditional Chinese medicine preparation of claim 1, wherein the solvent is an alcohol solution with an ethanol mass fraction of 65% -82%.
3. The traditional Chinese medicine preparation according to claim 2, which is characterized by comprising the following components in parts by mass: 18 parts of radix tinosporae, 26 parts of coptis chinensis, 16 parts of nux vomica, 15 parts of cattail pollen, 4 parts of turmeric, 137 parts of solvent, 4 parts of borneol and 10 parts of azone.
4. The Chinese medicinal preparation as claimed in claim 3, wherein the solvent is an alcohol solution with 75% ethanol by mass.
5. A method of preparing a Chinese medicinal preparation according to any one of claims 1 to 4, comprising the steps of:
s1: preparing raw materials: weighing the raw materials according to the mass parts, crushing the tinospora root, the coptis root, the nux vomica, the cattail pollen and the turmeric into powder, putting the powder into a breathable container, then soaking the powder into a solvent, stirring the powder once every 7 to 8 hours, taking the breathable container out of the solvent after soaking the powder for 6 to 8 days, and filtering the liquid to obtain a solution A;
s2: adding borneol and azone into the solution A, and fully dissolving to obtain the traditional Chinese medicine preparation.
6. The method for preparing a Chinese medicinal preparation according to claim 5, wherein the air-permeable container is an air-permeable cloth bag.
7. The method for preparing a Chinese medicinal preparation according to claim 5, wherein the particle size of the powder pulverized in step S1 is 10-20 mesh.
CN201911017781.4A 2019-10-24 2019-10-24 Chinese medicinal preparation and its preparation method Expired - Fee Related CN110538304B (en)

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Publication number Priority date Publication date Assignee Title
CN1327860C (en) * 2003-01-21 2007-07-25 贵州本草堂药业有限公司 Prepared Chinese medicine for treating yang disease of boil caused by accumulated noxious heat

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