CN110495461A - A kind of bactericidal composition containing coumoxystrobin and probenazole - Google Patents
A kind of bactericidal composition containing coumoxystrobin and probenazole Download PDFInfo
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- CN110495461A CN110495461A CN201810484246.9A CN201810484246A CN110495461A CN 110495461 A CN110495461 A CN 110495461A CN 201810484246 A CN201810484246 A CN 201810484246A CN 110495461 A CN110495461 A CN 110495461A
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- probenazole
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- Pest Control & Pesticides (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of bactericidal composition containing coumoxystrobin and probenazole, it includes the effective component being made of coumoxystrobin and probenazole, the composition includes the effective component being made of coumoxystrobin and probenazole, and the mass ratio of coumoxystrobin and probenazole is 20:1~1:20.It is wherein added with suitable agricultural bactericidal agent aid, common disinfectant use in agriculture dosage form is made.The present invention has a higher control efficiency to crop fungal disease, and there are notable synergistic effects between two medicaments；Dosage can be reduced, ecological disruption and environmental pollution is effectively reduced, and crop yield and quality can be improved；Coumoxystrobin and probenazole belong to low toxicity in the present invention, and to people and animals, beneficial organism, Environmental security；Germ can be delayed to the drug resistance of single medicament.
Description
Technical field
The invention belongs to disinfectant use in agriculture fields, and in particular to a kind of bactericidal composition of coumoxystrobin and probenazole.
Background technique
Fusarium graminearum (Fusarium graminearum) caused by wheat scab be a kind of pole in Wheat Production
Have menace and propagated disease, widely distributed, Major Wheat planting area nearly all has generation in the world, in weather temperature
And moisten rainy area and be easier to cause to infect and spread between the time, wheat is infected and is extended not only serious after sprawling
The yield of wheat is influenced, and pathogen can excrete poison, such as deoxynivalenol, be difficult to clear up, it can be long-term
It remains in food chain, severe threat is come to the health care belt of humans and animals.
By Fusorium moniliforme Sheldon (Fusarium moniliforme) caused by bakanae disease of rice be on rice one kind it is common
Worldwide disease is a kind of seed-borne disease, infects from plumule after the rice seed germination to carry disease germs, forms systematicness and infects,
Cause the rice significantly underproduction.Infected seed is the main earliest infection source of bakanae disease of rice, after Rice Flowering, the mitogenetic spore of germ
Son can directly infect spike of rice, to form seed in spite of illness.
Currently, also lacking the wheat breed that there is complete resistance to wheat scab in the market, wheat scab is prevented
Control still relies primarily on use and the early prevention of chemical pesticide, and it is total to have reached prevention and control substantially between yangtse-huaihe region at present
Know, that is, sees colored laxative, second of prevention and control is carried out after 7 days.And bakanae disease of rice is seed-borne disease, therefore, is carried out using seed coat agent
Cotton seeds are one of essential preventions, can utmostly mitigate the possibility occurrence of disease.Therefore, how
Delay wheat scab drug resistance to generate and develop to a greater extent, extends the service life of each component in bactericidal composition, together
The effective prevention and control medicament and dosage form of Shi Kaifa bakanae disease of rice realize economic, efficient, environmental protection, sustainable prevention and control, it has also become small
Strategic project urgently to be resolved in wheat and Rice Production.
Coumoxystrobin (Coumoxystrobin) belongs to methoxy acrylic bactericide, and chemical name is (E) -2- (2-
(- 4 methyl-coumarin -7- base oxygroup of 3- normal-butyl) aminomethyl phenyl) -3- methoxy-methyl acrylate.96% raw medicine appearance is cream
White or pale yellow powder；109-111 DEG C of fusing point；It is soluble in acetone, ethyl acetate, methanol, dimethylformamide, is slightly soluble in stone
Oily ether, is insoluble in water.It is not easily decomposed under normal temperature condition.Coumoxystrobin acts on the compound of the electron transport chain of fungal mitochondria
III, by inhibiting the synthesis of the electron transmission ATP between cytochrome b and c, inhibits energy synthesis, play bacteriostasis.It kills
Bacterium spectrum is wide, effective to melon fruits and vegetables, fruit tree downy mildew, late blight, scab, anthracnose, leaf mold；Simultaneously to ring spot, charcoal
Subcutaneous ulcer disease, cotton wilt, rice pestilence, banded sclerotial blight, root rotof flax, corn southern leaf blight are also effective.But due to methoxy propyl
Alkene bactericide of phosphate (phosphinium) ester action site is more single, and there are certain resistance risks., in order to delay or overcome the anti-medicine of pathogen
Property formation and development, avoid it is continuous it is single use cyanogen alkene bacterium vinegar, should with other kinds of fungicide rotation or be used in mixed way.
Probenazole (Thiabendazole) belongs to benzimidazole germicide, and chemical name is 2- (4- thiazolyl)-benzo
Imidazoles.Mainly by influence the formation of spindle, dividing to influence cell in conjunction with the 'beta '-tubulin of fungal cell
It splits, inhibits the respiration and cell Proliferation of fungal mitochondria.Probenazole is a kind of wide-spectrum bactericide, and local permeability is strong, tool
There are protection and therapeutic effect.It can be effectively controlled the fungus-caused crop disease such as sac fungus, basidiomycetes.
Coumoxystrobin and probenazole belong to efficient, less toxic, environmentally friendly fungicide, and the two mechanism of action is different,
There is no cross resistance.But methoxy acrylic and benzimidazole germicide all have more single action site, on
It tells that the exclusive use of two class medicaments can make pathogen mutate in a relatively short period of time, forms drug resistance, lead to disease
Imitate failure.Therefore, the composite reagent of different role mechanism is used, can to avoid or delay the generation of drug resistance.
Summary of the invention
It is good that the present invention provides a kind of bactericidal effects, to wheat scab, bakanae disease of rice control efficiency significant synergy
Composition.
The technical solution of the present invention is as follows:
A kind of bactericidal composition containing coumoxystrobin and probenazole, it is characterised in that: the composition includes by coumoxystrobin and thiophene
The mass ratio of the effective component of bacterium spirit composition, the coumoxystrobin and probenazole is 20:1~1:20.
The bactericidal composition of the coumoxystrobin and probenazole, it is characterised in that: the coumoxystrobin and probenazole
Mass ratio is 1:1~1:10.
The bactericidal composition containing coumoxystrobin and probenazole, it is characterised in that: the dosage form dosage form be suspending agent,
Wettable powder, micro-capsule suspension, water-dispersible granules, thermal fog or suspension seed-coating agent.The auxiliary agent that can choose have solvent,
Surfactant, emulsifier, wetting agent, dispersing agent, thickener, defoaming agent, antifreezing agent, stabilizer, disintegrating agent, filler etc. are all kinds of
Auxiliary agent.
The present composition has good control efficiency for various crops diseases such as wheat scab, bakanaes disease of rice.
Remarkable result and advantage of the invention is:
Two classes are had to the fungicide of different structure type and discrepant mechanism of action, it is upper easy-to-use to be processed into production
Preparation, bioactivity is high, and total dosage decline on unit area, times for spraying reduces, reduces dispenser cost, delay cause of disease
Object drug resistance generates and development, extends the service life of each component in bactericidal composition, good to crop safety, to realize
Goal of the invention economic, efficiently, environmentally friendly.
Application of the bactericidal composition in prevention and treatment crop fungal disease.
Careful analysis is done to the sterilization idiocratic of coumoxystrobin and probenazole.It measures coumoxystrobin first and probenazole two is single
The EC of compound (hereinafter referred to as medicament)50(drug safety index), according to the EC of two single medicaments50It is set by Wadley method
The portfolio ratio of two medicaments, and according to Wadley coefficient of synergism SR value.
Test objective object be cause wheat scab Fusarium graminearum (Fusarium graminearum), cause rice
Bakanae disease Fusorium moniliforme Sheldon (Fusarium moniliforme), but not limited to this.Coumoxystrobin and probenazole are taken, is configured to
Need medical fluid plate, about 15 ml of every ware.The mycelia block of 5mm diameter is produced in the punch of preculture colony edge sterilizing, respectively
It moves on on different culture medium plate, 25 DEG C of cultures.Test uses mycelia growth measurement method, makes drug containing culture by different disposal
Base produces the mycelia block of 5mm diameter in the punch of preculture colony edge sterilizing, moves on to the different culture of content of dispersion respectively
On base plate, colony diameter is measured using crossing method, measures colony diameter (mm), growth inhibition is calculated by following equation
Rate:
Mycelial growth inhibition rate %=(1- chemicals treatment colony diameter -5/ compares colony diameter -5) × 100%
Mycelial growth inhibition rate is converted into and inhibits probit value (y), drug concentration is converted into log concentration (x), by log concentration
It is that ordinate makees toxicity regression straight line for abscissa, probit value, acquires coumoxystrobin and probenazole single dose and its mixture to germ
Virulence regression equation, and calculate EC50Value and correlation coefficient r value.
The interaction of mixture is evaluated according to Wadley method, calculation formula is as follows:
EC50(theoretical value)=(a+b)/(a/EC50a+ b/EC50B),
SR = EC50(theoretical value)/EC50(actual value).
Wherein a, b are each component content ratios in mixture, with the effect of SR value analysis mixture.SR≤0.5, then two kinds of medicines
Agent mixture has antagonism；SR=0.5~1.5, then two kinds of medicament mixtures have addition；SR >=1.5, then two kinds of medicaments are mixed
Equipped with synergistic effect.
Table 1, coumoxystrobin and probenazole single dose and its mixture are to Fusarium graminearum toxicity test result
As can be seen from the above table, the coumoxystrobin of different proportion and probenazole composition to the fungistatic effect of Fusarium graminearum respectively not
Identical, on the whole, ratio has synergistic effect in the range of 20:1 to 1:20, among these, ratio 5:1-1:5 synergy more
It is significant.
Table 2, coumoxystrobin and probenazole single dose and its mixture are to fusarium moniliforme toxicity test result
As can be seen from the above table, the coumoxystrobin of different proportion and probenazole composition are each to the fungistatic effect of fusarium moniliforme
Not identical, on the whole, ratio has synergistic effect in the range of 20:1 to 1:20, and among these, ratio is in 5:1-1:5 synergy
It is more significant.
Indoor synergy measurement result shows that the present invention has the fungal diseases such as wheat scab, bakanae disease of rice
Higher growth inhibitory effect, there are notable synergistic effects between two components；Two components compound according to a certain percentage can reduce use
Dose is effectively reduced ecological disruption and environmental pollution, and can improve crop yield and quality；Coumoxystrobin and thiophene bacterium in the present invention
Spirit belongs to low toxicity, and to people and animals, beneficial organism, Environmental security；Germ can be delayed to the drug resistance of single medicament.
Specific embodiment
Below with reference to embodiment, the invention will be further described, but essence of the invention is not limited to following embodiments.
Embodiment 1
The preparation of 28% coumoxystrobin probenazole suspending agent, by mass percentage.
Coumoxystrobin 14%, probenazole 14%, calcium lignosulfonate 6%, alkylphenol polyoxyethylene phosphate 4%, xanthan gum
0.1%, organic silicon defoamer 0.3%, water surplus.
Preparation method: according to formula, the above component being weighed in proportion, and ball mill ball milling 30min is added, and is filtered, and is pumped into
It is fully ground after dispersion tank high speed shear 3min through sand mill, solid component particle diameter is controlled within 2 μm, after grinding
It stirs evenly to get suspending agent product.
Embodiment 2
The preparation of 24% coumoxystrobin probenazole thermal fog, by mass percentage.
Coumoxystrobin 4%, probenazole 20%, No. 2 aromatic naphtha 20%, castor oil polyoxyethylene ether 4%, sodium dodecyl benzenylsulfonate
2%, xanthan gum 0.1%, urea 3%, propylene glycol 1%, attapulgite Ultramicro-powder 2%, dimethyl silicone polymer 0.1%, water surplus.
Preparation method: coumoxystrobin, probenazole, No. 2 aromatic naphtha are added in modulation kettle, temperature controls the stirring at 60 DEG C
Be dissolved into oil mutually keep the temperature it is spare；By castor oil polyoxyethylene ether, sodium dodecyl benzenylsulfonate, xanthan gum, urea, propylene glycol, recessed
Convex stick soil Ultramicro-powder, dimethyl silicone polymer, water etc. are added in modulation kettle, and temperature is controlled at 60 DEG C, are stirred and dissolved into water phase guarantor
Warm standby is used；The oil of preparation is mutually introduced into the water phase reserve liquid of preparation under the revolving speed of 3000 rpm, mutually adds continuation to oil
After stirring 30 min, 1h is stirred with low speed 200rpm, filtering removal residue is to get thermal fog product.It sufficiently shakes up, converts when use
Enter the smoke agents such as suitable diesel oil to prevent and treat crop.
Embodiment 3
The preparation of 40% coumoxystrobin probenazole missible oil, by mass percentage.
Coumoxystrobin 20%, probenazole 20%, dimethylbenzene 20%, DMF 2%, anhydrous calcium salt 5%, tween (80) 5%, four
Chlorination carbon surplus.
Preparation method: active component coumoxystrobin is sufficiently dissolved in dimethylbenzene reaction kettle, A liquid is made；By active group
Divide probenazole sufficiently to dissolve in carbon tetrachloride and DMF reaction kettle, B liquid be made, A liquid is mixed into B liquid under the state that keeps stirring,
It stirs, anhydrous calcium salt and Tween 80 is added, then adjust content with solvent carbon tetrachloride.
Embodiment 4
The preparation of 42% coumoxystrobin probenazole wettable powder, by mass percentage.
Coumoxystrobin 7%, probenazole 35%, sodium dodecyl benzenylsulfonate 2%, sodium lignin sulfonate 4%, white carbon black 7%, kaolinite
Native surplus/2, attapulgite surplus/2.
Preparation method: mixing machine is added by formula rate in the above component and carries out air-flow crushing after mixing, has been crushed
It is stirred at the rear a small amount of purified water of addition, wettable powder product can be obtained after drying.
Embodiment 5
The preparation of 48% coumoxystrobin probenazole water dispersible granules, by mass percentage.
Coumoxystrobin 24%, probenazole 24%, sodium lignin sulfonate 6%, polyvinyl alcohol 4%, ammonium sulfate 8%, white carbon black 10% are high
Ridge soil surplus.
Preparation method: mixing machine is added by formula rate in the above component and carries out air-flow crushing after mixing, has been crushed
It is stirred at the rear a small amount of purified water of addition, extrusion granulation can obtain water dispersible granules product after drying.
Embodiment 6
The preparation of 18% coumoxystrobin probenazole suspension seed-coating agent, by mass percentage.
Coumoxystrobin 15%, probenazole 3%, fulvic acid 2%, aliphatic acid polyethenoxy ether phosphate 3%, polyvinyl acetate
3%, acid scarlet 0.01%, xanthan gum 0.2%, Kathon CG 0.3%, ethylene glycol 5%, water surplus.
Preparation method: according to formula, the above component being weighed in proportion, and ball mill ball milling 60min is added, and is filtered, and is pumped into
It is fully ground after dispersion tank high speed shear 3min through sand mill, solid component particle diameter is controlled within 2 μm, after grinding
It stirs evenly to get suspension seed-coating agent product.
Embodiment 7
The preparation of 15% coumoxystrobin probenazole microcapsule suspension seed-coating agent, by mass percentage.
Coumoxystrobin 7.5%, probenazole 7.5%, dimethylformamide 2%, methyl diphenylene diisocyanate 3%, fatty acyl
Amine N methyl taurine salt 2%, ethylenediamine 0.5%, 1,3-PD 1.2%, sodium methylene bis-naphthalene sulfonate 2%, aluminium-magnesium silicate 3.2%,
Gum arabic 2%, polyvinyl alcohol 2%, polyacrylate 2.5%, permanent bordeaux 4%, water surplus.
Preparation method: by medicament dissolution in solvent, diphenylmethane diisocyanate vinegar is added and is uniformly mixing to obtain oily phase；
Emulsifier is added in water, adjuvant is uniformly mixing to obtain water phase；Water phase is added in oily phase, high speed homogenizing formation oil-in-water cream
Liquid；Under the conditions of 450 rpm speed, ethylenediamine is added and participates in interface polymerization reaction, reaction temperature rises to 55 DEG C, and 3h is kept to be solidified into
Capsule；Be added di-2-ethylhexylphosphine oxide tea sodium sulfonate, aluminium-magnesium silicate, permanent bordeaux, polyvinyl alcohol and polyacrylate, stir evenly be made it is micro-
Capsule suspension seed-coating agent.
The experiment of wheat scab field efficacy.
Comparison medicament selects 20% coumoxystrobin suspending agent (comparison medicament 1), 40% probenazole suspending agent (comparison medicament 2).
It tests in being carried out in wheat paddock, is administered for the first time in wheat flowering initial stage, carries out Disease investigation after 20 days.It the results are shown in Table 3
Table 3, coumoxystrobin probenazole are to the control effect of wheat scab
Field experiment the result shows that, the compounded combination of coumoxystrobin probenazole to wheat scab have it is preferable imitate, with
Single dose is compared, and whole control effect synergistic effect is obvious.According to field investigation, within the range of experimental dose, plant growth is normal,
Have no that plant generates drug damage and abnormal phenomena, to wheat safety.
The field efficacy of bakanae disease of rice is tested.
Experiment carries out seed pelleting processing using suspension seed-coating agent, and the seed rice after coating is seeded in seedling after drying in the shade naturally
Disk is managed with dry rice seedling cultivation mode, divides shoot transplanting equipment to the Anhui academy of agricultural sciences proving ground Gang Ji is located at after 22 days
Preventive effect is not investigated and calculates in tillering stage and boot stage, investigation result is shown in Table 4
Control effect of the 4 coumoxystrobin probenazole of table to bakanae disease of rice
Field experiment the result shows that, coumoxystrobin probenazole be formed by suspension seed-coating agent have to bakanae disease of rice it is preferable
It imitates, whole control effect effect is obvious.According to field investigation, within the range of experimental dose, plant growth is normal, has no plant
Drug damage and abnormal phenomena is generated, to wheat safety.
The above list is only a few specific embodiments of the present invention for finally, it should also be noted that.Obviously, this hair
It is bright to be not limited to above embodiments, there can also be many variations.Those skilled in the art can be from disclosed by the invention interior same
All deformations for directly exporting or associating, are considered protection scope of the present invention.
Claims (3)
1. a kind of bactericidal composition containing coumoxystrobin and probenazole, it is characterised in that: the composition include by coumoxystrobin and
The mass ratio of the effective component of probenazole composition, the coumoxystrobin and probenazole is 20:1~1:20.
2. the bactericidal composition of coumoxystrobin according to claim 1 and probenazole, it is characterised in that: the coumoxystrobin
Mass ratio with probenazole is 5:1~1:5.
3. the bactericidal composition containing coumoxystrobin and probenazole according to claim 1, it is characterised in that: the dosage form agent
Type is suspending agent, missible oil, wettable powder, water-dispersible granules, thermal fog, suspension seed-coating agent or microcapsule suspension seed-coating agent.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349531A (en) * | 2011-09-13 | 2012-02-15 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing coumoxystrobin and benzimidazole bactericide |
| CN103053572A (en) * | 2012-09-21 | 2013-04-24 | 吉林省八达农药有限公司 | Agricultural antifungal composition containing coumoxystrobin and thiophanate-methyl |
-
2018
- 2018-05-19 CN CN201810484246.9A patent/CN110495461A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349531A (en) * | 2011-09-13 | 2012-02-15 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing coumoxystrobin and benzimidazole bactericide |
| CN103053572A (en) * | 2012-09-21 | 2013-04-24 | 吉林省八达农药有限公司 | Agricultural antifungal composition containing coumoxystrobin and thiophanate-methyl |
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Application publication date: 20191126 |