CN110478449B - Traditional Chinese medicine composition for preventing and treating dog hyperlipidemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating dog hyperlipidemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating dog hyperlipidemia and a preparation method thereof. The invention belongs to the technical field of medicines. Wherein, the blood fat refers to triglyceride and cholesterol in serum. The pharmaceutical composition of the invention comprises the following components: 5-15 parts of coix seeds, 3-10 parts of dried orange peels, 3-12 parts of malt and 4-15 parts of combined spicebush roots. The composition can be added into dog food after being crushed, and a preparation prepared from the composition has an obvious effect of preventing and treating the dog hyperlipidemia. The composition has simple preparation method and convenient use, can well prevent and treat the hyperlipemia of dogs, and fills the blank of the prior art.
Description
Technical Field
The invention belongs to the technical field of medicines. The invention relates to a traditional Chinese medicine composition for preventing and treating dog hyperlipidemia, and also relates to a preparation method and a use method of the traditional Chinese medicine composition.
Background
Canine hyperlipidemia refers to an increase in the concentration of lipids in blood, generally triglycerides and cholesterol, and can be classified into postprandial hyperlipidemia, primary hyperlipidemia and secondary hyperlipidemia according to the cause. Hyperlipidemia is caused by an increase in the concentration of lipids in blood, particularly cholesterol or triglycerides and lipoproteins. With the increasing consumption, many people often feed dogs with a large amount of nutritional diets and high-energy substances, and the dogs can be induced with high-fat foods for a long time, and the diseases can be induced by insufficient exercise and obesity. Conditions that lead to hyperlipidemia in dogs are numerous.
The dog hyperlipemia mainly has 2 primary and secondary causes, and is mainly characterized by obesity, weight gain, abundant subcutaneous fat, reluctance to move, easy fatigue and dyspepsia. It is characterized by liver fat infiltration, blood lipid increase and abnormal blood appearance, and has tendency to suffer from diabetes; in severe cases, the blood looks like milky tea, and the serum looks like milk.
For secondary hyperlipidemia, the potential cause of hyperlipidemia is directly treated, and the low-fat diet is supplemented, and the hypolipidemic is taken as necessary. For primary hyperlipidemia, treatment is required when clinical symptoms appear, and mainly comprises feeding low-fat diet. Drugs that lower cholesterol and triglycerides in sick dogs have not been much studied and are not recommended because of their potential side effects. Fish oil supplements are considered safe, but their benefit for hyperlipidemia treatment remains to be determined. Therefore, the development of safe and effective medicaments for reducing the blood fat of dogs is a problem to be urgently solved.
The Coicis semen is dried mature seed of Coicis semen of Gramineae. Sweet and bland in flavor and cool in nature. It enters meridians, spleen, stomach and lung meridians. Has the functions of facilitating water permeation and moisture permeation, strengthening spleen and stopping diarrhea, removing arthralgia, expelling pus, detoxifying and dissipating stagnation. Can be used for treating edema, loempe, dysuresia, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, and intestinal abscess; wart, cancerous protuberance.
The pericarpium Citri Tangerinae is dried mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. The medicinal materials are classified into pericarpium citri reticulatae and pericarpium citri reticulatae. Bitter and pungent in flavor and warm in nature. It enters meridians, lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Malt is a processed product of mature barley of the family Gramineae, which is germinated and dried. Sweet and mild in nature and flavor. It enters spleen and stomach meridians. Move qi and promote digestion, invigorate spleen and stimulate appetite, and promote lactation to relieve distension. Can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, breast milk loss, hypochondriac pain due to stagnation of liver-qi, and pain of liver and stomach.
The radix Linderae is dried root tuber of radix Linderae of Lauraceae. Wu Yao is fragrant, slightly bitter and pungent in flavor and has a cool feeling. Pungent and warm in nature. It enters lung, spleen, kidney and bladder meridians. It was first recorded in Bencao Shiyi of Tang Dynasty and has the actions of moving qi and alleviating pain, warming kidney and dispelling cold. It is mainly used for treating cold congealing and qi stagnation, chest and abdomen distending pain, adverse qi, dyspnea, bladder deficiency cold, enuresis, pollakisuria, hernia pain, cold channel, abdominal pain, etc.
The research progress of the effect of the medicine and food dual-purpose traditional Chinese medicine on reducing blood fat (Yantenglong, 2014, reported in food safety quality detection) document discloses that the coix seed medicinal material has the effect of reducing blood fat, and the influence of the dried orange peel extract on the growth performance, blood fat index and antioxidant function of broilers (Li Ling, 2009, Heilongjiang animal veterinarian) document discloses the effect of the dried orange peel on reducing blood fat, but the effect is not verified in dog clinic. The invention fills the blank in the prior art and provides a new treatment scheme for treating the hyperlipemia of the pets.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for preventing and treating dog hyperlipidemia and a preparation method thereof. The invention has the characteristics of no influence on the palatability of the dog food, obvious curative effect and convenient use. Fills the blank of the prior art.
The invention is realized by the following technical scheme:
the inventor prepares powder by crushing 5-15 parts of coix seeds, 3-10 parts of dried tangerine peels, 3-12 parts of malt and 4-15 parts of combined spicebush roots, adds the powder into dog food, feeds dogs according to daily feed amount, and adds 0.5-1.0% of medicinal powder into 1kg of feed; animal models and clinical tests prove that the composition can reduce the content of triglyceride and cholesterol of hyperlipidemic dogs and has better clinical effect.
Detailed Description
The invention is further illustrated, but is not intended to be limited, by the following examples. It should be understood that modifications and changes may be made by those skilled in the art in light of the teachings herein and that such modifications and changes are to be included within the purview of the appended claims.
Example 1 preparation of the drug: 10 parts of coix seeds, 8 parts of dried orange peels, 6 parts of malt and 11 parts of combined spicebush roots, crushing and sieving with a 200-mesh sieve.
Example 1 application amounts of the powders: the 5g of powder is mixed into 1kg of dog food and fed according to daily food consumption.
Example 2 preparation of the drug: pulverizing 9 parts of semen Coicis, 6 parts of pericarpium Citri Reticulatae, 7 parts of fructus Hordei Germinatus, and 8 parts of radix Linderae, and sieving with 50 mesh sieve.
Example 2 usage amounts of powders: the 10g of powder is mixed into 1kg of dog food and fed according to daily food consumption.
Example 3 preparation of the drug: taking 10 parts of coix seeds, 6 parts of dried orange peels, 8 parts of malts and 9 parts of combined spicebush roots, crushing, and sieving by a 50-mesh sieve to obtain the traditional Chinese medicine composition.
Example 3 usage amounts of powder: the powder of 7g is mixed into dog food of 1kg and fed according to daily food consumption.
Example 4 preparation of the drug: pulverizing Coicis semen, and sieving with 50 mesh sieve.
Example 4 application amounts of powder: the powder of 7g is mixed into dog food of 1kg and fed according to daily food consumption.
Example 5 preparation of the drug: pulverizing pericarpium Citri Tangerinae, and sieving with 50 mesh sieve.
Example 5 usage amounts of powder: the powder of 7g is mixed into dog food of 1kg and fed according to daily food consumption.
Example 6 preparation of the drug: pulverizing fructus Hordei Germinatus, and sieving with 50 mesh sieve.
Example 6 application amounts of powders: the powder of 7g is mixed into dog food of 1kg and fed according to daily food consumption.
Example 7 preparation of the drug: pulverizing radix Linderae, and sieving with 50 mesh sieve.
Example 7 application amounts of powders: the powder of 7g is mixed into dog food of 1kg and fed according to daily food consumption.
1. The drug effect of example 2 on the prevention and treatment of hyperlipidemia was observed by constructing a high-lipid animal model.
1.1 test materials:
CD-1(ICR) IGS Male mice 60 (16-18g), lard, cod liver oil, egg, milk powder (whole milk powder), example 2.
1.2 test methods:
1.2.1 preparing high fat feed:
adding 20g lard, 20g milk powder, 1 egg (about 70g) and 10 drops of cod liver oil into per 100g common feed for common mouse, and steam cooking for 15 min. And (5) pelleting after the completion. The mice in the group were fed with 0.7% of example 2.
1.2.2 Experimental grouping and treatment:
the ICR male mice are randomly divided into three groups, 20 model control groups, 20 prevention administration groups and 20 blank control groups, wherein each 10 mice are provided with a mouse box, the model groups and the administration groups are fed with high-fat feed, and the blank control groups are fed with common feed without limitation on drinking and eating. Feeding continuously for 80 days. After the test is finished, the test is not performed for 12 hours, blood is collected in the fundus venous plexus, and triglyceride and total cholesterol are measured.
1.3 analysis of test results.
1.3.1 serum triglyceride levels in groups of mice after 80 days of feeding are shown in Table 1.
TABLE 1 serum triglyceride levels in groups of mice tested for 80 days
The blank control and the model control have obvious difference (P <0.05), which indicates that the model is successfully established; compared with the model group, the triglyceride content of the administration group is obviously reduced (P <0.05), which indicates that the example 2 has a remarkable effect; the blank control had no significant difference (P >0.05) compared to the administered group, indicating that example 2 had the effect of maintaining the triglyceride level of mice at a normal level.
1.3.2 Cholesterol levels in groups of mice after 80 days of feeding are shown in Table 2.
TABLE 2 serum cholesterol levels in groups of mice tested for 80 days
The blank control and the model control have extremely significant difference (P <0.01), which indicates that the model is successfully established; compared with the model group, the serum cholesterol content of the administration group is obviously reduced (P <0.05), which indicates that the example 2 has obvious effect; the blank control had no significant difference (P >0.05) compared to the dosed group, indicating that example 2 had the effect of maintaining the serum cholesterol level in mice at a normal level.
2. The drug effect of the examples 3-7 on preventing and treating the canine hyperlipidemia is observed by constructing a canine hyperlipidemia model.
2.1 test methods:
70 Chinese male garden dogs, aged 8-10 months, were randomly assigned to a high fat model control group (10 fed with high fat dog food), a control group of example 3 (10 added with 0.7% of the example 3 drug), a control group of example 4 (10 added with 0.7% of the example 4 drug), a control group of example 5 (10 added with 0.7% of the example 5 drug), a control group of example 6 (10 added with 0.7% of the example 6 drug), a control group of example 7 (10 added with 0.7% of the example 7 drug) and a blank control group (10 fed with regular food); after dogs were eligible for physical examination, the experiment was started.
The control group was given regular dog food at 08:00 and 16:00 daily. Each rural dog was fed the same weight of dog food.
Feeding a high-fat diet: each 1000g of the conventional dog food is added with 150g of cooked beef tallow, and each dog eats about 400-500g of cooked beef tallow each day. The feed is fed for 150 days. Measuring fasting body weight, and blood sampling for triglyceride and cholesterol in early morning of 0 and 150 days, respectively.
2.2 statistical analysis of the test results, i.e. the results of example 3-7 and the control group of high lipid model were compared with each other in the difference of the effect of canine hyperlipidemia, as detailed in Table 3.
TABLE 3 Effect of examples 3-7 on canine serum triglyceride, cholesterol
Note: "+" represents P <0.01, and "+" represents P <0.05
Experimental research on a hyperlipemia animal model shows that example 3 can obviously reduce the blood lipid level of a hyperlipemia dog. The results of examples 4, 5, 6 and 7 using single treatment are inferior to the results of example 3, which shows that the formulation of the present invention has better effect than any single treatment and has significant effect on preventing and treating canine hyperlipidemia. The invention makes up the defects of the prior art in the aspect of application of the pet hyperlipemia medicament.
Claims (4)
1. A traditional Chinese medicine composition for preventing and treating dog hyperlipidemia is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: 5-15 parts of coix seeds, 3-10 parts of dried orange peels, 3-12 parts of malt and 4-15 parts of combined spicebush roots, crushing and preparing into powder, adding the powder into dog food, feeding dogs according to daily feed amount, wherein the addition amount of the crushed medicinal materials is 0.5-1.0% of medicinal powder added into 1kg of feed.
2. The traditional Chinese medicine composition for preventing and treating canine hyperlipidemia as claimed in claim 1, wherein: the traditional Chinese medicine composition comprises the following components in parts by weight: 8-13 parts of coix seeds, 4-8 parts of dried orange peels, 5-9 parts of malt and 6-12 parts of combined spicebush roots.
3. The traditional Chinese medicine composition for preventing and treating canine hyperlipidemia as claimed in claim 1, wherein: the traditional Chinese medicine composition comprises the following components in parts by weight: 10 parts of coix seeds, 6 parts of dried orange peels, 8 parts of malt and 9 parts of combined spicebush roots.
4. The preparation method of the traditional Chinese medicine composition for preventing and treating canine hyperlipidemia according to any one of claims 1 to 3, characterized by comprising the following steps: the components of the traditional Chinese medicine composition are weighed and mixed uniformly according to the proportion, and are crushed into 50-100 meshes, so that the traditional Chinese medicine composition for preventing and treating the canine hyperlipidemia is obtained.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107865237A (en) * | 2017-11-28 | 2018-04-03 | 侯娟 | A kind of fat dog dog food |
| CN107873952A (en) * | 2017-11-28 | 2018-04-06 | 侯娟 | The anti-three high dog foods of one kind |
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| CN106177619A (en) * | 2016-08-04 | 2016-12-07 | 朱晓科 | A kind of dog feed containing Chinese medicine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107865237A (en) * | 2017-11-28 | 2018-04-03 | 侯娟 | A kind of fat dog dog food |
| CN107873952A (en) * | 2017-11-28 | 2018-04-06 | 侯娟 | The anti-three high dog foods of one kind |
Non-Patent Citations (1)
| Title |
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| 张道亮治疗高脂血症经验;张晓琴等;《湖北中医杂志》;20061225;第28卷(第12期);第28-29页 * |
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