CN110464763A - A kind of antipruritic antibacterial Moringa external application object and preparation method thereof - Google Patents
A kind of antipruritic antibacterial Moringa external application object and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of antipruritic antibacterial Moringa external application object and preparation method thereof, and the external application object includes following materials in percentage by mass: Moringa raw material 20~30%, Chinese prickly ash 0.3~0.5%, peppermint 0.2~0.3%, citric acid 0.5~3%, sodium isoascorbate 0.5~2%；The antioxidation and color-protecting leaching liquor compounded with citric acid and sodium isoascorbate is extracted using temperature, time, material layering multistage, and low temperature launches moringa root, stem item and Chinese prickly ash, and medium temperature launches leaf of Moringa, seed shell and dried peppermint leaf.Gained leaching liquor obtains Moringa external application object after compound microorganism ferments, filtering, by extracting and fermenting, the anti-inflammatory and anti-oxidation active substance being enriched in Moringa, have the function of antipruritic anti-inflammatory, antibacterial antivirus, natural herb is non-stimulated, and preparation cost is low, easy to use, the advantages that quick, itch suitable for acute and chronic dermatitis, eczema, tinea of feet and hands, trick decortication, foot, bite by mosquitos, prickly heat etc. it is various using pruitus as the dermatopathy of cardinal symptom.
Description
Technical field
The present invention relates to health care manufacture field, in particular to a kind of antipruritic antibacterial Moringa external application object and preparation method thereof.
Background technique
Skin disease is the general name occurred in skin and skin accessory organ's disease；Skin is the maximum organ of human body, skin
Sick is many kinds of, and common skin disease includes tinea of feet and hands, favus of the scalp, eczema, psoriasis etc..Its outstanding feature is clinical incidence
Higher, pathogenic factor is complicated, mostly chronic, and effect is unobvious after medication, and some of them skin disease is also easy to infect, and gives people
Life and work bring inconvenience, have become clinically more intractable disease at present.Cause dermopathic reason very much,
Such as skin disease caused by infective agent, such as fungi, bacterium infection usually have certain infectiousness, and it is strong not only to influence body
Health, and cause social discrimination.Once suffering from skin disease, itch unbearably, not only influences work, but also influence daily life often, special
It is not psoriasis, the course of disease is longer, there is tendency easy to recur, and some cases almost cannot be cured all one's life.Itch is the one of above-mentioned skin problem
A common and typical symptom.When itch, if excessive scratching affected part, can all make skin damage, just be unfavorable in this way
The recovery of illness.Therefore, antipruritic in time to be very important.The dermopathic topical agent of general treatment antimycotic is mostly anti-
Raw element parahormone class drug, such medicament are easy to produce skin drug resistance, dependence, are easy recurrence.Therefore there is an urgent need to have one
Kind can the antibacterial external application object of Quick itch stopping, and safety it is without side-effects.
Moringa (Moringa spp.) is Moringa suborder (Moringineae) Moringaceae (Moringaceae) Moringa
The perennial tropical evergreen of (Moringa Adans) or fallen leaves fast-growing arbor, belong to branch list category xylophyta.Moringa because of bark and
Root has pungent and there is plantation on Moringa of gaining the name, the ground such as Yunnan Province of China, Guangdong, Guangxi, Hainan, Taiwan.Moringa because it is abnormal abundant and
Comprehensive nutritional ingredient causes global concern and attention.Moringa rich in several mineral materials, vitamin and pharmacological activity at
Point, in many countries of India and Africa, Moringa is a kind of plant of integration of drinking and medicinal herbs, it not only has very high nutritive value, and
And a variety of diseases such as be often used guard against and treat diabetes, hypertension.Moringa is a kind of torrid zone for possessing unique economic value
Plant, nutritive value and medical value confirm and be just exploited by wide, enjoy " Tree of Life ", " tree of miracle ",
The laudatory titles such as " diamond in plant ", " medical treasure case ".
Guevara etc. has found that Moringa has anti-inflammatory bactericidal effect, can inhibit staphylococcus aureus, Pseudomonas alba and big
Enterobacteria growth, experiment effect are consistent with neomycin；The oil ben that Moringa seed extracts can promote the healing of animal wound；
The vitamin being rich in Moringa can treat because of a variety of diseases caused by hypovitaminosis, such as athlete's foot and scurvy；From peppery
The plant polyose extracted in the wooden cauline leaf is stronger to the elimination effect of free radical with the increase of concentration.Sharifudin and Sinha
Etc. results of study show to be able to suppress lipid peroxidation containing ascorbic acid, phenolic substances etc. in Moringa blade.Moringa blade
Contained in polyphenol have anti-inflammatory, anti-oxidant, antibacterial activity；Moringa fresh leaf, which is sticked, also has a constant current modulation to skin infection and ulcer
Effect.Therefore contain polyphenol more abundant, polysaccharide, vitamin, pterigospermin isoreactivity substance in Moringa cauline leaf, have preferable anti-
Aoxidize anti-inflammatory, itch-stopping bactericidal effect.
In conclusion problem of the existing technology is: dermatopathy at present based on pruritis is easy to recur to be difficult to
It cures, at present without safely effectively therapeutic agent.Multinomial research confirm Moringa have it is antipruritic, antibacterial, anti-oxidant well and
Antiinflammation can be effectively improved skin problem.It is without side-effects and can be outside the antibacterial Moringa of Quick itch stopping to need a kind of safety
Use object.
Summary of the invention
In consideration of it, the present invention proposes a kind of antipruritic antibacterial Moringa external application object and preparation method thereof, to solve the above problems.
The technical scheme of the present invention is realized as follows: the antipruritic antibacterial Moringa external application object of one kind, including following matter
Measure percentage raw material: Moringa raw material 20~30%, Chinese prickly ash 0.3~0.5%, peppermint 0.2~0.3%, citric acid 0.5~3%, different
Sodium ascorbate 0.5~2%
A kind of preparation method of antipruritic antibacterial Moringa external application object, comprising the following steps:
S1, raw material select: selecting mass ratio for 30~50:45~60:3~8:1~5 moringa root, Moringa stem item, peppery
The wooden leaf and moringa seeds shell, Moringa stem item cut into section, and length is 0.5~0.8cm, moringa root slice, with a thickness of 0.2~0.3cm,
Moringa seeds shell is smashed, and 80~110 meshes are crossed；
S2, cleaning: being cleaned Moringa raw material 1~3 time with clear water, removes impurity, and drain away the water；
S3, antioxidation and color-protecting: being added citric acid in water and sodium isoascorbate prepares leaching liquor and carries out anti-oxidant and shield
Color processing；
S4, multistage extraction: (1) temperature is 40~50 DEG C, will be soaked in moringa root, stem item and Chinese prickly ash into the water leaching liquor
1~3h is mentioned, leaching liquor I is obtained；(2) temperature is 60~70 DEG C, extraction leaf of Moringa, moringa seeds shell and dried peppermint leaf being put into (1)
1~3h is extracted in liquid, obtains leaching liquor II；(3) it is 90~120 DEG C in temperature, extracts 0.3~0.7h jointly, obtain leaching liquor III；
S5, microbial fermentation: the compound probiotic of S. cervisiae and lactobacillus plantarum is added to the extraction obtained to S4
In liquid III, effective viable bacteria concentration is preferably 50~100cfu/g, sealing, and ferment 36~48h at 35~37 DEG C, obtains fermentation Moringa
Liquid,
S6, filtering: fermentation Moringa liquid is filtered to get Moringa external use liquid using 50~100 mesh screens.
Compared with prior art, the beneficial effects of the present invention are:
(1) Moringa raw material and Chinese prickly ash, peppermint, citric acid, sodium isoascorbate scientific matching are selected, wherein Moringa raw material packet
Moringa root, Moringa stem item, leaf of Moringa and moringa seeds shell, preferably optimal mass ratio are included, the external application object prepared can cooperate with hair
Wave antipruritic antibacterial effect.
(2) using layering investment multistage extraction, Polyphenols, polysaccharide active material is made sufficiently to discharge and be enriched with, root
According to the difference of active material contained by different material and property, keep active material extraction more abundant, can keep activity and be not easy by
It destroys, and carries out color protection using compound anti-oxidation color protection leaching liquor, prevent active material to be oxidized, improve anti-oxidant anti-inflammatory work
With.
(3) microbial fermentation technology is used, probiotics fermention can improve the biological nature of Moringa, to Moringa effective component
Ingredient is extracted, polyphenol, polysaccharide material content are enriched with, Polyphenols and polysaccharose substance have stronger anti-oxidant, anti-inflammatory work
Property, a large amount of free radicals of body metabolism generation can be removed, are had the effects that antipruritic, antibacterial, antiviral.
(4) dermatopathy itch, quick (tinea pedis can once take effect), significant effect, Nantural non-toxic are solved the problems, such as
Side effect.It is used through hundred patients, antipruritic effective percentage is as a treatment course up to 96%, 1~2 week, adheres to improving using to dermatopathy
Significantly.
Specific embodiment
In order to be best understood from the technology of the present invention content, specific embodiment is provided below, the present invention is described further.
Experimental method used in the embodiment of the present invention is conventional method unless otherwise specified.
Material used in the embodiment of the present invention, reagent etc., are commercially available unless otherwise specified.
Embodiment 1
A kind of antipruritic antibacterial Moringa external application object, including following materials in percentage by mass: Moringa raw material 20%, Chinese prickly ash
0.3%, peppermint 0.2%, citric acid 0.5%, sodium isoascorbate 0.5%.
Embodiment 2
A kind of antipruritic antibacterial Moringa external application object, including following materials in percentage by mass: Moringa raw material 30%, Chinese prickly ash
0.5%, peppermint 0.3%, citric acid 3%, sodium isoascorbate 2%.
Embodiment 3
A kind of antipruritic antibacterial Moringa external application object, including following materials in percentage by mass: Moringa raw material 25%, Chinese prickly ash
0.4%, peppermint 0.25%, citric acid 1.7%, sodium isoascorbate 1.3%.
The preparation method of the antipruritic antibacterial Moringa external application object of above-described embodiment 1~3, comprising the following steps:
S1, raw material select: selecting the mass ratio for the moringa root of 40:52:5:2, Moringa stem item, leaf of Moringa and moringa seeds
Shell, Moringa stem item cut into section, and length 0.7cm, moringa root slice, with a thickness of 0.25cm, moringa seeds shell is smashed, and crosses 100 mesh
Sieve；
S2, cleaning: being cleaned Moringa raw material 2 times with clear water, removes impurity, and drain away the water；
S3, antioxidation and color-protecting: being added citric acid in water and sodium isoascorbate prepares leaching liquor and carries out anti-oxidant and shield
Color processing；
S4, multistage extraction: (1) temperature is 45 DEG C, and moringa root, stem item and Chinese prickly ash are extracted 2h into the water, must be extracted
Liquid I；(2) temperature is 65 DEG C, will extract 2h in leaching liquor that leaf of Moringa, moringa seeds shell and dried peppermint leaf are put into (1), obtains leaching liquor
II；(3) temperature is 100 DEG C, extracts 0.5h jointly, obtains leaching liquor III；
S5, microbial fermentation: the compound probiotic of S. cervisiae and lactobacillus plantarum is added to the extraction obtained to S4
In liquid III, effective viable bacteria concentration is preferably 80cfu/g, and sealing, ferment 40h at 36 DEG C, and must ferment Moringa liquid,
S6, filtering: being filtered to get Moringa external use liquid fermentation Moringa liquid using 80 mesh screens,
The present embodiment can make paste.
Embodiment 4
S1, raw material select: selecting the mass ratio for the moringa root of 30:45:3:1, Moringa stem item, leaf of Moringa and moringa seeds
Shell, Moringa stem item cut into section, and length 0.5cm, moringa root slice, with a thickness of 0.2cm, moringa seeds shell is smashed, and crosses 80 meshes；
S2, cleaning: being cleaned Moringa raw material 1 time with clear water, removes impurity, and drain away the water；
S3, antioxidation and color-protecting: being added citric acid in water and sodium isoascorbate prepares leaching liquor and carries out anti-oxidant and shield
Color processing；
S4, multistage extraction: (1) temperature is 40 DEG C, and moringa root, stem item and Chinese prickly ash are extracted 1h into the water, must be extracted
Liquid I；(2) temperature is 60 DEG C, will extract 1h in leaching liquor that leaf of Moringa, moringa seeds shell and dried peppermint leaf are put into (1), obtains leaching liquor
II；(3) temperature is 90 DEG C, extracts 0.3h jointly, obtains leaching liquor III；
S5, microbial fermentation: the compound probiotic of S. cervisiae and lactobacillus plantarum is added to the extraction obtained to S4
In liquid III, effective viable bacteria concentration is preferably 50cfu/g, and sealing, ferment 36h at 35 DEG C, and must ferment Moringa liquid,
S6, filtering: fermentation Moringa liquid is filtered to get Moringa external use liquid using 50 mesh screens；
The present embodiment is golden solution, can do bubble liquid, for brothers' bath and bathing.
Embodiment 5
A kind of preparation method of antipruritic antibacterial Moringa external application object, comprising the following steps:
S1, raw material select: selecting the mass ratio for the moringa root of 50:60:8:5, Moringa stem item, leaf of Moringa and moringa seeds
Shell, Moringa stem item cut into section, and length 0.8cm, moringa root slice, with a thickness of 0.3cm, moringa seeds shell is smashed, and crosses 110 mesh
Sieve；
S2, cleaning: being cleaned Moringa raw material 3 times with clear water, removes impurity, and drain away the water；
S3, antioxidation and color-protecting: being added citric acid in water and sodium isoascorbate prepares leaching liquor and carries out anti-oxidant and shield
Color processing；
S4, multistage extraction: (1) temperature is 50 DEG C, and moringa root, stem item and Chinese prickly ash are extracted 3h into the water, must be extracted
Liquid I；(2) temperature is 70 DEG C, will extract 3h in leaching liquor that leaf of Moringa, moringa seeds shell and dried peppermint leaf are put into (1), obtains leaching liquor
II；(3) temperature is 120 DEG C, and the common 0.7h that extracts obtains leaching liquor III；
S5, microbial fermentation: the compound probiotic of S. cervisiae and lactobacillus plantarum is added to the extraction obtained to S4
In liquid III, effective viable bacteria concentration is preferably 100cfu/g, and sealing, ferment 48h at 37 DEG C, and must ferment Moringa liquid,
S6, filtering: being filtered to get Moringa external use liquid fermentation Moringa liquid using 100 mesh screens,
The present embodiment is golden solution, can do spray, refrigerant antipruritic.
Embodiment 6
The present embodiment and the difference of embodiment 3 are, in S3 step, the mass percent of citric acid and sodium isoascorbate
Respectively 0.1%, 0.3%；
Comparative example 1
Comparative example 1 and the difference of embodiment 3 are, layering investment multistage extraction is not used, but directly by Moringa
Raw material, Chinese prickly ash, dried peppermint leaf are put into together, extract 2h at a temperature of 100 DEG C.
Comparative example 2
Comparative example 2 and the difference of embodiment 3 are that microbial fermentation uses S. cervisiae.
Comparative example 3
Control group 3 the difference from embodiment 1 is that, microbial fermentation use lactobacillus plantarum.
One, measuring
The present invention is as follows: according to the Moringa external application analyte detection acquired results of embodiment 3
Moringa external application analyte detection result prepared by Examples 1 to 6 and comparative example 1~3 is as follows:
| Project | Total phenol content | Scavenging ability | Lipid peroxidation rejection ability |
| Embodiment 1 | 1.90 | 40.4 | 58.6 |
| Embodiment 2 | 1.92 | 41.1 | 54.3 |
| Embodiment 3 | 1.93 | 42.6 | 57.4 |
| Embodiment 4 | 1.90 | 41.0 | 53.7 |
| Embodiment 5 | 1.91 | 41.2 | 53.0 |
| Embodiment 6 | 1.89 | 40.3 | 52.1 |
| Comparative example 1 | 1.41 | 35.4 | 48.6 |
| Comparative example 2 | 1.34 | 35.1 | 44.3 |
| Comparative example 3 | 1.28 | 33.5 | 46.2 |
Result of study shows the fermented utilization rate for improving polyphenols in raw material really, and reference state polyphenol passes through
In microbe metabolite degrading enzyme degradation, hydrolase (amylase, pectase, cellulase, hemicellulase etc.) hydrolysis and
It is converted to free state polyphenol.In addition, the reference state polyphenol in food can be converted to trip to a certain extent after Mechanical Crushing
Amorph polyphenol can also improve free state polyphenol in raw material to a certain extent, so that antioxidant activity improves.
Compared with existing product, the present invention is by adopting the above-described technical solution, only need to be by external application object of the present invention when using
Painting is put on the skin in affected part, daily 1~2 time, can be obvious antipruritic, adheres to that dermatopathy can obviously improve using 3-4 weeks, has auxiliary
Therapeutic effect.Instant component is simple, prepare and application is convenient, quick；It is the dermatopathy of cardinal symptom suitable for itch,
Can be antipruritic antibacterial, facilitate dermatopathy rehabilitation.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Typical case 1: Zhang, male, 62 years old, tinea pedis was peeled seriously for many years, between toe, and sole has a large amount of white scurfs, long
Time itch, Da Kening (miconazole nitrate cream) smearing of using by oneself, no positive effect.It is impregnated using Moringa external application object of the present invention,
It is primary antipruritic.Continuous bubble foot one month, foot's skin smooth is almost recovered.
Typical case 2: Chen, male, 56 years old, psoriasis many years, because itch medial leg skin scratches ulceration, surrounding skin
It is coarse.It is unobvious using a variety of effect of drugs.It is smeared using Moringa external application object of the present invention, two times a day, is used continuously 2 months, scabies
Symptom of itching disappears substantially, ulceration wound healing, surrounding skin elasticity and improving gloss.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of antipruritic antibacterial Moringa external application object, it is characterised in that: the external application object includes following percentage raw material: Moringa is former
Expect 20~30%, Chinese prickly ash 0.3~0.5%, peppermint 0.2~0.3%, citric acid 0.5~3%, sodium isoascorbate 0.5~2%.
2. a kind of antipruritic antibacterial Moringa external application object as described in claim 1, it is characterised in that: the Moringa raw material is quality
Than for 30~50:45~60:3~8:1~5 moringa root, Moringa stem item, leaf of Moringa and moringa seeds shell mixture.
3. a kind of preparation method of antipruritic antibacterial Moringa external application object as described in claim 1, it is characterised in that: will be described peppery
Color protection is carried out after wood raw material cleaning, carries out microbial fermentation after extracting using the multistage, is filtered up to Moringa external use liquid.
4. a kind of preparation method of antipruritic antibacterial Moringa external application object as claimed in claim 3, it is characterised in that: including following
Step:
S1, Moringa raw material: select mass ratio for 30~50:45~60:3~8:1~5 moringa root, Moringa stem item, leaf of Moringa and
Moringa seeds shell；
S2, cleaning: being cleaned Moringa raw material 1~3 time with clear water, removes impurity, and drain away the water；
S3, antioxidation and color-protecting: being added citric acid in water and sodium isoascorbate is prepared leaching liquor and carried out at anti-oxidant and color protection
Reason；
S4, multistage extraction: (1) temperature is 40~50 DEG C, and moringa root, stem item and Chinese prickly ash are extracted 1~3h into the water, must be soaked
Extract I；(2) temperature is 60~70 DEG C, and leaf of Moringa, moringa seeds shell and dried peppermint leaf are put into (1) and extract 1~3h, obtains leaching liquor
II；(3) it is 90~120 DEG C in temperature, extracts 0.3~0.7h jointly, obtain leaching liquor III；
S5, microbial fermentation: the compound probiotic of S. cervisiae and lactobacillus plantarum is added to the leaching liquor III obtained to S4
In, sealing, ferment 36~48h at 35~37 DEG C, and must ferment Moringa liquid,
S6, filtering: fermentation Moringa liquid is filtered to get Moringa external use liquid using 50~100 mesh screens.
5. the preparation method of the antipruritic antibacterial Moringa external application object of one kind as claimed in claims 3 and 4, it is characterised in that: S1 step
In rapid, Moringa stem item cuts into section, and length is 0.5~0.8cm, and moringa root slice, with a thickness of 0.2~0.3cm, moringa seeds shell is beaten
It is broken, cross 80~110 meshes.
6. the preparation method of the antipruritic antibacterial Moringa external application object of one kind as claimed in claims 3 and 4, it is characterised in that: S5 step
In rapid, effective viable bacteria concentration of microbial fermentation is 50~100cfu/g.
7. a kind of antipruritic antibacterial Moringa external application object, feature exists, by a kind of described in any item antipruritic suppressions of claim 1~6
The preparation method of the Moringa external application object of bacterium is made.
8. the antipruritic antibacterial Moringa external application object of one kind according to any one of claims 1 to 7, it is characterised in that: described
External application object is one of bubble liquid, spray, paste.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116196343A (en) * | 2023-03-29 | 2023-06-02 | 华南农业大学 | Application of moringa leaf extract and/or borneol essential oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104606295A (en) * | 2015-02-09 | 2015-05-13 | 程贵昌 | Non-antibiotic antifungal externally used medicine |
| CN105497318A (en) * | 2015-12-28 | 2016-04-20 | 上海普乐拜格健康科技有限公司 | Biological agent used for enhancing immunity of organism and preparation method thereof |
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2019
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Patent Citations (2)
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| CN104606295A (en) * | 2015-02-09 | 2015-05-13 | 程贵昌 | Non-antibiotic antifungal externally used medicine |
| CN105497318A (en) * | 2015-12-28 | 2016-04-20 | 上海普乐拜格健康科技有限公司 | Biological agent used for enhancing immunity of organism and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| BRAHMA N. SINGH等: "Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera", 《FOOD AND CHEMICAL TOXICOLOGY》 * |
| 李倩等: "辣木叶提取液在发酵过程营养成分及其抗氧化活性的变化", 《食品工业科技》 * |
| 梁鹏等: "辣木茎叶中水溶性多糖的提取及抗氧化活性的研究", 《食品研究与开发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116196343A (en) * | 2023-03-29 | 2023-06-02 | 华南农业大学 | Application of moringa leaf extract and/or borneol essential oil |
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| CN110464763B (en) | 2021-08-27 |
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