CN110456088A - Specific protein analyzer - Google Patents
Specific protein analyzer Download PDFInfo
- Publication number
- CN110456088A CN110456088A CN201910794639.4A CN201910794639A CN110456088A CN 110456088 A CN110456088 A CN 110456088A CN 201910794639 A CN201910794639 A CN 201910794639A CN 110456088 A CN110456088 A CN 110456088A
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- dilution
- sample
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- liquid
- disk
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
Abstract
The present invention discloses specific protein analyzer, comprising: rack；It is arranged on the rack, the sample introduction module for conveying sample；It is arranged on the rack, for the transfer component of transfer liquid；It is arranged on the rack, the agent bin component for storing detection reagent；It is arranged on the rack, the reaction tray component for being reacted；And be arranged in rack, the detection components on the downside of reaction tray component, it further include dilution component；The present invention adds dilution component, carries out pre-dilution to blood by dilution component, is not necessarily to place diluted cup on reaction tray component, accordingly increases reaction cup quantity on reaction tray component, increase the quantity of detection project while improving detection rates.
Description
Technical field
The present invention relates to specific protein detection fields, specifically specific protein analyzer.
Background technique
Specific protein analyzer is mainly used for detecting the various albumen in sample, has to the clinical diagnosis of doctor
Highly important meaning, the accuracy of specific protein analyzer is high, reproducible, either single sample or great amount of samples,
It can detect at any time, immediately result out.
Traditional full automatic detecting instrument, sampling, liquid feeding, cleaning, stirring, detection are all according to regular hour logic
It is required that operation.As shown in Figure 1, being respectively arranged with sample application position 01, reagent pipetting volume position 02, stirring position 03, photoelectricity in reaction tray
Check bit 04, cleaning position 05, and have certain location interval, and a mobile arm component is provided on each position, it is used for
Implement corresponding operation on corresponding position.A moving arm connection sample needle is equipped with i.e. above reagent pipetting volume position 02 to be added
Sample is equipped with moving arm connection stirring rod above stirring position 03 and is stirred to liquid, is equipped on cleaning position 05
One moving arm connection cleaning pipe is cleaned etc..In the detection process they need according to it is certain when ordered pair liquid at
Reason, to the treatment process of a sample are as follows: empty reaction cup turns to reagent pipetting volume position with reaction tray and adds the first reagent, then moves
The addition of sample is carried out to sample application position, reaction cup follows reaction tray when going to reagent pipetting volume position again by sample needle addition second
Reagent, reaction cup are stirred by stirring rod again when going to stirring position, and reaction cup is detected again when going to Photoelectric Detection position, and
Test result is obtained according to detection data, and the reaction cup after having will test cleans up waiting and adds reagent again.
But for former blood class sample, in order to improve its detection accuracy, before being detected, need to carry out sample pre-
Dilution.Therefore existing full automatic detecting instrument is additionally arranged dilution to adapt to this testing requirements in original reaction tray
Position, this dilution position needs to occupy the reaction cup in reaction tray, and is added in the original workflow of reaction tray prediluted
Movement has upset the temporal logic of reaction tray operation originally, has thereby reduced detection speed.
Summary of the invention
The purpose of the present invention is to provide specific protein analyzers, add dilution component, by dilution component to blood into
Row pre-dilution accordingly increases reaction cup quantity on reaction tray component, improves inspection without placing diluted cup on reaction tray component
The number of entry of survey improves detection rates simultaneously.
The purpose of the present invention can be achieved through the following technical solutions:
Specific protein analyzer, comprising: rack；It is arranged on the rack, the sample introduction module for conveying sample；It is arranged in machine
Transfer component on frame, for transfer liquid；It is arranged on the rack, the agent bin component for storing detection reagent；Setting exists
Reaction tray component in rack, for being reacted；And it is arranged in rack, the detection group on the downside of reaction tray component
Part.
Specific protein analyzer further includes dilution component, and dilution component includes: dilution frame；It is rotatably connected on dilution frame
, dilution disk for storing dilution and mixed diluting liquid and sample, dilute and be provided with several reaction cups on disk；Setting exists
It is on dilution frame, add liquid component to dilution disk addition dilution；And it is arranged on the rack, to drive dilution disk rotation
Actuator.
Further, dilution component further includes the dilution evenly mixing device that dilution disk side is arranged in, and dilutes evenly mixing device packet
It includes mixing part and is fixedly connected on and mix the mixing frame that on part, driving mixes the separate or close reaction cup of part, mix part
It is moved far from the one end for mixing frame along the direction close to reaction cup and puts in reaction cup, turns over the liquid in reaction cup to gush.
Further, transfer component includes: sample rocker arm and reagent rocker arm, and sample rocker arm is for drawing sample to load
Have in the dilution disk of dilution or by sample and dilution mixed liquid assimilating to reaction tray component, reagent rocker arm is used
It draws in by the reagent in agent bin component to reaction tray component.
Further, adding liquid component includes: to be arranged on dilution frame to add liquid bracket；Several groups, which are fixedly connected on, adds liquid branch
On frame and parallel arrangement flushing pipe；And it is fixedly connected on the liquid adding tube added on liquid bracket, the axis and flushing pipe of liquid adding tube
Axis it is parallel.
Further, dilution disk remains static, and mixes part and flushing pipe and liquid adding tube is put in dilution disk, respectively
Be stirred, rinse and add the work that surges to the reaction cup of its corresponding position, and at this time sample rocker arm on its operating position edge
Sample is added in the reaction cup equipped with dilution by the direction movement close to dilution disk.
Further, it is mobile towards the direction far from dilution disk until taking out that part, flushing pipe, liquid adding tube and sample rocker arm are mixed
When from reaction cup, dilution disk the reaction cup rotatable around its axis that mix sample and dilution after part mixes well that will be loaded with is moved
It moves to sample rocker arm lower end.
Further, the dilution disk reaction cup rotatable around its axis drawn sample rocker arm after liquid is moved to flushing
The lower end of pipe.
Further, sample rocker arm will dilute the sample on disk and the mixed liquid assimilating of dilution to reaction tray component
In the upper reaction cup equipped with reagent.
Further, the position of sample rocker arm addition sample to dilution disk is drawn sample with sample rocker arm and is mixed with dilution
The position of liquid afterwards is in same position.
Further, flushing pipe includes inlet tube and liquid suction pipe, and liquid suction pipe is lower than inlet tube close to one end of dilution disk
Close to one end of dilution disk.
Beneficial effects of the present invention:
1, the present invention adds dilution component, carries out pre-dilution to blood by dilution component, is not necessarily to put on reaction tray component
Diluted cup is set, reaction cup quantity on reaction tray component is accordingly increased, the number of entry of detection is improved while improving detection
Rate；
2, present invention dilution component includes dilution evenly mixing device, by dilution evenly mixing device to mixed sample and dilute
It releases liquid progress liquid and turns over and gush, mix sample and dilution more thorough；
3, present invention dilution component includes to add liquid component, and dilution disk is cleaned and supplemented in time in time by adding liquid component
Dilution reuses the reaction cup diluted on disk；
4, when dilution disk remains static, sample of the present invention rocker arm adds sample, mixes part to sample and dilution
Stirring, the cleaning of flushing pipe reaction cup and liquid adding tube carry out simultaneously to the reaction cup addition dilution after cleaning, improve dilution component
To Sample Dilution efficiency；
5, present invention addition sample into dilution component is added in reaction tray with by the sample after dilution, by same
Sample rocker arm is completed, and keeps structure of the invention more compact.
Detailed description of the invention
The present invention will be further described below with reference to the drawings.
Fig. 1 is existing protein analyzer reaction tray structural schematic diagram；
Fig. 2 specific protein analyzer structural schematic diagram of the present invention；
Fig. 3 is sample of the present invention rocker structure schematic diagram；
Fig. 4 is present invention dilution component structure diagram；
Fig. 5 is present invention dilution evenly mixing device structural schematic diagram.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts all other
Embodiment shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " aperture ", "upper", "lower", " thickness ", "top", " in ",
Indicating positions or the positional relationship such as " length ", "inner", " surrounding ", are merely for convenience of description of the present invention and simplification of the description, without
It is that the component of indication or suggestion meaning or element must have a particular orientation, is constructed and operated in a specific orientation, therefore not
It can be interpreted as limitation of the present invention.
As shown in Fig. 2, specific protein analyzer, comprising: rack 1；It is arranged in rack 1, the sample introduction for conveying sample
Component；It is arranged in rack 1, for the transfer component 2 of transfer liquid；It is arranged in rack 1, for storing detection reagent
Agent bin component 3；It is arranged in rack 1, the reaction tray component 4 for being reacted；And it is arranged in rack 1, is located at instead
The detection components 5 of 4 lower end of component should be coiled.
Specific protein analyzer further includes the dilution component 8 for carry out to sample beforehand dilution.
In the prior art, dilution is completed on reaction tray component 4, first by sampling into reaction tray component 4
One reaction cup is diluted, then extracts sample to reaction cup, then the addition inspection into reaction cup from the sample cup after dilution
Test agent, to carry out coherent detection and output test result after the reaction was completed.Therefore, diluted cup can account on reaction tray component 4
According to a position, same detection main body needs occupy two positions on reaction tray component 4, and the position on reaction tray component 4
It sets and is limited, so that the project that can be detected in a detection plate is less, detection rates are lower.
The present invention adds dilution component 8, carries out pre-dilution to sample by dilution component 8, is not necessarily on reaction tray component 4
Diluted cup is placed, reaction cup quantity on reaction tray component 4 is accordingly increased, improves number of inspection items while improving detection
Rate.
Transferring component 2 includes: sample rocker arm 6 and reagent rocker arm 7, and sample rocker arm 6 and reagent rocker arm 7 are arranged at rack
On 1, while in embodiments of the present invention, sample rocker arm 6 is consistent with 7 structure of reagent rocker arm.
As shown in figure 3, sample rocker arm 6 includes: the puncture needle fixing seat 61 being arranged in rack 1；It is provided on the downside of one end
The puncture needle support frame 62 of puncture needle；Support rod 63 of the puncture needle support frame 62 far from puncture needle one end, support rod 63 are set
Activity is assemblied in puncture needle fixing seat 61；It is fixed in puncture needle fixing seat 61 and to drive support rod 63 to move up and down
Puncture needle movement mechanism 64；And it is fixed in puncture needle fixing seat 61 and to drive support rod 63 rotatable around its axis
Rotational motion mechanism 65.
Sample rocker arm 6 further include: reinforce linear guide 66, reinforcing linear guide 66 includes that the first guide rod 661 and first is sliding
Block 662, the first guide rod 661 and 662 activity of the first sliding block are assembled, and the first sliding block 662 is sliding along the axis direction of the first guide rod 661
It moves, the first sliding block 662 is fixedly connected on rotational motion mechanism 65, and the first guide rod 661 is fixedly connected on puncture needle support frame 62
On, the first guide rod 661 is arranged in parallel with support rod 63.
It is added in the present invention and reinforces linear guide 66, reduce the lateral torsion for deviating its axis that support rod 63 is subject to, into
And the frictional force between support rod 63 and puncture needle fixing seat 61 is reduced, make the abrasion of the contact site of support rod 63 and fixing seat
It reduces, guarantees that support rod 63 operates normally.
Puncture needle movement mechanism 64 includes the puncture needle synchronous belt mechanism 641 being fixed in puncture needle fixing seat 61, fixes
The up and down motion supporting block 642 being mounted on the synchronous belt of puncture needle synchronous belt mechanism 641 is propped up with up and down motion is fixedly mounted on
Rotating block 643 on bracer 642, wherein rotating block 643 and 63 lower end of support rod are rotatablely connected, and support rod 63 is close to rotating block
643 position is equipped with positive stop lug boss.
In use, starting puncture needle synchronous belt mechanism 641, the synchronous belt of puncture needle synchronous belt mechanism 641 drives fortune up and down
Dynamic supporting block 642 is moved along up and down motion direction, and further, up and down motion supporting block 642 drives support by rotating block 643
The realization of bar 63 moves up and down, and then realizes the puncture needle up and down motion movement on puncture needle support frame 62.
Rotational motion mechanism 65 includes: the puncture needle rotation synchronization belt mechanism 651 being fixed in puncture needle fixing seat 61；With
The lower end rotating seat 652 that the synchronizing wheel of puncture needle rotation synchronization belt mechanism 651 is fixedly and coaxially connected, lower end rotating seat 652 are fixed
The synchronizing wheel and 63 coaxial line of support rod of the puncture needle rotation synchronization belt mechanism 651 of connection；It is fixed on 652 upper end of lower end rotating seat
Vertical straight line guide rail 653, vertical straight line guide rail 653 include the second guide rod 6531 and the second sliding block 6532, the second guide rod 6531
It is fixedly connected with lower end rotating seat 652, the second guide rod 6531 and 6532 activity of the second sliding block are assembled, and the second sliding block 6532 is along second
The axis direction of guide rod 6531 slides, and the second guide rod 6531 is arranged in parallel with support rod 63；It is fixedly connected on the second sliding block 6532
On grip block 654, the one end of grip block 654 far from the second sliding block 6532 is gripped with support rod 63.
Wherein, the axis of the axis of the first guide rod 661 and the second guide rod 6531 is respectively positioned on axis and the puncture of support rod 63
Between the axis of needle.
Wherein, the one end of the first guide rod 661 far from puncture needle support frame 62 is fixedly connected with grip block 654, the first sliding block
662 are fixedly connected with 6531 upper end of the second guide rod.
Wherein, puncture needle rotation synchronization belt mechanism 651 is located at 61 lower end of puncture needle fixing seat.
In use, starting puncture needle rotation synchronization belt mechanism 651, the synchronizing wheel of puncture needle rotation synchronization belt mechanism 651 is logical
Crossing lower end rotating seat 652, vertical straight line guide rail 653 and grip block 654 drives support rod 63 around own axis, and then realizes
Puncture needle on puncture needle support frame 62 is acted around 63 axis rotation of support rod, when wherein support rod 63 moves up and down,
Grip block 654 is slided up and down along the second guide rod 6531 of vertical straight line guide rail 653；651, puncture needle rotation synchronization belt mechanism
In 61 lower end of puncture needle fixing seat, reduce the space layout of 61 upper end of puncture needle fixing seat, makes 61 upper end of puncture needle fixing seat
It is more compact.
Turning connecting assembly (being equivalent to the vertical straight line guide rail 653 and grip block 654 in the present invention) in the prior art
It is design in bottom, design is that will lead to bottom overall volume larger, and Turning connecting assembly of the invention in the shortcomings that bottom
Design makes full use of the space on top of the invention at middle part, reduces bottom overall volume.
Bumper bar 67 is fixedly connected in puncture needle fixing seat 61, bumper bar 67 and support rod 63 are arranged in parallel, wherein protecting
Dangerous bar 67 is arranged through up and down motion supporting block 642, and 67 lower end of bumper bar, which is arranged with, holds up spring 68.
Start the motor for driving puncture needle synchronous belt mechanism 641, realizes 641 synchronous belt of puncture needle synchronous belt mechanism
Puncture needle support frame 62 is driven to move up and down, when puncture needle synchronous belt mechanism 641 shuts down, the locking of motor itself
Power is supported puncture needle support frame 62, when motor occurs to the locking loosening of puncture needle synchronous belt mechanism 641, punctures at this time
Needle support frame 62 is since self gravity moves down, when puncture needle is in reaction tray component 4 or dilutes the reaction on component 8
When right above cup, cause to hinder in the puncture needle intercalation reaction cup on puncture needle support frame 62 rotation reaction tray component 4 or
The reaction cup rotation on component 8 is diluted, the reaction cup on puncture needle, reaction tray component 4 or dilution component 8 is caused to be damaged
It is bad, by holding up spring 68, when motor can not lock puncture needle synchronous belt mechanism 641, spring 68 is held up to puncture needle branch
Support 62 carries out height of drop limit, so that the puncture needle on puncture needle support frame 62 is in certain altitude, avoids pricker support frame
On puncture needle intercalation reaction cup in.
In use, sample introduction module by the sample tube in sample box successively being moved to immediately below sample rocker arm 6 one by one, puncture
Needle pump control puncture needle draws the sample in sample tube, by puncture needle movement mechanism 64 and rotational motion mechanism 65, makes to wear
Pricker realizes puncture needle on sample rocker arm 6 by the sampling in sample tube up and down and around 63 axis rotation of support rod
To dilution component 8 in, puncture needle pump control puncture needle to the sample in sample tube discharge or sample rocker arm 6 on wear
Pricker will dilute the sample after component 8 dilutes and draw to discharging in reaction tray component 4.
As shown in figure 4, dilution component 8 includes: the dilution frame 81 being arranged in rack 1；It is rotatably connected on dilution frame 81
, dilution disk 82 for storing dilution and mixed diluting liquid and sample, dilute and be provided with several reaction cups on disk 82；
Be arranged in it is on dilution frame 81, add dilution to dilution disk 82 and add liquid component 83；And it is arranged in rack 1, to drive
The actuator that dynamic dilution disk 82 rotates.
Wherein, adding liquid component 83 includes: to be arranged on dilution frame 81 and add liquid bracket 831 along up and down motion；If
Dry group is fixedly connected on the flushing pipe 832 for adding on liquid bracket 831 and being arranged in parallel；And it is fixedly connected on and adds on liquid bracket 831
Liquid adding tube 833, the axis of liquid adding tube 833 is parallel with the axis of flushing pipe 832.
Flushing pipe 832 includes inlet tube and liquid suction pipe, and liquid suction pipe is close lower than inlet tube close to one end of dilution disk 82
Dilute one end of disk 82.
In use, wherein feed liquor tube pump is infused by inlet tube to 82 reaction cup of dilution disk after 6 sample drawn of sample rocker arm
Enter cleaning solution, drawing liquid tube pump is extracted the cleaning solution of pollution by liquid suction pipe, several groups flushing pipe 832, is realized to sample
82 reaction cup of dilution disk after 6 sample drawn of rocker arm is cleaned multiple times, and flushing pipe 832 is set as three groups in the embodiment of the present invention.
In use, liquid adding tube pump is reacted by the dilution disk 82 that liquid adding tube 833 injects dilution after flushing pipe 832 is cleaned
In cup, dilution is generally physiological saline.
Dilution component 8 further includes the dilution evenly mixing device 84 that dilution 82 side of disk is arranged in, as shown in figure 5, dilution mixes
Device 84 includes mixing part 841 and mixing frame.
Mixing part 841 in the embodiment of the present invention is the mixing needle of rotation, when mixing needle puts in dilution 82 reaction cup of disk,
It is rotated by motor driven mixing needle, the liquid in dilution 82 reaction cup of disk turn over gushing.
Wherein, mixing frame includes: the stirring stant 842 for being arranged in and mixing on part；842 sports limiting of stirring stant is stirred
Mix linear guide 843；The stirring movement synchronous belt that driving stirring stant 842 moves up and down along stirring linear guide 843
Mechanism 844；It is fixedly mounted on plastics spline 845 in stirring stant 842；Stirring stant 842 is driven to rotate by plastics spline 845
Stirring rotation synchronization belt mechanism 846；And to support fixed stirring linear guide 843, stirring movement synchronous belt mechanism 844
With the stirring support base 847 of stirring rotation synchronization belt mechanism 846, wherein 843 activity of stirring stant 842 and stirring linear guide
Installation, stirring stant 842 and stirring movement synchronous belt mechanism 844 synchronize be fixedly connected, stir support base 847 and be fixed on branch
1 upper end of frame, synchronous pulley of the plastics spline 845 through stirring rotation synchronization belt mechanism 846.
In use, plastics spline 845 can move up and down with stirring stant 842, when puncture needle rotation synchronization belt mechanism
When 651 synchronous pulley rotation, since plastics spline 845 rotates on the synchronous pulley of puncture needle rotation synchronization belt mechanism 651
Limit, the synchronous pulley rotation of puncture needle rotation synchronization belt mechanism 651 drives stirring stant 842 by plastics spline 845 at this time
Rotation, the synchronous belt of stirring movement synchronous belt mechanism 844 drive stirring stant 842 to carry out up and down along stirring linear guide 843
Movement, thus realize mix part up and down and rotary motion, and then realize driving mix part far from or close to dilution disk 82 in
Reaction cup.
When dilution disk 82 remains static, mixes part 841 and flushing pipe 832 and liquid adding tube 833 puts in dilution disk
In 82, it is stirred, rinses and adds the work that surges to reaction cup in the dilution disk 82 of its corresponding position respectively, and sample at this time
Rocker arm 6 is moved along the direction close to dilution disk 82 in its operating position and is added to sample in the reaction cup equipped with dilution；
Part 841, flushing pipe 832, liquid adding tube 833 and sample rocker arm 6 are mixed towards the direction far from dilution 82 reaction cup of disk
It is mobile until when detaching reaction cup, dilution disk 82 is rotatable around its axis will be loaded with mix sample after part 841 mixes well with
The reaction cup of dilution is moved to 6 lower end of sample rocker arm, and sample rocker arm 6 will dilute the sample on disk 82 and dilution is mixed
In reaction cup on liquid assimilating to reaction tray component 4 equipped with reagent.
Wherein, sample rocker arm 6 adds sample to the position of dilution 82 reaction cup of disk and sample rocker arm 6 and draws dilution 82 sample of disk
The position of this and the mixed liquid of dilution is in same position.
Dilution disk 82 reaction cup rotatable around its axis drawn sample rocker arm 6 after liquid is moved to flushing pipe 832
Lower end, carry out reaction cup flushing.
Agent bin component 3 includes the driving that the agent bin 31 being mounted in rack 1 and driving agent bin 31 are rotated about axis
Part, be provided on agent bin 31 be axially distributed for placing the detection reagent slot 311 of detection reagent and for placing R1 reagent
R1 reagent trough 312, R1 reagent reacted in advance with the sample in reaction tray component 4 so that the detection effect of detection reagent more
Good, wherein R1 reagent trough 312 is located at 311 inside of detection reagent slot, will be used to react with the sample on reaction tray component 4
The detection reagent for carrying out turbidimetric analysis turbidimetry afterwards is placed in detection reagent slot 311, will be used for sample to be reacted on reaction tray component 4
The R1 reagent that this progress cleans in advance is placed in R1 reagent trough 312.
In use, reagent needle on reagent rocker arm 7 is in advance by the empty reaction cup of R1 reagent aspiration to reaction tray component 4,
Puncture needle on sample rocker arm 6 will dilute the sampling after diluting in component 8 to the reaction tray component for being previously implanted R1 reagent
In reaction cup on 4, R1 reagent carries out reacting removal impurity with the impurity in sample at this time, and the reagent needle on reagent rocker arm 7 is again
It will test and reacted in the sample after cleaning in the reaction cup on reagent aspiration to reaction tray component 4.
The prior art generally will test reagent and R1 reagent and is neatly placed on 7 side of reagent rocker arm in the form of distributed rectangular
Or two sides, it is influenced by 7 scope of activities of reagent rocker arm, detection reagent and the type of R1 reagent are limited at this time, and detection reagent can only
There is 3-4 kind, cause the number of entry of detection limited, the present invention is distributed by rotating disc type, is made on agent bin 31 equipped with more different
The detection reagent and R1 reagent of type need to only try corresponding detection when the type of detection reagent and R1 reagent needs to switch
Agent and R1 reagent turn to immediately below reagent rocker arm 7, increase the quantity of detection project.
Reaction tray component 4 includes the reaction turntable 41 and drive response turntable for being mounted in rack 1 and being equipped with reaction cup
41 actuators rotatable around its axis.
Reaction 41 side of turntable is sequentially installed with the reaction that the sample mixed in reaction turntable 41 and reagent are stirred and turns
Disk rabbling mechanism 42 and the reaction turntable that the reaction turntable 41 after turbidimetric analysis turbidimetry is cleaned and dried wash station 43, react turntable
Rabbling mechanism 42 and reaction turntable wash station 43 and are fixedly mounted on 1 upper end of rack, wherein reaction turntable rabbling mechanism 42 and reaction
Turntable washes the two sides that station 43 is located at detection components 5.
Turntable rabbling mechanism 42 is reacted compared with diluting evenly mixing device 84, and difference structure feature is, reaction turntable stirring
Installation is realized instead there are two part 841, reaction turntable rabbling mechanism 42 is mixed by two mixing parts 841 on the mixing frame of mechanism 42
It answers detection reagent and sample reactant or R1 reagent and sample reactant on turntable 41 in adjacent reaction cup to carry out while stirring
It mixes, improves the working efficiency of whole device of the present invention.
It includes the cleaning bracket 431 being arranged in rack 1 that reaction turntable, which washes station 43,；Several groups are fixedly connected on cleaning bracket
On 431 and parallel arrangement flushing pipe 832.
In use, reaction of the reaction turntable rabbling mechanism 42 first to sample and R1 reagent in reaction 41 reaction cup of turntable
Liquid is stirred, and comes into full contact with R1 reagent with sample, and the sample impurity accelerated in reaction 41 reaction cup of turntable removes speed, together
When more thorough, the reaction turntable rabbling mechanism 42 secondly reaction to sample and detection reagent after removal of impurities that removes the impurity of sample
Liquid is stirred, and comes into full contact with detection reagent with the sample after removal of impurities, and the sample reaction speed accelerated in colour disk after removal of impurities is same
When keep reaction more thorough, pass through equipped with the sample thoroughly reacted and the reaction cup of detection reagent reactant and react turntable 41 and turn to
At detection components 5, detection components 5 carry out turbidimetric analysis turbidimetry to the sample and detection reagent reactant that thoroughly react, after turbidimetric analysis turbidimetry,
It reacts turntable 41 to rotate, reaction turntable 41 is provided with sample and turned to the reaction cup of detection reagent reactant and reacts turntable and washes
It stands immediately below 43, the reaction cup that reaction turntable washes the 43 pairs of reactants equipped with sample and detection reagent in station is removed simultaneously to going
Reaction cup after removing is cleaned, and is prepared for next time addition sample.
Detection components 5 can be common turbidity analyser, to reactant in the reaction cup turned at detection components 5 into
Row turbidimetric analysis turbidimetry.
Above-mentioned actuator can be common synchronous belt mechanism or motor, respectively to drive dilution disk 82, agent bin
31 is rotatable around its axis.
The invention also includes reaction turntable rabbling mechanism 42 is arranged in and dilutes the service sink immediately below evenly mixing device 84, make
Used time, reaction turntable rabbling mechanism 42 and dilution evenly mixing device 84 to the liquid in reaction cup will turn over the mixing part after gushing
841 move in service sink, clean to part 841 is mixed, and prevent from mixing the raffinate on part 841 and generate shadow to detection next time
It rings.
In the description of this specification, the description of reference term " one embodiment ", " example ", " specific example " etc. means
Particular features, structures, materials, or characteristics described in conjunction with this embodiment or example are contained at least one implementation of the invention
In example or example.In the present specification, schematic expression of the above terms may not refer to the same embodiment or example.
Moreover, particular features, structures, materials, or characteristics described can be in any one or more of the embodiments or examples to close
Suitable mode combines.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.
Claims (10)
1. specific protein analyzer, comprising:
Rack (1)；
It is arranged on the rack (1), the sample introduction module for conveying sample；
It is arranged on the rack (1), for the transfer component (2) of transfer liquid；
It is arranged on the rack (1), the agent bin component (3) for storing detection reagent；
It is arranged on the rack (1), the reaction tray component (4) for being reacted；And
It is arranged in the rack (1), is located at the detection components (5) of reaction tray component (4) lower end；
It is characterized in that, the specific protein analyzer further includes dilution component (8), the dilution component (8) includes:
It dilutes frame (81)；
It is rotatably connected on dilution disk on dilution frame (81), for storing dilution and mixed diluting liquid and sample
(82), several reaction cups are provided on the dilution disk (82)；
Be arranged it is on dilution frame (81), add liquid component (83) to dilution disk (82) the addition dilution；And
It is arranged on the rack (1), the actuator to drive dilution disk (82) to rotate.
2. specific protein analyzer according to claim 1, which is characterized in that the dilution component (8) further includes setting
It is described dilution disk (82) side dilution evenly mixing device (84), the dilution evenly mixing device (84) include mixing part (841) with
And it is fixedly connected on mixing part (841), the separate or close described reaction cup of driving mixing part (841) mixed
Even frame, it is described mix part (841) moved far from described one end for mixing frame along the direction close to the reaction cup put in it is described anti-
It answers in cup, turn over the liquid in the reaction cup to gush.
3. specific protein analyzer according to claim 2, which is characterized in that the transfer component (2) includes: that sample shakes
Arm (6) and reagent rocker arm (7), the sample rocker arm (6) are used to draw in sample interior to the dilution disk (82) for being loaded with dilution
Or by sample and the mixed liquid assimilating of dilution to the reaction tray component (4), the reagent rocker arm (7) is used for will
Reagent in the agent bin component (3) is drawn to the reaction tray component (4).
4. specific protein analyzer according to claim 3, which is characterized in that the liquid component (83) that adds includes:
It is arranged and adds liquid bracket (831) on dilution frame (81)；
Several groups are fixedly connected on the flushing pipe (832) for adding and on liquid bracket (831) and being arranged in parallel；And
It is fixedly connected on the liquid adding tube (833) added on liquid bracket (831), the axis of the liquid adding tube (833) and the punching
The axis for washing pipe (832) is parallel.
5. specific protein analyzer according to claim 4, which is characterized in that the dilution disk (82) is in static shape
State, the mixing part (841) and the flushing pipe (832) and the liquid adding tube (833) put in the dilution disk (82), point
The other reaction cup to its corresponding position is stirred, rinses and adds the work that surges, and at this time the sample rocker arm (6) in its work
Make position sample is added in the reaction cup equipped with dilution along the direction movement close to dilution disk (82).
6. specific protein analyzer according to claim 5, which is characterized in that the mixing part (841), flushing pipe
(832), liquid adding tube (833) and sample rocker arm (6) are mobile until detaching reaction cup towards the direction far from dilution disk (82)
When, dilution disk (82) sample and dilution rotatable around its axis that will be loaded with after mixing part (841) mixes well
Reaction cup be moved to sample rocker arm (6) lower end.
7. specific protein analyzer according to claim 6, which is characterized in that the dilution disk (82) is rotatable around its axis
The sample rocker arm (6) was drawn to the lower end that the reaction cup after liquid is moved to the flushing pipe (832).
8. specific protein analyzer according to claim 7, which is characterized in that the sample rocker arm (6) is by the dilution
The reaction cup of reagent is housed on the sample and the mixed liquid assimilating of dilution to the reaction tray component (4) on disk (82)
It is interior.
9. specific protein analyzer according to claim 3, which is characterized in that sample rocker arm (6) the addition sample is extremely
The position and the sample rocker arm (6) for diluting disk (82) draw sample and the position of the mixed liquid of dilution is in same position
It sets.
10. specific protein analyzer according to claim 4, which is characterized in that the flushing pipe (832) includes inlet tube
And liquid suction pipe, the liquid suction pipe is close to one end of dilution disk (82) lower than the inlet tube close to the dilution disk (82)
One end.
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| CN110456088B (en) | 2023-05-09 |
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