CN110448687A - A kind of whitening lozenge containing SOD component - Google Patents
A kind of whitening lozenge containing SOD component Download PDFInfo
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- CN110448687A CN110448687A CN201910898242.XA CN201910898242A CN110448687A CN 110448687 A CN110448687 A CN 110448687A CN 201910898242 A CN201910898242 A CN 201910898242A CN 110448687 A CN110448687 A CN 110448687A
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- whitening
- sod
- melanin
- lozenge containing
- component according
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- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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Abstract
The present invention provides a kind of whitening lozenge containing SOD component, is made of the raw material of following parts by weight: SOD 0.5-1%, resveratrol 5-10%, niacinamide 5-10%, vitamin C 5-10%, starch slurry 10-12%, lubricant 1-2%, microcrystalline cellulose cellulose content 30-40%, corrigent 20-32%.Free radical is removed by addition SOD, melanin is reduced and is formed；Mechanism of resveratrol inhibiting tyrosinase activity is added, melanin is reduced and is formed；Niacinamide is added to inhibit melanin granule to horn cell transmitting, accelerate skin renewal speed；Add vitamin C reduction melanin intermediates and melanin polymer, number of ways skin whitening, significant effect, and component safety.Dissolution time can not only guarantee soak time of the antioxidant by mucous membrane of mouth between 18.53-22.60min, but will not the time too long, it is inconvenient to use.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of whitening lozenge for adding SOD component.
Background technique
As the saying goes: " a white screening three is ugly ", current mainstream is aesthetic or pursues pale skin.The variation of skin color is
One complicated dynamic process, is influenced by many factors, such as pigment, epidermis and thickness of corium in skin etc..Whitening
Method have very much, such as:
(1) B16 cell is prevented
Tyrosinase, dopachrome interconvertible enzyme, 5,6- dihydroindole -2- carboxylic oxidase are main in melanin forming process
Biological enzyme, wherein tyrosinase is the rate-limiting enzyme of the process, and tyrosinase major catalytic monohydric phenol hydroxylating generates dihydroxy
Compound and catechol oxidation generate adjacent benzene diquinone, and these two types reaction has oxygen radical participation, and scavenging activated oxygen can also
To destroy tyrosinase activity.Analog of the resveratrol as DOPA, the active site with substrate competitive desmoenzyme are reduced
Melanin generates.
(2) melanin is prevented to transmit
Azelaic acid, niacinamide (VB3) etc. can inhibit melanin granule from melanocyte to keratoprotein cell shift, therefore
With white-skinned face function.
(3) accelerate melanin metabolism
Oxidation state melanin granule can be reduced to the reduction-state melanin of white by vitamin e, vitamin c and its derivative
Grain, to achieve the effect that whitening.
(4) anti-oxidant whitening
After being irradiated with ultraviolet radiation, active oxygen can be generated, causes the destruction of immobilized artificial membrane, so as to cause the destruction of skin histology, into
And the problems such as generating erythema, pigmentation, carry out pressure to skin tape, more melanin is caused to generate.Superoxide dismutase
(Superoxide dismutase, SOD) is the important composition member of Antioxidant Enzymes in biosystem, is widely distributed in micro-
In biology, plant and animal body.It can efficiently remove intracorporal free radical.Internal extra free radical can cause cellular damage with
And pigmentation, human senility are the consequences due to free radical accumulation and removing obstacles.Supplemented with exogenous SOD can with skin whitening,
It delays senescence.
Patent relevant to research contents of the present invention is as follows:
CN110192994A discloses a kind of white tomato whitening piece and preparation method thereof, and the white tomato whitening piece is mainly by white tomato
Freeze-dried powder 200mg-900mg, acerola concentrate extract 10mg-280mg, kudzu-vine root powder 1mg-120mg, grape seed extract 1mg-
200mg and Fructus piperis nigrum extract 1mg-15mg are made by way of tabletting after mixed in equal amounts, in order to which improvement effect can also be
Increase L-cysteine 90mg-500mg or yeast extract 90mg-500mg and seabuckthorn fruit powder 1mg-180mg in formula.Change
Lozenge passes through anti-oxidant approach whitening.
CN103655446B provides a kind of product and preparation method thereof with skin beauty health-care function；The system
Each component in product are as follows: lotus seeds, lily, the root of straight ladybell, Chinese yam, hawthorn, fructus lycii, tremella each water extract be 1-3 parts, radix polygonati officinalis water extract 1-
4 parts, it is 2-4 parts that the root of Dahurain angelica, Amomum cardamomum water, which mention volatile oil respectively, 3-5 parts of Flos Rosae Rugosae extract, 0.05-0.1 parts of water soluble pearl powder,
0.01-0.05 parts of vitamin C, 0.001-0.005 parts of vitamin E, 50-90 parts of auxiliary material；The form of the product is granule
Or buccal tablet.Combination is optimized with the homologous article of tender skin, the medicine of white-skinned face function, food, then with vitamin C and vitamin
E prevents skin oxidative as antioxidant.Change lozenge and two approach whitenings are metabolized by anti-oxidant and reinforcement melanin.
CN105267435A discloses a kind of three eggplant piece of compound and the preparation method and application thereof of speckle removing, antisenescence.It is described multiple
Three eggplant pieces of side are mainly made by the following raw material by weight: 10-20 parts of eggplant powder, 10-20 parts of tomato meal, pyracantha fortuneana fruit powder
10-20 parts, 10-20 parts of red date powder, 0.5-1 parts of medlar powder, 0.5-1 parts of codonopsis pilosula powder and 0.5-1 parts of peach kernel powder.Of the invention answers
Solanaceae Triratna in conjunction with the advantage of pyracantha fortuneana fruit, jujube, Radix Codonopsis and peach kernel, is formed characteristic by three eggplant pieces of side, has reduction skin black
Pigment generates and deposition, improvement skin blood circulation, removing free radical, anti-oxidant, adjustment endocrine, relax bowel and defecation and enhancing are exempted from
The effects of epidemic disease, play significant nti-freckle and improve the colour of skin and other effects, it can be used for preventing and treating the pigmentations such as freckle, chloasma, sunburn
Skin blackening caused by skin disease, it may also be used for anti-aging etc., effect is obvious, and without any side effects.Change lozenge by resisting
Oxidative pathway whitening.
CN107865423A discloses a kind of SOD oral solution of anti-enteron aisle oxidation, is mainly main former with marine low temperature SOD
Material, addition safflower extract, Fructus lycii P.E, Rhizoma Chuanxiong extract, jujube concentrate stir evenly vacuum packaging to get,
Specific proportion are as follows: the anti-enteron aisle of the present invention aoxidizes SOD oral solution, directly takes in postprandial half an hour.The features of the present invention exists
In: marine low temperature SOD:2 ~ 3 part, crude extract from carthamus tinctorius L. with water: 1 ~ 2 part, fructus lycii water extract: 1 ~ 2 part, Rhizoma Chuanxiong water extract: 1 ~ 2
Part, 3 ~ 4 parts of jujube concentrate.Change lozenge and passes through anti-oxidant approach whitening.
CN107541502A, which is disclosed, a kind of prepares SOD multienzyme alkalinity oral solution with rich in the cereal crops of SOD multienzyme
Pulvis is mixed with water, is mixed this method comprises: pulvis is made after crushing in the cereal crops that 1) will be enriched in SOD multienzyme by method
Close liquid A；2) amylase and activator are added into mixed liquor A, 25~35min is digested at 60 DEG C~85 DEG C, obtains mixed liquor
B；The pH value for adjusting mixed liquid B is 8~12, and alkali cellulose enzyme and protease is added, 4h~5h is digested at 40~50 DEG C, is obtained
To mixed liquor C；Beer complex enzyme, distiller's yeast are added into mixed liquor C, carries out anaerobic fermentation under conditions of 30~40 DEG C, obtains
Fermentation liquid；Alkaline pectase is added into fermentation liquid, is stirred to react at 35~50 DEG C, filtering to get.This method maintains grain
The activity of the primitive environment of the multienzyme such as SOD in food crop, each function factor is high, and healthcare function is good.Change lozenge and passes through anti-oxidant way
Diameter whitening.
CN108835630A discloses a kind of oral solution and preparation method thereof with high SOD enzyme activity, including will be edible
Plant material is squeezed the juice, and is then centrifuged (1000-4000rpm, 0-30min) removal bulky grain, uses twice ultrafiltration membrane
It is separated and (is separated for the first time using tubular membrane, aperture 60-120kD；Second is separated into rolled film, aperture 8-30kD)；It
Afterwards, ultra high pressure treatment, pressure 200-600MPa, time 1-20min are carried out then.It is had activated after the method for the present invention is handled
SOD enzyme, enzyme activity have been increased to 10000U/ml or more, efficiently solve the problems, such as that SOD enzyme activity is low in product.Through this hair
Product made from bright method is relatively beneficial to human health.Change lozenge and passes through anti-oxidant approach whitening.
CN1072090 discloses a kind of preparation method of SOD oral liquid, is by natural crude drugs Rosa roxburghii Tratt through adding
Work separation and Extraction, protection processing, it is a variety of effectively to obtain erythrocuprein SOD, cat catalase, selenium, VC, VE, tannin etc.
Ingredient cooperates Radix Codonopsis, Radix Astragali, fructus lycii, longan, jujube percolate, is a kind of new oral liquid formulations containing SOD.Change lozenge
Pass through anti-oxidant approach whitening.
Summary of the invention
It is an object of the invention to for only by one or two kinds of approach come whitening, effect is not prominent enough currently on the market
Defect, provide a kind of from preventing melanin production, prevent melanin from transmitting, accelerate melanin metabolism, anti-oxidant multipath beauty
White lozenge.
Above-mentioned purpose to realize the present invention, using following technical scheme:
It is made of raw material from the following weight: SOD 0.5-1%, resveratrol 5-10%, niacinamide 5-10%, vitamin C 5-
10%, starch slurry 10-12%, lubricant 1-2%, microcrystalline cellulose cellulose content 30-40%, corrigent 20-32%.Corrigent be mannitol,
One of sorbierite, glucose, lactose.Lubricant is one of magnesium stearate, talcum powder, polyethylene glycol-4000.
Part material purchase information of the present invention is as follows:
SOD is purchased from the long-range development in science and technology Co., Ltd in Wuhan；
Resveratrol is purchased from Suzhou Fu Lu Biotechnology Co., Ltd；
Niacinamide is purchased from Wuhan Chu Fengyuan Science and Technology Ltd.；
Vitamin C is purchased from one hundred Xinda raw-food material Co., Ltd of Wuhan.
Preparation process the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, corrigent sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, and more easy mold release adds lubricant, are uniformly mixed, send
Enter tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Specifically, SOD can remove the ultra-oxygen anion free radical and hydroxyl radical free radical of organism metabolism generation, together
When, it also can be used as the substrate for induction enzyme of superoxide anion, protect body cell from the damage of aerobic metabolism object.SOD is as one
The good free radical scavenger of kind is improving immunity of organisms, and delay senescence etc. has fine effect.
Resveratrol is a kind of phytoalexin of polyatomic phenol, is plant in external source sexual stimulus such as ultraviolet light, machine
It generates, is widely distributed in root, stem, leaf and the fruit of plant under the action of tool damage or fungal infection, had anti-well
Oxidisability and tyrosinase inhibitory action, resveratrol can reach arbutin and ethyl Vc more highly concentrated under low concentration
Whitening effect under the conditions of degree.Williams etc. grinds the safety of the resveratrol of high-purity by animal experiment
Study carefully.Studies have shown that resveratrol to skin and eyes without irritation, and pass through micronucleus assay in vivo, it was demonstrated that resveratrol
There is no genetoxic.Found by 90 d subchronic toxicity tests, in maximum 700 mg/(kgd of study dosage) when white black false hellebore
Alcohol does not cause any adverse effect to body and does not have genotoxicity, so that preliminary proof resveratrol is nontoxic peace
Complete.
Niacinamide also known as niacinamide (NAA), vitamin B3, nicotinic acid, being widely used in clinic prevents rough skin
The treatment of disease, glossitis, stomatitis, dermatitis.It can inhibit the formation of melanin granule, it can also be inhibited to epidermal cell uplink
To cuticula, effectively melanin is inhibited to transmit to horn cell, after thering is part melanin inevitably to reach superficial skin,
Niacinamide again can be by with accelerating Skin Cell renewal speed to promote melanocyte to fall off.
Vitamin C is a kind of water-soluble powerful antioxidant, can combine with oxygen radical reduction reaction occurs in vivo,
Mitigate esters peroxidization, reduce the generation of lipid peroxide, protects SOD isoreactivity, moreover it is possible to aoxidize with preventing melanin
Process inhibits melanin to be formed, poly- by influencing multiple links such as reduction melanin intermediates and melanin that melanin is formed
Object is closed, DOPA is reduced and DOPA quinones substance is formed, inhibit the generation of melanin.
Compared with prior art, the invention has the benefit that removing free radical by addition SOD, melanin shape is reduced
At；Mechanism of resveratrol inhibiting tyrosinase activity is added, melanin is reduced and is formed；Adding niacinamide inhibits melanin granule to cutin
Skin renewal speed is accelerated in cell transmitting；Vitamin C reduction melanin intermediates and melanin polymer are added, DOPA is reduced
It is formed with DOPA quinones substance, number of ways skin whitening, significant effect, and component safety.Dissolution time is in 18.53-
Between 22.60min, can not only guarantee soak time of the antioxidant by mucous membrane of mouth, but will not the time too long, use not side
Just.
Detailed description of the invention
The variation of Fig. 1 skin brightness
The variation of Fig. 2 melanin.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the present invention is not limited only to this.
Embodiment one
SOD 0.5%, resveratrol 5%, niacinamide 5%, vitamin C 5%, starch slurry 12%, magnesium stearate 2%, microcrystalline cellulose contain
Measure 40%, mannitol 30.5%.The present embodiment is dissolved as 15.30min.
Preparation the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, mannitol sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, and more easy mold release adds magnesium stearate, are uniformly mixed,
It is sent into tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Embodiment two
It is formulated SOD 0.6%, resveratrol 6%, niacinamide 6%, vitamin C 6%, starch slurry 11%, talcum powder 1.4%, microcrystalline cellulose
Cellulose content 37%, sorbierite 32%.The dissolution time of the present embodiment is 19.53min.
Preparation the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, sorbierite sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, and more easy mold release adds talcum powder, are uniformly mixed, send
Enter tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Embodiment three
Formula: SOD 0.7%, resveratrol 7%, niacinamide 7%, vitamin C 7%, starch slurry 10%, polyethylene glycol-4000 1%,
Microcrystalline cellulose cellulose content 38%, glucose 29.3%.The dissolution time of the present embodiment is 17.25min.
Preparation the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, glucose sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, more easy mold release, add polyethylene glycol-4000, mixing
Uniformly, it is sent into tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Example IV
Formula: SOD 0.8%, resveratrol 8%, niacinamide 8%, vitamin C 8%, starch slurry 12%, magnesium stearate 1%, crystallite are fine
Tie up cellulose content 32%, lactose 30.2%.The dissolution time of the present embodiment is 20.30min.
Preparation the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, lactose sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, and more easy mold release adds magnesium stearate, are uniformly mixed,
It is sent into tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Embodiment five
Formula: SOD 0.9%, resveratrol 9%, niacinamide 9%, vitamin C 9%, starch slurry 12%, talcum powder 2%, microcrystalline cellulose
Cellulose content 30%, sorbierite 28.1%.The dissolution time of the present embodiment is 18.93min.
Preparation the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, sorbierite sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, and more easy mold release adds talcum powder, are uniformly mixed, send
Enter tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Embodiment six
Formula: SOD 1%, veratryl alcohol 10%, niacinamide 10%, vitamin C 10%, starch slurry 12%, polyethylene glycol-4000 2%, micro-
Crystalline cellulose content 35%, mannitol 20%.
Preparation the following steps are included:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, mannitol sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, more easy mold release, add polyethylene glycol-4000, mixing
Uniformly, it is sent into tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
Whitening spot-removing experiment
Laboratory apparatus: Minolta company, Minolta Chromameter CM-700d(Japan), Mexameter MX18 skin
Melanin and ferroheme tester (German Courage+Khazak company).
Experimental method:
1. recruiting trial volunteer 100.
2. subject takes embodiment 61 daily.
3. before taking product, the 4th week, the 8th week, the 12nd week respectively use apparatus measures subject skin condition.Skin
Brightness measures skin brightness L value using Minolta Chromameter (CM-700d), is measured in parallel 3 times, is averaged every time,
The L value of all trial volunteers is averaged again.Dermal melanin value is measured with Mexameter MX18, is measured in parallel every time
It 3 times, is averaged, calculates melanin down ratio, all volunteer's melanin down ratios are averaged again.
4. experimental result is as shown in Figure 1, 2.
It can be seen from experimental result this product can bright color, reduce melanin whitening effect.
Claims (9)
1. a kind of whitening lozenge containing SOD component, which is characterized in that be made of the components of following parts: SOD 0.5-1%,
Resveratrol 5-10%, niacinamide 5-10%, vitamin C 5-10%, starch slurry 10-12%, lubricant 1-2%, microcrystalline cellulose contain
Measure 30-40%, corrigent 20-32%.
2. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that SOD is to mention from plant
It takes, the enzyme activity of SOD is 100000U/g.
3. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that resveratrol is from Portugal
It is extracted in grape skin, purity >=99%.
4. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that niacinamide purity >=
99%。
5. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that vitamin C >=99%.
6. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that lubricant is stearic acid
One of magnesium, talcum powder, polyethylene glycol-4000.
7. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that corrigent be mannitol,
One of sorbierite, glucose, lactose.
8. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that preparation process include with
Lower step:
Step 1: it weighs after SOD, resveratrol, niacinamide, vitamin C, microcrystalline cellulose, corrigent sieve with 100 mesh sieve and mixes；
Step 2: granulation is added starch slurry and softwood is made, is granulated by 20 meshes；
Step 3: it is dry, 30 DEG C of drying temperature；
Step 4: whole grain and tabletting keep lozenge surface smooth after whole grain, and more easy mold release adds lubricant, are uniformly mixed, send
Enter tabletting machine；
Step 4: tablet is irradiated 15min under ultraviolet light, carries out blister package by sterilizing and packaging.
9. a kind of whitening lozenge containing SOD component according to claim 1, which is characterized in that in mouth when dissolving
Between be 15.30-20.30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910898242.XA CN110448687A (en) | 2019-09-23 | 2019-09-23 | A kind of whitening lozenge containing SOD component |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910898242.XA CN110448687A (en) | 2019-09-23 | 2019-09-23 | A kind of whitening lozenge containing SOD component |
Publications (1)
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| CN110448687A true CN110448687A (en) | 2019-11-15 |
Family
ID=68492514
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910898242.XA Withdrawn CN110448687A (en) | 2019-09-23 | 2019-09-23 | A kind of whitening lozenge containing SOD component |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632992A (en) * | 2021-09-07 | 2021-11-12 | 何泽剑 | Skin beautifying food formula and preparation method of buccal tablets thereof |
| CN116616448A (en) * | 2023-05-08 | 2023-08-22 | 石药集团中诺药业（泰州）有限公司 | Vitamin C tablet containing organic selenium and production process thereof |
-
2019
- 2019-09-23 CN CN201910898242.XA patent/CN110448687A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632992A (en) * | 2021-09-07 | 2021-11-12 | 何泽剑 | Skin beautifying food formula and preparation method of buccal tablets thereof |
| CN116616448A (en) * | 2023-05-08 | 2023-08-22 | 石药集团中诺药业（泰州）有限公司 | Vitamin C tablet containing organic selenium and production process thereof |
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Effective date of registration: 20210420 Address after: 417010 group 4, guanjiawei Committee, Changqing office, Louxing District, Loudi City, Hunan Province Applicant after: Liu Jianhui Address before: 510070 no.76-2, yard 81, Xianlie Middle Road, Yuexiu District, Guangzhou City, Guangdong Province 122c Applicant before: Guangzhou Yihui Biotechnology Co.,Ltd. |
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Application publication date: 20191115 |