CN110441276A - Capillary embedded structure and multi-channel detection mechanism - Google Patents
Capillary embedded structure and multi-channel detection mechanism Download PDFInfo
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- CN110441276A CN110441276A CN201910745556.6A CN201910745556A CN110441276A CN 110441276 A CN110441276 A CN 110441276A CN 201910745556 A CN201910745556 A CN 201910745556A CN 110441276 A CN110441276 A CN 110441276A
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- Prior art keywords
- capillary
- frame
- tube fixing
- fixing structure
- buried
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
Abstract
The invention discloses a kind of capillary embedded structure and multi-channel detection mechanisms, the capillary embedded structure buries frame in including, frame is buried in described equipped with capillary-tube fixing structure, the capillary-tube fixing structure is face contact for capillary to be linearly fixed, between the capillary and capillary-tube fixing structure or line contacts or point contact；The multi-channel detection mechanism includes capillary embedded structure, it further include several testing agencies, several sense channels are equipped on frame in interior bury, several sense channels are along the interior length direction distribution for burying frame, the testing agency is mounted on the sense channel, the testing agency matches with the capillary, for receiving detection signal.The present invention is by the capillary pipe structure design of built-in type, it can be achieved that the detection of more luminous points, enhances the function of detection device.
Description
Technical field
The present invention relates to a kind of testing agencies for detection of nucleic acids.
Background technique
The length for the capillary being presently used on genetic fragment analysis and detecting instrument designs very short, can only in fluid path
One detection luminous point is set, and multiple test points cannot be set simultaneously on the length direction of capillary, because capillary is superfine
It is small, as the deformation that its length increases capillary itself also can be more serious, light path misalignment can be made, thus cannot be to fluorescence
Signal is accurately captured, and the detection of nucleic acids to sample to be tested in capillary cannot be achieved.Therefore, existing detection of nucleic acids instrument
Device is low to the utilization rate of capillary, and detection efficiency is low.
Summary of the invention
Of the existing technology in order to solve the problems, such as, the present invention provides a kind of capillary embedded structure and multi-channel detections
Tiny capillary can be maintained on straight line, avoid deformation by mechanism, so that the purpose of multi-channel detection can be realized.
To achieve the above object, the technical solution adopted by the present invention is that a kind of capillary embedded structure, including interior frame, institute are buried
Frame is buried in stating equipped with capillary-tube fixing structure, the capillary-tube fixing structure is for linearly being consolidated capillary
It is fixed.
In one embodiment of the invention, the interior frame that buries includes burying to bury frame in frame and second in first, is buried in described first
Frame is connect with burying frame in second and be detachably fixed, and the capillary-tube fixing structure includes the first capillary-tube fixing structure and second mao
Tubule fixed structure, the first capillary-tube fixing structure setting are buried on frame in described first, and second capillary is fixed
Structure, which is located in described second, buries on frame, and first capillary-tube fixing structure is matched with the second capillary-tube fixing structure, institute
Capillary is stated between first capillary-tube fixing structure and the second capillary-tube fixing structure.The capillary and first mao
It is face contact or line contact or point contact between tubule fixed structure and the second capillary-tube fixing structure.
In one embodiment of the invention, first capillary-tube fixing structure is to be provided with buried on frame in described first
One holding tank, second capillary-tube fixing structure are to be provided with the second holding tank buried on frame in described second, described first
Capillary accommodating chamber is formed after holding tank and the second holding tank pairing, the capillary is fixed in the capillary accommodating chamber.
In one embodiment of the invention, first holding tank and the second holding tank are succeeding vat or Disjunct distribution
Slot.
In one embodiment of the invention, the cross sectional shape of first holding tank and the second holding tank can be V-type or U
Type is arc-shaped.
In one embodiment of the invention, is buried in described first and bury frame in frame and second and be fixedly connected by fastener.
A kind of multi-channel detection mechanism, including capillary embedded structure further include several testing agencies, interior are buried described
Frame is equipped with several sense channels, and several sense channels are along the interior length direction distribution for burying frame, the testing agency
It is mounted on the sense channel, the testing agency matches with the capillary, for receiving detection signal
In one embodiment of the invention, the testing agency includes detector, and the detector spy extends to the capillary
Outer wall at, the detector is vertical with the capillary.
In one embodiment of the invention, the sense channel is to be provided with the mounting groove buried on frame in described.
It further include laser body in one embodiment of the invention.
The technical program has the advantages that
The capillary linear state that capillary-tube fixing structure by burying frame inside enables is buried on frame in being fixed on, thus
The longer capillary of length can be applied on detection device, without being limited by the flexible deformation of capillary；It can pass through
The mode that point is fixed, line is fixed or face is fixed is buried to capillary progress, and the capillary after fixing, which is located in described, buries frame
Inside, i.e., penetrate, the other end is drawn from interior one end for burying frame, capillary pass straight through by bury in first buried in frame and second it is rack-mounted
With burying frame in formation.Further settable multiple sense channels detect the sample in capillary, improve detection effect
Rate makes the with better function of detection device.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the capillary embedded structure of the embodiment of the present invention 1；
Fig. 2 is the enlarged drawing in Fig. 1 at A；
Fig. 3 be first in the embodiment of the present invention 1 in bury the structural schematic diagram of frame；
Fig. 4 is the partial enlarged view of Fig. 3；
Fig. 5 be second in the embodiment of the present invention 1 in bury the structural schematic diagram of frame；
Fig. 6 is the partial enlarged view of Fig. 5；
Fig. 7 is the structural schematic diagram that capillary is fixed in the embodiment of the present invention 1；
Fig. 8 is the partial structure diagram of the embodiment of the present invention 2；
Fig. 9 is the side view of Fig. 8；
Figure 10 is the structural schematic diagram of the embodiment of the present invention 2；
Description of symbols: inside burying frame 100, and frame 11 is buried in first, and frame 22, the first holding tank 110, the second folder are buried in second
Hold slot 220, capillary 111, capillary accommodating chamber 1, sense channel 3, testing agency 4, detector 41.
Specific embodiment
Below with reference to examples and drawings 1 to 10, the invention will be further described.
Embodiment 1
A kind of capillary embedded structure, as shown in figures 1 to 6, including it is interior bury frame 100, it is described in bury frame 100 include in first
It buries and buries frame 22 in frame 11 and second, burying in described first and burying frame 22 in frame 11 and second is the block structure for having length, width and height.
It buries to bury frame 22 in frame 11 and second and be detachably fixed by fixing piece in described first and be assembled together, used fixing piece can
To be screw or pin.It is buried in described first and is provided with the first capillary-tube fixing structure on frame 11, buried in described second
The second capillary-tube fixing structure is provided on frame, second capillary-tube fixing structure of the first capillary-tube fixing structure will be for that will grow
Longer capillary is spent linearly to be fixed.First capillary-tube fixing structure and the second capillary-tube fixing structure can
Be respectively with first in bury the structure burying frame in frame and second and being fixedly connected with, be also possible to directly be provided with described first
Inside bury the slot structure buried on frame in frame and second.
In the present embodiment, first capillary-tube fixing structure is to be provided with the first clamping buried on frame 11 in described first
Slot 110, as shown in Figure 3；Second capillary-tube fixing structure is to be provided with the second holding tank buried on frame 22 in described second
220, as shown in Figure 5.It is buried in described first after burying the assembly of both framves 22 in frame 11 and second, first holding tank 110 and the
Two holding tanks 220, which are combined to form, is located at the interior capillary accommodating chamber buried inside frame 100, as shown in Figure 2.The capillary, which accommodates, to be used
It is fixed in capillary, the capillary 111 that length is greater than existing capillary pipe length is placed on the capillary and is accommodated, is led to
The side wall that the capillary accommodates is crossed to limit capillary, as shown in fig. 7, with ensure capillary 111 linearly into
Row is fixed, and is guaranteed the straightness of capillary 111, is easy to use multiple testing agencies in multiple test points to the sample in capillary
It is detected.
First holding tank 110 and the second holding tank 220 are the slot of succeeding vat or Disjunct distribution, the capillary
It can be face contact between 111 and the first capillary-tube fixing structure and the second capillary-tube fixing structure or line contacts or point
Contact.Slot in the present embodiment is continuously distributed along capillary pipe length direction, can also be several dotted in other embodiments
Distribution, to form several fixed points, capillary 111 and the first capillary-tube fixing structure and the second capillary-tube fixing structure at this time
Between be exactly point contact fixed form.The cross sectional shape of first holding tank 110 and the second holding tank 220 can be V
Type is U-shaped or arc-shaped.In the present embodiment, the cross sectional shape of first holding tank 110 and the second holding tank 220 is
V-type, as shown in Fig. 4,6, because the periphery of the capillary 111 is circle, the capillary 111 is located at two mouth-to-mouth V-types
Slot is formed by capillary accommodating chamber 1, at this time capillary 111 and the first capillary-tube fixing structure and the second capillary fixed knot
It is exactly the fixed form of line contact between structure.
In other embodiments, the cross sectional shape of first holding tank 110 and the second holding tank 220 can also be semicircle
Shape, as soon as two semicircles will form a circular cavity to being combined, the peripheral wall of the capillary accommodating chamber 1 is by the capillary
111 are wrapped in the capillary accommodating chamber 1, and capillary 111 and the first capillary-tube fixing structure and the second capillary are solid at this time
Determine be exactly between structure face contact fixed form.
Embodiment 2
A kind of multi-channel detection mechanism, as seen in figs. 8-10, including the capillary embedded structure in embodiment 1, described
Frame 100 is inside buried equipped with several sense channels 3, several sense channels 3 are along the interior length direction for burying frame i.e. capillary
111 length direction distribution, several testing agencies 4 are mounted on the sense channel 3.The sense channel 3 is to be provided with
The mounting groove on frame 100 is buried in described, is connected with V-groove, so that the detector 41 of the testing agency 4 can be via institute
Sense channel 3 is stated to visit at the outer wall for extending to the capillary 111, meanwhile, the detector 41 is vertical with the capillary 111,
To guarantee preferably to receive fluorescence signal.
The multi-channel detection mechanism further includes laser body, and a laser transmitter is provided at each test point
Structure, the intercalative dye in light source activation sample in laser body generate fluorescence signal, then capture this by detector
Real-time fluorescent signals are further converted to real-time tele-communication number and read in real time by software by fluorescence signal, obtain the complete core of sample
Acid fragment is distributed peak figure.
For the present invention is compared to existing detection device, the present invention is designed by the capillary pipe structure of built-in type, by capillary
Pipe 111 bury inside the inside of frame 100 linearly on be fixed, ensure that 111 not bending deformation of capillary, thus to be real
Now more luminous points dock place mats premise；Further by the way that more sense channels are arranged, realize to a sample in multiple test points
It is detected, detection sensitivity is high, resolution ratio is strong, flux is big, analyzes speed faster.
Above-mentioned specific embodiment is used only to illustrate the present invention, rather than limits the invention, in structure of the present invention
Think and claims are interior to any change and replacement not made the creative labor of the invention made, falls within this
The protection scope of patent of invention.
Claims (10)
1. a kind of capillary embedded structure, which is characterized in that bury frame including interior, the interior frame that buries is equipped with capillary fixed knot
Structure, the capillary-tube fixing structure is for capillary to be linearly fixed.
2. capillary embedded structure according to claim 1, which is characterized in that it is described in bury frame include first in bury frame and
Frame is buried in second, frame is buried in described first and is connect with burying frame in second and be detachably fixed, and the capillary-tube fixing structure includes the
One capillary-tube fixing structure and the second capillary-tube fixing structure, the first capillary-tube fixing structure setting are buried in described first
On frame, second capillary-tube fixing structure, which is located in described second, to be buried on frame, first capillary-tube fixing structure and second
Capillary-tube fixing structure matches, and the capillary is located at first capillary-tube fixing structure and the second capillary-tube fixing structure
Between.
3. capillary embedded structure according to claim 2, which is characterized in that first capillary-tube fixing structure is to open
It is located at the first holding tank buried on frame in described first, second capillary-tube fixing structure is to be provided in described second to bury frame
On the second holding tank, capillary accommodating chamber is formed after first holding tank and the second holding tank pairing, the capillary is solid
It is scheduled in the capillary accommodating chamber.
4. capillary embedded structure according to claim 3, which is characterized in that first holding tank and the second holding tank
For succeeding vat or the slot of Disjunct distribution.
5. capillary embedded structure according to claim 1-4, which is characterized in that first holding tank and
The cross sectional shape of two holding tanks can be V-type or U-shaped or arc-shaped.
6. capillary embedded structure according to claim 5, which is characterized in that buried in described first in frame and second and bury frame
It is fixedly connected by fastener.
7. a kind of multi-channel detection mechanism, which is characterized in that including burying knot in capillary described in any one of claims 1-6
Structure further includes several testing agencies, several sense channels is equipped on frame in interior bury, several sense channels are described in
The length direction distribution of frame is inside buried, the testing agency is mounted on the sense channel, the testing agency and the capillary
Pipe matches, for receiving detection signal.
8. multi-channel detection mechanism according to claim 7, which is characterized in that the testing agency includes detector, institute
It states detector to visit at the outer wall for extending to the capillary, the detector is vertical with the capillary.
9. multi-channel detection mechanism according to claim 7, which is characterized in that the sense channel is to be provided in described
Bury the mounting groove on frame.
10. multi-channel detection mechanism according to any one of claims 7 to 9, which is characterized in that further include laser transmitter
Structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910745556.6A CN110441276A (en) | 2019-08-13 | 2019-08-13 | Capillary embedded structure and multi-channel detection mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910745556.6A CN110441276A (en) | 2019-08-13 | 2019-08-13 | Capillary embedded structure and multi-channel detection mechanism |
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| CN110441276A true CN110441276A (en) | 2019-11-12 |
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| CN201910745556.6A Pending CN110441276A (en) | 2019-08-13 | 2019-08-13 | Capillary embedded structure and multi-channel detection mechanism |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105424633A (en) * | 2016-01-19 | 2016-03-23 | 东北农业大学 | Capillary-type optical path-adjustable spectrophotometer absorption cell suitable for veterinary molecule detection |
| CN107020569A (en) * | 2017-05-19 | 2017-08-08 | 太原理工大学 | A kind of stainless steel capillary polishes special fixture |
| CN104677876B (en) * | 2015-03-27 | 2017-11-24 | 临海市鸥巡电子科技有限公司 | A kind of gaseous material detection device based on transparent capillary structure and fluorescence |
-
2019
- 2019-08-13 CN CN201910745556.6A patent/CN110441276A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104677876B (en) * | 2015-03-27 | 2017-11-24 | 临海市鸥巡电子科技有限公司 | A kind of gaseous material detection device based on transparent capillary structure and fluorescence |
| CN105424633A (en) * | 2016-01-19 | 2016-03-23 | 东北农业大学 | Capillary-type optical path-adjustable spectrophotometer absorption cell suitable for veterinary molecule detection |
| CN107020569A (en) * | 2017-05-19 | 2017-08-08 | 太原理工大学 | A kind of stainless steel capillary polishes special fixture |
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Effective date of registration: 20221220 Address after: 518000 12th floor, building 1, Baiwang R & D building, 5158 xilishahe West Road, Nanshan District, Shenzhen City, Guangdong Province Applicant after: Shenzhen maiketian Biomedical Technology Co.,Ltd. Address before: Room 101, 1st floor, building 2, 2636 yuhangtang Road, Cangqian street, Yuhang District, Hangzhou City, Zhejiang Province Applicant before: Hangzhou Xinghaohui Biotechnology Co.,Ltd. |