CN110437339B - 一种以白介素15为活性成分的融合蛋白型药物前体 - Google Patents

一种以白介素15为活性成分的融合蛋白型药物前体 Download PDF

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CN110437339B
CN110437339B CN201810420739.6A CN201810420739A CN110437339B CN 110437339 B CN110437339 B CN 110437339B CN 201810420739 A CN201810420739 A CN 201810420739A CN 110437339 B CN110437339 B CN 110437339B
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CN110437339A (zh
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傅阳心
彭华
郭静雅
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Yiming Kangda Beijing Biopharmaceutical Co ltd
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Immune Targeting Inc
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Priority to CN201810420739.6A priority Critical patent/CN110437339B/zh
Application filed by Immune Targeting Inc filed Critical Immune Targeting Inc
Priority to CN201980045118.7A priority patent/CN112585161B/zh
Priority to CN202510533077.3A priority patent/CN120463817A/zh
Priority to AU2019262590A priority patent/AU2019262590B2/en
Priority to CN202510533066.5A priority patent/CN120463816A/zh
Priority to JP2020560958A priority patent/JP7684047B2/ja
Priority to KR1020207034734A priority patent/KR20210028150A/ko
Priority to PCT/US2019/030594 priority patent/WO2019213517A1/en
Priority to CA3099039A priority patent/CA3099039A1/en
Priority to EP19796151.9A priority patent/EP3788068A4/en
Priority to US17/051,160 priority patent/US12441781B2/en
Publication of CN110437339A publication Critical patent/CN110437339A/zh
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Priority to JP2025082038A priority patent/JP2025124695A/ja
Priority to US19/330,743 priority patent/US20260070957A1/en
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201810420739.6A 2018-05-04 2018-05-04 一种以白介素15为活性成分的融合蛋白型药物前体 Active CN110437339B (zh)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CN201810420739.6A CN110437339B (zh) 2018-05-04 2018-05-04 一种以白介素15为活性成分的融合蛋白型药物前体
US17/051,160 US12441781B2 (en) 2018-05-04 2019-05-03 Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof
AU2019262590A AU2019262590B2 (en) 2018-05-04 2019-05-03 Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof
CN202510533066.5A CN120463816A (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
JP2020560958A JP7684047B2 (ja) 2018-05-04 2019-05-03 インターロイキン１５融合タンパク質、およびその組成物ならびに治療方法
KR1020207034734A KR20210028150A (ko) 2018-05-04 2019-05-03 인터루킨 15 융합 단백질, 이의 조성물 및 치료 방법
CN201980045118.7A CN112585161B (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
CA3099039A CA3099039A1 (en) 2018-05-04 2019-05-03 Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof
EP19796151.9A EP3788068A4 (en) 2018-05-04 2019-05-03 Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof
CN202510533077.3A CN120463817A (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
PCT/US2019/030594 WO2019213517A1 (en) 2018-05-04 2019-05-03 Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof
JP2025082038A JP2025124695A (ja) 2018-05-04 2025-05-15 インターロイキン１５融合タンパク質、およびその組成物ならびに治療方法
US19/330,743 US20260070957A1 (en) 2018-05-04 2025-09-16 Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof

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CN201810420739.6A CN110437339B (zh) 2018-05-04 2018-05-04 一种以白介素15为活性成分的融合蛋白型药物前体

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CN201810420739.6A Active CN110437339B (zh) 2018-05-04 2018-05-04 一种以白介素15为活性成分的融合蛋白型药物前体
CN202510533077.3A Pending CN120463817A (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
CN202510533066.5A Pending CN120463816A (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
CN201980045118.7A Active CN112585161B (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法

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CN202510533077.3A Pending CN120463817A (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
CN202510533066.5A Pending CN120463816A (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法
CN201980045118.7A Active CN112585161B (zh) 2018-05-04 2019-05-03 白介素15融合蛋白及其组合物和治疗方法

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US (1) US12441781B2 (https=)
EP (1) EP3788068A4 (https=)
JP (2) JP7684047B2 (https=)
KR (1) KR20210028150A (https=)
CN (4) CN110437339B (https=)
AU (1) AU2019262590B2 (https=)
CA (1) CA3099039A1 (https=)
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JP2025507733A (ja) * 2022-02-28 2025-03-21 ウーシー バイオロジクス アイルランド リミテッド Ｉｌ－１５変異体を含むヘテロ二量体ポリペプチド錯体とその使用
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EP3788068A4 (en) 2022-01-26
AU2019262590A1 (en) 2020-12-03
CN112585161B (zh) 2025-05-16
JP2021522786A (ja) 2021-09-02
AU2019262590B2 (en) 2024-09-05
CN120463817A (zh) 2025-08-12
WO2019213517A1 (en) 2019-11-07
US12441781B2 (en) 2025-10-14
EP3788068A1 (en) 2021-03-10
CN120463816A (zh) 2025-08-12
KR20210028150A (ko) 2021-03-11
CN110437339A (zh) 2019-11-12
CA3099039A1 (en) 2019-11-07
CN112585161A (zh) 2021-03-30
JP2025124695A (ja) 2025-08-26
JP7684047B2 (ja) 2025-05-27
US20240218047A1 (en) 2024-07-04

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