CN110418650A - 用于治疗过敏的核酸 - Google Patents

用于治疗过敏的核酸 Download PDF

Info

Publication number
CN110418650A
CN110418650A CN201780077275.7A CN201780077275A CN110418650A CN 110418650 A CN110418650 A CN 110418650A CN 201780077275 A CN201780077275 A CN 201780077275A CN 110418650 A CN110418650 A CN 110418650A
Authority
CN
China
Prior art keywords
glu
gln
gly
arg
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780077275.7A
Other languages
English (en)
Chinese (zh)
Inventor
特瑞·海兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunomic Therapeutics Inc
Original Assignee
Immunomic Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomic Therapeutics Inc filed Critical Immunomic Therapeutics Inc
Publication of CN110418650A publication Critical patent/CN110418650A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201780077275.7A 2016-11-16 2017-11-15 用于治疗过敏的核酸 Pending CN110418650A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662423111P 2016-11-16 2016-11-16
US62/423,111 2016-11-16
US201762536088P 2017-07-24 2017-07-24
US62/536,088 2017-07-24
PCT/US2017/061847 WO2018093932A2 (en) 2016-11-16 2017-11-15 Nucleic acids for treatment of allergies

Publications (1)

Publication Number Publication Date
CN110418650A true CN110418650A (zh) 2019-11-05

Family

ID=60582661

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780077275.7A Pending CN110418650A (zh) 2016-11-16 2017-11-15 用于治疗过敏的核酸

Country Status (6)

Country Link
US (1) US11826423B2 (https=)
EP (1) EP3541420A2 (https=)
JP (2) JP7078620B2 (https=)
CN (1) CN110418650A (https=)
CA (1) CA3044074A1 (https=)
WO (1) WO2018093932A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111138514A (zh) * 2020-01-08 2020-05-12 海南大学 一种腰果多肽及其提取方法和应用
CN117003848A (zh) * 2022-11-10 2023-11-07 浙江鼎持生物制品有限公司 猫主要过敏原蛋白表达、纯化和组合应用
WO2025139524A1 (zh) * 2023-12-28 2025-07-03 江苏众红生物工程创药研究院有限公司 猫重组变应原及其药用组合物、制备方法和应用
WO2025247235A1 (en) * 2024-05-29 2025-12-04 Therorna Shanghai Co., Ltd. Methods of inducing tumor specific t cells with a circular rna cancer vaccine

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3808361A1 (en) * 2012-06-15 2021-04-21 Immunomic Therapeutics, Inc. Nucleic acids for treatment of allergies
US10149904B2 (en) 2015-02-20 2018-12-11 The Board Of Trusteees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US10166286B2 (en) 2015-02-20 2019-01-01 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US11452774B2 (en) 2015-02-20 2022-09-27 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
NZ760884A (en) 2017-07-18 2023-05-26 Nestle Sa Methods for making mixed allergen compositions
US20210163957A1 (en) * 2018-05-11 2021-06-03 Astellas Pharma Inc. Nucleic acid for treating mite allergy
CA3099505A1 (en) * 2018-05-11 2019-11-14 Astellas Pharma Inc. Nucleic acid for treating crustacean allergy
US12398195B2 (en) * 2018-05-15 2025-08-26 Immunomic Therapeutics, Inc. Lamp constructs comprising allergens
WO2019242662A1 (zh) * 2018-06-22 2019-12-26 江苏众红生物工程创药研究院有限公司 重组尘螨变应原蛋白药物合剂及其应用
CN113507844A (zh) 2019-01-23 2021-10-15 前品牌股份有限公司 制备混合型过敏原组合物的方法
WO2024153710A2 (en) * 2023-01-17 2024-07-25 Société des Produits Nestlé S.A. Mixed nut allergen formulations and methods of making and using the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008279A1 (en) * 1991-10-16 1993-04-29 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
WO2004109291A2 (en) * 2003-06-02 2004-12-16 Mount Sinai School Of Medecine Of New York University Method for diagnosis and therapy of hazelnut-induced systemic reaction
CN1705492A (zh) * 2002-08-29 2005-12-07 新加坡国立大学 用于诱发抗过敏原保护性免疫应答的重组核酸
CN104080481A (zh) * 2012-01-31 2014-10-01 库瑞瓦格有限责任公司 包含聚合载体货物复合物和至少一种蛋白或肽抗原的药物组合物
CN104519896A (zh) * 2012-06-15 2015-04-15 免疫治疗有限公司 用于治疗变态反应的核酸
US9040054B2 (en) * 2007-08-21 2015-05-26 Biomay Ag Hypoallergenic molecules
WO2015200357A2 (en) * 2014-06-23 2015-12-30 Immunomic Therapeutics, Inc. Nucleic acids for treatment of peanut allergies

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237115A (en) 1977-11-23 1980-12-02 Bactex, Inc. Method of immunization against enterotoxogenic infection by Escherichia coli
US4397844A (en) 1978-02-24 1983-08-09 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
GB2026340B (en) 1978-07-03 1982-12-22 Ash P Stabilising microvesicles
US4681762A (en) 1979-05-23 1987-07-21 Research Corporation Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4593002A (en) 1982-01-11 1986-06-03 Salk Institute Biotechnology/Industrial Associates, Inc. Viruses with recombinant surface proteins
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4592002A (en) 1983-12-13 1986-05-27 Honeywell Inc. Method of digital temperature compensation and a digital data handling system utilizing the same
ZA858044B (en) 1984-11-01 1987-05-27 American Home Prod Oral vaccines
FR2583429B1 (fr) 1985-06-18 1989-11-03 Transgene Sa Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
DE3642912A1 (de) 1986-12-16 1988-06-30 Leybold Ag Messeinrichtung fuer paramagnetische messgeraete mit einer messkammer
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5744166A (en) 1989-02-25 1998-04-28 Danbiosyst Uk Limited Drug delivery compositions
US5100587A (en) 1989-11-13 1992-03-31 The United States Of America As Represented By The Department Of Energy Solid-state radioluminescent zeolite-containing composition and light sources
US5179993A (en) 1991-03-26 1993-01-19 Hughes Aircraft Company Method of fabricating anisometric metal needles and birefringent suspension thereof in dielectric fluid
SE503225C2 (sv) 1991-10-30 1996-04-22 Leif Lindholm Konsult Ab Virus-antikroppskomplex för införing av virus i mammalieceller
US5747323A (en) 1992-12-31 1998-05-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Retroviral vectors comprising a VL30-derived psi region
US5633234A (en) 1993-01-22 1997-05-27 The Johns Hopkins University Lysosomal targeting of immunogens
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2707091B1 (fr) 1993-06-30 1997-04-04 Cohen Haguenauer Odile Vecteur rétroviral pour le transfert et l'expression de gènes dans des cellules eucaryotes.
US5928944A (en) 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
FI955320A7 (fi) 1994-03-07 1995-11-24 Univ Michigan Bioaktiivisia ja/tai kohdennettuja dendriimikonjugaatteja
WO1995028494A1 (en) 1994-04-15 1995-10-26 Targeted Genetics Corporation Gene delivery fusion proteins
FR2719316B1 (fr) 1994-04-28 1996-05-31 Idm Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules.
AU2946295A (en) 1994-06-27 1996-01-19 Johns Hopkins University, The Targeted gene delivery system
FR2722506B1 (fr) 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
FR2727689A1 (fr) 1994-12-01 1996-06-07 Transgene Sa Nouveau procede de preparation d'un vecteur viral
US5837520A (en) 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
FR2737222B1 (fr) 1995-07-24 1997-10-17 Transgene Sa Nouveaux vecteurs viraux et lignee pour la therapie genique
WO1997035996A1 (en) 1996-03-25 1997-10-02 Transgene S.A. Packaging cell line based on human 293 cells
EP0944717A1 (fr) 1996-07-01 1999-09-29 Aventis Pharma S.A. Procede de production d'adenovirus recombinants
EP0920339A2 (en) 1996-07-09 1999-06-09 The Johns Hopkins University Gene delivery system
ATE477320T1 (de) 1996-12-13 2010-08-15 Schering Corp Methoden zur virus-reinigung
FR2759382A1 (fr) 1997-02-10 1998-08-14 Transgene Sa Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
FR2760193B1 (fr) 1997-02-28 1999-05-28 Transgene Sa Lipides et complexes de lipides cationiques et de substances actives, notamment pour la transfection de cellules
FR2763958A1 (fr) 1997-05-29 1998-12-04 Transgene Sa Produit de combinaison associant un acide nucleique a une substance desorganisant la matrice extracellulaire pour la therapie genique
AU749032B2 (en) 1997-06-13 2002-06-20 Johns Hopkins University, The Therapeutic nanospheres
CA2242035C (en) 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
ES2210081T3 (es) 1998-07-07 2004-07-01 Transgene S.A. Utilizacion de los marcos de lectura de la region e4 para la mejora de la expresion de genes.
EP1155120B1 (fr) 1999-02-22 2006-07-05 Transgene S.A. Procede d'obtention d'une preparation virale purifiee
DK1385538T3 (da) 2001-04-05 2013-04-29 Univ Johns Hopkins Kimære vacciner omfattende det lumenale domæne fra LAMP-1 eller LAMP-2

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008279A1 (en) * 1991-10-16 1993-04-29 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
CN1705492A (zh) * 2002-08-29 2005-12-07 新加坡国立大学 用于诱发抗过敏原保护性免疫应答的重组核酸
WO2004109291A2 (en) * 2003-06-02 2004-12-16 Mount Sinai School Of Medecine Of New York University Method for diagnosis and therapy of hazelnut-induced systemic reaction
US9040054B2 (en) * 2007-08-21 2015-05-26 Biomay Ag Hypoallergenic molecules
CN104080481A (zh) * 2012-01-31 2014-10-01 库瑞瓦格有限责任公司 包含聚合载体货物复合物和至少一种蛋白或肽抗原的药物组合物
CN104519896A (zh) * 2012-06-15 2015-04-15 免疫治疗有限公司 用于治疗变态反应的核酸
WO2015200357A2 (en) * 2014-06-23 2015-12-30 Immunomic Therapeutics, Inc. Nucleic acids for treatment of peanut allergies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI KIANG TAN等: "Intramuscular immunization with DNA construct containing Der p 2 and signal peptide sequences primed strong IgE production" *
韩起等: "溶酶体相关膜蛋白2A shRNA对乳腺癌细胞株紫杉醇耐药的影响", 《细胞与分子免疫学杂志》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111138514A (zh) * 2020-01-08 2020-05-12 海南大学 一种腰果多肽及其提取方法和应用
CN111138514B (zh) * 2020-01-08 2023-09-22 海南大学 一种腰果多肽及其提取方法和应用
CN117003848A (zh) * 2022-11-10 2023-11-07 浙江鼎持生物制品有限公司 猫主要过敏原蛋白表达、纯化和组合应用
WO2025139524A1 (zh) * 2023-12-28 2025-07-03 江苏众红生物工程创药研究院有限公司 猫重组变应原及其药用组合物、制备方法和应用
WO2025247235A1 (en) * 2024-05-29 2025-12-04 Therorna Shanghai Co., Ltd. Methods of inducing tumor specific t cells with a circular rna cancer vaccine

Also Published As

Publication number Publication date
US20190351050A1 (en) 2019-11-21
WO2018093932A3 (en) 2018-06-28
JP2022119861A (ja) 2022-08-17
CA3044074A1 (en) 2018-05-24
JP2019537447A (ja) 2019-12-26
US11826423B2 (en) 2023-11-28
JP7078620B2 (ja) 2022-05-31
EP3541420A2 (en) 2019-09-25
WO2018093932A2 (en) 2018-05-24

Similar Documents

Publication Publication Date Title
US11826423B2 (en) Nucleic acids for treatment of allergies
US11110164B2 (en) Lysosomal targeting of antigens employing nucleic acids encoding lysosomal membrane polypeptide/antigen chimeras
US12116396B2 (en) LAMP constructs
AU2002307145A1 (en) Chimeric vaccines
JP7742900B2 (ja) アレルゲンを含む改善されたｌａｍｐ構築物
CN114641306A (zh) 包含癌抗原的改良lamp构建物
HK40123095A (en) Improved lamp constructs
HK40014081A (en) Improved lamp constructs
HK40014081B (en) Improved lamp constructs

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
AD01 Patent right deemed abandoned

Effective date of abandoning: 20240510