CN110402140A - 加波沙朵在治疗耳鸣中的用途 - Google Patents

加波沙朵在治疗耳鸣中的用途 Download PDF

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Publication number
CN110402140A
CN110402140A CN201880017336.5A CN201880017336A CN110402140A CN 110402140 A CN110402140 A CN 110402140A CN 201880017336 A CN201880017336 A CN 201880017336A CN 110402140 A CN110402140 A CN 110402140A
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CN
China
Prior art keywords
hours
gaboxadol
acceptable salt
pharmaceutically acceptable
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880017336.5A
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English (en)
Chinese (zh)
Inventor
马修·杜林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ovid Therapeutics Inc
Original Assignee
Ovid Therapeutics Inc
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Filing date
Publication date
Application filed by Ovid Therapeutics Inc filed Critical Ovid Therapeutics Inc
Publication of CN110402140A publication Critical patent/CN110402140A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880017336.5A 2017-02-03 2018-02-02 加波沙朵在治疗耳鸣中的用途 Pending CN110402140A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762454280P 2017-02-03 2017-02-03
US62/454,280 2017-02-03
US201762530528P 2017-07-10 2017-07-10
US62/530,528 2017-07-10
US201762536669P 2017-07-25 2017-07-25
US62/536,669 2017-07-25
PCT/US2018/016602 WO2018144827A1 (en) 2017-02-03 2018-02-02 Use of gaboxadol in the treatment of tinnitus

Publications (1)

Publication Number Publication Date
CN110402140A true CN110402140A (zh) 2019-11-01

Family

ID=63038963

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880017336.5A Pending CN110402140A (zh) 2017-02-03 2018-02-02 加波沙朵在治疗耳鸣中的用途

Country Status (17)

Country Link
US (3) US10071083B2 (enExample)
EP (1) EP3576738B1 (enExample)
JP (3) JP2020505432A (enExample)
KR (1) KR20190112046A (enExample)
CN (1) CN110402140A (enExample)
AU (1) AU2018215363A1 (enExample)
BR (1) BR112019015832A2 (enExample)
CA (1) CA3051586A1 (enExample)
DK (1) DK3576738T3 (enExample)
ES (1) ES2930899T3 (enExample)
HU (1) HUE060609T2 (enExample)
IL (1) IL268210A (enExample)
MX (1) MX393900B (enExample)
PE (1) PE20191407A1 (enExample)
PL (1) PL3576738T3 (enExample)
PT (1) PT3576738T (enExample)
WO (1) WO2018144827A1 (enExample)

Families Citing this family (9)

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CN108024997A (zh) 2015-07-17 2018-05-11 奥维德医疗公司 用加波沙朵治疗发育障碍的方法
KR20230050474A (ko) 2016-08-11 2023-04-14 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
EP3833351A4 (en) 2018-09-20 2021-10-13 Ovid Therapeutics Inc. USE OF GABOXADOL TO TREAT TOURETTE SYNDROME, TICKS, AND STUTTERS
KR20210110585A (ko) 2018-11-21 2021-09-08 썰테고 테라퓨틱스 아이엔씨. 자살의 위험을 감소시키고 우울증의 신속한 완화를 위한 가복사돌
MX2021007224A (es) * 2018-12-17 2021-09-23 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del trastorno del sue?o vigilia que no es de 24 horas.
US11364228B2 (en) 2019-12-18 2022-06-21 Ovid Therapeutics Inc. Gaboxadol for therapeutic treatment of 1p36 deletion syndrome
IL298334A (en) 2020-05-20 2023-01-01 Certego Therapeutics Inc Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders
EP4299059A1 (en) 2022-07-01 2024-01-03 Labelic Analysis, S.L. Composition for the treatment of tinnitus

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US20160228418A1 (en) * 2014-06-06 2016-08-11 Ovid Therapeutics Inc. Methods of increasing tonic inhibition and treating secondary insomnia
US20170014393A1 (en) * 2015-07-17 2017-01-19 Ovid Therapeutics Inc. Methods of treating developmental disorders with gaboxadol

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KR20230050474A (ko) 2016-08-11 2023-04-14 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
KR20210110585A (ko) * 2018-11-21 2021-09-08 썰테고 테라퓨틱스 아이엔씨. 자살의 위험을 감소시키고 우울증의 신속한 완화를 위한 가복사돌

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US20120035207A1 (en) * 2003-09-10 2012-02-09 Mckernan Ruth Use of GABAA Receptor Agonists for the Treatment of Hearing, Vestibular and Attention Disorders, Intention Tremor and Restless Leg Syndrome
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WO2006118897A1 (en) * 2005-04-29 2006-11-09 H.Lundbeck A/S Acid and base salt forms of gaboxadol
US20100297181A1 (en) * 2007-12-26 2010-11-25 Eisai R&D Management Co., Ltd. AMPA Receptor Antagonists for Epilepsy, Mental Disorders or Deficits in Sensory Organ
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US20170014393A1 (en) * 2015-07-17 2017-01-19 Ovid Therapeutics Inc. Methods of treating developmental disorders with gaboxadol

Also Published As

Publication number Publication date
JP2020505432A (ja) 2020-02-20
US20180344709A1 (en) 2018-12-06
AU2018215363A1 (en) 2019-08-15
BR112019015832A2 (pt) 2020-03-31
MX2019009190A (es) 2019-09-26
PL3576738T3 (pl) 2023-02-06
EP3576738B1 (en) 2022-10-12
MX393900B (es) 2025-03-24
EP3576738A4 (en) 2021-02-17
ES2930899T3 (es) 2022-12-22
US20190111033A1 (en) 2019-04-18
CA3051586A1 (en) 2018-08-09
US20180221355A1 (en) 2018-08-09
US10188635B2 (en) 2019-01-29
PE20191407A1 (es) 2019-10-04
HUE060609T2 (hu) 2023-04-28
DK3576738T3 (da) 2022-11-28
KR20190112046A (ko) 2019-10-02
WO2018144827A1 (en) 2018-08-09
IL268210A (en) 2019-09-26
US10071083B2 (en) 2018-09-11
PT3576738T (pt) 2022-11-30
JP2024178317A (ja) 2024-12-24
EP3576738A1 (en) 2019-12-11
JP2023011630A (ja) 2023-01-24

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