CN110402137A - 一种用于靶向活化cd44分子的硅质体递送系统、其制备方法和用途 - Google Patents

一种用于靶向活化cd44分子的硅质体递送系统、其制备方法和用途 Download PDF

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CN110402137A
CN110402137A CN201880015119.2A CN201880015119A CN110402137A CN 110402137 A CN110402137 A CN 110402137A CN 201880015119 A CN201880015119 A CN 201880015119A CN 110402137 A CN110402137 A CN 110402137A
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silica nodule
delivery system
vulnerable plaque
nodule
silica
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CN110402137B (zh
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马茜
孙洁芳
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Beijing Inno Medicine Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase

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Abstract

一种用于靶向活化的CD44分子的硅质体递送系统、制备方法及其用途，所述硅质体的表面部分地被靶向配体修饰，所述靶向配体是能与活化的CD44分子特异性结合的配体。该硅质体递送系统可用于易损斑块或与易损斑块相关的疾病的诊断、预防和治疗。

Description

PCT国内申请，说明书已公开。

Claims (47)

  1. PCT国内申请，权利要求书已公开。
CN201880015119.2A 2017-04-12 2018-04-12 一种用于靶向活化cd44分子的硅质体递送系统、其制备方法和用途 Active CN110402137B (zh)

Applications Claiming Priority (3)

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CN2017102366798 2017-04-12
CN201710236679 2017-04-12
PCT/CN2018/082850 WO2018188635A1 (zh) 2017-04-12 2018-04-12 一种用于靶向活化cd44分子的硅质体递送系统、其制备方法和用途

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CN110402137A true CN110402137A (zh) 2019-11-01
CN110402137B CN110402137B (zh) 2021-03-09

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US (1) US11737977B2 (zh)
EP (1) EP3610859A4 (zh)
JP (2) JP7485366B2 (zh)
CN (1) CN110402137B (zh)
WO (1) WO2018188635A1 (zh)

Cited By (3)

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CN112779317A (zh) * 2019-11-11 2021-05-11 香港中文大学深圳研究院 一种用于小分子核糖核酸检测的试剂及其应用
CN116603101A (zh) * 2023-07-20 2023-08-18 北京大学第三医院（北京大学第三临床医学院） 一种金-硅质体-聚己内酯支架体系及其制备方法和用途
CN116942850A (zh) * 2023-09-21 2023-10-27 北京茵诺医药科技有限公司 一种用于易损斑块的纳米药物递送系统

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112274646B (zh) * 2019-07-12 2023-06-02 北京茵诺医药科技有限公司 用于靶向活化cd44分子的双亲性蛋白质-高分子结合体递送系统、其制备方法和应用
CN112899224A (zh) * 2021-02-08 2021-06-04 高连如 一种用于负载冠脉支架的细胞外纳米囊泡，制备方法和应用

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CN105708800A (zh) * 2016-02-02 2016-06-29 湖南师范大学 一种靶向乳腺癌干细胞的洛伐他汀硅质体

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JP5142982B2 (ja) * 2006-03-07 2013-02-13 国立大学法人 奈良先端科学技術大学院大学 金属被覆された脂質二分子膜小胞体及びその製造方法
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112779317A (zh) * 2019-11-11 2021-05-11 香港中文大学深圳研究院 一种用于小分子核糖核酸检测的试剂及其应用
CN116603101A (zh) * 2023-07-20 2023-08-18 北京大学第三医院（北京大学第三临床医学院） 一种金-硅质体-聚己内酯支架体系及其制备方法和用途
CN116603101B (zh) * 2023-07-20 2023-10-03 北京大学第三医院（北京大学第三临床医学院） 一种金-硅质体-聚己内酯支架体系及其制备方法和用途
CN116942850A (zh) * 2023-09-21 2023-10-27 北京茵诺医药科技有限公司 一种用于易损斑块的纳米药物递送系统
CN116942850B (zh) * 2023-09-21 2023-12-05 北京茵诺医药科技有限公司 一种用于易损斑块的纳米药物递送系统

Also Published As

Publication number Publication date
US20210145747A1 (en) 2021-05-20
WO2018188635A1 (zh) 2018-10-18
EP3610859A1 (en) 2020-02-19
CN110402137B (zh) 2021-03-09
US11737977B2 (en) 2023-08-29
EP3610859A4 (en) 2021-01-27
JP7485366B2 (ja) 2024-05-16
JP2022188222A (ja) 2022-12-20
JP2020516686A (ja) 2020-06-11

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