CN110393749A - A kind of Chinese medicine composition of external curing irritable bowel syndrome - Google Patents
A kind of Chinese medicine composition of external curing irritable bowel syndrome Download PDFInfo
- Publication number
- CN110393749A CN110393749A CN201910166485.4A CN201910166485A CN110393749A CN 110393749 A CN110393749 A CN 110393749A CN 201910166485 A CN201910166485 A CN 201910166485A CN 110393749 A CN110393749 A CN 110393749A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- extract
- chinese medicine
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of Chinese medicine composition of external curing irritable bowel syndrome, and the bulk pharmaceutical chemicals of the Chinese medicine composition include: monkshood, Radix Salviae Miltiorrhizae, borneol, Radix Codonopsis, Rhizoma Chuanxiong.The overall clinical efficacy rate of the traditional chinese medicine composition of the invention external curing irritable bowel syndrome is 79.6%, and can significantly improve the tcm syndrome of the irritable bowel syndrome patients insufficiency of the spleen with overabundance of dampness, the insufficiency of both the spleen and the kindey.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions, and in particular to a kind of Chinese traditional medicine composition of external curing irritable bowel syndrome
Object belongs to field of medicaments.
Background technique
Irritable bowel syndrome (Irritable bowel syndrome, IBS) is with abdominal pain or abdominal discomfort with defecation
A kind of functional bowel disorder that shape or bowl evacuation habit are characterized extremely is worldwide common disease, one of frequently-occurring disease.The disease
The easy recurrent exerbation of symptom, curative effect is undesirable, has seriously affected the quality of life of patient.Clinic can divide 4 hypotypes, diarrhea-type
(IBS-D), constipation type (IBS-C), alternate type and indefinite form, wherein it is most commonly seen with IBS-D, account for 60% of IBS or more.
The cause of disease and pathogenesis of IBS are unclear at present, it is believed that and it is related with many factors, it is clinical mainly using calm, stomach
Intestinal motive force adjusts the verification treatment of the drugs such as medicine and antidiarrheal or defaecation, less effective.Traditional Chinese medicine, which treats IBS, has certain advantage
And characteristic, curative effect affirmative, but at present oral drugs it is poor there are still compliance the problems such as.Trouble can obviously improve using the external application of Chinese medicine
Person's symptom, and patient compliance is preferable, shows significant advantage and treatment prospect.Previously researches show that on the basis of Western medicine,
Combined with Chinese Herbal sticks SHENQUE acupoint treatment diarrhea-type irritability syndrome, patient's diarrhea, colic symptoms can be effectively relieved, curative effect is better than
Western medicine is used merely.
Summary of the invention
In view of the problems of the existing technology, the purpose of the present invention is to provide a kind of external curing irritable bowel syndrome
Chinese medicine composition and its application.
As one aspect of the present invention, the present invention provides a kind of Chinese medicine composition of external curing irritable bowel syndrome,
The bulk pharmaceutical chemicals of the Chinese medicine composition include: monkshood, Radix Salviae Miltiorrhizae, borneol, Radix Codonopsis, Rhizoma Chuanxiong.
Preferably, the bulk pharmaceutical chemicals composition of the Chinese medicine composition are as follows: monkshood 3-20 parts by weight, Radix Salviae Miltiorrhizae 15-50 parts by weight, ice
Piece 3-20 parts by weight, Radix Codonopsis 5-30 parts by weight, Rhizoma Chuanxiong 5-30 parts by weight；
It is further preferred that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: monkshood 5-17 parts by weight, Radix Salviae Miltiorrhizae 18-45 weight
Measure part, borneol 5-17 parts by weight, Radix Codonopsis 7-25 parts by weight, Rhizoma Chuanxiong 7-25 parts by weight；
Or, the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: monkshood 6-15 parts by weight, Radix Salviae Miltiorrhizae 20-40 parts by weight, borneol 6-
15 parts by weight, Radix Codonopsis 10-20 parts by weight, Rhizoma Chuanxiong 10-20 parts by weight；
Most preferably, the bulk pharmaceutical chemicals composition of the Chinese medicine composition are as follows: 10 parts by weight of monkshood, 30 parts by weight of Radix Salviae Miltiorrhizae, borneol
10 parts by weight, 15 parts by weight of Radix Codonopsis, 15 parts by weight of Rhizoma Chuanxiong；
Or, 8 parts by weight of monkshood, 35 parts by weight of Radix Salviae Miltiorrhizae, 8 parts by weight of borneol, 18 parts by weight of Radix Codonopsis, 12 parts by weight of Rhizoma Chuanxiong；
Or, 12 parts by weight of monkshood, 25 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of borneol, 12 parts by weight of Radix Codonopsis, 18 parts by weight of Rhizoma Chuanxiong.
The traditional chinese medicine composition of the invention the preparation method comprises the following steps:
Each bulk pharmaceutical chemicals are taken in proportion, crush or routinely extracting method is extracted with water or organic solvent, and routinely preparation
Technique is prepared into external preparation.
Above-mentioned general extraction methods include any one in refluxing extraction, Soakage extraction, ultrasonic extraction or seepage pressure effects
The combination of mode or Different Extraction Method；The organic solvent is methanol, 20~95% ethanol solution, one in acetone
Kind is several.The exterior-applied formulation includes patch, cataplasm, ointment, plaster, gelling agent, liniment, lotion, plastics etc..
Bulk pharmaceutical chemicals monkshood in the traditional chinese medicine composition of the invention, Radix Salviae Miltiorrhizae, Radix Codonopsis, Rhizoma Chuanxiong in addition to fed intake in the form of crude drug with
Outside, it can also use and be fed intake with the extract (active component) of above-mentioned crude drug, therefore the present invention further discloses one
The Chinese medicine composition of kind external curing irritable bowel syndrome:
A kind of Chinese medicine composition of external curing irritable bowel syndrome, the bulk pharmaceutical chemicals of the Chinese medicine composition include: monkshood
Extract, Salvia root P.E, borneol, Radix Codonopsis extract, Rhizoma Chuanxiong extract.
Preferably, the bulk pharmaceutical chemicals composition of the Chinese medicine composition are as follows: monkshood extract 3-20 parts by weight, Salvia root P.E
15-50 parts by weight, borneol 3-20 parts by weight, Radix Codonopsis extract's 5-30 parts by weight, Rhizoma Chuanxiong extract 5-30 parts by weight；
It is further preferred that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: monkshood extract 5-17 parts by weight, Radix Salviae Miltiorrhizae mention
Take object 18-45 parts by weight, borneol 5-17 parts by weight, Radix Codonopsis extract's 7-25 parts by weight, Rhizoma Chuanxiong extract 7-25 parts by weight；
Or, the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: monkshood extract 6-15 parts by weight, Salvia root P.E 20-40
Parts by weight, borneol 6-15 parts by weight, Radix Codonopsis extract's 10-20 parts by weight, Rhizoma Chuanxiong extract 10-20 parts by weight；
Most preferably, the bulk pharmaceutical chemicals composition of the Chinese medicine composition are as follows: 10 parts by weight of monkshood extract, Salvia root P.E 30
Parts by weight, 10 parts by weight of borneol, 15 parts by weight of Radix Codonopsis extract, 15 parts by weight of Rhizoma Chuanxiong extract；
Or, 8 parts by weight of monkshood extract, 35 parts by weight of Salvia root P.E, 8 parts by weight of borneol, 18 weight of Radix Codonopsis extract
Part, 12 parts by weight of Rhizoma Chuanxiong extract；
Or, 12 parts by weight of monkshood extract, 25 parts by weight of Salvia root P.E, 12 parts by weight of borneol, 12 weight of Radix Codonopsis extract
Measure part, 18 parts by weight of Rhizoma Chuanxiong extract.
Above-mentioned raw materials medicament extract can be the water extract or extractive with organic solvent or water extract/organic of each bulk pharmaceutical chemicals
Solvent extractable matter passes through the refined substance that further polishing purification technique obtains.
The organic solvent is selected from one or more of methanol, 20~95% ethanol solutions, acetone；
Preparing extracting method used in said extracted object includes refluxing extraction, Soakage extraction, ultrasonic extraction or seepage pressure effects
In any one mode or Different Extraction Method combination.
Bulk pharmaceutical chemicals monkshood according to the present invention, Radix Salviae Miltiorrhizae, borneol, Radix Codonopsis, Rhizoma Chuanxiong meet " Chinese Pharmacopoeia " (2015 editions)
Record.The wherein black suitable piece of the preferred processed product of monkshood.
Monkshood returns spleen, kidney, the heart channel of Hang-Shaoyin, property belong to the big heat of great Xin, can warming kidney and enhancing body, dispelling cold and removing dampness thus be monarch；Radix Codonopsis tonifying middle-Jiao and Qi,
Invigorating the spleen to arrest diarrhea is for ministerial drug；Radix Salviae Miltiorrhizae nourishing blood and tranquilization, it is adjutant that the promoting the circulation of qi of Rhizoma Chuanxiong pungent-warm can help clear sun and open Zhu Yu altogether；Borneol fragrance is walked
It alters, priming is transdermal, and having " then gesture of walking alone is weak, and assistant makes, active " Ji Zhiyu from ancient times is to make medicine.
As another aspect of the present invention, the present invention also provides the Chinese medicine compositions to prepare external curing intestines easily swash
Application in the drug of syndrome.
Clinical and experimental study the result shows that, the clinic of the traditional chinese medicine composition of the invention external curing irritable bowel syndrome is total effective
Rate is 79.6%, and can significantly improve the tcm syndrome of the irritable bowel syndrome patients insufficiency of the spleen with overabundance of dampness, the insufficiency of both the spleen and the kindey.
Specific embodiment
Embodiment 1
Prescription: monkshood 10g, Radix Salviae Miltiorrhizae 30g, borneol 10g, Radix Codonopsis 15g, Rhizoma Chuanxiong 15g；
Preparation method: each bulk pharmaceutical chemicals crush, and are added after yellow rice wine stirs evenly and navel patch herbal cake is made, be put into the application bag made
Sealing.
Usage: patient's SHENQUE acupoint, each application time 2h are placed in.
Clinical trial:
1 clinical data
Select the patient for meeting Rome III IBS diagnostic criteria of in June, 2015~2016 year Wangjing in October hospital admission
60, wherein male 28, women 32；Age 20~68 years old, average (36.41 ± 16.15) year；The course of disease is most 1 year short, longest
11 years, average (6.31 ± 1.54) year.By all patients be randomly divided into experimental group (give embodiment 1 preparation stick agent) with it is right
According to group, (prescription: evodia rutaecarpa 20g, radix bupleuri 12g, dried immature fruit of citron orange 10g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 5g are prepared into 1 method of embodiment and stick
Agent).Chinese medical discrimination selection meets syndrome of stagnation of liver qi and spleen deficiency, the insufficiency of the spleen with overabundance of dampness, syndrome of yang deficiency of spleen and kidney patient.
2 diagnostic criteria
2.1IBS Western medicine diagnostic criteria (RomeIII standard) is (referring to Drossman DA.The functional
Gastrointestinal disorders and the Rome III process [J] .Gastroenterology, 2006,
130 (5): 1377-1390.):
The abdominal pain or discomfort of recurrent exerbation, there is symptom at least 3 days every month in nearest 3 months, merge following 2 or
It is a plurality of:
(1) remission after defecation；
(2) change when breaking out with stool interval；
(3) change when breaking out with stool (appearance).
* there is at least six moon in symptom before diagnosing, and meets the above standard within nearly 3 months.
* discomfort means to feel under the weather rather than pain.In Pathological Physiology research and clinical trial, screening can be commented
When the patient estimated, pain and (or) the uncomfortable frequency occurred are at least 2 days weekly.
2.2 IBS parting standards
(1) diarrhea-type IBS (IBS-D): at least 25% defecation be loose (paste) just or watery stool, firmly just or dry bulb just
< 25%；
(2) constipation type IBS (IBS-C): at least 25% defecation be it is hard just or dry bulb just, loose (paste) just or watery stool
< 25%；
(3) mixed type IBS (IBS-M): at least 25% defecation be it is hard just or dry bulb just, at least 25% defecation is loose
(paste) just or watery stool；
(4) indefinite form IBS: the character of excrement does not meet above-mentioned IBS-C, D or M standard extremely.
2.3 TCM syndrome diagnostic criteria
Referring to and " diarrhea-type irritability syndrome Chinese medicine common recognition " (version in 2010) (reference Zhang Shengsheng, prune structure, Wei Wei,
Et a1. irritable bowel syndrome Chinese medicine diagnosis and treatment National Consensus [J] China traditional Chinese medicine magazine, 2010 (7): 1062-1065.) syndrome
Determine: primary symptom is indispensable, add minor symptom two or more it is i.e. diagnosable.
2.3.1 spleen asthenia and dampness retention demonstrate,proves primary symptom: 1. rushing down when half congealed during stool；2. abdominal pain is indistinct.Minor symptom: 1. tired or break out after suffering from cold
Or it aggravates；2. refreshing tired indigestion and loss of appetite, four limbs burnout；3. pale tongue, while there is indentation, whitish tongue is greasy；4. deficient and weak pulse.
2.3.2 syndrome of yang deficiency of spleen and kidney primary symptom: 1. abdominal pain is rushed down from morning；2. abdomen crymodynia obtains warm pain and subtracts；The limb cold 3. shape is trembled with fear.It is secondary
Disease: 1. soreness and weakness of waist and knees；2. do not feel like eating；3. pale tongue is fat, white,slippery and moist fur；4. deep thready pulse.
3 cases are included in standard
(1) meet diarrhea-type IBS Western medicine diagnostic criteria；
(2) age is in 18-70 year person；
(3) initial IBS-SSS integral > 75 divides；
(4) subject knows, and voluntarily signs informed consent form；
(5) permanent local, can guarantee follow up, there is certain reading ability.
4 case exclusion criterias
(1) constipation type, mixed type and indefinite form IBS patient；
(2) with patients such as the main organs serious change such as conscience kidney person, disease of hematopoietic system and tumours；
(3) have alimentary canal organic disease (such as chronic pancreatitis), or the general disease (example for the digestive tract power that has an impact
Such as: hyperthyroidism, diabetes, chronic renal insufficiency, Neurotoxicity lesion)；
(4) or need continue use may influence gastrointestinal function drug (anticholinergic agents, calcium channel blocking
Agent, 5-HT3 receptor antagonist, antidiarrheic, antiacid, motor activation regulator, antidepressants, anxiolytic, laxative, intestinal flora tune
Save medicine etc.) person；
(5) person's (such as cholecystectomy) that has Previous abdominal surgery；
(6) the related drugs allergies for having research used and serious food hypersenstivity history person；；
(7) Pregnant and lactant women；
(8) there are nervous system and mental disease history；
(9) other clinical and experimental studies patient is being participated in.
5 research approaches
This experiment is perspective random, control, double blind experiment.Meet the standard of being included in, do not meet exclusion criteria patient by with
Machine table is randomized into experimental group, control group, and two groups are given Trimebutine Maleate capsule 0.2g tid, and the course for the treatment of 14 days.Experimental group
Give acupoint application of Chinese herb (example 1 drug) once a day, acupuncture point SHENQUE acupoint, qd, the course for the treatment of 14 days.Control group gives in once a day
Medicine point-application (control drug), acupuncture point SHENQUE acupoint, qd, the course for the treatment of 14 days.Pretherapy and post-treatment curative effect index is carried out after treatment end
Statistics compares.
6 curative effect index
6.1 main indicators:
Severity of symptoms scores (IBS-SSS) (referring to Irvine EJ, Whitehead WE, Chey WD, et
al.Design of treatment trials for functional gastrointestinal disorders[J]
.Gastroenterology, 2006,130 (5): 1538-1551.), before and after evaluation medication the score value of IBS-SSS integral change with
And improvement rate.
The score value for evaluating medication front and back IBS-SSS integral changes and improvement rate
6.1.1 the integral of IBS-SSS
(1) calculation method of abdominal pain frequency integrator: abdominal pain frequency integrator=practical abdominal pain number of days/14*100；
(2) calculation method of IBS-SSS scale total score: IBS-SSS scale total score=abdominal pain degree integral+abdominal pain frequency product
Point+the influence integral of abdominal distension degree integral+defecation satisfaction integral+to life.
6.1.2 the treatment improvement rate of IBS-SSS scale
According to former document report, score value is considered at paracmasis (Remission) lower than 75 points, is between 75-175
Slightly (Mild) is moderate (Moderate) between 175-300, and at 300 points, the above are severe (Severe)；Clinical efficacy changes
The kind following rule evaluation of grade.
(1) fully recover: integral < 75 divides；
(2) effective: to improve 2 ranks；
(3) effectively: improving 1 rank；
(4) invalid: without improvement or to be deteriorated.
6.2 secondary indexs
Tcm syndrome improves situation,；
By symptom be divided into without, it is light, in, weight level Four: 0 point=asymptomatic；1 point=slight, to daily routines and sleep without shadow
It rings；3 points=severe, daily routines cannot be engaged in, hence it is evident that influence sleep；2 points=moderate, between slightly between severe.
Overall treatment effect judgment criteria: effective: syndrome symptom total mark is clearly better after treatment, integral decline >=1/2；
Effective: syndrome symptom total mark improves after treatment, 1/3≤integral decline < 1/2；Invalid: syndrome symptom total mark is without changing after treatment
It is kind, integral decline < 1/3.
7 statistical analysis
Data are indicated with mean ± standard deviation (X ± S), carry out data analysis using SPSS19.0 statistical software.2 groups of data
Compare using independent samples t test；Compare two-by-two between 3 groups of data groups using one-way analysis of variance (One-Way ANOVA), side
It is to have statistical difference with P < 0.05 with DunnettT3 method when heterogeneity of variance with LSD method when poor neat.
8 experimental results
8.1 IBS-SSS scale situations
It is shown in Table 1.Treat preceding two groups of IBS-SSS integral no difference of science of statistics (P > 0.05), experimental group patient IBS- after treatment
SSS integral alleviates situation and effective percentage is superior to control group, as a result has statistical significance (P < 0.05).
1 two groups of table pretherapy and post-treatment IBS-SSS scale situations
8.2 Chinese medicine syndrome integrals change
It is shown in Table 2.Preceding two groups of Chinese medicine syndrome integral no difference of science of statistics (P > 0.05) are treated, experimental group spleen deficiency is wet after treatment
Sheng card, the improvement of syndrome of yang deficiency of spleen and kidney syndrome integral are superior to control group, as a result have statistical significance (P < 0.05).
2 two groups of table pretherapy and post-treatment Chinese medicine syndrome integral situations of change
8.3 tcm syndromes are efficient
It the results are shown in Table 3.Experimental group is significantly better than control group (P < 0.05) in syndrome of yang deficiency of spleen and kidney, syndrome of stagnation of liver qi and spleen deficiency effective percentage,
Total effective rate experimental group is better than control group (P < 0.05).
3 two groups of table pretherapy and post-treatment tcm syndromes are efficient
| Group | Spleen-asthenia with excessive damp card | Syndrome of yang deficiency of spleen and kidney | Total effective rate |
| Experimental group | 81.4% | 83.9% | 79.9% |
| Control group | 73.1% | 69.3% | 70.7% |
It to sum up tells, we's treatment diarrhea type irritable bowel, patient's IBS severity of symptom amount integral can be effectively relieved, treat
Effect is better than control group.In terms of tcm syndrome improvement, the insufficiency of the spleen with overabundance of dampness, syndrome of yang deficiency of spleen and kidney therapeutic effect are substantially better than experimental group, in
It cures syndrome general curative effect and is better than control group (P < 0.05).
Embodiment 2
Prescription: monkshood 8g, Radix Salviae Miltiorrhizae 35g, borneol 8g, Radix Codonopsis 18g, Rhizoma Chuanxiong 12g；
Preparation method: each bulk pharmaceutical chemicals mixing and water adding decocts twice, and 1 hour every time, filtration, merging filtrate, concentration；High speed from
The heart takes supernatant；Conventional formulation auxiliary material is added, external use plaster is made.
Embodiment 3
Prescription: monkshood 12g, Radix Salviae Miltiorrhizae 25g, borneol 12g, Radix Codonopsis 12g, Rhizoma Chuanxiong 18g；
Preparation method: twice, 1 hour every time, filtration, merging filtrate was concentrated each bulk pharmaceutical chemicals mixing and water adding refluxing extraction；Add
Enter conventional formulation auxiliary material, externally used paste is made.
Embodiment 4
Prescription: monkshood 7g, Radix Salviae Miltiorrhizae 38g, borneol 7g, Radix Codonopsis 19g, Rhizoma Chuanxiong 11g；
Preparation method: twice, 1 hour every time, filtration merged filter for each bulk pharmaceutical chemicals mixing plus 70% ethanol solution refluxing extraction
Liquid, concentration；High speed centrifugation takes supernatant；Conventional formulation auxiliary material is added, external application cataplasm is made.
Embodiment 5
Prescription: monkshood 14g, Radix Salviae Miltiorrhizae 22g, borneol 14g, Radix Codonopsis 11g, Rhizoma Chuanxiong 19g；
Preparation method: twice, each 40min, filtration merges filter for each bulk pharmaceutical chemicals mixing plus 70% ethanol solution ultrasonic extraction
Liquid, concentration；High speed centrifugation takes supernatant；Conventional formulation auxiliary material is added, external application cataplasm is made.
Embodiment 6
Prescription: monkshood 5g, Radix Salviae Miltiorrhizae 42g, borneol 6g, Radix Codonopsis 24g, Rhizoma Chuanxiong 8g；
Preparation method: each bulk pharmaceutical chemicals crush, and are added after yellow rice wine stirs evenly and navel patch herbal cake is made, be put into the application bag made
Sealing.
Embodiment 7
Prescription: monkshood 16g, Radix Salviae Miltiorrhizae 18g, borneol 16g, Radix Codonopsis 7g, Rhizoma Chuanxiong 24g；
Preparation method: each bulk pharmaceutical chemicals mixing and water adding decocts twice, and 1 hour every time, filtration, merging filtrate, concentration；High speed from
The heart takes supernatant；Conventional formulation auxiliary material is added, external use plaster is made.
Embodiment 8
Prescription: monkshood 4g, Radix Salviae Miltiorrhizae 48g, borneol 4g, Radix Codonopsis 27g, Rhizoma Chuanxiong 6g；
Preparation method: twice, 1 hour every time, filtration, merging filtrate was concentrated each bulk pharmaceutical chemicals mixing and water adding refluxing extraction；Add
Enter conventional formulation auxiliary material, externally used paste is made.
Embodiment 9
Prescription: monkshood 19g, Radix Salviae Miltiorrhizae 15g, borneol 18g, Radix Codonopsis 6g, Rhizoma Chuanxiong 27g
Preparation method: twice, 1 hour every time, filtration merged filter for each bulk pharmaceutical chemicals mixing plus 70% ethanol solution refluxing extraction
Liquid, concentration；High speed centrifugation takes supernatant；Conventional formulation auxiliary material is added, external application cataplasm is made.
Embodiment 10
Prescription: monkshood 6g, Radix Salviae Miltiorrhizae 40g, borneol 6g, Radix Codonopsis 20g, Rhizoma Chuanxiong 10g；
Preparation method: twice, each 40min, filtration merges filter for each bulk pharmaceutical chemicals mixing plus 70% ethanol solution ultrasonic extraction
Liquid, concentration；High speed centrifugation takes supernatant；Conventional formulation auxiliary material is added, external application cataplasm is made.
Embodiment 11
Prescription: monkshood 15g, Radix Salviae Miltiorrhizae 20g, borneol 15g, Radix Codonopsis 10g, Rhizoma Chuanxiong 20g；
Preparation method: each bulk pharmaceutical chemicals crush, and are added after yellow rice wine stirs evenly and navel patch herbal cake is made, be put into the application bag made
Sealing.
Embodiment 12
Prescription: monkshood 17g, Radix Salviae Miltiorrhizae 18g, borneol 17g, Radix Codonopsis 7g, Rhizoma Chuanxiong 25g；
Preparation method: each bulk pharmaceutical chemicals mixing and water adding decocts twice, and 1 hour every time, filtration, merging filtrate, concentration；High speed from
The heart takes supernatant；Conventional formulation auxiliary material is added, external use plaster is made.
Embodiment 13
Prescription: monkshood 5g, Radix Salviae Miltiorrhizae 45g, borneol 5g, Radix Codonopsis 25g, Rhizoma Chuanxiong 7g；
Preparation method: twice, 1 hour every time, filtration, merging filtrate was concentrated each bulk pharmaceutical chemicals mixing and water adding refluxing extraction；Add
Enter conventional formulation auxiliary material, externally used paste is made.
Embodiment 14
Prescription: monkshood extract 10g, Salvia root P.E 30g, borneol 10g, Radix Codonopsis extract 15g, Rhizoma Chuanxiong extract 15g；
The extract is respectively the water extract of each bulk pharmaceutical chemicals；
Preparation method: each bulk pharmaceutical chemicals crush, and are added after yellow rice wine stirs evenly and navel patch herbal cake is made, be put into the application bag made
Sealing.
Embodiment 15
Prescription: monkshood extract 8g, Salvia root P.E 35g, borneol 8g, Radix Codonopsis extract 18g, Rhizoma Chuanxiong extract 12g；Institute
State 70% ethanol extract that extract distinguishes each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 16
Prescription: monkshood extract 12g, Salvia root P.E 25g, borneol 12g, Radix Codonopsis extract 12g, Rhizoma Chuanxiong extract 18g；
The extract distinguishes 90% ethanol extract of each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 17
Prescription: monkshood extract 6g, Salvia root P.E 40g, borneol 6g, Radix Codonopsis extract 20g, Rhizoma Chuanxiong extract 10g；Institute
State 50% ethanol extract that extract distinguishes each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 18
Prescription: monkshood extract 15g, Salvia root P.E 20g, borneol 15g, Radix Codonopsis extract 10g, Rhizoma Chuanxiong extract 20g；
The extract distinguishes the water extract of each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 19
Prescription: monkshood extract 17g, Salvia root P.E 18g, borneol 17g, Radix Codonopsis extract 7g, Rhizoma Chuanxiong extract 25g；
The extract distinguishes the water extract of each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 20
Prescription: monkshood extract 5g, Salvia root P.E 45g, borneol 5g, Radix Codonopsis extract 25g, Rhizoma Chuanxiong extract 7g；Institute
State 50% ethanol extract that extract distinguishes each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 21
Prescription: monkshood extract 7g, Salvia root P.E 38g, borneol 7g, Radix Codonopsis extract 19g, Rhizoma Chuanxiong extract 11g；Institute
State 75% ethanol extract that extract distinguishes each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 22
Prescription: monkshood extract 14g, Salvia root P.E 22g, borneol 14g, Radix Codonopsis extract 11g, Rhizoma Chuanxiong extract 19g；
The extract distinguishes the water extract of each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 23
Prescription: monkshood extract 5g, Salvia root P.E 42g, borneol 6g, Radix Codonopsis extract 24g, Rhizoma Chuanxiong extract 8g；Institute
State 90% ethanol extract that extract distinguishes each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 24
Prescription: monkshood extract 16g, Salvia root P.E 18g, borneol 16g, Radix Codonopsis extract 7g, Rhizoma Chuanxiong extract 24g；
The extract distinguishes 50% ethanol extract of each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 25
Prescription: monkshood extract 4g, Salvia root P.E 48g, borneol 4g, Radix Codonopsis extract 27g, Rhizoma Chuanxiong extract 6g；Institute
State the water extract that extract distinguishes each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
Embodiment 26
Prescription: monkshood extract 19g, Salvia root P.E 15g, borneol 18g, Radix Codonopsis extract 6g, Rhizoma Chuanxiong extract 27g；
The extract distinguishes 70% ethanol extract of each bulk pharmaceutical chemicals；
The preparation method is the same as that of Example 14.
External preparation prepared by above embodiments 2- embodiment 26 has by treatment irritable bowel syndrome and improves wherein
Cure the effect of syndrome.
Claims (10)
1. a kind of Chinese medicine composition of external curing irritable bowel syndrome, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition
It include: monkshood, Radix Salviae Miltiorrhizae, borneol, Radix Codonopsis, Rhizoma Chuanxiong.
2. Chinese medicine composition as described in claim 1, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: attached
Sub- 3-20 parts by weight, Radix Salviae Miltiorrhizae 15-50 parts by weight, borneol 3-20 parts by weight, Radix Codonopsis 5-30 parts by weight, Rhizoma Chuanxiong 5-30 parts by weight；
Or, monkshood 5-17 parts by weight, Radix Salviae Miltiorrhizae 18-45 parts by weight, borneol 5-17 parts by weight, Radix Codonopsis 7-25 parts by weight, Rhizoma Chuanxiong 7-25
Parts by weight；
Or, the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: monkshood 6-15 parts by weight, Radix Salviae Miltiorrhizae 20-40 parts by weight, borneol 6-15 weight
Measure part, Radix Codonopsis 10-20 parts by weight, Rhizoma Chuanxiong 10-20 parts by weight.
3. Chinese medicine composition as claimed in claim 2, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: attached
Sub 10 parts by weight, 30 parts by weight of Radix Salviae Miltiorrhizae, 10 parts by weight of borneol, 15 parts by weight of Radix Codonopsis, 15 parts by weight of Rhizoma Chuanxiong；
Or, 8 parts by weight of monkshood, 35 parts by weight of Radix Salviae Miltiorrhizae, 8 parts by weight of borneol, 18 parts by weight of Radix Codonopsis, 12 parts by weight of Rhizoma Chuanxiong；
Or, 12 parts by weight of monkshood, 25 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of borneol, 12 parts by weight of Radix Codonopsis, 18 parts by weight of Rhizoma Chuanxiong.
4. the preparation method of Chinese medicine composition as described in claim any one of 1-3, which is characterized in that the method are as follows: by than
Example takes each bulk pharmaceutical chemicals, crushes or routinely extracting method is extracted with water or organic solvent, routinely preparation process is prepared into external application
Preparation.
5. preparation method as claimed in claim 4, which is characterized in that the exterior-applied formulation includes patch, cataplasm, ointment
Agent, plaster, gelling agent, liniment, lotion or plastics.
6. a kind of Chinese medicine composition of external curing irritable bowel syndrome, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition
Composition are as follows: monkshood extract 3-20 parts by weight, Salvia root P.E 15-50 parts by weight, borneol 3-20 parts by weight, Radix Codonopsis extract 5-
30 parts by weight, Rhizoma Chuanxiong extract 5-30 parts by weight.
7. Chinese medicine composition as claimed in claim 6, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: attached
Seed extract 5-17 parts by weight, Salvia root P.E 18-45 parts by weight, borneol 5-17 parts by weight, Radix Codonopsis extract's 7-25 parts by weight,
Rhizoma Chuanxiong extract 7-25 parts by weight；
Or, monkshood extract 6-15 parts by weight, Salvia root P.E 20-40 parts by weight, borneol 6-15 parts by weight, Radix Codonopsis extract
10-20 parts by weight, Rhizoma Chuanxiong extract 10-20 parts by weight.
8. Chinese medicine composition as claimed in claim 7, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: attached
10 parts by weight of seed extract, 30 parts by weight of Salvia root P.E, 10 parts by weight of borneol, 15 parts by weight of Radix Codonopsis extract, Rhizoma Chuanxiong extract
15 parts by weight of object；
Or, 8 parts by weight of monkshood extract, 35 parts by weight of Salvia root P.E, 8 parts by weight of borneol, 18 parts by weight of Radix Codonopsis extract, river
12 parts by weight of rhizome of chuanxiong extract；
Or, 12 parts by weight of monkshood extract, 25 parts by weight of Salvia root P.E, 12 parts by weight of borneol, 12 parts by weight of Radix Codonopsis extract,
18 parts by weight of Rhizoma Chuanxiong extract.
9. such as the described in any item Chinese medicine compositions of claim 6-8, which is characterized in that the extract is the water of each bulk pharmaceutical chemicals
Extract or extractive with organic solvent or water extract/extractive with organic solvent pass through the purification that further polishing purification technique obtains
Object.
10. Chinese medicine composition is in the drug for preparing external curing irritable bowel syndrome as described in any one of claim 1-3,6-8
In application.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810376882 | 2018-04-24 | ||
| CN201810376882X | 2018-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110393749A true CN110393749A (en) | 2019-11-01 |
Family
ID=68322450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910166485.4A Pending CN110393749A (en) | 2018-04-24 | 2019-03-05 | A kind of Chinese medicine composition of external curing irritable bowel syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110393749A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110882308A (en) * | 2019-12-16 | 2020-03-17 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for treating irritable bowel syndrome and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| CN1939477A (en) * | 2006-09-27 | 2007-04-04 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Chinese-medicinal composition for treating enterogastric diseases |
| CN102430075A (en) * | 2008-12-24 | 2012-05-02 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof |
| CN105250417A (en) * | 2015-11-19 | 2016-01-20 | 扈国杰 | Pharmaceutical composition for treating diarrheic type irritable bowel syndrome and application thereof |
-
2019
- 2019-03-05 CN CN201910166485.4A patent/CN110393749A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| CN1939477A (en) * | 2006-09-27 | 2007-04-04 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Chinese-medicinal composition for treating enterogastric diseases |
| CN102430075A (en) * | 2008-12-24 | 2012-05-02 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof |
| CN105250417A (en) * | 2015-11-19 | 2016-01-20 | 扈国杰 | Pharmaceutical composition for treating diarrheic type irritable bowel syndrome and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 丁茉兰，等: "中西医结合治疗肠易激综合征28例", 《实用中医药杂志》 * |
| 李依洁，等: "穴位贴敷疗法防治消化系统疾病经验体会", 《河北中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110882308A (en) * | 2019-12-16 | 2020-03-17 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for treating irritable bowel syndrome and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100518807C (en) | A Medicine for treatment of ascites due to cirrhosis | |
| CN102988821B (en) | Chinese medicine composition for treating carcinomatosis postoperation, postchemotherapy and postradiotherapy and preparation method of Chinese medicine composition | |
| CN103007206A (en) | Oral liquid for treating chronic atrophic gastritis | |
| CN101716318B (en) | Traditional Chinese medicine preparation for treating tumor of digestive system | |
| CN101711848B (en) | Chinese medicinal composition capable of adjunctively treating tumour | |
| CN1660395A (en) | Formula of treating apoplexy | |
| CN102198203B (en) | Traditional Chinese medicine for treating nonalcoholic fatty liver diseases | |
| CN103341092A (en) | Preparation method of powder for treating atrophic vaginitis | |
| CN110393749A (en) | A kind of Chinese medicine composition of external curing irritable bowel syndrome | |
| CN104547902A (en) | Application of traditional Chinese preparation in preparation of drugs used for treating chronic enteritis and appendicitis | |
| CN101564464A (en) | Chinese medicament for adjusting organism immunity of tumor patients | |
| CN104436048A (en) | Use of traditional Chinese medicine preparation in preparation of medicine for treating qi stagnation and blood stasis type chloasma | |
| CN105250954B (en) | A kind of Chinese medicine for treating IBS and preparation method thereof | |
| CN105012793A (en) | Preparation method of skin-wash liquid for treating vulvar cell hyperplasia | |
| CN103585449A (en) | Traditional Chinese medicine composition for treating migraine | |
| CN103301353A (en) | Pharmaceutical composition for treating atrophic vaginitis | |
| CN100394976C (en) | Chinese medicine for withdrawal of drug dependence | |
| CN101940758A (en) | Traditional Chinese medicinal composition for treating liver diseases, preparation method thereof and application thereof | |
| CN105012552A (en) | Traditional Chinese medicine for treating wind-prevailing migratory arthralgia type rheumatic arthritis and preparation method | |
| CN111870650A (en) | Dong minority medicinal liquor and preparation method thereof | |
| CN104398920A (en) | Drug for consolidating effects of radiotherapy and chemotherapy of cervical cancer and preparation method of drug | |
| CN104840864B (en) | A kind of Chinese medicine preparation for the treatment of infantile spleen deficiency type diarrhoea | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method | |
| CN102846794A (en) | Medicine composition for treating cancer and preparation method thereof | |
| CN102961662B (en) | Medicine for treating gastric ulcer and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20191101 |
|
| WD01 | Invention patent application deemed withdrawn after publication |