CN110389197A - A kind of measuring device and measuring method of exhaled gas concentration - Google Patents
A kind of measuring device and measuring method of exhaled gas concentration Download PDFInfo
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- CN110389197A CN110389197A CN201810359986.XA CN201810359986A CN110389197A CN 110389197 A CN110389197 A CN 110389197A CN 201810359986 A CN201810359986 A CN 201810359986A CN 110389197 A CN110389197 A CN 110389197A
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- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000005070 sampling Methods 0.000 claims abstract description 27
- 238000004458 analytical method Methods 0.000 claims abstract description 20
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 239000007789 gas Substances 0.000 claims description 168
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical group O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 36
- 230000008569 process Effects 0.000 claims description 26
- 238000012360 testing method Methods 0.000 claims description 19
- 238000004891 communication Methods 0.000 claims description 17
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 claims description 10
- 238000000691 measurement method Methods 0.000 claims description 9
- 238000003745 diagnosis Methods 0.000 claims description 7
- 238000007639 printing Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- 210000000664 rectum Anatomy 0.000 claims description 4
- 230000035945 sensitivity Effects 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 210000003928 nasal cavity Anatomy 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims 1
- 230000005611 electricity Effects 0.000 claims 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 8
- 239000003814 drug Substances 0.000 abstract description 4
- 238000007619 statistical method Methods 0.000 abstract 1
- 230000009123 feedback regulation Effects 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000011897 real-time detection Methods 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000005085 air analysis Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0037—NOx
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/004—CO or CO2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0044—Sulphides, e.g. H2S
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/005—H2
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides a kind of measuring device and measuring method of exhaled gas concentration, including shell, enclosure interior is equipped with the gas path module and control module communicated with each other, handhold part is connected on the shell, housing side is equipped with dismountable placing part, the shell other side is provided with ventilating part, and shell is connected with by a hose and can be made of with the expiration entrance of human contact, the gas path module sampling module and analysis module；The sampling module includes sequentially connected flow controller, triple valve one, gas buffer region, flow detector two and aspiration pump one.The present invention improves the success rate and accuracy of exhaled gas measurement of concetration, and acquires and handle by the data that big data platform measures all appts, to realize personalized medicine and the statistical analysis to similar disease.
Description
Technical field
The present invention relates to gas analysis field, specially a kind of measuring device and measuring method of exhaled gas concentration.
Background technique
Diagnosis patient's illnesses can be assisted by the measurement of characteristics of contaminated respiratory droplets gas componant and its concentration, monitor disease
Diseased state and observation therapeutic effect etc..
Expiration nitric oxide for inflammation in respiratory system diagnosis and monitoring, this is because endogenous gas signaling molecule NO
It is decomposed and is generated by cortex cell arginine deamination, the pro-inflammatory cytokines such as infection, allergy, wound can be by increasing inductivity
The expression of NO synzyme and cause NO concentration to significantly rise, and can be quantitative determined by expired air analysis.Pulmonary inflammatory disease is led
Cause that eNO is increased has: bronchial asthma, upper respiratory tract infection, bronchiectasis, fibrosing alveolitis.And exhaled NO
Concentration has significant decrease during steroid therapy, this has eNO detection means potentially in monitoring lung inflammation
Value.
Patent No. ZL201510880965.9 " a kind of measuring device of expiration nitric oxide and carbonomonoxide concentration " at present
Patent in, have associated description to the measuring device of Exhaled nitric oxide before, but have the following problems in this patent:
1) patent requirements user of service is when exhaling, from its expiratory gas flow of main regulation to meet preset flow, but expiratory gas flow
Generally in 200 ~ 300ml/s, and preset flow is 50ml/s, and user of service is needed deliberately to control respiration rate, and success rate is lower,
Poor user experience, and during multiple adjustment exhales and reaches preset flow, airway physiology state changes, test knot
Fruit accidental error increases, moreover, clinically more difficult for the exhalation test of respiratory system patient and child；
2) flow of aspiration pump one and aspiration pump two is not monitored in the patent, since the gas in characteristics of contaminated respiratory droplets gas is dense
Spend very low, mostly ppm or ppb(10-6Or 10-9) magnitude, during sampling and analysis, flowing gas state can direct shadow
Ring final measurement result；
3) in the prior art, single machine is not all connect with background server or big data platform, since the personalization of human body is poor
Different, the result of single measurement is difficult to provide accurate assessment to the health status of the user of service, is unfavorable for diagnosing it
And treatment；
4) in the prior art, data processing relies on operator and is summarized according to more instruments to the test result of a large amount of personnel
And statistics, it acquires similar Disease and grouies busy the initial data of outlet, then carry out data analysis, this method acquires data sample
Amount work take time and effort, and and do not have statistical significance, be unfavorable for medicine and the disease be compared, analyze and is studied.
Summary of the invention
Present invention seek to address that above-mentioned items problem, improves the success rate and accuracy of exhaled gas measurement of concetration, and lead to
It crosses the data that big data platform measures all appts to acquire and handle, to realize personalized medicine and the system to similar disease
Count credit analysis.
To achieve the goals above, the present invention provides a kind of measuring device of exhaled gas concentration, including shell 1, shells
It is equipped with the gas path module 10 and control module 20 communicated with each other inside body 1, is connected with handhold part 2,1 side of shell on the shell 1
Face is equipped with dismountable placing part 3, and 1 other side of shell is provided with ventilating part 4, and shell 1 is connected with and can be connect with human body by a hose 6
The expiration entrance 5 of touching.
Further, the gas path module 10 is made of sampling module 11 and analysis module 12；The sampling module 11 includes
Sequentially connected flow controller 101, triple valve 1, gas buffer region 104, aspiration pump 1, the flow controller
It is connected with flow detector 1 on 101, is connected with flow detector 2 107 on the aspiration pump 1, described three
One 103 normal open both ends of port valve connect flow controller 101 and atmosphere, and the switched path both ends of triple valve 1 connect flow control
Device 101 processed and gas buffer region 104, the branch road between the gas buffer region 104 and aspiration pump 1 are equipped with solenoid valve
105；The analysis module 12 include sequentially connected gas buffer region 104, triple valve 2 108, gas humidity adjuster 110,
Aspiration pump 2 111, gas concentration sensor 113；The 2 108 normal open both ends of triple valve connect 104 front end of gas buffer region, gas
The switched path both ends of body humidistat 110, triple valve 2 108 connect pneumatic filter 109, gas humidity adjuster 110,
The aspiration pump 2 111 is connected with flow detector 3 112.
Further, the gas concentration sensor can be nitric oxide sensor, carbon monoxide transducer, hydrogen or sulphur
Change hydrogen sensor.
Further, the control module 20 includes master control borad 21, and master control borad 21 is equipped with for driving flow controller
First driver 22, for driving the third driver 24 of aspiration pump two, is used for driving the second driver 23 of aspiration pump one
In the communication unit 25 communicated with other terminal devices 30, the storage unit for cache test result.
Further, the communication unit 25 includes the USB unit communicated with PC computer 31, with mobile phone 32 or tablet computer 33
The WIFI unit of communication, the mobile network's unit communicated with background server 34.
The present invention also provides a kind of measurement method of exhaled gas concentration, step includes:
1) when user of service exhales beginning, flow controller 101, solenoid valve 104, flow detector sampling process: are opened
One 102 real-time detection expiratory gas flows, and flow controller 101 is transferred data to, flow controller 101 is by the data and presets
Target expiratory gas flow be compared, and in time adjust flow controller 101 latus rectum, guarantee that expiratory gas flow meets and preset
Flow, collect the exhaled gas under default constant flow in gas buffer region 104, when collecting gas and reaching preset vol, close
Close solenoid valve 105, flow controller 101；
2) analytic process: to sampling process 1) in collected gas when analyzing, open aspiration pump 2 111, gas made to exist
Passed sequentially through in analysis module triple valve 2 108, gas humidity adjuster 110, flow detector 3 112, aspiration pump 2 111,
Gas concentration sensor 113 reads the current value one that gas concentration sensor 113 measures, then switching three-way valve two, keeps gas logical
Cross pneumatic filter 109, triple valve 2 108, gas humidity adjuster 110, flow detector 3 112, aspiration pump 2 111, gas
Concentration sensors 113 read the current value two that gas concentration sensor measures；
3) concentration calculation: process of calculation analysis 2) in the difference of two current values that measures, divided by the spirit of gas concentration sensor
Sensitivity, as sampling process 1) in collected gas concentration；
4) result storage and printing: process 3) concentration results calculated and local data is stored in after tester's information association
In library, tester opens test result report in software and prints.
Further, when user of service's expiration starts, triple valve 1 is normally opened access, opens flow controller 102, this
When exhale be expelled directly out atmosphere, after the expiratory air of about 1-3 airway dead space volume capacity to be discharged, the first driver 22 is according to pre-
If flow carries out feedback regulation to flow controller, when expiration meets preset flow, the switching for opening triple valve 1 is logical
Solenoid valve 105 is opened on road, enters gas buffer region 104 so that exhaling, and when expiration is not up to preset flow, maintains triple valve
One 103 normally opened access, so that exhaling is discharged into atmosphere；User of service, which is repeated several times, to exhale, until expired volume is more than or equal to 2 times
Gas buffer region volume, close the flow controller 101, solenoid valve 105.
Further, the sampling process 1) it further include acquisition to nasal cavity gas or airbag gas, process are as follows: open flow
Under test gas acquisition is entered gas buffer region with the flow of 5 ~ 20ml/s by controller 101, solenoid valve 105 and aspiration pump 1
In, until the gas volume of acquisition is more than or equal to 2 times of gas buffer region volume.
It further, further include 4) big data processing: by the analytic process information of under test gas in user information and its expiration
The concentration information finally calculated is sent to background server or big data platform by communication unit, and big data platform is according to people
Body medical model analyzes the physical condition of user, carries out medical diagnosis on disease, records in conjunction with the treatment of user, provides profession
Personalized scheme.
Further, the aspiration pump 1 or aspiration pump 2 111 work according to preset flow, and are examined by flow
It surveys device 2 107 or flow detector 3 112 to detect its practical working flow, when detecting that real work flow is inclined
When difference is more than 3 ~ 10%, the control module is by the second driver 23 or third driver 24 respectively to aspiration pump one or pumping
The operating voltage of pump two is adjusted, so that the working flow of aspiration pump one or aspiration pump two meets preset flow.
Further, when the measuring device is communicated with mobile phone or tablet computer, process 3) concentration results calculated with
It after tester's information association, is cached in the storage unit together, when the measuring device is communicated with PC again, by this phase
Between all test record be uploaded in the database of PC, tester inquires in the software of the end PC and the report of printing test result.
A kind of measuring device and measuring method of exhaled gas concentration provided by the invention, it is real-time by flow detector
Expiratory gas flow is detected, and transfers data to flow controller, flow controller is by the data and preset target expiratory gas flow
It is compared, and adjusts the latus rectum of expiration pipeline in time, guarantee that expiratory gas flow meets preset flow, and pass through triple valve
One switching makes qualified exhale enter gas buffer region, until expired volume is more than or equal to 2 times of gas buffer region body
Product, the present invention does not need user of service and deliberately controls respiration rate, more friendly to the exhalation test of respiratory system patient and child
It is good, sampling success rate is also improved, user experience is strengthened, user of service's expiration state is more consistent, ensure that the accurate of result
Property.
The present invention is by increasing flow detector two and flow detector in aspiration pump one and two front end of aspiration pump
Three pairs of its practical working flows detect, and according to the real work flow detected, feed back to control module, and pass through second
Driver or third driver are respectively adjusted the operating voltage of aspiration pump one or aspiration pump two, so that aspiration pump one or pumping
The working flow of air pump two meets preset flow, maintains the stability of whole system class gas flowing, improves measurement accuracy.
The present invention passes through the concentration that by the analytic process information of under test gas in user information and its expiration and finally calculates
Information is sent to background server or big data platform by communication unit, and big data platform is according to human medical model, analysis
The physical condition of user carries out medical diagnosis on disease, records in conjunction with the treatment of user, provides the personalized scheme of profession.Together
When, cloud can also be handled and be analyzed to all collected data, be conducive to medicine and carried out statistics meaning to the disease
Comparison, analysis and research in justice.
The present invention can be communicated with mobile phone or tablet computer, for be hospitalized or handicapped crowd, can be by measuring device
With tablet computer or mobile phone, it is moved to tester at one's side, after being successfully tested, then measuring device is moved back to by PC computer, to knot
Fruit is stored and is printed, and does not have to reduce the accuracy measured while expanding application range.
Detailed description of the invention
By reading the following detailed description of the preferred embodiment, various other advantages and benefits are common for this field
Technical staff will be apparent, be illustrated.The drawings are only for the purpose of illustrating a preferred embodiment, and is not considered as to the present invention
Limitation.And throughout the drawings, the same reference numbers will be used to refer to the same parts.In the accompanying drawings:
Fig. 1 is measuring device overall structure diagram of the invention.
Fig. 2 is measuring device overall structure side schematic view of the invention.
Fig. 3 is the function simplified schematic diagram of measuring device of the invention.
Fig. 4 is the schematic internal view of measuring device of the invention.
Fig. 5 is another schematic internal view of measuring device of the invention.
Fig. 6 is the flow chart of measurement method of the invention.
Fig. 7 is another flow chart of measurement method of the invention.
Specific embodiment
The illustrative embodiments of the disclosure are more fully described below with reference to accompanying drawings.Although showing this public affairs in attached drawing
The illustrative embodiments opened, it being understood, however, that may be realized in various forms the disclosure without the reality that should be illustrated here
The mode of applying is limited.It is to be able to thoroughly understand the disclosure on the contrary, providing these embodiments, and can be by this public affairs
The range opened is fully disclosed to those skilled in the art.
As shown in Fig. 1 ~ 3, the present invention proposes a kind of measuring device of exhaled gas concentration, including shell 1, inside shell 1
It is constituted equipped with the gas path module 10, control module 20 and terminal 30 communicated with each other, is connected with handhold part 2, shell on the shell 1
1 side is equipped with dismountable placing part 3, and 1 other side of shell is provided with ventilating part 4, and shell 1 is connected with by a hose 6 can be with people
The expiration entrance 5 of body contact.
A kind of embodiment according to the present invention, as shown in figure 4, gas path module 10 is by sampling module 11 and analysis module 12
It constitutes, exhaled gas passes sequentially through flow controller 101, triple valve 1,104 and of gas buffer region in sampling module 11
Aspiration pump 1, wherein flow controller 101 is equipped with flow detector 1, and the normal open both ends of triple valve 1 connect
Connect flow controller 101 and atmosphere, the switched path both ends connection flow controller 101 of triple valve 1 and gas buffer region
104, the branch road between gas buffer region 104 and aspiration pump 1 is equipped with solenoid valve 105, and aspiration pump 1 is equipped with flow
Detection device 2 107；Analysis module 12 includes the triple valve 2 108 connecting with gas buffer region 104, triple valve 2 108 it is normal
Logical both ends connection 104 front end of gas buffer region and gas humidistat 110, the switched path both ends connection of triple valve 2 108
Pneumatic filter 109 and gas humidistat 110,110 rear end of gas humidity adjuster are connected with 2 111 He of aspiration pump in turn
Nitric oxide concentration sensor 113 is additionally provided with flow detector 3 112 on aspiration pump 2 111.
The master control borad 21 of control module 20 is equipped with the first driver 22 for driving flow controller, takes out for driving
Second driver 23 of air pump one, for driving the third driver 24 of aspiration pump two, for other terminal equipment in communication
Communication unit 25.
Communication unit 25 includes the USB unit communicated with PC31, the WIFI unit with 33 compunlcation of mobile phone 32 or plate,
The mobile network's unit communicated with background server 34.
In order to realize a kind of measuring device of above-mentioned exhaled gas concentration, a kind of measurement of exhaled gas concentration is additionally provided
Method, this method comprises:
1) when user of service exhales beginning, flow controller 101, solenoid valve 105, flow detector sampling process: are opened
One 102 real-time detection expiratory gas flows, and flow controller 101 is transferred data to, flow controller 101 is by the data and presets
Target expiratory gas flow be compared, and in time adjust expiration pipeline latus rectum, guarantee that expiratory gas flow meets preset stream
Amount collects the exhaled gas under default constant flow in gas buffer region, when acquisition gas reaches preset vol, closes solenoid valve
105, flow controller 101；
2) analytic process: to sampling process 1) in collected gas when analyzing, open aspiration pump 2 111, gas made to exist
Passed sequentially through in analysis module triple valve 2 108, gas humidity adjuster 110, flow detector 3 112, aspiration pump 2 111,
Gas concentration sensor 113 reads the current value one that nitric oxide concentration sensor measures, then switching three-way valve 2 108, makes sky
Gas passes through pneumatic filter 109, triple valve 2 108, gas humidity adjuster 110, flow detector 3 112, aspiration pump two
111, the current value two that nitric oxide concentration sensor measures is read in gas concentration sensor 113；
3) concentration calculation: process of calculation analysis 2) in the difference of two current values that measures, divided by nitric oxide concentration sensor
Sensitivity, as sampling process 1) in collected nitric oxide concentration.
4) big data is handled: by the analytic process information of nitric oxide gas in user information and its expiration and last calculating
Concentration information background server or big data platform are sent to by communication unit, big data platform is according to human medical mould
Type analyzes the physical condition of user, carries out medical diagnosis on disease, records in conjunction with the treatment of user, provides the personalization of profession
Scheme.
When user of service starts to exhale by disposable filter tip 13, triple valve 1 is normally opened access, opens flow control
Device 101 processed exhales be expelled directly out atmosphere at this time, after the expiratory air of about 3 airway dead space volume capacities (about 100ml) to be discharged,
First driver 22 carries out feedback regulation to flow controller 101, when expiration meets default stream according to the preset flow of 50ml/s
When amount, opens the switched path of triple valve 1, opens solenoid valve 105, enter gas buffer region 104 so that exhaling, work as expiration
Not up to preset flow when, maintain triple valve 1 normally opened access so that exhale be discharged into atmosphere.User of service is repeated several times
It exhales, until expired volume is more than or equal to 2 times of gas buffer region volume, closing flow controller 102, solenoid valve 105, the gas
Volume buffer volume is about 50ml.
In 1) sampling in 2) analytic process, aspiration pump 2 111 works according to preset flow, and passes through flow detection
Device 3 112 detects its practical working flow, when detecting that real work flow deviation is more than 3%, the control mould
Block 20 is respectively adjusted the operating voltage of aspiration pump 2 111 by third driver 24, so that the work of aspiration pump 2 111
Flow meets preset flow, and the preset flow of the aspiration pump 2 111 in the present embodiment is 1.5ml/s.
Another embodiment according to the present invention, as shown in figure 5, gas path module 10 is by sampling module 11 and analysis module
12 are constituted, and exhaled gas passes sequentially through flow controller 101, triple valve 1, gas buffer region 104 in sampling module 11
With aspiration pump 1, wherein flow controller 101 is equipped with flow detector 1, the normal open both ends of triple valve 1
Connect flow controller 101 and atmosphere, the switched path both ends connection flow controller 101 and gas buffer of triple valve 1
Area 104, the branch road between gas buffer region 104 and aspiration pump 1 are equipped with solenoid valve 105, and aspiration pump 1 is equipped with stream
Amount detecting device 2 107；Analysis module 12 includes the triple valve 2 108 connecting with gas buffer region 104, triple valve 2 108
Normal open both ends connect 104 front end of gas buffer region and gas humidistat 110, and the switched path both ends of triple valve 2 108 connect
Pneumatic filter 109 and gas humidistat 110 are connect, the both ends of pneumatic filter 109 are separately connected 104 He of gas buffer region
Triple valve 2 108,110 rear end of gas humidity adjuster are connected with aspiration pump 2 111 and nitric oxide concentration sensor in turn
113, flow detector 3 112, the rear end of nitric oxide concentration sensor 113 and gas are additionally provided on aspiration pump 2 111
Buffer area 104 is connected.
The master control borad 21 of control module 20 is equipped with the first driver 22 for driving flow controller, takes out for driving
Second driver 23 of air pump one, for driving the third driver 24 of aspiration pump two, for other terminal equipment in communication
Communication unit 25.
Communication unit 25 includes the USB unit communicated with PC31, the WIFI unit with 33 compunlcation of mobile phone 32 or plate,
The mobile network's unit communicated with background server 34.
In order to realize a kind of measuring device of above-mentioned exhaled gas concentration, a kind of measurement of exhaled gas concentration is additionally provided
Method, this method comprises:
1) sampling process: flow controller 101, solenoid valve 105 and aspiration pump one are opened in the acquisition to nasal cavity gas or airbag gas
106, under test gas acquisition is entered in gas buffer region 104 with the flow of 10ml/s, acquisition time 10s；
2) analytic process: to sampling process 1) in collected gas when analyzing, open aspiration pump 2 111, gas made to exist
Passed sequentially through in analysis module triple valve 2 108, gas humidity adjuster 110, flow detector 3 112, aspiration pump 2 111,
Gas concentration sensor 113 is returned in gas buffer region 104, reads the current value one that nitric oxide concentration sensor measures,
Switching three-way valve 2 108 again, make the gas returned in gas buffer region 104 pass through again pneumatic filter 109, triple valve 2 108,
Gas humidity adjuster 110, flow detector 3 112, aspiration pump 2 111, gas concentration sensor 113 read nitric oxide
The current value two that concentration sensor measures；
3) concentration calculation: process of calculation analysis 2) in the difference of two current values that measures, divided by nitric oxide concentration sensor
Sensitivity, as sampling process 1) in collected nitric oxide concentration.
4) result storage and printing: process 3) concentration results calculated and local is stored in after tester's information association
In database, tester opens test result report in software and prints.
5) big data is handled: by the analytic process information of nitric oxide gas in user information and its expiration and last calculating
Concentration information background server or big data platform are sent to by communication unit, big data platform is according to human medical mould
Type analyzes the physical condition of user, carries out medical diagnosis on disease, records in conjunction with the treatment of user, provides the personalization of profession
Scheme.
When user of service starts to exhale by disposable filter tip 13, triple valve 1 is normally opened access, opens flow control
Device 101 processed exhales be expelled directly out atmosphere at this time, after the expiratory air of about 3 airway dead space volume capacities (about 100ml) to be discharged,
First driver 22 carries out feedback regulation to flow controller 101, when expiration meets default stream according to the preset flow of 50ml/s
When amount, opens the switched path of triple valve 1, opens solenoid valve 105, enter gas buffer region 104 so that exhaling, work as expiration
Not up to preset flow when, maintain triple valve 1 normally opened access so that exhale be discharged into atmosphere.User of service is repeated several times
It exhales, until expired volume is more than or equal to 2 times of gas buffer region volume, closing flow controller 102, solenoid valve 105, the gas
Volume buffer volume is about 50ml.
In 1) sampling in 2) analytic process, aspiration pump 1 or aspiration pump 2 111 work according to preset flow,
And its practical working flow is detected by flow detector 2 107 or flow detector 3 112, when detecting reality
When border working flow deviation is more than 3%, the control module 20 is by the second driver 23 or third driver 24 respectively to pumping
Pump 1 or the operating voltage of aspiration pump 2 111 be adjusted so that the working flow of aspiration pump 1 or aspiration pump 2 111
Meet preset flow, the flow of the aspiration pump 2 111 in the present embodiment is 1ml/s.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
In the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of by anyone skilled in the art,
It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention answers the protection model with claim
Subject to enclosing.
Claims (10)
1. a kind of measuring device of exhaled gas concentration, including shell, enclosure interior is equipped with the gas path module and control communicated with each other
Molding block, it is characterised in that: handhold part is connected on the shell, housing side is equipped with dismountable placing part, and shell is another
Side is provided with ventilating part, and shell is connected with by a hose can be with the expiration entrance of human contact.
2. a kind of measuring device of exhaled gas concentration as described in claim 1, it is characterised in that；The gas path module is by adopting
Egf block and analysis module are constituted；The sampling module includes sequentially connected flow controller, triple valve one, gas buffer
Area, aspiration pump one are connected with flow detector one on the flow controller, are connected with flow detection on the aspiration pump one
Device two, one normal open both ends of the triple valve connection flow controller and atmosphere, the switched path both ends connection flow of triple valve one
Amount controller and gas buffer region, the branch road between the gas buffer region and aspiration pump one are equipped with solenoid valve；The analysis
Module includes sequentially connected gas buffer region, triple valve two, gas humidity adjuster, aspiration pump two, gas concentration sensor；
The two normal open both ends of triple valve connect gas buffer region front end, gas humidity adjuster, the switched path both ends of triple valve two
Pneumatic filter, gas humidity adjuster are connected, the aspiration pump two is connected with flow detector three.
3. a kind of measuring device of exhaled gas concentration as described in claim 1, it is characterised in that: the gas concentration sensing
Device is nitric oxide sensor, carbon monoxide transducer, hydrogen or hydrogen sulfide sensor.
4. a kind of measuring device of exhaled gas concentration as described in claim 1, it is characterised in that: the control module includes
Master control borad, master control borad is equipped with the first driver for driving flow controller, for driving the second of aspiration pump one to drive
Device, for the communication unit with other terminal equipment in communication, is used for cache test for driving the third driver of aspiration pump two
As a result storage unit；The communication unit includes the USB unit communicated with PC or tablet computer, logical with mobile phone or tablet computer
The WIFI unit of letter, the mobile network's unit communicated with background server.
5. a kind of measurement method for exhaled gas apparatus for measuring concentration, it is characterised in that:
1) sampling process: when user of service exhales beginning, flow controller, solenoid valve are opened, flow detector one is real-time
Expiratory gas flow is detected, and transfers data to flow controller, flow controller is by the data and preset target expiratory gas flow
It is compared, and adjusts the latus rectum of flow controller in time, guarantee that expiratory gas flow meets preset flow, collect presetting
Exhaled gas under flow when collection gas reaches preset vol, closes solenoid valve, flow controller in gas buffer region；
2) analytic process: to sampling process 1) in collected gas when analyzing, open aspiration pump two, analyzing gas
Triple valve two, gas humidity adjuster, flow detector three, aspiration pump two, gas concentration sensor are passed sequentially through in module, are read
The current value one for taking gas concentration sensor to measure, then switching three-way valve two, pass the gas through pneumatic filter, triple valve two,
Gas humidity adjuster, flow detector three, aspiration pump two, gas concentration sensor read what gas concentration sensor measured
Current value two；
3) concentration calculation: process of calculation analysis 2) in the difference of two current values that measures, divided by the spirit of gas concentration sensor
Sensitivity, as sampling process 1) in collected gas concentration；
4) result storage and printing: process 3) concentration results calculated and local data is stored in after tester's information association
In library, tester opens test result report in software and prints.
6. a kind of measurement method for exhaled gas apparatus for measuring concentration as claimed in claim 5, it is characterised in that: use
When personnel's expiration starts, triple valve one is normally opened access, opens flow controller, exhales be expelled directly out atmosphere at this time, to be discharged
After the expiratory air of about 1-3 airway dead space volume capacity, the first driver feeds back flow controller according to preset flow
It adjusts, when expiration meets preset flow, opens the switched path of triple valve one, opens solenoid valve, enter gas so that exhaling
Buffer area maintains the normally opened access of triple valve one when expiration is not up to preset flow, so that exhaling is discharged into atmosphere；User
Member, which is repeated several times, to exhale, and until gas buffer region volume of the expired volume more than or equal to 2 times, closes the flow controller, electricity
Magnet valve.
7. a kind of measurement method for exhaled gas apparatus for measuring concentration as claimed in claim 5, it is characterised in that: described
Sampling process 1) it further include acquisition to nasal cavity gas or airbag gas, process are as follows: open flow controller, solenoid valve and pumping
Pump one, with the flow of 5 ~ 20ml/s by under test gas acquisition enter gas buffer region in, until acquisition gas volume be greater than etc.
In 2 times of gas buffer region volume.
8. a kind of measurement method for exhaled gas apparatus for measuring concentration as claimed in claim 5, it is characterised in that: also wrap
Include the processing of 4) big data: the concentration information by the analytic process information of under test gas in user information and its expiration and finally calculated
It is sent to background server or big data platform by communication unit, big data platform analyzes user according to human medical model
Physical condition, carry out medical diagnosis on disease, recorded in conjunction with the treatment of user, provide the personalized scheme of profession.
9. a kind of measurement method for exhaled gas apparatus for measuring concentration as claimed in claim 5, it is characterised in that: described
Aspiration pump one or aspiration pump two work according to preset flow, and right by flow detector two or flow detector three
Its practical working flow is detected, and when detecting that real work flow deviation is more than 3 ~ 10%, the control module passes through the
Two drivers or third driver are respectively adjusted the operating voltage of aspiration pump one or aspiration pump two so that aspiration pump one or
The working flow of aspiration pump two meets preset flow.
10. a kind of measurement method for exhaled gas apparatus for measuring concentration as claimed in claim 5, it is characterised in that: with
When mobile phone or tablet computer communicate, process 3) after the concentration results and tester's information association calculated, it is cached in institute together
It states in storage unit, when the measuring device is communicated with PC again, test record all during this is uploaded to the number of PC
According in library, tester inquires in the software of the end PC and the report of printing test result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810359986.XA CN110389197A (en) | 2018-04-20 | 2018-04-20 | A kind of measuring device and measuring method of exhaled gas concentration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810359986.XA CN110389197A (en) | 2018-04-20 | 2018-04-20 | A kind of measuring device and measuring method of exhaled gas concentration |
Publications (1)
| Publication Number | Publication Date |
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| CN110389197A true CN110389197A (en) | 2019-10-29 |
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ID=68283767
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810359986.XA Pending CN110389197A (en) | 2018-04-20 | 2018-04-20 | A kind of measuring device and measuring method of exhaled gas concentration |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114577861A (en) * | 2022-01-27 | 2022-06-03 | 苏州科技大学 | Gas detection device and method and storage medium |
| CN114652298A (en) * | 2022-05-26 | 2022-06-24 | 南京诺令生物科技有限公司 | Gas detection system and control method thereof |
| CN114814103A (en) * | 2022-04-28 | 2022-07-29 | 青岛华仁医疗用品有限公司 | Off-line exhaled gas nitric oxide detection device |
| WO2023155612A1 (en) * | 2022-02-16 | 2023-08-24 | 南京诺令生物科技有限公司 | Multi-respiratory-tract gas detection system and control method therefor |
| CN117347609A (en) * | 2023-12-04 | 2024-01-05 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit and expiration diagnostic apparatus |
| CN117347610A (en) * | 2023-12-04 | 2024-01-05 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit system and expiration sampling detection equipment |
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2018
- 2018-04-20 CN CN201810359986.XA patent/CN110389197A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114577861A (en) * | 2022-01-27 | 2022-06-03 | 苏州科技大学 | Gas detection device and method and storage medium |
| CN114577861B (en) * | 2022-01-27 | 2024-04-26 | 苏州科技大学 | Gas detection device, method and storage medium |
| WO2023155612A1 (en) * | 2022-02-16 | 2023-08-24 | 南京诺令生物科技有限公司 | Multi-respiratory-tract gas detection system and control method therefor |
| CN114814103A (en) * | 2022-04-28 | 2022-07-29 | 青岛华仁医疗用品有限公司 | Off-line exhaled gas nitric oxide detection device |
| CN114652298A (en) * | 2022-05-26 | 2022-06-24 | 南京诺令生物科技有限公司 | Gas detection system and control method thereof |
| CN114652298B (en) * | 2022-05-26 | 2022-08-23 | 南京诺令生物科技有限公司 | Gas detection system and control method thereof |
| CN117347609A (en) * | 2023-12-04 | 2024-01-05 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit and expiration diagnostic apparatus |
| CN117347610A (en) * | 2023-12-04 | 2024-01-05 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit system and expiration sampling detection equipment |
| CN117347609B (en) * | 2023-12-04 | 2024-03-22 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit and expiration diagnostic apparatus |
| CN117347610B (en) * | 2023-12-04 | 2024-03-26 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit system and expiration sampling detection equipment |
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Application publication date: 20191029 |