CN110382117B - 微芯片及微粒测量装置 - Google Patents

微芯片及微粒测量装置 Download PDF

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Publication number
CN110382117B
CN110382117B CN201880016751.9A CN201880016751A CN110382117B CN 110382117 B CN110382117 B CN 110382117B CN 201880016751 A CN201880016751 A CN 201880016751A CN 110382117 B CN110382117 B CN 110382117B
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China
Prior art keywords
substrate layer
microchip
cavity
substrate
flow channel
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Chinese (zh)
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CN110382117A (zh
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河西弘人
秋山昭次
高桥和也
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Sony Corp
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Sony Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201880016751.9A 2017-03-14 2018-02-27 微芯片及微粒测量装置 Active CN110382117B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017-049011 2017-03-14
JP2017049011A JP6922281B2 (ja) 2017-03-14 2017-03-14 マイクロチップ、及び微小粒子測定装置
PCT/JP2018/007158 WO2018168436A1 (en) 2017-03-14 2018-02-27 Microchip and microparticle measuring apparatus

Publications (2)

Publication Number Publication Date
CN110382117A CN110382117A (zh) 2019-10-25
CN110382117B true CN110382117B (zh) 2022-09-27

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CN201880016751.9A Active CN110382117B (zh) 2017-03-14 2018-02-27 微芯片及微粒测量装置

Country Status (5)

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US (2) US20200070152A1 (enExample)
EP (1) EP3595814B1 (enExample)
JP (1) JP6922281B2 (enExample)
CN (1) CN110382117B (enExample)
WO (1) WO2018168436A1 (enExample)

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US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
SG11201706777QA (en) 2015-02-19 2017-09-28 Premium Genetics (Uk) Ltd Scanning infrared measurement system
JP6919215B2 (ja) 2017-02-17 2021-08-18 ソニーグループ株式会社 マイクロチップ及び微小粒子分取装置
EP3796998A1 (en) 2018-05-23 2021-03-31 ABS Global, Inc. Systems and methods for particle focusing in microchannels
CN113260848B (zh) 2018-12-21 2025-04-01 Abs全球公司 亚群识别的系统和方法
EP3955735B1 (en) 2019-04-18 2024-05-22 ABS Global, Inc. System and process for continuous addition of cryoprotectant
US11628439B2 (en) * 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
CN116368237A (zh) 2020-10-21 2023-06-30 Abs全球股份有限公司 用于处理遗传样本以确定特性或检测污染的方法及系统
WO2022108840A1 (en) 2020-11-23 2022-05-27 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
USD1118965S1 (en) 2021-11-12 2026-03-17 Abs Global, Inc. Flow cytometry device
WO2023238564A1 (ja) * 2022-06-10 2023-12-14 ソニーグループ株式会社 情報処理システム、情報処理方法、情報処理装置、及びプログラム

Citations (5)

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CN101258397A (zh) * 2005-07-14 2008-09-03 毫微创新科技公司 微流装置和制备及使用方法
CN103717308A (zh) * 2011-08-03 2014-04-09 索尼公司 微芯片和微粒分析装置
CN105556279A (zh) * 2013-07-16 2016-05-04 普里米欧姆遗传学（英国）有限公司 微流体芯片
CN105659069A (zh) * 2013-10-16 2016-06-08 索尼公司 颗粒分取设备、颗粒分取方法与程序
CN105874316A (zh) * 2013-10-30 2016-08-17 普里米欧姆遗传学（英国）有限公司 具有聚焦能量装置的微流体系统和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2832117B2 (ja) * 1991-11-29 1998-12-02 キヤノン株式会社 サンプル測定デバイス及びサンプル測定システム
US7413709B2 (en) * 2003-02-12 2008-08-19 Agilent Technologies, Inc. PAEK-based microfluidic device with integrated electrospray emitter
JP5487638B2 (ja) * 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
JP2011237201A (ja) * 2010-05-06 2011-11-24 Sony Corp 微小粒子分取装置、マイクロチップ及びマイクロチップモジュール
JP5859974B2 (ja) * 2010-10-29 2016-02-16 コニカミノルタ株式会社 マイクロチップ、及びマイクロチップの製造方法
US8961904B2 (en) * 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101258397A (zh) * 2005-07-14 2008-09-03 毫微创新科技公司 微流装置和制备及使用方法
CN103717308A (zh) * 2011-08-03 2014-04-09 索尼公司 微芯片和微粒分析装置
CN105556279A (zh) * 2013-07-16 2016-05-04 普里米欧姆遗传学（英国）有限公司 微流体芯片
CN105659069A (zh) * 2013-10-16 2016-06-08 索尼公司 颗粒分取设备、颗粒分取方法与程序
CN105874316A (zh) * 2013-10-30 2016-08-17 普里米欧姆遗传学（英国）有限公司 具有聚焦能量装置的微流体系统和方法

Also Published As

Publication number Publication date
JP2018151319A (ja) 2018-09-27
US20200070152A1 (en) 2020-03-05
WO2018168436A1 (en) 2018-09-20
EP3595814B1 (en) 2025-07-30
JP6922281B2 (ja) 2021-08-18
US20230063086A1 (en) 2023-03-02
EP3595814A1 (en) 2020-01-22
CN110382117A (zh) 2019-10-25

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