CN110354302A - A kind of dressing for skin and preparation method thereof - Google Patents

A kind of dressing for skin and preparation method thereof Download PDF

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Publication number
CN110354302A
CN110354302A CN201910791823.3A CN201910791823A CN110354302A CN 110354302 A CN110354302 A CN 110354302A CN 201910791823 A CN201910791823 A CN 201910791823A CN 110354302 A CN110354302 A CN 110354302A
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CN
China
Prior art keywords
parts
water
skin
sodium hyaluronate
dressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910791823.3A
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Chinese (zh)
Inventor
杨鸣
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Wuhan Meixinkang Medical Equipment Co Ltd
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Wuhan Meixinkang Medical Equipment Co Ltd
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Priority to CN201910791823.3A priority Critical patent/CN110354302A/en
Publication of CN110354302A publication Critical patent/CN110354302A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines

Abstract

The present invention relates to medical treatment and nursing technical fields, disclose a kind of dressing for skin, by following mass fraction material composition preparation form: 15000 parts of lightweight water, 10 parts of macromolecular Sodium Hyaluronate, 10 parts of middle numerator sodium hyaluronate, 10 parts of micromolecule hyaluronic acid sodium, 5 parts of ceramide and 10 parts of micromolecular collagen, preparation process include: lightweight water produce, be pre-mixed, being mixed and preparing finished articles four step.The utility model has the advantages that dressing for skin provided by the invention effectively can form breathable films in skin surface so as to obstruct alien bacteria, dust and the erosion of ultraviolet light using macromolecular Sodium Hyaluronate; protect the skin from damage; numerator sodium hyaluronate firm skin in utilization; long-term moisturizing; effectively skin is retained using using micromolecule hyaluronic acid sodium, collagen and ceramide simultaneously; and the lightweight water in this product also can preferably promote blood circulation; accelerate metabolism; to keep skin elasticity, avoid having dry skin.

Description

A kind of dressing for skin and preparation method thereof
Technical field
The present invention relates to medical treatment and nursing technical field, specially a kind of dressing for skin and preparation method thereof.
Background technique
Li Shizhen (1518-1593 A.D.) Compendium of Material Medica: " La Xuegan is cold nontoxic, solves all poison.Gas pestilence when controlling day row, the hot epilepsy of children is mad to crow, Adult's borax starts, after drinking sudden-heat, and jaundice is still small to warmly take it.Hiding device wash mesh move back it is red;It simmers tea and cooks congee, it is antipyretic to quench the thirst." civil, People often store snow-broth with terrine in winter and put prickly heat on the skin to summer with this snow-broth, there is good curative effect.Snow-broth is red to curing Eye disease, skin scald, frostbite are all effective.Particularly with light patient, only need to apply for 3-4 hours washes it is primary, can not medication, 4-5 It can fully recover.If common snow-broth is had a bath, the resistance of skin can be enhanced, promote blood circulation, reduces disease.Through grinding Study carefully discovery snow-broth why there is said effect to be because the heavy water in snow-broth is fewer by 25% than the heavy water in light water, and heavy water It is inhibited to the metabolism and blood circulation of human body.Therefore it can use less containing heavy water as snow-broth Lightweight water is as basic raw material, and adding Sodium Hyaluronate, collagen and ceramide is that raw material is made dressing for skin and is used for Skin is maintained, to effectively improve the protecting effect to skin.
Summary of the invention
The purpose of the present invention is to provide a kind of dressing for skin and preparation method thereof, to solve to propose in above-mentioned background technique The problem of.
To achieve the above object, the invention provides the following technical scheme: a kind of dressing for skin, by the original of following mass fraction Expect into assignment system to form: 12000-18000 parts of lightweight water, 6-12 parts of macromolecular Sodium Hyaluronate, middle numerator sodium hyaluronate 6- 12 parts, 6-12 parts of micromolecule hyaluronic acid sodium, -7 parts of Cer NP and 5-12 parts of micromolecular collagen.
Preferably, be made of the material composition preparation of following mass fraction: 14000-16000 parts of lightweight water, macromolecular are saturating 8-10 parts of bright matter acid sodium, numerator sodium hyaluronate 8-10 parts middle, 8-10 parts of micromolecule hyaluronic acid sodium, 4-5 parts of ceramide and 6-10 parts of micromolecular collagen.
Preferably, it is made of the material composition preparation of following mass fraction: 15000 parts of lightweight water, macromolecular hyaluronic acid 10 parts of sodium, 10 parts of middle numerator sodium hyaluronate, 10 parts of micromolecule hyaluronic acid sodium, 5 parts of ceramide and micromolecular collagen 10 parts.
Preferably, what the lightweight water attached most importance to water constituent fewer than light water 25% manually produces water or natural snow water.
Preferably, the molecular weight ranges of the macromolecular Sodium Hyaluronate are 1800000 dalton to 2200000 dalton Between, and the molecular weight ranges of middle molecule matter acid sodium are 1000000 dalton between 1800000 dalton, the small molecule The molecular weight of Sodium Hyaluronate is 400000 dalton between 1000000 dalton.
Preferably, the micromolecular collagen is collagen of the molecular weight less than 2000 dalton.
A kind of preparation method of dressing for skin includes the following steps:
S1. lightweight water is produced: being taken pure water to be heated to 98 degrees Celsius to 100 degrees Celsius at normal atmospheric pressure, is selected preferential steam Preceding 3/4ths vapor of hair liquefies, and the water after liquefaction is then reheated to 98 degrees Celsius to 100 degrees Celsius, And preferentially evaporate preceding 3/4ths water is selected to liquefy again, after repeating this process again four to five times until will liquefy Water in heavy water constituent reduction can be obtained required lightweight water at least 25% degree fewer than light water, can also be direct Required lightweight water is obtained by melting qualified snow naturally;
S2. it is pre-mixed: selecting lightweight water 500ml, 1000mg micromolecule hyaluronic acid sodium is then added at normal temperature, concentration is made For the 500ml solution A of 2mg/ml;Lightweight water 500ml is selected, numerator sodium hyaluronate in 1000mg is then added at normal temperature, The 500ml solution B that concentration is 2mg/ml is made;Lightweight water 500ml is selected, it is transparent that 1000mg small molecule is then added at normal temperature The 500ml solution C that concentration is 2mg/ml is made in matter acid sodium;
S3. it is mixed: solution A, solution B and solution C is mixed and added into the micromolecular collagen of 1000mg at normal temperature It is stirred 3 minutes to 10 minutes using high-speed mixer, obtains solution D;
S4. preparing finished articles: being heated to 55 degrees Celsius for solution D, 500mg ceramide is then added and in 55 degrees Celsius of environment It is stirred 5 minutes to 15 minutes using high-speed mixer, obtains finished product.
Compared with prior art, the beneficial effects of the present invention are: dressing for skin provided by the invention can be utilized effectively Macromolecular Sodium Hyaluronate forms breathable films in skin surface so as to obstruct invading for alien bacteria, dust and ultraviolet light Erosion, protects the skin from damage, numerator sodium hyaluronate firm skin in utilization, long-term moisturizing, while utilizing small molecule Sodium Hyaluronate, collagen and ceramide are effectively retained skin, and the lightweight water in this product also can be more Good promotes blood circulation, and accelerates metabolism, to keep skin elasticity, avoids having dry skin.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the technical solution in the present invention, this field is general Logical technical staff every other embodiment obtained without making creative work belongs to what the present invention protected Range.
The present invention provides a kind of technical solution: a kind of dressing for skin, is made of the material composition preparation of following mass fraction: 15000 parts of lightweight water, 10 parts of macromolecular Sodium Hyaluronate, 10 parts of middle numerator sodium hyaluronate, 10 parts of micromolecule hyaluronic acid sodium, 5 parts and 10 parts of micromolecular collagen of ceramide;
The lightweight water attach most importance to water constituent fewer than light water 25% manually produce water or natural snow water, the macromolecular is transparent The molecular weight ranges of matter acid sodium are 1800000 dalton between 2200000 dalton, and the molecular weight model of middle molecule matter acid sodium It encloses for 1000000 dalton between 1800000 dalton, the molecular weight of the micromolecule hyaluronic acid sodium is 400000 dongles Pause between 1000000 dalton, the micromolecular collagen is collagen of the molecular weight less than 2000 dalton.
A kind of preparation method of dressing for skin, includes the following steps:
S1. lightweight water is produced: take pure water to be heated to 99 degrees Celsius at normal atmospheric pressure, select preferentially evaporate preceding four/ Three vapor liquefies, and the water after liquefaction is then reheated to 99 degrees Celsius, and before selecting and preferentially evaporating again 3/4ths water liquefies, repeat this process four to five times again until the heavy water constituent reduction in water after liquefying extremely At least 25% degree fewer than light water can be obtained required lightweight water, can also be directly by melting qualified nature Snow is to obtain required lightweight water;
S2. it is pre-mixed: selecting lightweight water 500ml, 1000mg micromolecule hyaluronic acid sodium is then added at normal temperature, concentration is made For the 500ml solution A of 2mg/ml;Lightweight water 500ml is selected, numerator sodium hyaluronate in 1000mg is then added at normal temperature, The 500ml solution B that concentration is 2mg/ml is made;Lightweight water 500ml is selected, it is transparent that 1000mg small molecule is then added at normal temperature The 500ml solution C that concentration is 2mg/ml is made in matter acid sodium;
S3. it is mixed: solution A, solution B and solution C is mixed and added into the micromolecular collagen of 1000mg at normal temperature It is stirred 6 minutes using high-speed mixer, obtains solution D;
S4. preparing finished articles: being heated to 55 degrees Celsius for solution D, 500mg ceramide is then added and in 55 degrees Celsius of environment It is stirred 10 minutes using high-speed mixer, obtains finished product.
The dressing for skin that the present invention produces is mainly using lightweight water, Sodium Hyaluronate, collagen and ceramide as raw material It is made, absorption of the skin to moisture can be effectively promoted.Wherein lightweight water is the water or logical after the snow thawing in nature The water less containing heavy water ingredient of product in laboratory is crossed, experimental study shows that the heavy water ingredient contained in snow-broth compares light water In few 25%, and heavy water plays the role of inhibition to the metabolism and blood circulation of human body, therefore using snow-broth or uses people The same lightweight water energy few containing heavy water ingredient that work is produced enough effectively reduces the damage to human body.It is utilized in the present invention general The boiling point difference of protium water in water flowing and heavy water produces lightweight water, and wherein the boiling point of protium water is about 100 degrees Celsius and heavy water Boiling point is 101.431 degrees Celsius, thus by allowing protium water first to boil between 98 degrees Celsius and 100 degrees Celsius temperature control And the mode being collected removes heavy water, thus lightweight water required for obtaining, when using melt nature avenge come or lightweight water When then preferably select accumulated snow middle layer, avoid snow deposit upper and lower impurity pollute raw material.Molecular weight ranges are 1800000 dalton Macromolecular Sodium Hyaluronate to 2200000 dalton can make skin smooth in skin surface one layer of ventilative film of formation It is wet, and the erosion of alien bacteria, dust and ultraviolet light can be obstructed, protect the skin from damage;Molecular weight ranges are The middle numerator sodium hyaluronate of 1000000 dalton to 1800000 dalton can firm skin, long-term moisturizing;Molecular weight model The micromolecule hyaluronic acid sodium enclosed for 400000 dalton to 1000000 dalton can penetrate into corium, have mild dilation hair Thin blood vessel, the effect for increasing blood circulation, improving skin aging.Ceramide is a kind of water-soluble lipid matter, can be penetrated into Reticular structure is formed in skin in conjunction with the water in skin and cuticula so as to effectively play the role of moisturizing water lock, and And the effect that ceramide can also effectively prevent anaphylaxis dermatosis and melanin element foxiness is inhibited to generate, along with the age Growth, the ceramide in human body gradually decreases, is easier to become dry skin and pachylosis so as to cause the middle-aged and the old, This product can sufficiently supplement required ceramide by being applied with part mode, while the collagen in this product can also have Effect plays the role of water conservation and recovery skin elasticity.This product was using 25 years old to 35 years old crowd as subjects, by six months Test after discovery carry out skin nursing using this product participation testing crew skin relative usage before obtain good skin Matter improves, and not only dry skin is eliminated but also skin is more flexible, while melanin deposition phenomenon has also obtained good suppression System has significant using effect.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (7)

1. a kind of dressing for skin, which is characterized in that be made of the material composition preparation of following mass fraction:
12000-18000 parts of lightweight water, 6-12 parts of macromolecular Sodium Hyaluronate, numerator sodium hyaluronate 6-12 parts middle, small molecule 6-12 parts of Sodium Hyaluronate, -7 parts of Cer NP and 5-12 parts of micromolecular collagen.
2. a kind of dressing for skin according to claim 1, which is characterized in that prepared by the material composition of following mass fraction Composition: 14000-16000 parts of lightweight water, 8-10 parts of macromolecular Sodium Hyaluronate, numerator sodium hyaluronate 8-10 parts middle, small molecule 8-10 parts of Sodium Hyaluronate, 4-5 parts of ceramide and 6-10 parts of micromolecular collagen.
3. a kind of dressing for skin according to claim 1, which is characterized in that prepared by the material composition of following mass fraction Composition: 15000 parts of lightweight water, 10 parts of macromolecular Sodium Hyaluronate, 10 parts of middle numerator sodium hyaluronate, micromolecule hyaluronic acid sodium 10 parts, 5 parts of ceramide and 10 parts of micromolecular collagen.
4. a kind of dressing for skin according to claim 1, it is characterised in that: lightweight water water constituent of attaching most importance to compares light water Few 25% manually produces water or natural snow water.
5. a kind of dressing for skin according to claim 1, it is characterised in that: the molecular weight of the macromolecular Sodium Hyaluronate Range is 1800000 dalton between 2200000 dalton, and the molecular weight ranges of middle molecule matter acid sodium are 1000000 For Er Dun between 1800000 dalton, the molecular weight of the micromolecule hyaluronic acid sodium is 400000 dalton to 1000000 Between you pause.
6. a kind of dressing for skin according to claim 1, it is characterised in that: the micromolecular collagen is that molecular weight is small In the collagen of 2000 dalton.
7. a kind of a kind of preparation method of dressing for skin as described in claim 1, which comprises the steps of:
S1. lightweight water is produced: being taken pure water to be heated to 98 degrees Celsius to 100 degrees Celsius at normal atmospheric pressure, is selected preferential steam Preceding 3/4ths vapor of hair liquefies, and the water after liquefaction is then reheated to 98 degrees Celsius to 100 degrees Celsius, And preferentially evaporate preceding 3/4ths water is selected to liquefy again, after repeating this process again four to five times until will liquefy Water in heavy water constituent reduction can be obtained required lightweight water at least 25% degree fewer than light water, can also be direct Required lightweight water is obtained by melting qualified snow naturally;
S2. it is pre-mixed: selecting lightweight water 500ml, 1000mg micromolecule hyaluronic acid sodium is then added at normal temperature, concentration is made For the 500ml solution A of 2mg/ml;Lightweight water 500ml is selected, numerator sodium hyaluronate in 1000mg is then added at normal temperature, The 500ml solution B that concentration is 2mg/ml is made;Lightweight water 500ml is selected, it is transparent that 1000mg small molecule is then added at normal temperature The 500ml solution C that concentration is 2mg/ml is made in matter acid sodium;
S3. it is mixed: solution A, solution B and solution C is mixed and added into the micromolecular collagen of 1000mg at normal temperature It is stirred 3 minutes to 10 minutes using high-speed mixer, obtains solution D;
S4. preparing finished articles: being heated to 55 degrees Celsius for solution D, 500mg ceramide is then added and in 55 degrees Celsius of environment It is stirred 5 minutes to 15 minutes using high-speed mixer, obtains finished product.
CN201910791823.3A 2019-08-26 2019-08-26 A kind of dressing for skin and preparation method thereof Pending CN110354302A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113750286A (en) * 2021-09-30 2021-12-07 振德医疗用品股份有限公司 Skin wound covering film and preparation method thereof
US20230233441A1 (en) * 2022-01-24 2023-07-27 The Procter & Gamble Company Skin care composition containing sodium hyaluronate and method of making the same

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US20230233441A1 (en) * 2022-01-24 2023-07-27 The Procter & Gamble Company Skin care composition containing sodium hyaluronate and method of making the same

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Application publication date: 20191022

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