CN1021292C

CN1021292C - Process of external use medicine for infant cold and cough

Info

Publication number: CN1021292C
Application number: CN 89103924
Authority: CN
Inventors: 张作仁
Original assignee: Individual
Current assignee: Individual
Priority date: 1989-06-08
Filing date: 1989-06-08
Publication date: 1993-06-23
Anticipated expiration: 2004-06-08
Also published as: CN1038763A

Abstract

The present invention relates to a method of producing external preparation for infant cold and cough, which belongs to the field of producing external medicine compounds by materials derived from plants. The production method provided by the present invention comprises the following steps of substrate preparation, extraction of active ingredients in medicine materials of mulberry twig, loquat branch, etc., borneol and pepper addition during modulation, spread coating, or use, and the external medicine which can effectively treat the disease symptoms of wind-cold lung closure, wind temperature lung closure, phlegm-heat lung closure, long-bout cough (whooping cough), etc. can be obtained.

Description

Process of external use medicine for infant cold and cough

The present invention is a kind of production method of external use medicine for infant cold and cough, and it belongs to the field of manufacture of materials external used medicine chemical compound that derives from plant, and it comprises the technical process that extraction, modulation and the stand of preparation, the spice of substrate are coated with.

Children's's sentiment below seven years old cough can comprise that cold closed lung, pathogenic wind-warm close lung, phlegm-heat closed lung, pertussis (pertussis) etc., all belongs to lung pattern disease.So far, though doctor trained in Western medicine is to this sick can treatment, because children's's private prosecution unclear (particularly infant) is given to make a definite diagnosis and brought difficulty, thereby easily produces mistaken diagnosis; And children's all is reluctant to take medicine to have an injection, and this has brought difficulty to treatment again, very easily incurs loss through delay children's's state of an illness.Though it is disconnected that the traditional Chinese medical science can be taken pulse-taking, also need to take medicine the purpose that reaches treatment to children's." pharmacy of Chinese materia medica " (Cao Chunlin chief editor, Shanghai science tech publishing house in November, 1986 front page, 324～349 pages) introduced the production method of some external preparation in the book, their purpose is the effect that reaches the treatment by oral administration of medicines disease by the external application of this type of preparation, its formation comprises that the preparation of substrate, extraction, modulation and the stand of spice are coated with, and weak point is selected spice.The technical process that adopts can not be produced the external preparation of treatment medicine for infant cold and cough.

The production method that the objective of the invention is to avoid above-mentioned weak point of the prior art and a kind of external use medicine for infant cold and cough is provided.

Purpose of the present invention can reach by following measure: place solvent to soak in Ramulus Mori, Folium Eriobotryae branch, so that active ingredient is wherein gone out by lixiviate.Select for use branch to be because they all are the forks of tree, the daytime inhales carbon dioxide and tells oxygen, and the oxygen uptake at night is told carbon dioxide as elder generation, and it is in harmony similar in the effect of people's lung, all plays the effect of gas exchanger.Selecting Ramulus Mori, Folium Eriobotryae branch for use then is that also wind dispelling heat radiation, preventing phlegm from forming and stopping coughing, circulation of qi promoting are relievingd asthma, the effect of spasmolytic preventing or arresting vomiting with having because of two.The operating process that can use that afterwards the known equipment of those of ordinary skill and mode in the externally used paste preparation technology field carry out that the preparation of substrate, extraction, modulation and the stand of spice are coated with etc., but be coated with at modulation or stand or must add Borneolum Syntheticum, Fructus Piperis when using and make external preparation.Borneolum Syntheticum and Fructus Piperis and with being the pioneer, broken closing (saturating key is dirty) are cut and (gas exorcises evil spirits) swung bandit's (phlegm retention) peace help (helping pure sun), play the effect of the efficacy of a drug being permeated and acted on the old complaint place as early as possible.

Purpose of the present invention can also reach by following measure: can add Rumulus Pruni, bamboo branch to play better effect in the quilt immersion spice of being made up of Ramulus Mori, Folium Eriobotryae branch.Also can in above-mentioned four, add Ramulus Persicae again, because of Ramulus Persicae has the effect of invigorating blood circulation, can avoid external preparation long paste to cause pasted the position because of pore can not normally be drained the blister, the pain that cause, side effect such as scratch where it itches.Select for use the bright branch of air-dry belt leather to be advisable for above-mentioned five, the ratio between them can be 1～3: 1～3: 1～3: 1～3: 1～3(by weight).Solvent can select for use fatty oil or glycerol or propylene glycol or ethanol or ether or acetone or chloroform all can.When using fatty oil or glycerol or propylene glycol as solvent, its initial temperature of soaking spice is better between 30～80 ℃, and the time of soaking spice is 48 hours or above being advisable.Borneolum Syntheticum and Fructus Piperis are used pulverous for well, and Fructus Piperis employing black pepper is better.

The present invention has following advantage compared to existing technology:

1, the external preparation of producing with this method can effectively be treated various medicine for infant cold and cough diseases, and do not take medicine, must not have an injection, only need to stick two external preparation at two lung eyes place of patient (in the depression of the margo vertebralis scapulae of fourth dorsal vertebra spinous process prosposition), took a turn for the better in two days, recovery from illness in seven to 15 days, no longer recurrence.From 8 or four years to eight or seven at the beginning of, through more than 200 clinical trials, As the medicine took effect, the symptoms lessened invariably.Huoshan County, Anhui Province secondary school teachers Xu * one full year of life child cough to June in January, 806, big infirmary has run several, expensive 300 yuan, does not heal.After use this external preparation, changed once, and just fully recovered in the two weeks in seven days.Simultaneously, said preparation is easy to use, have no side effect, and both can illly cure the disease, anosis diseases prevention, can exempt the melancholy of being tired of, being stricken with anxiety and fear that patient and his family see a doctor again, to the outlying district advantageous particularly of shortage of medical services and medicines.

2, produce the required spice wide material sources of this kind preparation and cheap.

3, the technological process of production is simple and easy to grasp, and equipment is not had specific (special) requirements, is suitable for suitability for industrialized production.

The present invention will now be further detailed embodiment:

Embodiment 1

With the Oleum Sesami in the fatty oil (also available Oleum Gossypii semen or rapeseed oil or Oleum Arachidis hypogaeae semen or maize embryo oil or soybean oil) 500 grams, put into iron pan and temper to dripping into pearl, when fire is cooled to 30 ℃ (between 30～80 ℃ all can), Ramulus Mori, Folium Eriobotryae branch, Rumulus Pruni, bamboo branch, each 30 gram of Ramulus Persicae (respectively between 30 to 90 grams all can) be put into the oil immersion; Again this oil is heated to oil together with five after 48 hours and opens, drag for five (five also can be dragged for) immediately before heating; Cross Plumbum preparatium 180 gram of 100 mesh sieves (150 to 210 grams all can) and be sprinkled into slowly frying dry doubling, and ceaselessly stir evenly.For checking the old tender degree of plaster, desirable small amount of sample splashes in the water, takes out after the several seconds, if plaster is tack-free, denseness is moderate again, it is qualified promptly to represent.Again powdered Borneolum Syntheticum 100 grams, black pepper 150 grams are blended in the plaster and stir, the stand is painted 1000 then; Also Borneolum Syntheticum, the black pepper of isodose can be divided into 1000 parts, when the stand is coated with or use, be sprinkling upon on the plaster.

Embodiment 2

Get Oleum Glycines 500 grams, put into the copper pot and temper, when fire is cooled to 80 ℃, Ramulus Mori 20 grams, Folium Eriobotryae branch 60 grams are put into oil and soaked to dripping into pearl; Drag for above-mentioned two after 50 hours, oil is heated to about 100 ℃, slowly add hydrocerussitum 600 grams, stir while adding, make it be reacted into cream; Add powdered Borneolum Syntheticum 150 grams, Fructus Piperis 250 grams afterwards again, and stir, the stand is painted 1000.

Embodiment 3

1, the extraction of spice: Ramulus Mori, Folium Eriobotryae branch, Rumulus Pruni, bamboo branch, each 30 gram of Ramulus Persicae are put into ethanol (also can be ether or acetone or chloroform or glycerol or propylene glycol) and soaked 48 hours, use infusion process or percolation or reflux extraction to obtain above-mentioned five extract afterwards, and it is standby that it is condensed into paste (or dried paste).Again Borneolum Syntheticum 120 gram black peppers 200 are restrained in the extract that is blended into paste behind the powderings and mix thoroughly.

2, the preparation of substrate: get that raw rubber is thinly sliced or strip, drop in the gasoline, stir after the dipping swelling and make moltenly, gradation adds vaseline, lanoline, aqueous paraffin wax and Colophonium etc., and stirring and evenly mixing is standby.

3, modulation: the extract of paste is blended in the substrate slurry stirs.

4, coating: the creme that modulates is put on the plaster coating machine that installs the clothed mounting back of the body is coated with cream.

5, reclaim solvent: the cream cloth that will coat creme transmits and enters Solvent Recovery Unit so that solvent is reclaimed, and is rolled into the cream yardage roll automatically.

6, cutting lining: 1000 of bulks that the cream yardage roll cut into 5 * 5 centimetres.

Embodiment 4

1, the extraction of spice: 1 method obtains the extract of paste among the usefulness embodiment 3.

2, the preparation of substrate: it is standby or refine to the Cheng Zhuhou that drips hydrocerussitum with Oleum Glycines 500 grams standby through stirring into cream through stirring into cream to temper to the Cheng Zhuhou that drips Plumbum preparatium with Oleum Sesami 500 gram.

3, modulation: the extract of paste is blended in the substrate stirs.

4, the stand is painted 1000.

Claims

1, a kind of production method of external use medicine for infant cold and cough comprises that refining medicine oil and preparation, modulation and the stand of pilling and pasting or substrate are coated with, and feature of the present invention is:

(1) spice is selected for use

The spice that (1,1) needs to soak is Ramulus Mori, Folium Eriobotryae branch, Rumulus Pruni, bamboo branch, and the ratio between them is 1～3: 1～3: 1～3: 1～3 (by weight),

All the other are Borneolum Syntheticum, Fructus Piperis for (1,2),

(2) solvent is fatty oil or glycerol or propylene glycol or ethanol or ether or acetone or chloroform,

When (3) using fatty oil as solvent, the spice that needs in the 500 gram fatty oils to soak is respectively 30～90 grams, the Borneolum Syntheticum consumption is 100 grams, the Fructus Piperis consumption is 150 grams, or when using glycerol or propylene glycol or ethanol or ether or acetone or chloroform as solvent, the spice that needs to soak is respectively 30 grams, and Borneolum Syntheticum is 120 grams, Fructus Piperis is 200 grams

(4) spice that soaks is placed at normal temperatures time that solvent soaks more than or equal to 48 hours, if when using fatty oil as solvent, its initial temperature of soaking spice is 30～80 ℃,

(5) add Borneolum Syntheticum, Fructus Piperis when being coated with in modulation or stand.

2, method according to claim 1 is characterized in that and can also be added to Ramulus Persicae in the solvent and soak with Ramulus Mori, Folium Eriobotryae branch, Rumulus Pruni, bamboo branch, and when the consumption of Ramulus Persicae was 30～90 grams, the consumption of fatty oil was 500 grams.

3, method according to claim 1 and 2 is characterized in that Ramulus Mori, Folium Eriobotryae branch, Rumulus Pruni, bamboo branch and Ramulus Persicae use the bright branch of air-dry belt leather.

4, method according to claim 1, it is pulverous to it is characterized in that Borneolum Syntheticum, Fructus Piperis use.

5, method according to claim 1 and 2 when it is characterized in that solvent is selected fatty oil for use, is tempered it to dripping into pearl before soaking spice.