CN108969613A - A kind of novel analgesic plaster - Google Patents
A kind of novel analgesic plaster Download PDFInfo
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- CN108969613A CN108969613A CN201811181307.0A CN201811181307A CN108969613A CN 108969613 A CN108969613 A CN 108969613A CN 201811181307 A CN201811181307 A CN 201811181307A CN 108969613 A CN108969613 A CN 108969613A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention particularly discloses a kind of novel analgesic plasters, belong to Chinese medicine external preparation technical field.A kind of novel analgesic plaster is the material pvc 40g, dibatyl phithalate 200g, colophony powder 360g by following weight, zinc oxide 360g, Chinese medical concrete 40g, borneol 12g, menthol 12g camphor 25g, extractum belladonnae 2.2g is made, plaster of the invention has compared with traditional black plaster and does not need softening before patch, do not slide after pollution clothes, patch, reusable good result, and product is more stable, non-aging to become fragile, the shelf-life is longer.Plaster dosage of the present invention is small, easy to use, and patient generally gladly receives, and product has better application prospect.
Description
Technical field
The invention belongs to external drug preparation technical fields, are related to a kind of plaster, and in particular to one kind does not have to grease and oxygen
Change lead and makees novel analgesic plaster made of matrix.
Background technique
Traditional Chinese medicine and pharmacy is the traditional medicine in China, and interior disease external therapy is one of main rule of Chinese medicine.External treatment with Chinese medicine (" warp
Skin administration ") method is of long standing and well established, and it is just on the books in B.C. twoth century, China's medicine ancient books and records " interior through Plain Questions ".Motherland's medicine is certainly
The application of inner disease outer treat is just taken much count of since Gu, and is constantly able to summarize and improve, in-depth, development, leap.Over the years, interior disease is outer
Control the normality rule for having become clinical treatment.
Plaster is one of the Typical Representative of one of China's traditional Chinese medicine preparation conventional dosage forms and inner disease outer treat, early in
Has the record of " cream " made of oily, pellet is tempered in the written handbook of Prescription for Emergency of Jin Daige flood.Liu Song's " Liu Juanzi Guiyi Fang, Liu Juanzi "
In also there are many " plaster " record." thin " refers to ointment, and " note " refers to plaster.Plaster is more widely applied since Tang, Song, clearly
" Li Yue Pianwen, Rhymed Discourse for Topical Remedies " written by Dai Haoshi machine is plaster in the monograph of application aspect, tcm clinical practice and civil cream is still widely used at present
Medicine.
Plaster is commonly applied to control aspect outside detumescence, detoxification, myogenic etc., but it passes through outer patch, moreover it is possible to control in playing the role of, such as
Wind dispelling is cold and qi and blood, dissolving phlegm ruffian, clearing and activating the channels and collaterals, wind-damp dispelling, controls traumatic injury etc..The effect of plaster is referred on " Li Yue Pianwen, Rhymed Discourse for Topical Remedies "
When, there is saying for " cutting " " pulling out ", " all diseases gather place to meaning, and the then disease pulled out goes out certainly, the trouble without deep invagination；Sick institute except,
The then heresy cut is autotomyed, the anxiety without the absurd row progress of disease ".
It is civil because chill, channels and collaterals it is unsmooth caused by cold-dampness flaccidity syndrome and arthralgia syndrome, the disease of muscles and bones muscular constricture, the diseases such as arthralgia is also very much, by
In being all chronic disease mostly, often to treatment zone come much bother and pain, external application application plaster is the treatment that people gladly select
Method.
The common plaster of existing market medical institutions is mostly black plaster, and black plaster is external application traditional Chinese medicine traditional preparation methods
It is obtained, then it is a kind of diachylon being combined under certain condition with grease type and lead oxide etc., after softening, although having
Certain elasticity and viscosity, but elasticity is insufficient, and viscosity is excessively high.Therefore, increase elasticity, it is appropriate to reduce viscosity, it is that should seek in plaster
Direction.It using modern scientific method, is improved in the black plaster of original preferable effect, prepares a kind of unleaded novel plaster
It is purpose of the present invention place.
Summary of the invention
Do not have to grease the object of the present invention is to provide one kind and lead oxide makees plaster made of matrix.
The object of the present invention is to provide a kind of novel analgesic plasters.
In order to realize the present invention, the following technical solutions are specifically adopted:
A kind of novel analgesic plaster, it is characterized in that by the material pvc 40g of following weight, dibatyl phithalate 200g,
Colophony powder 360g, zinc oxide 360g, Chinese medical concrete 40g, borneol 12g, menthol 12g camphor 25g, extractum belladonnae 2.2g, by with
Lower section method is made: weighing material pvc powder, is placed in copper pot, dibatyl phithalate is added, stirs evenly, on straight fire
Heating, and is stirred continuously, and to be heated to 102-105 DEG C, white paste, being further continued for heating makes temperature rise to 138-142
DEG C, and be stirred continuously turning over materials, until gradually transparent viscous body when, rosin fine powder (45 mesh) is added by several times, it is stirring while adding,
It is appropriate to cool down after making yellow transparent and homogeneous viscous body, 115-118 DEG C is maintained the temperature at, oxide powder and zinc is added by several times, fills
Divide stirring, then adds Chinese medical concrete fine powder, be sufficiently stirred, be then placed in borneol, menthol and camphor in mortar sufficiently
Grinding be allowed to congruent melting after be added, add extractum belladonnae, and be sufficiently stirred make uniformly, quantitatively spread onto mount on material while hot,
To obtain the final product；The Chinese medical concrete is made by following methods: by Radix Aconiti 112.5g, Radix Aconiti Kusnezoffii 112.5g, arisacma consanguineum schott 112.5g are graceful
Top sieve (fruit) 112.5g, asarum 37.5g are smashed respectively, weigh each medicine, are mixed, are with 8 times of content concns of Chinese medicine weight
After the ethyl alcohol of 86%v/v impregnates 12 days, leaching soak, recycling ethyl alcohol obtains concentrate, and spare, the dregs of a decoction after ethyl alcohol is impregnated add
The pure water that 10 times of Chinese medicine weight decocts 2.5 hours, leaching decoction liquor, and the dregs of a decoction are then added 5 times of Chinese medicine weight again
Pure water decocts 1.5 hours, and leaching decoction liquor merges secondary decoction liquor, is incorporated to above-mentioned concentrate, is filtered, is concentrated, and does
It is dry to water content less than 3%, through crush sieve with 100 mesh sieve to get Chinese medical concrete.
The Chinese medicine that Chinese medical concrete of the present invention is related to:
Monkshood, radix aconiti agrestis, for wild Ranunculaceae aconitum plant rhizome of Chinese monkshood Aconitum Carmichaeli Debx. or the northern rhizome of Chinese monkshood
The root tuber (female root) of Akusnezoffii Reichb. etc..The rhizome of Chinese monkshood of Sichuan cultivation claims monkshood, and wild produces with other areas
Title radix aconiti agrestis.Nature and flavor and channel tropism: acrid in flavour and warm in nature.It is very toxic.Return heart, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.For chill
Arthritis with fixed pain caused by dampness, arthralgia, trusted subordinate's crymodynia, cold hernia are had a pain, narcotic analgesic.
Arisacma consanguineum schott, nature,taste and action: bitter, pungent, warm.It is toxic.Dispelling wind and relieving convulsion, reducing phlegm and resolving masses, mass dissipating and swelling eliminating.
Datura flower fruit: bitter and warm.It is very toxic.With anesthesia, analgesia is relievingd asthma, cough-relieving function, is used for rheumatalgia, damage pain
Bitterly, surgery anesthesia, bronchial asthma, stomachache.
Asarum: acrid in flavour and warm in nature.Return heart, lung, stomach meridian.With relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid function.For
Rheumatic arthralgia, sputum cough, anemofrigid cold are had a headache, toothache, nose cold current tears etc..
All Chinese medicine materials used in the present invention are commercially available standard compliant commodity.
Borneol, menthol, camphor and the extractum belladonnae used in the present invention is the commercially available production for meeting Chinese Pharmacopoeia standard
Product；Wherein extractum belladonnae should conform to every 1g containing alkaloid with atropine sulfate [(C17H23NO3)2·H2SO4] meter, it must not be less than
The regulation of 9.7mg.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
The present invention is a kind of method for not using grease and lead oxide to prepare plaster, has saved edible oil, the method for the present invention is simple,
It is easy to operate, it is easy to grasp, the cumbersome works such as " wasting lamp oil by not sleeping at night " when preparing traditional black plaster matrix, " descending pellet ", " releasing fire-toxin " can be omitted
Skill also avoids the danger for easily causing burning and lead poisoning etc..The present invention extracts its alcohol-soluble using the extraction process of Chinese medicine
With water-soluble biological ingredient, keep the plaster dosage of preparation small, it is easy to reach absorption performance therapeutic efficiency by sticking, be allowed to reach
To wind dispelling cold dispelling, inducing meastruation to relieve menalgia effect.Borneol, menthol, camphor and extractum belladonnae are added in plaster of the present invention, can enhance it
Wind-expelling pain-stopping effect.
Plaster of the invention has and does not slide after not needing softening, not pollution clothes, patch before pasting compared with traditional black plaster
Dynamic, reusable good result, and product is more stable, non-aging to become fragile, the shelf-life is longer.
The present invention prepares that plaster dosage is small, easy to use, and every note is pasted on arthritis sore spot, and dressing is primary weekly.Through number
Ten patients compare use, as a result do not have significant difference with the black plaster of Chinese medicine formula preparation, obtain preferable clinical
Therapeutic effect, and patient generally gladly receives, novel plaster prepared by the present invention, can show that plaster of the present invention is more black than conventional
Plaster has better application prospect.
Specific embodiment
Following embodiment is not represent whole of the invention, the present embodiment is not to the statement further implemented of the invention
Influence protection scope of the present invention.
Embodiment 1
The preparation of plaster:
Material pvc 40g is weighed, is placed in copper pot, dibatyl phithalate 200g is added, stirs evenly, is added on straight fire
Heat, and being stirred continuously, to be heated to 102 DEG C, white paste, temperature rises to 140 DEG C when being further continued for heating, and constantly stirs
Mix turning over materials, until gradually transparent viscous body when, by several times be added rosin fine powder (45 mesh) 360g, it is stirring while adding, be allowed into
For yellow with clear viscous body after, it is appropriate to cool down, maintain the temperature at 115 DEG C, oxide powder and zinc 360g be added by several times, sufficiently stirs
It mixes, then adds Chinese medical concrete fine powder 40g, be sufficiently stirred, be then co-located in borneol 12g, menthol 12g and camphor 25g
Be fully ground after being allowed to congruent melting and be added in dry mortar, add extractum belladonnae 2.2g, and be sufficiently stirred make uniformly, take while hot
Amount 6g spread on material of mounting to get；
Wherein Chinese medical concrete fine powder the preparation method is as follows:
By Radix Aconiti 112.5g, Radix Aconiti Kusnezoffii 112.5g, arisacma consanguineum schott 112.5g, datura (fruit) 112.5g, asarum 37.5g difference
It smashes, weighs each medicine, mix, after being impregnated 12 days with the ethyl alcohol that 3900g content concn is 86%v/v, filling takes soak, recycles second
Alcohol obtains concentrate, spare, and the dregs of a decoction after ethyl alcohol is impregnated add the pure water of 4875g, decocts 2.5 hours, leaching decoction liquor, then
The dregs of a decoction are added to the pure water of 2437.5g again, are decocted 1.5 hours, leaching decoction liquor merges secondary decoction liquor, is incorporated to above-mentioned
Concentrate is filtered, is concentrated, and drying, less than 3%, is sieved with 100 mesh sieve to water content through crushing to get Chinese medical concrete.
Clinical efficacy:
Case 1: Wu, female, 42 years old, left three wheat harvesting period of gonalgia, analgesic, more than 10 day of antirheumatic Western medicine, had no by oral administration
It improves.Then lose money in a business invention plaster affected part, and dressing is primary weekly, after pasting 6 notes altogether, cures, there are no any adverse reaction.
Case 2: item so-and-so, female 34 years old, flank pain three months or more, influences to work normally, and patient treats through many places,
Have no and be clearly better, with plaster of the present invention is sticked, stick affected part, dressing is primary weekly, paste 10 notes altogether, cure, after two months with
It visits, no relapse.
Case 3: Jiang, female, 50 years old, left knee joint endoprosthesis inflammation pain 1 year or more, regular medication control pain, without
It is any routinely to treat.With plaster of the present invention is sticked, affected part is pasted, dressing is primary weekly, after pasting 4 notes altogether, pain relief, hence it is evident that good
Turn, with adhering to sticking, totally 12 patch, pain disappear, and it is basic to cure, it there are no adverse reaction.
Case 4: the summer so-and-so, male, 60 years old, flank pain 1 year or more, influence to work normally, taken antirheumatic anodyne
It three months, has no pain relief, with plaster of the present invention is sticked, sticks affected part, dressing is primary weekly, pastes 15 notes altogether, and pain is basic
It disappears, it is basic to cure.
Claims (1)
1. a kind of novel analgesic plaster, which is characterized in that it is the material pvc 40g by following weight, phthalic acid two
Butyl ester 200g, colophony powder 360g, zinc oxide 360g, Chinese medical concrete 40g, borneol 12g, menthol 12g camphor 25g, extractum belladonnae
2.2g is made, and preparation method is as follows: weighing material pvc powder, is placed in copper pot, dibatyl phithalate, stirring is added
Uniformly, it heats, and is stirred continuously on straight fire, to be heated to 102-105 DEG C, white paste, being further continued for heating makes temperature
Degree rises to 138-142 DEG C, and is stirred continuously turning over materials, until gradually transparent viscous body when, 45 mesh fine powder of rosin is added by several times,
It is stirring while adding, it is appropriate to cool down after making yellow transparent and homogeneous viscous body, 115-118 DEG C is maintained the temperature at, is added by several times
Oxide powder and zinc is sufficiently stirred, and then adds Chinese medical concrete fine powder, is sufficiently stirred, and is then placed in borneol, menthol and camphor
Be fully ground after being allowed to congruent melting and be added in mortar, add extractum belladonnae, and be sufficiently stirred make uniformly, quantitatively spread onto mounting while hot
Stick one piece of cloth or paper on top of another on material to get；The Chinese medical concrete is made by following methods: by Radix Aconiti 112.5g, Radix Aconiti Kusnezoffii 112.5g, arisacma consanguineum schott
112.5g, datura (fruit) 112.5g, asarum 37.5g are smashed respectively, weigh each medicine, are mixed, with 8 times of contents of Chinese medicine weight
After the ethyl alcohol that concentration is 86%v/v impregnates 12 days, leaching soak, recycling ethyl alcohol obtains concentrate, spare, after ethyl alcohol is impregnated
The dregs of a decoction add 10 times of Chinese medicine weight of pure water, decoct 2.5 hours, leaching decoction liquor, and Chinese medicine weight then is added in the dregs of a decoction again
The pure water of 5 times of amount decocts 1.5 hours, and leaching decoction liquor merges secondary decoction liquor, is incorporated to above-mentioned concentrate, filtered,
Concentration, drying, less than 3%, are sieved with 100 mesh sieve to water content through crushing to get Chinese medical concrete.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811181307.0A CN108969613A (en) | 2018-10-11 | 2018-10-11 | A kind of novel analgesic plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811181307.0A CN108969613A (en) | 2018-10-11 | 2018-10-11 | A kind of novel analgesic plaster |
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| Publication Number | Publication Date |
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| CN108969613A true CN108969613A (en) | 2018-12-11 |
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|---|---|---|---|
| CN201811181307.0A Withdrawn CN108969613A (en) | 2018-10-11 | 2018-10-11 | A kind of novel analgesic plaster |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112716920A (en) * | 2021-01-22 | 2021-04-30 | 香港大学深圳医院(深圳市滨海医院) | Matrix of lead-free traditional Chinese medicine externally-applied hard plaster and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5476816A (en) * | 1977-11-26 | 1979-06-19 | Teika Seiyaku Kk | Anodyne and antiiinflammatory surgical agent |
| CN1640483A (en) * | 2004-05-17 | 2005-07-20 | 潘金来 | Musk radix thunbergiae grandiflorae ointment |
| CN1824265A (en) * | 2005-12-23 | 2006-08-30 | 郝集峰 | External use pain relieving spray liquid |
-
2018
- 2018-10-11 CN CN201811181307.0A patent/CN108969613A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5476816A (en) * | 1977-11-26 | 1979-06-19 | Teika Seiyaku Kk | Anodyne and antiiinflammatory surgical agent |
| CN1640483A (en) * | 2004-05-17 | 2005-07-20 | 潘金来 | Musk radix thunbergiae grandiflorae ointment |
| CN1824265A (en) * | 2005-12-23 | 2006-08-30 | 郝集峰 | External use pain relieving spray liquid |
Non-Patent Citations (2)
| Title |
|---|
| 曹春林: "《中药制剂汇编》", 31 October 1983, 人民卫生出版社 * |
| 曹春林: "《中药药剂学》", 31 October 1996, 上海科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112716920A (en) * | 2021-01-22 | 2021-04-30 | 香港大学深圳医院(深圳市滨海医院) | Matrix of lead-free traditional Chinese medicine externally-applied hard plaster and preparation method thereof |
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Application publication date: 20181211 |