CN114748557A - Hot compress physiotherapy uterus warming patch for gynecology - Google Patents
Hot compress physiotherapy uterus warming patch for gynecology Download PDFInfo
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- CN114748557A CN114748557A CN202210142309.9A CN202210142309A CN114748557A CN 114748557 A CN114748557 A CN 114748557A CN 202210142309 A CN202210142309 A CN 202210142309A CN 114748557 A CN114748557 A CN 114748557A
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Abstract
The invention discloses a hot compress physical therapy uterus warming plaster for gynecology, which consists of a heating sheet and a traditional Chinese medicine ointment, and is characterized in that the traditional Chinese medicine ointment comprises, by weight, 1-5 parts of sambucus chinensis, 5-10 parts of chicken liver powder, 5-10 parts of radix cynanchi wilfordii, 1-5 parts of celastrus paniculatus, 1-3 parts of three-paired burls, 2-4 parts of cinnamomum camphora, 3-5 parts of toddalia asiatica and 1-4 parts of schisandra yunnanensis. The medicinal materials used in the invention are characteristic medicinal materials in Yunnan, are representative dominant varieties in Yunnan, and are common medicines for local residents to treat uterus cold. The radix cynanchi wilfordii is also reputed to be nourishing and strengthening, and promoting qi circulation by wind. Compared with the traditional medicinal materials, the Yunnan special medicinal material has higher content of effective components, more obvious treatment effect and higher safety. The traditional Chinese medicine ointment is matched with the heating sheet for use, so that the local blood circulation can be promoted, and the symptoms of cold hands and feet, menstrual pain, waist soreness and the like caused by cold uterus can be relieved. Can regulate menstruation, nourish blood, warm uterus, resist inflammation, repair uterus, and regulate uterus environment after long-term use.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a hot compress physical therapy uterus warming patch for gynecology and a preparation method and application thereof.
Background
"Cold uterus" is a concept of traditional Chinese medicine, namely "cold uterus", also called "cold uterus". It is manifested by cold hands and feet, obesity, soreness of waist, menoxenia, frequent micturition, enuresis, hyposexuality, and abortion. Is one of the common gynecological diseases, and is recurrent along with the menstrual cycle, which seriously affects the work and life of women. At present, the symptoms of western medicine are generally relieved by taking analgesic drugs or anti-inflammatory drugs clinically, but after the taking is stopped, the symptoms mostly recur, and the western medicine needs to be taken again when the symptoms recur. The fertility of women has been affected for a long time ago. The traditional Chinese medicine treatment for cold womb has the advantages of good curative effect and few side effects, and the traditional Chinese medicine treatment has the greatest advantages of dialectical treatment, improvement of body functions, regulation of uterine functions and removal of the root cause of diseases, namely treatment of the root cause.
Domestic data show that some medicinal materials produced in specific natural conditions and ecological environment regions have high content of effective components, and have remarkable advantages for treating certain diseases. For example, Toddalia asiatica in Yunnan has higher ability of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain than other areas, and is usually added into a formula for treating cold womb in Yunnan, so that the Toddalia asiatica has good effect on treating pain and amenorrhea. The radix cynanchi wilfordii is reputed to be nourishing and strengthening, and the local people are called as the angelica archang lica and the angelica archang lica, and are recorded in various local recipes for treating cold uterus. Compared with common schisandra chinensis in the market, the Yunnan schisandra chinensis is mainly used for treating female pain and amenorrhea, is known as holy medicine in Yunnan, has obvious treatment effect on female uterine cold, and is also imported into the herbal work. In addition, many other medicinal effects of the medicinal materials are not discovered, and the development potential is huge.
Modern medical research shows that, compared with oral preparations, the external patch is taken through skin for administration, so that the administration is convenient, and the intervention of gastrointestinal environment on drug effect and the first pass effect of liver can be avoided. The medicine penetrates the skin to enter the blood circulation, has the effects of long acting and slow release, not only maintains the stable blood concentration, but also avoids the peak valley phenomenon. Therefore, compared with an oral preparation, the uterus warming patch has better treatment effect. Secondly, the preparation process of the oral preparation is more complex, the product is easy to deteriorate and inconvenient to use for specific people, while the preparation of the uterus warming patch is simple, and the product is easy to store and transport and can be used for various conditions.
Disclosure of Invention
The invention aims to provide a uterus warming patch for treating female cold in uterus.
In order to realize the aim, the invention discloses a hot compress physical therapy uterus warming plaster for gynecology, which consists of a heating sheet and a traditional Chinese medicine ointment, and the specific implementation scheme is as follows:
(1) cleaning herba Sambuci Adnatae, hepar gallus Domesticus powder, radix Cynanchi Wilfordii, caulis Celastri Conveniae, cortex Cinnamomi Camphorae, radix Toddaliae Asiaticae, radix Tripterygii Wilfordii, and fructus Schisandrae Sphenantherae, removing impurities, pulverizing, sieving with 100 mesh sieve, and mixing to obtain Chinese medicinal fine powder; (2) mixing the fine powder with essential oil, soaking at 20 deg.C, stirring for 30s every 3 hr for 1 time, heating with middle fire to slightly boil after stirring for 8 times, maintaining for 5s, and cooling to small fire. When the powder is heated to brown, pouring out and filtering while it is hot to obtain primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with isolating membranes with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to finish the hot compress physical therapy uterus warming paste for gynecology.
The invention relates to a hot compress physiotherapy uterus warming plaster for gynecology, which is prepared from the following components in part by weight of (1) Chinese medicinal ointment, namely 1-5 parts of herba sambuci chinensis, 5-10 parts of chicken liver powder, 5-10 parts of radix cynanchi wilfordii, 1-5 parts of oriental paperbush root, 1-3 parts of three-paired burls, 2-4 parts of cinnamomum camphora, 3-5 parts of asiatic toddalia root and 1-4 parts of Yunnan schisandra chinensis.
The invention relates to a hot compress physical therapy uterus warming patch for gynecology, wherein in the step (2), the essential oil is extracted from one or more of lemon, orange, grapefruit and patchouli;
the invention relates to a hot compress physical therapy uterus warming patch for gynecology, wherein the weight ratio of the amount of essential oil in the step (2) to the weight of the traditional Chinese medicine fine powder is 2-5: 1;
the invention relates to a hot compress physiotherapy uterus warming patch for gynecology, wherein the weight ratio of the addition amount of medicinal gelatin to primary medicinal oil in the step (2) is 1-2: 1.
The invention adopts the comprehensive effects of the sambucus chinensis, the chicken liver powder, the cynanchum wilfordii, the celastrus orbiculatus, the cinnamomum japonicum, the asiatic toddalia root, the three pairs of knots and the Yunnan schisandra chinensis, and is combined with the essential oil, thereby having obvious curative effect on pain caused by cold uterus.
Herba Sambuci Chiensis: distributed in Shaanxi, Ningxia, Gansu, Qinghai, Sichuan, Guizhou, Yunnan, Tibet, etc. Has the effects of dispelling pathogenic wind, promoting diuresis, promoting blood circulation, and dredging collaterals. It is often used for treating acute and chronic nephritis, rheumatalgia, rubella pruritus, poliomyelitis sequela, chronic lumbago and skelalgia, sprain pain due to blood stasis, and fracture. Modern researches show that the herba Sambuci Adnatae also has effects of warming uterus and dispelling cold.
Chicken liver powder: distributed in the southwest of Guangxi, southeast of Guizhou, southwest of Yunnan, and southwest of Tibet and southeast of southeast. Has the effects of inducing sweat, relieving exterior syndrome, promoting diuresis and relieving itching. It is used for treating nephritis and pyelonephritis, and has good therapeutic effect on dysmenorrhea due to kidney deficiency and nephritis.
E, isolating mountain incense: distributed in Yunnan province, Fujian province, etc. The radix cynanchi wilfordii has the functions of dispelling wind, clearing heat, promoting blood circulation, removing blood stasis, promoting qi circulation, relieving pain and the like when used as a medicine. Can be used for treating amenorrhea, leucorrhea, cold womb, gastralgia, malaria, dysentery, traumatic injury, etc.
Celastrus orbiculatus: distributed in Yunnan province, Guangdong province, etc. Astringent taste and cool nature. Has effects of clearing pathogenic fire, removing toxic substances, relieving cough, eliminating phlegm, relieving swelling and pain, astringing, relieving diarrhea, and caring skin. When used externally, the medicine can treat rhagadia manus et pedis and stubborn tinea, can protect the applied part and reduce the irritation of the medicine to the skin.
Cinnamomum japonicum Thunb Var nakai: distributed in southeast and south of Yunnan province. The medicine is grown beside a ditch or in a valley compact forest in mountain sparse forest with elevation of 380-600 meters, has the effects of dehumidifying, detoxifying, dispelling cold and the like, and has certain effects on cold in uterus, rheumatic arthralgia, abdominal pain and the like.
Asiatic toddalia root: toddalia asiatica is distributed in Yunnan and Guangdong provinces. The whole plant is used as herbal medicine, bitter in taste and numb. Warm in nature, promoting blood circulation, removing blood stasis, dispelling pathogenic wind, removing dampness, and relieving swelling and pain. It can be used for treating common cold, wind cold, gastralgia, intercostal neuralgia, rheumatic osteodynia, traumatic injury, and hemoptysis.
Yunnan schisandra chinensis: also known as Yunnan Wu Wei Zi, produced from the south of Yunnan to the southeast and the southeast of Tibet. Has effects in promoting immunity, resisting oxidation and aging, protecting liver, inducing liver metabolism enzyme, relieving cough, eliminating phlegm, resisting tumor, lowering blood sugar, tonifying heart, improving adaptability, resisting nephropathy, and resisting bacteria. It is reported that: the Yunnan schisandra chinensis water extract has the function of relieving the uterus of normal rabbits and can resist uterine contraction caused by prostaglandin.
Compared with the prior art, the invention has the following beneficial effects:
at present, no uterus warming patch with related traditional Chinese medicine compatibility is available in the market, various Yunnan characteristic medicinal materials capable of warming uterus and relieving pain are matched for use, a new compatibility idea is provided, the effect of treating various symptoms caused by cold uterus is obvious, the blank of the corresponding field is filled, the preparation process is simple, and the uterus warming patch is suitable for industrial production. The invention is safe, has no side effect, can be used for a long time, improves the physical condition and fundamentally solves the problem of cold in uterus.
Drawings
FIG. 1 is a graph showing the change of the tension of an animal in the pharmacodynamic test after the addition of 0.4ml of oxytocin.
FIG. 2 is a graph showing the change of the tension of the animal drug effect test after adding 1ml of ointment aqueous solution.
Detailed Description
The present invention is further described in detail below with reference to specific examples, which are provided for illustration only and are not intended to limit the scope of the present invention. The test methods used in the following examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are, unless otherwise specified, commercially available reagents and materials.
Example 1
(1) Taking 2 parts of herba Sambuci Adnatae, 6 parts of herba Elsholtziae Blandae, 6 parts of radix Kadsurae Longipedunculatae, 2 parts of Celastrus paniculatus, 2 parts of radix Tripterygii Wilfordii, 3 parts of Cinnamomum longepaniculatum, 4 parts of radix Toddaliae Asiaticae and 2 parts of Yunnan Schisandra chinensis, cleaning, removing impurities, pulverizing, sieving with a 120-mesh sieve, and mixing to obtain traditional Chinese medicine fine powder for use; (2) adding lemon essential oil at a weight ratio of 2:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3h for 30s every time, stirring for 8 times, heating with medium fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 2
(1) Taking 1 part of herba Sambuci Adnatae, 5 parts of herba Elsholtziae Blandae, 5 parts of radix Kadsurae Longipedunculatae, 1 part of Celastrus paniculatus, 1 part of radix Tripterygii Wilfordii, 2 parts of Cinnamomum longepaniculatum, 3 parts of radix Toddaliae Asiaticae and 1 part of Yunnan Schisandra chinensis, cleaning, removing impurities, pulverizing, sieving with a 120-mesh sieve, and mixing to obtain traditional Chinese medicine fine powder for use; (2) adding grapefruit essential oil at a weight ratio of 3:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3h for 30s every time, stirring for 8 times, heating with medium fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 3
(1) Taking 3 parts of herba Sambuci Adnatae, 8 parts of herba Elsholtziae Blandae, 8 parts of radix Kadsurae Longipedunculatae, 3 parts of Celastrus orbiculatus, 3 parts of radix Trifolii Pratentis, 4 parts of Cinnamomum longepaniculatum, 5 parts of radix Toddaliae Asiaticae and 4 parts of Yunnan Schisandra chinensis, cleaning, removing impurities, pulverizing, sieving with a 120-mesh sieve, and mixing to obtain traditional Chinese medicine fine powder for use; (2) adding orange essential oil at a weight ratio of 4:1, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3h for 30s every time, stirring for 8 times, heating with middle fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 4
(1) Taking 4 parts of herba Sambuci Adnatae, 9 parts of herba Elsholtziae Blandae, 9 parts of radix seu folium Gaultheriae Forrestii, 4 parts of caulis Celastri Angustifoliae, 3 parts of radix seu caulis Jasmini sambac, 4 parts of Cinnamomum camphora, 5 parts of radix Toddaliae Asiaticae and 4 parts of Yunnan fructus Schisandrae chinensis, cleaning, removing impurities, pulverizing, sieving with 120 mesh sieve, and mixing to obtain traditional Chinese medicine fine powder; (2) adding herba Agastaches essential oil at a weight ratio of 5:1, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3 hr, each time for 30s, stirring for 8 times, heating with middle fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1.5:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal ointment; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 5
(1) Taking 5 parts of herba sambuci chinensis, 10 parts of chicken liver powder, 10 parts of radix cynanchi wilfordii, 5 parts of celastrus orbiculatus, 3 parts of three-paired burls, 4 parts of cinnamomum camphora, 5 parts of asiatic toddalia root and 4 parts of Yunnan schisandra chinensis, cleaning, removing impurities, crushing, sieving with a 120-mesh sieve, and uniformly mixing to obtain traditional Chinese medicine fine powder for later use; (2) adding lemon essential oil at a weight ratio of 5:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3h for 30s every time, stirring for 8 times, heating with medium fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder is heated to brown, pouring out and filtering while it is hot to obtain primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 2:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 6
(1) Taking 1 part of herba sambuci chinensis, 8 parts of chicken liver powder, 8 parts of radix cynanchi wilfordii, 1 part of celastrus orbiculatus, 1 part of three-paired burls, 2 parts of cinnamomum japonicum, 5 parts of asiatic toddalia root and 4 parts of Yunnan schisandra chinensis, cleaning, removing impurities, crushing, sieving with a 120-mesh sieve, and uniformly mixing to obtain traditional Chinese medicine fine powder for later use; (2) adding grapefruit essential oil at a weight ratio of 5:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3h for 30s every time, stirring for 8 times, heating with medium fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 7
(1) Taking 5 parts of herba Sambuci Adnatae, 8 parts of herba Elsholtziae Blandae, 8 parts of radix Kadsurae Longipedunculatae, 4 parts of Celastrus paniculatus, 2 parts of radix Tripterygii Wilfordii, 2 parts of Cinnamomum longepaniculatum, 5 parts of radix Toddaliae Asiaticae and 4 parts of Yunnan Schisandra chinensis, cleaning, removing impurities, pulverizing, sieving with a 120-mesh sieve, and mixing to obtain traditional Chinese medicine fine powder for use; (2) adding grapefruit and lemon essential oil at a weight ratio of 2:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 8 times every 3 hr for 1 time and 30s each time, heating with middle fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping fire, cooling, adding medicinal gelatin at a weight ratio of 1.5:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly spreading the mixture on the first piece of non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolation film with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the medicine.
Example 8
(1) Taking 3 parts of herba Sambuci Adnatae, 8 parts of herba Elsholtziae Blandae, 8 parts of radix Kadsurae Longipedunculatae, 3 parts of Celastrus orbiculatus, 3 parts of radix Trifolii Pratentis, 4 parts of Cinnamomum longepaniculatum, 5 parts of radix Toddaliae Asiaticae and 4 parts of Yunnan Schisandra chinensis, cleaning, removing impurities, pulverizing, sieving with a 120-mesh sieve, and mixing to obtain traditional Chinese medicine fine powder for use; (2) adding orange and lemon essential oil at a weight ratio of 4:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 8 times every 3 hours for 1 time and 30s each time, heating to slightly boil with medium fire, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 2:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 9
(1) Taking 5 parts of herba Sambuci Adnatae, 5 parts of herba Elsholtziae Blandae, 5 parts of radix seu folium Gaultheriae Forrestii, 1 part of caulis Celastri Angustifoliae, 1 part of radix seu caulis Jasmini Lanceolatae, 4 parts of Cinnamomum camphora, 5 parts of radix Toddaliae Asiaticae and 4 parts of Yunnan fructus Schisandrae chinensis, cleaning, removing impurities, pulverizing, sieving with 120 mesh sieve, and mixing to obtain traditional Chinese medicine fine powder; (2) adding grapefruit and lemon essential oil at a weight ratio of 4:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 8 times every 3 hr for 1 time and 30s each time, heating with middle fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping fire, cooling, adding medicinal gelatin at a weight ratio of 1:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly spreading the mixture on the first piece of non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 10
(1) Taking 5 parts of herba sambuci chinensis, 8 parts of chicken liver powder, 10 parts of radix cynanchi wilfordii, 3 parts of celastrus orbiculatus, 5 parts of three-paired burls, 4 parts of cinnamomum camphora, 5 parts of asiatic toddalia root and 4 parts of Yunnan schisandra chinensis, cleaning, removing impurities, crushing, sieving with a 120-mesh sieve, and uniformly mixing to obtain traditional Chinese medicine fine powder for later use; (2) adding herba Agastaches and fructus Citri Limoniae essential oil at a weight ratio of 5:1, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 8 times every 3 hr for 1 time and 30s each time, heating with middle fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder is heated to brown, pouring out and filtering while it is hot to obtain primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1.5:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal ointment; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 11
(1) Taking 5 parts of herba Sambuci Adnatae, 5 parts of herba Elsholtziae Blandae, 10 parts of radix Kadsurae Longipedunculatae, 5 parts of Celastrus orbiculatus, 3 parts of radix seu caulis Jasmini Lanceolatae, 4 parts of Cinnamomum camphora, 5 parts of radix Toddaliae Asiaticae and 4 parts of Yunnan Schisandra chinensis, cleaning, removing impurities, pulverizing, sieving with a 120-mesh sieve, and mixing to obtain traditional Chinese medicine fine powder for use; (2) adding grapefruit and herba Agastaches essential oil at a weight ratio of 2:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 8 times for 1 time every 3 hr, each time for 30s, heating with middle fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder is heated to brown, pouring out and filtering while it is hot to obtain primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 1:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
Example 12
(1) Taking 3 parts of herba sambuci chinensis, 8 parts of chicken liver powder, 8 parts of radix cynanchi wilfordii, 3 parts of celastrus orbiculatus, 1 part of three-paired burls, 4 parts of cinnamomum camphora, 5 parts of asiatic toddalia root and 4 parts of Yunnan schisandra chinensis, cleaning, removing impurities, crushing, sieving with a 120-mesh sieve, and uniformly mixing to obtain traditional Chinese medicine fine powder for later use; (2) adding lemon essential oil at a weight ratio of 2:1 to the fine powder, mixing the essential oil and the fine powder uniformly, soaking at 20 deg.C, stirring for 1 time every 3h for 30s every time, stirring for 8 times, heating with medium fire to slightly boil, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping heating, cooling, adding medicinal gelatin at a weight ratio of 2:1 to the medicinal oil when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent; (3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly paving the mixture on the first non-woven fabric to obtain a heating sheet for later use; (4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use; (5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with an isolating membrane with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to obtain the heating sheet.
The curative effect and safety of the uterus warming patch prepared in example 12 were studied, and the drug effect experiment and the skin irritation experiment were performed, specifically as follows:
1. clinical curative effect experiment:
the experimental principle is as follows: clinical curative effects of the uterus warming patch prepared in the example 12 are compared with the traditional uterus warming patches on the market, so that the curative effects and advantages of the uterus warming patch can be obtained.
Case selection: randomly extracting 80 clinically recorded patients with cold uterus of 30-40 years old, numbering the patients according to the treatment sequence, and dividing the patients into two groups: 40 cases of A group and B group.
The treatment method comprises the following steps: both groups were treated over the first 2 months and treatment was discontinued at month 3. Group A used the conventional uterus warming patch on the market, and the treatment period was 30min each time at noon 1 time daily. Group B used the uterus warming patch prepared in example 12, and the treatment period was 30min 30 times per day at noon. During treatment, rain, swimming, strenuous exercise and the like are avoided. It has effects of supplementing nutrition, and eating food rich in protein, vitamins, calcium, and ferrum, and avoiding pungent food such as pungent food and uncooked food.
Grading standard: pain in the lower abdomen before and after menstrual period is divided into 5 points; dripping cold sweat for 2 minutes; cold limbs 1 minute; abdominal pain refused to be counted for 1 point; sitting and lying uneasy 1 point; soreness of the waist is 1 point; the face color is white for 1 minute; the lower the total score, the better the therapeutic effect.
The statistical method comprises the following steps: data were analyzed using SPSS21.0 statistical software. In the experiment, before treatment, a plurality of time points of a third menstrual period and a fourth menstrual period after treatment are counted, and repeated measurement variance design is adopted for analysis.
As a result: symptom scores of the first two groups are treated, and the difference is not statistically significant; the monthly cycle symptom score in both groups decreased compared to pre-treatment. In the third menstrual cycle, due to the cessation of treatment, the score for a increased over the month 2 score, with values approaching those before treatment; group B scored higher than month 2 and lower than pre-treatment scores. See table 1.
TABLE 1 two groups of symptoms score comparison (score) before and after treatment of cold type dysmenorrhea
Note: p < 0.05 compared to pre-treatment;
and (4) conclusion: the curative effect of the uterus warming patch prepared in the embodiment 12 after being continuously used for 2 months is more remarkable than that of the traditional uterus warming patch on the market.
2. Animal efficacy experiment:
the experimental principle is as follows: the uterus of the mouse is taken out of the body, the oxytocin is utilized to contract the uterus to simulate the effect of dysmenorrhea, and the water solution of the ointment in the embodiment 12 is added to judge the treatment effect of the uterus on the dysmenorrhea.
Preparing an ointment aqueous solution: the uterus warming patch prepared in example 12 was taken, and the ointment portion was added with 10ml of distilled water and stirred until completely dissolved.
Preparing an isolated uterus specimen: dividing two female rats in estrus into two groups, removing cervical vertebrae, killing, cutting abdominal cavity, finding uterus, and gently stripping; cutting the lower end of the joint of the two uterine horns, taking out the uterus, placing the uterus in a culture dish containing nutrient solution, and carefully cutting off connective tissues and adipose tissues attached to the uterus.
And (3) data measurement: the joint of the two uterine horns is cut, one horn is taken, 2cm is subtracted, one end of the horn is fixed at the bottom of the bath by a specimen hook, and the other end of the horn is tied to the sensor by a thread knot. The nutrient solution in the bath is added to submerge the uterus. The water bath temperature is 36 + -0.5 deg.C, and standing for 10 min. After the uterus adapts, the biological function experiment system is opened, and the tension is adjusted to 0.5-1 g. Starting the experiment and drawing a normal curve, then adding 0.04ml of oxytocin with the concentration of 2.5 mu/ml and marking; then adding 0.4ml of oxytocin with the concentration of 2.5 mu/ml for marking; and finally adding 1ml of ointment aqueous solution and marking.
As a result: after the addition of the aqueous solution, the uterine contractility decreased significantly. See fig. 1 and 2.
And (4) experimental conclusion: the tension is reduced after the water solution is added, which indicates that the uterus relaxes, namely, the traditional Chinese medicine ointment prepared in the example 12 can effectively treat dysmenorrhea and abdominal pain caused by cold in uterus.
3. Skin irritation test:
the experimental principle is as follows: the irritation of the uterus warming patch to the animal skin can be judged by observing the skin condition of the rabbit patch after the rabbit patch is applied in example 12.
Preparing materials: cutting the uterus warming patch prepared in the embodiment 12 into pieces of 4.0cm multiplied by 4.0cm for later use;
and (3) experimental operation: taking 4 New Zealand rabbits (3-4 months old) with half female and half male, no pregnancy and no damage to skin health, and performing tests at room temperature of 25-30 ℃. Removing hair on two sides of the spine of the back of the rabbit by about 10.0cm multiplied by 10.0cm 4-6 hours before the test to serve as a test and observation part. The prepared uterus warming patch is covered on the experimental part by 4.0cm × 4.0cm and fixed by a bandage. When the uterus warming patch stops heating and is cooled to room temperature, the uterus warming patch is taken down, then the contact part is marked by using lasting ink, and residual experimental materials are removed by using warm water. And recording the erythema and edema conditions of the applied part at each time point of 1 hour, 24 hours, 48 hours and 72 hours after the application.
Evaluation criteria: scoring 0-4 points from erythema to severe erythema; no to severe edema note: 0-4 minutes.
The experimental results are as follows: the female and male groups were all 0, see Table 2 below
TABLE 2 results of the animal skin irritation test
And (4) conclusion: example 12 the resulting uterus warming patch prepared was non-irritating to the animal's skin.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (7)
1. The uterus warming plaster is characterized in that the traditional Chinese medicine ointment comprises, by weight, 1-5 parts of herba sambuci, 5-10 parts of chicken liver powder, 5-10 parts of radix cynanchi wilfordii, 1-5 parts of celastrus paniculatus, 1-3 parts of three-in-one herb, 2-4 parts of cinnamomum camphora, 3-5 parts of asiatic toddalia root and 1-4 parts of Yunnan schisandra chinensis.
2. The hot compress physical therapy uterus warming patch for gynecology of claim 1, which is prepared by the following steps:
(1) cleaning herba Sambuci Adnatae, hepar gallus Domesticus powder, radix Cynanchi Wilfordii, caulis Celastri Conveniae, cortex Cinnamomi Camphorae, radix Toddaliae Asiaticae, radix Tripterygii Wilfordii, and fructus Schisandrae Sphenantherae, removing impurities, pulverizing, sieving with 100 mesh sieve, and mixing to obtain Chinese medicinal fine powder;
(2) Mixing the fine powder with essential oil, soaking at 20 deg.C, stirring for 30s every 3 hr for 1 time, heating with middle fire to slightly boil after stirring for 8 times, maintaining for 5s, and cooling to small fire. When the powder turns brown, pouring out and filtering while it is hot to obtain the primary medicinal oil. Decocting the primary medicinal oil with slow fire until no water vapor is generated, stopping fire, cooling, adding medicinal gelatin when the temperature of the medicinal oil is reduced to 180 deg.C, and stirring to obtain Chinese medicinal unguent;
(3) preparing two pieces of non-woven fabrics with the same size, uniformly mixing iron powder, activated carbon, salt, super absorbent resin and water, and uniformly spreading the mixture on the first piece of non-woven fabric to obtain a heating sheet for later use;
(4) uniformly coating the traditional Chinese medicine ointment obtained in the step (2) on a second non-woven fabric to obtain a medicine application for later use;
(5) and (4) relatively covering the heating sheet prepared in the step (3) on the medicine application paste obtained in the step (4), then wrapping the medicine application paste with isolating membranes with the same size, pressing and sealing the periphery completely, and then filling the medicine application paste into a vacuum aluminum foil bag to finish the hot compress physical therapy uterus warming paste for gynecology.
3. The preparation method according to claim 2, wherein the essential oil in step (2) is extracted from one or more of lemon, orange, grapefruit and patchouli.
4. The preparation method according to claim 2, wherein the ratio of the amount of the essential oil in the step (2) to the weight of the traditional Chinese medicine fine powder is 1-5: 1.
5. The method according to claim 2, wherein the ratio of the amount of the gelatin to the weight of the primary medicinal oil in step (2) is 1-2: 1.
6. The application of the gynaecologic hot compress physiotherapy uterus warming patch obtained according to the claim 1 in the auxiliary treatment of female menstrual lower abdomen psychroalgia, menstrual disorder, puerperal uterus warming and abortion uterus warming.
7. The use according to claim 6, wherein the female menstrual cold pain in the lower abdomen, menstrual disorder, etc. are caused by cold womb.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641311A (en) * | 2016-03-24 | 2016-06-08 | 长沙佰顺生物科技有限公司 | Uterus warming paste |
| CN105816559A (en) * | 2016-03-24 | 2016-08-03 | 长沙佰顺生物科技有限公司 | Uterus warming paste |
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- 2022-02-18 CN CN202210142309.9A patent/CN114748557A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641311A (en) * | 2016-03-24 | 2016-06-08 | 长沙佰顺生物科技有限公司 | Uterus warming paste |
| CN105816559A (en) * | 2016-03-24 | 2016-08-03 | 长沙佰顺生物科技有限公司 | Uterus warming paste |
Non-Patent Citations (1)
| Title |
|---|
| 张明生: "关通舒胶囊治疗慢性腰肌劳损120例", 中国中医药现代远程教育, no. 22, pages 25 * |
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