CN110354187A - A kind of plant extract composition improving sleep - Google Patents

A kind of plant extract composition improving sleep Download PDF

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CN110354187A
CN110354187A CN201910711145.5A CN201910711145A CN110354187A CN 110354187 A CN110354187 A CN 110354187A CN 201910711145 A CN201910711145 A CN 201910711145A CN 110354187 A CN110354187 A CN 110354187A
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extract
improving sleep
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extraction
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殷世清
侯蒙蒙
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Hanzhui (tianjin) Biotechnology Co Ltd
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Hanzhui (tianjin) Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides a kind of plant extract compositions for improving sleep, the composition is made of the raw material of following parts by weight: 10-15 parts of bigarabe leaf extract, 25-40 parts of Herba Lysimachiae foenumgraeci extract, 20-35 parts of valerian root extract, 10-20 parts of santal seed extract, 10-15 parts of cloves flower extract, 5-10 parts of jasmine flower extract, 20-30 parts of marjoram extract, 10-20 parts of camomile extract.The plant extract composition of the present invention for improving sleep is easy to use, and portable, Transdermal absorption is rapid-action, without side-effects, will not generate dependence.

Description

A kind of plant extract composition improving sleep
Technical field
The invention belongs to plant composition fields, more particularly, to a kind of plant extract composition for improving sleep.
Background technique
In the modern life, due to the change of the factors such as physiology, psychology, environment, the whole world is asked with the presence of at least 27% people sleep Topic, common sleeping problems be usually expressed as difficulty falling asleep, dreaminess, shallow dormancys, Yi Xing, sleep insufficiency, it is awake after have taediumvitae etc.. Vigilance disorders are a global health problems, are increasingly valued by the people, and a variety of diseases can be induced, or even can accelerate to decline Always, the service life is reduced, threat to life.
The mode for usually solving sleeping problems is by taking drugs, and the drug for commonly using treatment insomnia currently on the market has Hypnotic sedative agent (including barbiturates, Benzodiazepines, atypia Benzodiazepines), antidepressants, antihistamine are (at present It is rarely used for hypnosis) and Chinese medicine, immunotherapy targeted autoantibody of such method mainly to severes sleeping problems such as insomnias, and also it is universal As long as thinking to take hypnotic will result in different degrees of medication habituation, and takes for a long time will appear and generate drug resistance, weary The problems such as power, depression, poisoning, parahypnosis, liver kidney be impaired, senile dementia, functions of intestines and stomach disorder.
In addition there are use Nd-Fe-B permanent magnet sleeping pad, repetitive transcranial magnetic stimulation, the various sides such as Division 30. Psychological Hypnosis treatment Formula, often shows that therapeutic process is cumbersome, works that slow, the duration is long, and has certain side effect.
Summary of the invention
In view of this, the present invention is directed to propose a kind of improve the plant extract composition slept, by smearing or smoking The mode that fragrant, suction is smelt achievees the purpose that sleeping using the ingredient synergistic effect wherein beneficial to sleep.It is easy to operate, rapid-action and It is without any side effects, dependence will not be generated.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
A kind of plant extract composition improving sleep, the composition are made of the raw material of following parts by weight:
Preferably, the composition is made of the raw material of following parts by weight:
Preferably, the composition is made of the raw material of following parts by weight:
Preferably, the composition is made of the raw material of following parts by weight:
The preparation method of the plant extract composition of the improvement sleep, includes the following steps: the Petitgrain Extract, Herba Lysimachiae foenumgraeci extract, valerian root extract, santal seed extract, cloves flower extract, jasmine flower extract, sweet tea horse Yu Lan extract and camomile extract are after mixing to obtain the final product.
Further, the bigarabe leaf extract is made of the method including the following steps: new orange leaf crushes, and is added Distilled water dissolves NaCl, makes water submerged blade, and after impregnating 2-3 hours, distillation pot bottom is passed through vapor heating, accesses simultaneously Distilling and extracting device equipped with n-hexane, 70 DEG C of constant temperature after Simultaneous distillation-extraction, are collected n-hexane extract, are rotated dense Contracting, uses N2It is bigarabe leaf extract that blowout residual solvent, which obtains grease,.
Further, the Herba Lysimachiae foenumgraeci extract is made of the method including the following steps: taking lavender herb, vacuum Freeze-drying crushes, and 60 meshes is crossed, using CO2Supercritical extraction process adjusts CO2Circular flow is 20kg/h, extraction temperature 45 DEG C, extracting pressure 22MPa, after extracting 2h, separating and extracting product and CO2, empty CO2, obtain Herba Lysimachiae foenumgraeci extract.
Further, the valerian root extract is made of the method including the following steps: valerian root is used as medicine, medicinal material Coarse powder, using carbon dioxide supercritical extraction technology, 30-40 DEG C of extraction temperature, extracting pressure 20-30MPa, the amount of entrainer It is 2-4 times of medicinal material weight, wherein the unit of the amount of entrainer is ml, and medicinal material unit of weight is g, and the entrainer is selected from first Alcohol, dehydrated alcohol or 95% ethyl alcohol, parse pressure 3-6MPa, CO by 30-40 DEG C of resolution temperature2Flow 10-20L/h, when extraction Between 1-2h, after extraction, isolated Valerian root P.E.
Further, the santal seed extract is made of the method including the following steps: santal seed coarse powder, adds water mixed It closes, after impregnating 2-3 hours, distillation pot bottom is passed through vapor heating, and cooled vapor obtains oil water mixture, and add diethyl ether extraction, ether Layer is dehydrated with anhydrous sodium sulfate, is filtered, is obtained santal seed extract.
Further, the cloves flower extract is made of the method including the following steps: lilac dries in the shade, and crushes, adds Enter the deionized water of 20 times of weight, impregnate 15-20 hours, ultrasound 1 hour filters, and is concentrated in vacuo filtrate, and drying to constant weight i.e. Cloves flower extract can be obtained；
The jasmine flower extract is made of the method including the following steps: taking Jasmine, vacuum freeze-drying crushes, mistake 60 meshes, using CO2Supercritical extraction process adjusts CO2Circular flow is 20kg/h, and extraction temperature is 40 DEG C, extracting pressure For 20MPa, extracts 2 hours, be entrainer, mass concentration 60%, separating and extracting product and CO using ethyl alcohol2, emptying CO2, obtain jasmine flower extract；
The marjoram extract is made of the method including the following steps: steam distillation is used, by Ma Yu Orchid, which is dried in the shade, is packed into alembic, adds water, is passed through vapor from the bottom of alembic and heats to extracting solution, extracting solution boiling After extract 1.5-2h, obtain mixed vapour；Mixed vapour is condensed by condenser, and oil water mixture is obtained after condensation；Through It crosses oil water separator and carries out water-oil separating, obtain marjoram crude oil and water；It is extracted using extractor, after layering, is separated Upper layer is marjoram extract；
The camomile extract is made of the method including the following steps: chamomile being cleaned up, juicing is used Then crusher machine such as uses to impregnate 30min at the ethanol water that the concentration of quality is 60%；Chamomile liquid after immersion is put Enter centrifuge and be centrifuged 15min at 1200r/min, obtains centrifugate；By above-mentioned centrifugate in 0.8 standard atmospheric pressure, 85 DEG C Lower distillation, removing slip out object, collect remaining liquid, obtain an extracting solution, and extracting solution is used to the screen to filtrate of 320 mesh, 75% ethanol solution that extracting solution equivalent is added in filtrate is uniformly mixed, is then steamed at 0.9 standard atmospheric pressure, 90 DEG C It evaporates, removal slips out object, and obtaining residue is camomile extract.
Bigarabe leaf extract: the tonka-bean in bigarabe leaf extract, which is known as, to be adjusted mood, compressive resistance, improves depression and mistake Dormancy problem.
Herba Lysimachiae foenumgraeci extract: linalool, linalyl acetate in Herba Lysimachiae foenumgraeci extract play the role of calming nerves, relax and sleep.
Valerian root extract: valerone, the valeric aldehyde of valerian root extract facilitate the heart caused by alleviating arrhythmia cordis Unbearably, it has a sleepless night, and lowers nervous excitation degree, so that people be allowed to reach deep sleep.
Santal seed extract: santalol contained in santal seed extract pacifies nerve, the effect felt relieved with fixed attention.
Cloves flower extract: α-caryophyllene in cloves flower extract plays the role of analgesia, psychology of releiving.
Jasmine flower extract: jasmine flower extract contains methyl anthranilate, jasmone, a small amount of to use active pair Sympathetic nerve plays the role of mood placating, promotes sleep.
Marjoram extract: there is marjoram extract excellent nerve to pacify and calm function, contained agalloch eaglewood Alcohol can substantially improve it is nervous, insomnia, spirit is excited, thyroid gland is hyperfunction, very sleeping.
Camomile extract: the angelic acid isobutyl ester contained by camomile extract can alleviate anxiety, anxiety, indignation It with fear, makes one to loosen, mitigates worry, soothing effect is excellent, helpful to having a sleepless night.
Calm and sleeping can almost draw equal sign, because the mankind are easiest to the state fallen asleep, exactly parasympathetic nerve is living When jump, that is, mood is steady, palmic rate reduces, in the case where hypothermia.And this kind of essential oils has stimulation The parasympathetic Holy Bible；It sets the mind at rest, promotes thrombocytin；Breathing is allowed to deepen length；Thinking is allowed slowly to act on.
The application method of the plant extract composition of the improvement sleep:
It smears: before sleeping daily, 5 drop essential oils being taken to be applied to two sides Anmian point after Renzhong acupoint, temple and ear, two hands respectively 1-2 minutes are rubbed to absorption.
Bubble foot: sleeping first 1 hour daily, takes 10 drop essential oils in warm bubbly water foot 15 minutes.
Stacte: first 30 minutes of sleep daily take 5 drop essential oils for stacte.
Suction is smelt: daily before sleep, taking 2 drop essential oils in bedside.
Compared with the existing technology, the plant extract composition of the present invention for improving sleep has the advantage that
(1) it is of the present invention improve sleep plant extract composition use extract contained in cumarin, The ingredients such as linalool, linalyl acetate, valerone, valeric aldehyde, santalol, α-caryophyllene, angelic acid isobutyl ester can be directly Or indirectly alleviate anxiety, anxiety, calming nerves, mood placating has very big facilitation to sleep.
(2) ingredient of the plant extract composition of the present invention for improving sleep is small molecule structure, absorbs fast, generation Thank fast, will not cause to bear to body, and application method simply can be used for sleeping acupoint smear, warm water mixing bubble foot, stacte and Suction is smelt, achieve the purpose that it is convenient and efficient, help for sleep.
Specific embodiment
In addition to being defined, technical term used in following embodiment has and the invention fields technology people The identical meanings that member is commonly understood by.Test reagent used in following embodiment is unless otherwise specified routine biochemistry examination Agent；The experimental method is unless otherwise specified conventional method.
Below in conjunction with embodiment, the present invention will be described in detail.
Embodiment 1
A kind of plant extract composition improving sleep, the composition are made of the raw material of following parts by weight: Petitgrain mentions Take 15 parts of object, 40 parts of Herba Lysimachiae foenumgraeci extract, 35 parts of valerian root extract, 20 parts of santal seed extract, cloves flower extract 10 Part, 10 parts of jasmine flower extract, 30 parts of marjoram extract, 10 parts of camomile extract.
The preparation method of the plant extract composition of the improvement sleep, includes the following steps: the Petitgrain Extract, Herba Lysimachiae foenumgraeci extract, valerian root extract, santal seed extract, cloves flower extract, jasmine flower extract, sweet tea horse Yu Lan extract and camomile extract are after mixing to obtain the final product.
Embodiment 2
A kind of plant extract composition improving sleep, the composition are made of the raw material of following parts by weight: Petitgrain mentions Take 10 parts of object, 35 parts of Herba Lysimachiae foenumgraeci extract, 25 parts of valerian root extract, 18 parts of santal seed extract, cloves flower extract 12 Part, 8 parts of jasmine flower extract, 20 parts of marjoram extract, 13 parts of camomile extract.
The preparation method of the plant extract composition of the improvement sleep, includes the following steps: the Petitgrain Extract, Herba Lysimachiae foenumgraeci extract, valerian root extract, santal seed extract, cloves flower extract, jasmine flower extract, sweet tea horse Yu Lan extract and camomile extract are after mixing to obtain the final product.
Embodiment 3
A kind of plant extract composition improving sleep, the composition are made of the raw material of following parts by weight: Petitgrain mentions Take 12 parts of object, 32 parts of Herba Lysimachiae foenumgraeci extract, 30 parts of valerian root extract, 15 parts of santal seed extract, cloves flower extract 13 Part, 7 parts of jasmine flower extract, 25 parts of marjoram extract, 16 parts of camomile extract.
The preparation method of the plant extract composition of the improvement sleep, includes the following steps: the Petitgrain Extract, Herba Lysimachiae foenumgraeci extract, valerian root extract, santal seed extract, cloves flower extract, jasmine flower extract, sweet tea horse Yu Lan extract and camomile extract are after mixing to obtain the final product.
Clinical test treats 100 patients using the composition in embodiment 1, treatment results statistics such as table 1 It is shown.
1 case statistics of table
Case Recovery from illness Significant curative effect Effectively In vain It is efficient
100 32 53 13 2 98.0%
The wherein above curative effect determinate standard are as follows: be confirmed as fully recovering using not recurring after product of the present invention 1 year；Use this hair It is effective that bright product recurs after 1 year；It the use of state of an illness mitigation after product of the present invention 1 year is effective；It uses product of the present invention 1 year After to be not improved be invalid.
Through the patient to 100 sleep disturbance after product of the present invention 1 year, share that 2 people are invalid, and total effective rate reaches To 98.0%.
Using wherein more typical two cases further illustrate curative effect of the invention after the present invention.
Example one: Lee, male, people from Hebei, 32 years old, city white collar, middle administrative staff, long-time Project Operation, work Pressure is big, nervous, falls asleep slow, and sleep quality significantly improves after using product of the present invention, and mood is calmed down fastly, falls asleep fast, by The normal phase is greatly improved using this product sleep quality.
Example two: Xue, female, people from Tianjin, 29 years old, full-time mother was in bring up and looks after child, often irritated, it is gloomy not Happy, sleep is shallow, Yi Xing, and sleep quality improves after using product of the present invention, and sleep is steady and sure, obtains the sense of security.
Example three: Zhang, male, people from Shandong, 61 years old, retired veteran cadre and retired ex employee were older, and it is difficult to fall asleep, and had taediumvitae after waking up, tasted Examination is bad using hypnotic instrument effect, happy after using product of the present invention, falls asleep fast, and deep sleep improves, and alleviates significantly Sleeping problems, and it is easy to use.
Example four: Mr. Wang, female, Pekinese, 26 years old, students boarded at school for a long time, and learning pressure is big, and sleep environment is not Good, mood swing is big, often feels anxiety, obvious using effect after product of the present invention, is in a cheerful frame of mind, tranquilizing and allaying excitement, sleep quality mentions It is high.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of plant extract composition for improving sleep, it is characterised in that: the composition is made of the raw material of following parts by weight:
2. the plant extract composition according to claim 1 for improving sleep, it is characterised in that: the composition is by such as The raw material of lower parts by weight is made:
3. the plant extract composition according to claim 1 for improving sleep, it is characterised in that: the composition is by such as The raw material of lower parts by weight is made:
4. the plant extract composition according to claim 2 for improving sleep, it is characterised in that: the composition is by such as The raw material of lower parts by weight is made:
5. the preparation method of the plant extract composition of any of claims 1-4 for improving sleep, it is characterised in that: Include the following steps: the bigarabe leaf extract, Herba Lysimachiae foenumgraeci extract, valerian root extract, santal seed extract, cloves Flower extract, jasmine flower extract, marjoram extract and camomile extract are after mixing to obtain the final product.
6. the preparation method of the plant extract composition according to claim 5 for improving sleep, it is characterised in that: described Bigarabe leaf extract is made of the method including the following steps: new orange leaf crushes, and distilled water is added, and dissolves NaCl, makes water logging No blade, after impregnating 2-3 hours, distillation pot bottom is passed through vapor heating, while accessing the distillation extraction equipped with n-hexane and filling It sets, 70 DEG C of constant temperature, after Simultaneous distillation-extraction, collects n-hexane extract, concentrated by rotary evaporation uses N2Blowout residual solvent obtains Grease is bigarabe leaf extract.
7. the preparation method of the plant extract composition according to claim 5 for improving sleep, it is characterised in that: described Herba Lysimachiae foenumgraeci extract is made of the method including the following steps: taking lavender herb, vacuum freeze-drying crushes, and crosses 60 meshes, uses CO2Supercritical extraction process adjusts CO2Circular flow is 20kg/h, and extraction temperature is 45 DEG C, extracting pressure 22MPa, extraction After 2h, separating and extracting product and CO2, empty CO2, obtain Herba Lysimachiae foenumgraeci extract.
8. the preparation method of the plant extract composition according to claim 5 for improving sleep, it is characterised in that: described Valerian root extract is made of the method including the following steps: valerian root is used as medicine, medicinal material coarse powder, using CO 2 supercritical Abstraction technique, 30-40 DEG C of extraction temperature, extracting pressure 20-30MPa, the amount of entrainer is 2-4 times of medicinal material weight, wherein pressing from both sides The unit of amount with agent is ml, and medicinal material unit of weight is g, and the entrainer is selected from methanol, dehydrated alcohol or 95% ethyl alcohol, parsing 30-40 DEG C of temperature, parse pressure 3-6MPa, CO2Flow 10-20L/h, extraction time 1-2h, after extraction, isolated figured silk fabrics Careless extract.
9. the preparation method of the plant extract composition according to claim 5 for improving sleep, it is characterised in that: described Santal seed extract is made of the method including the following steps: santal seed coarse powder adds water to mix, after impregnating 2-3 hours, alembic Bottom is passed through vapor heating, and cooled vapor obtains oil water mixture, and add diethyl ether extraction, and ether layer is dehydrated with anhydrous sodium sulfate, filtering, Obtain santal seed extract.
10. the preparation method of the plant extract composition according to claim 5 for improving sleep, it is characterised in that: described Cloves flower extract be made of the method including the following steps: lilac dries in the shade, crush, the deionization of 20 times of weight is added Water impregnates 15-20 hours, and ultrasound 1 hour filters, and is concentrated in vacuo filtrate, drying to constant weight can be obtained cloves flower extract；
The jasmine flower extract is made of the method including the following steps: taking Jasmine, vacuum freeze-drying crushes, and crosses 60 mesh Sieve, using CO2Supercritical extraction process adjusts CO2Circular flow is 20kg/h, and extraction temperature is 40 DEG C, and extracting pressure is 20MPa extracts 2 hours, is entrainer, mass concentration 60%, separating and extracting product and CO using ethyl alcohol2, empty CO2, obtain To jasmine flower extract；
The marjoram extract is made of the method including the following steps: steam distillation is used, by marjoram It dries in the shade and is packed into alembic, add water, be passed through vapor from the bottom of alembic and extracting solution is heated, extracted after extracting solution boiling 1.5-2h obtaining mixed vapour；Mixed vapour is condensed by condenser, and oil water mixture is obtained after condensation；By grease Separator carries out water-oil separating, obtains marjoram crude oil and water；It is extracted using extractor, after layering, separates upper layer i.e. For marjoram extract；
The camomile extract is made of the method including the following steps: chamomile cleaned up, it is broken using juice extractor It is broken, the ethanol water that the concentration of quality is 60% such as then use to impregnate 30min；Chamomile liquid after immersion is put into centrifugation Machine is centrifuged 15min at 1200r/min, obtains centrifugate；Above-mentioned centrifugate is distilled at 0.8 standard atmospheric pressure, 85 DEG C, Removing slips out object, collects remaining liquid, obtains an extracting solution, and extracting solution is used to the screen to filtrate of 320 mesh, by filtrate plus 75% ethanol solution for entering extracting solution equivalent is uniformly mixed, and is then distilled at 0.9 standard atmospheric pressure, 90 DEG C, removal is slipped Object out, obtaining residue is camomile extract.
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CN112891469A (en) * 2019-12-04 2021-06-04 杨春辉 Compound essential oil for improving sleep quality
CN113768960A (en) * 2021-06-23 2021-12-10 仙婷(广州)科技研发有限公司 Oral and external use method for improving sleep and application thereof

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CN106729068A (en) * 2016-12-23 2017-05-31 曾惠民 A kind of external application energy gauging that can be helped for sleep and preparation method thereof
CN108497853A (en) * 2017-05-18 2018-09-07 太仓市神英中草药专业合作社 A kind of medium-height grass medicine-filled pillow with tranquilizing the mind effect
CN107569616A (en) * 2017-09-08 2018-01-12 恩馨（北京）生物科技有限公司 A kind of compound oil for improving sleep and preparation method thereof
CN108837073A (en) * 2018-08-13 2018-11-20 河南中医药大学 A kind of essential oil of traditional Chinese medicine eye sticker improving sleep

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112891469A (en) * 2019-12-04 2021-06-04 杨春辉 Compound essential oil for improving sleep quality
CN113768960A (en) * 2021-06-23 2021-12-10 仙婷(广州)科技研发有限公司 Oral and external use method for improving sleep and application thereof

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Application publication date: 20191022