CN110123981A - A kind of Chinese medicine aromatotherapy composition and its application for having effects that intelligence promoting and tranquilization and helping sleep - Google Patents

A kind of Chinese medicine aromatotherapy composition and its application for having effects that intelligence promoting and tranquilization and helping sleep Download PDF

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Publication number
CN110123981A
CN110123981A CN201910446153.1A CN201910446153A CN110123981A CN 110123981 A CN110123981 A CN 110123981A CN 201910446153 A CN201910446153 A CN 201910446153A CN 110123981 A CN110123981 A CN 110123981A
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flower
drug
composition
sleep
organic solvent
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史坚鸣
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Shanghai Tongji Hospital
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Shanghai Tongji Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
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Abstract

The present invention relates to a kind of Chinese medicine aromatotherapy composition for having effects that intelligence promoting and tranquilization and helping sleep, the composition is made of the bulk pharmaceutical chemicals of such as the following parts by weight: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, west safflower, finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower, cloves, agalloch eaglewood, villous amomum flower.The invention also includes combination of the above objects to prepare the application in the drug that intelligence promoting and tranquilization helps sleep.The treatment method of the drug includes: fragrant inhalation and fragrant Transdermal absorption method, and advantage is shown: 1, with pure natural aromatics flowers and aromatics plant composition of prescription, not containing any artificial synthetic ingredient；2, under the guidance of diagnosis and treatment based on an overall analysis of the illness and the patient's condition principle, selected each herbal medicine all passes through four natures and five flavors of drug, ascending-aescending-floating-sinking, and channel tropism enters internal organs and modern pharmacology research, there was only excellent positive effect to human body, and without any side effects.

Description

It is a kind of have effects that intelligence promoting and tranquilization help sleep Chinese medicine aromatotherapy composition and its Using
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically, being a kind of Chinese medicine virtue for having effects that intelligence promoting and tranquilization and helping sleep Fragrant therapy composition and its application.
Background technique
The time that there is one third in all one's life of people is spent in sleep, and in sleep procedure, whole body includes maincenter mind It is all restored and rests through system.Neuron and linked groups' restoration and reconstruction and regeneration need the rest of body, and only sleep Dormancy state can provide this rest.Sleep has many functions, including restores attention, promotes growth and consolidating memory gentle Solve intense strain etc..Sleep is the important link of body recovery, integration and consolidating memory, and sleep is that health is indispensable important Component part is that healthy life institute is required.
Insomnia is the most common sleep disturbance, is one of most common psychosomatic disease symptom, caused by referring to a variety of causes Sleep insufficiency, difficulty falling asleep, early awakening, patient often have mental fatigue, feel dizzy, tinnitus of having a headache, shortness of breath and palpitation, memory do not collect In, the performance such as work efficiency drop.
Patient generally enters the prolongation of latency of sleep, and sleeping time shortens, and physiology sexual arousal increases in process of falling asleep. Main performance: less serious case's difficulty falling asleep, Yi Xing in sleep, and be difficult to fall asleep again；Early morning wakes up too early.Severe one is lain awake all night, often With headache and dizzy, spiritlessness and weakness, palpitation and amnesia, confused and worried, dreaminess etc., patient often experiences anxiety to insomnia and fear.
Primary insomnia generates insomnia since nervous, anxiety is frightened.Insomnia secondary, secondary to body Factor, environmental factor, neuropsychiatric disease etc..
The harm of insomnia: (1) insomnia causes body immunity to decline, and weakens to the resistance of various diseases.(2) insomnia is drawn Play failure of memory, headache.(3) insomnia influences work, studying and living.(4) insomnia can lead to vegetative nervous disorder.(5) it passes through Often insomnia can cause senile dementia.(6) often insomnia made one presenility, shortened the service life.(7) children sleeping deficiency will affect The growth and development of body.
At present from Chinese medicine angle, dialectical main sick position of having a sleepless night is had ants in one's pants and is lost due to mind dystrophy or uneasiness in the heart It sleeps, but related to the yin and yang qi and blood disorder of liver, gallbladder, spleen, stomach, kidney.Specifically have 7 card types: (1) internal heat is partially high；(2) liver depression Fire；(3) it is disturbed in phlegm heat；(4) stomach Qi is become estranged；(5) fire excess from yin deficiency；(6) insufficiency of heart and spleen；(7) the heart and gallbladder deficiency of vital energy.
Western medical treatment: the treatment having a sleepless night at present on the basis of active treatment primary disease, while taking some adjusting nerves The treatment insomnia of the methods of drug of system；Chinese traditional treatment: Chinese herbal medicine decoction of medicinal ingredients takes orally and acupuncture and moxibustion therapy.
Aromatotherapy is that dosage form appropriate is made with the plant of fragrant odour to act on whole body or part, with prevent and treat physiology with Mental disease, a kind of sanatory medical health method.
It is closely bound up that fragrant plant performance drug effect also functions approach.Current most widely used, most study method It is fragrant inhalation therapy and fragrant Transdermal absorption therapy.
Fragrant Transdermal absorption refers to that so that aromatic substance is passed through skin in a short period of time by massage method enters blood It recycles (cell tissues such as nerve, bone, muscle can be affected by it), so as to achieve the aim of preventing and treating diseases
Fragrant inhalation therapy, which then refers to, directly acts on central nervous system by olfactory pathway, while passing through lung, leads to Gas exchanges are crossed, into blood circulation, play the role for the treatment of disease.
As a branch of herbology, aromatotherapy is because the therapeutic effect of its natural quality and natural green is by increasingly More people are received.This method have the characteristics that letter, just, it is honest and clean, test, it is sufficient to make up the deficiency of decoction of medicinal ingredients for oral administration, can widely apply In clinical departments.
Aromatotherapy treatment insomnia has the advantage that
1. avoiding Chinese and western drugs takes side reaction orally, it is easy to be received by psychosomatic disease patient.
2. avoid the nociception of acupuncture and moxibustion therapy with it is invasive, be easy to be received by psychosomatic disease patient.
3. especially fragrant inhalation is treated due to directly acting on nervous centralis by olfactory pathway in nervous system disease In have unique advantage.
4. the effect of the therapeutic effect of its natural quality and natural green " controlling " existing to disease plays the role of " preventing ", easily again In by receiving popularization and application.
It although aromatotherapy is originating from Europe, is grown up on the basis of traditional medical theory between east and west, application It is more affected by the influence of west tradition herbology, but the herbal medicine theory in west is limited only to effect and usage, therewith There is more deep Clinical significance of MG to aromatotherapy compared to the traditional Chinese medicine theories of Chinese materia medica in China.
Inventor has studied Chinese medicine aromatotherapy composition and its application that a kind of intelligence promoting and tranquilization of the present invention helps sleep, this hair It is bright to use Chinese medicine aromatotherapy, the acceptance of patient is improved, yet there are no report about this patent.
Summary of the invention
The first purpose of this invention is that in view of the deficiencies of the prior art, providing one kind has effects that intelligence promoting and tranquilization helps sleep Chinese medicine aromatotherapy composition.
Second object of the present invention is in view of the deficiencies of the prior art, to provide the purposes of composition as above.
Third object of the present invention is that in view of the deficiencies of the prior art, providing one kind has effects that intelligence promoting and tranquilization helps sleep Chinese medicine aromatotherapy drug.
To realize above-mentioned first purpose, the technical solution adopted by the present invention is that:
A kind of Chinese medicine aromatotherapy composition for having effects that intelligence promoting and tranquilization and helping sleep, the composition is by such as the following weight The bulk pharmaceutical chemicals of part are made: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, west safflower, fingered citron Flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower (are based on " middle traditional Chinese medicines Allusion quotation ", " dictionary of medicinal plant ", " China book on Chinese herbal medicine " record, select nontoxic Saussurea laniceps flower, disable toxic snow lotus of big bud flower or new Boundary saussurea involucrata or Herba Saussureae Involueratae), cloves, agalloch eaglewood, villous amomum flower.
As a preferred embodiment of the invention, being prepared into according to Chinese medicine conventional formulation preparation method can clinically be connect The pharmaceutical preparation received.
As a preferred embodiment of the invention, the pharmaceutical preparation is aerosol, spray, paste, lotion, powder Agent or oral solution.
To realize above-mentioned second purpose, the technical solution adopted by the present invention is that:
Composition as described above has effects that intelligence promoting and tranquilization helps answering in the Chinese medicine aromatotherapy drug slept in preparation With.
A kind of Chinese medicine aromatotherapy drug for having effects that intelligence promoting and tranquilization and helping sleep, the composition of the drug from the above mentioned It is made.
As a preferred embodiment of the invention, the drug the preparation method is as follows:
(1) dry above-mentioned raw materials medicine, each bulk pharmaceutical chemicals are crushed and are mixed after the parts by weight such as taking fresh or dehydration It extracts to obtain plants essential oil by steam distillation or organic solvent extraction afterwards；
(2) plants essential oil for taking step (1) to obtain is dissolved as perfume ingredient, and to assign the ratio uniform that fragrant rate is 25% In the ethanol solution that concentration is 95%, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains drug.
As a preferred embodiment of the invention, the organic solvent extraction is selected from one of the following:
A. take smashed bulk pharmaceutical chemicals, organic solvent be added to medicinal material is just submerged, then using water-bath reflow method into Row extracts, and extracts 3 times altogether, extracts 1-3h every time, then extracting solution is recovered under reduced pressure after organic solvent under water-bath and obtains plant essence Oil；
B. take smashed each raw material mixing, and organic solvent be added to medicinal material is just submerged, then using cold-maceration into Row extracts, and extracts 3 times altogether, extracts 5-7d every time, then extracting solution is recovered under reduced pressure after organic solvent under water-bath and obtains plant essence Oil.
Organic solvent as a preferred embodiment of the invention, in the organic solvent extraction are as follows: petroleum ether, N-hexane, chloroform, ether or ethyl acetate.
As a preferred embodiment of the invention, the drug is treated by Chinese medicine aromatotherapy.
As a preferred embodiment of the invention, the Chinese medicine aromatotherapy is that fragrant inhalation therapy and fragrance are transdermal Absorb therapy.
As a preferred embodiment of the invention, the usual way of the drug includes: fragrant pendant method, fragrant hat method, perfume (or spice) Pillow method, fragrant pocket method, scent method, fragrant bath method, fragrant deposited method, perfume (or spice) press method.
As a preferred embodiment of the invention, the common formulations of the drug include: stacte, massage, brothers bath, It baths, steam sucking, smearing, cold compress, hot compress, gargles, is sprayed, aerosol, showering agent, medicine-filled pillow agent.
For insomnia, the present invention uses syndrome differentiation of zang-fu viscera, and differentiation of eight principles, the differentiation of tri-jiao, it is former that the differentiation of channels and collaterals formulates treatment Then, aromatics Chinese herbal medicine is selected with the property of Chinese materia medica theoretical (four gas, the five tastes, channel tropism, ascending-aescending-floating-sinking), formulates controlling for aromatotherapy Treatment scheme --- Chinese medicine aromatotherapy.Because of the guiding theory fundamental difference followed, it is totally different from the treatment of west fragrance Method.
For insomnia, current common Chinese medical discrimination, theoretical main threads is many, loses in touching briefly on the essentials, etiology and pathogenesis is caused to contain Mixed, parting is many and diverse.And true human five internal organs' six internal organs are integral, and work hard in glove with connection conduction by channels and collaterals, internal organs actual situation is each other in table Inside and outside sample relationship in-between.A certain card type is it is merely meant that in a certain internal organs, and pathological manifestations are a little prominent in a certain respect, and Remaining internal organs remaining aspect is not represented there is no pathologic problems.If therefore from syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of tri-jiao, warp Network is dialectical to start with, and analyzes under morbid state, the three burnt pathological states that cold and heat and asthenia and sthenia in what kind of yin-yang table is in the five internal organs, So etiology and pathogenesis of disease can often see the whole picture and very clear.
Below it is integrally recapitulative dialectical to the Chinese medicine of insomnia:
1, at the part of the body cavity above the diaphragm housing the heart and lungs (mark) --- deficiency of YIN-blood is disturbed in the fire of deficiency type.Lung: it is scorching on lung heat, based on lung-fire superinverse；The heart: in internal heat Inflammation, based on mind disturbance, liver: liver-fire flaming, based on liver-yang hyperactivity, and perverse and unreasonable manner gram taste, it is weakness of the spleen and the stomach so that under liver and gallbladder damp-heat Note.
2, in middle burnt (sheet) --- taste: weakness of the spleen and the stomach, deficiency-cold in spleen and stomach；Liver and gallbladder: stagnant heat in the liver and gall loses in catharsis；Taste are by wood Fire multiplies, and phlegm wet extravasated blood is stagnated.
3, in lower burnt (sheet) --- kidney: yang-energy, which loses, is lost in storage, and the mistake of the nephrons cold of insufficiency type in taking the photograph admittedly；Liver kidney: liver-kidney deficiency, liver Kidney deficiency；Water-wet and liver and gallbladder damp-heat bet.
Wherein part of the body cavity above the diaphragm housing the heart and lungs disease is often the mark of disease, and the sheet of its disease descends two cokes in really: lung-fire superinverse is mark, spleen Stomach weakness is this；Flaring up of heart fire, mind disturbance is mark, water-fire imbalance, and the insufficiency of the kidney yang is this；Liver-fire flaming liver-yang hyperactivity is mark, Kidney deficiency and liver, nephrons loss, water files to nourish wood for this；Phlegm wet extravasated blood is mark, and liver depression hyperactivity of fire is weakness of the spleen and the stomach, and wood fire gram soil, transporting is lost Department is this；So based on the part of the body cavity above the diaphragm housing the heart and lungs temporary solution, based on lower two cokes effect a permanent cure in.
Fang Xie: be based on syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of channels and collaterals, the differentiation of tri-jiao:
The part of the body cavity above the diaphragm housing the heart and lungs: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, west safflower.
Middle coke: finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower.
Lower coke: cortex cinnamomi, Saussurea laniceps flower, cloves, agalloch eaglewood, villous amomum flower.
Our principle of reatment:
In the part of the body cavity above the diaphragm housing the heart and lungs, conscience lung --- -- clearing away the heart-fire, tranquilizing mind；Pancake irascibility, drop of diving liver-yang；Clearing lung-heat fire, respectful drop lung heat.With Clearly, with drop, based on peace, based on temporary solution.
In middle coke, taste --- -- warm temperature supports taste, soothing liver-qi stagnation, activating microcirculation and removing stasis medicinal resolving sputum.With Wen Yangwenization, with transporting Based on dredging, based on effecting a permanent cure.
In lower coke, liver kidney --- -- temperature compensation nephrons tonifies the liver and kidney, gas of receiving holds back mind；It fills up deficit and damages tonifying for the deficiency, guiding fire to origin；In temperature On the basis of warming spleen and stomach, dispel damp and hot.Based on effecting a permanent cure.
The ingredient of armaticity Chinese medicine is mostly small-molecule substance, can quickly be absorbed by body, have priming uplink, resuscitation with aromatics more Effect, Central nervous system have dual regulation, balance brain excitement and inhibit, so that the function of nervous centralis is tended to be flat Weighing apparatus, sleeping of not only calming, but also consciousness regaining.Chinese medicine pharmacology points out that fragrant drug is inhaled by approach such as channels and collaterals, acupuncture point, skin, mucous membranes Human body is taken in, plays the role of Yin Yang balancing, open and let out space between skin and muscles, declare smooth lung to defend, activating microcirculation and removing stasis medicinal.It can be seen that armaticity Chinese medicine has town Quiet, syngignoscism can effectively treat insomnia, and adverse reaction is few.Modern pharmacological research proves that most of aromatics drugs can rise To stimulation nervous centralis, accelerate nerve impulse conduction, the balance of cerebral cortex excitement and inhibition is adjusted, to such as intractable aypnia Etc. illnesss improve significantly and therapeutic effect.Chinese medicine volatile materials is absorbed into body by skin, channels and collaterals, qi and blood etc., through gas The circulation of blood passages through which vital energy circulates and throughout whole body, play relieve stagnation sleeping, nourishing functional activities of the body fluid blood, soothing the liver spleen, adjust nervous system excitement with The effect of inhibition, to have the function that treatment of insomnia patients.
The invention has the advantages that:
1, natural aromatic advantage: the present invention is free of using pure natural aromatics flowers and aromatics plant as composition of prescription There is any artificial synthetic ingredient.
2, advantage without side-effects: under the guidance of diagnosis and treatment based on an overall analysis of the illness and the patient's condition principle, selected each herbal medicine all passes through four natures and five flavors of drug, Ascending-aescending-floating-sinking, channel tropism enter internal organs and modern pharmacology research, there was only excellent positive effect to human body, and without any side effects.
3, administration route advantage: fragrant inhalation and fragrant Transdermal absorption method are suitable for that overwhelming majority crowd uses, improve The acceptance of patient.
4, diagnosis and treatment advantage: syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of channels and collaterals, the differentiation of tri-jiao.
5, composition of prescription treating both manifestation and root cause of disease advantage: our tonifying spleen and stomach clearing lung-heat heat is with reinforcing earth to generate metal；Calming the liver is soothing the liver, the feeding taste of temperature, To help soil suppression wood, activating microcirculation and removing stasis medicinal, regulating qi-flowing for eliminating phlegm；Kidney tonifying drops internal heat with restoring normal coordination between heart and kidney, and guiding fire to origin restrains floating sun, and gas of receiving is calmed the nerves； Purpose is all treating both manifestation and root cause of disease.
6, composition of prescription is to be reduced to master, and based on heavy, to receive as main advantage: we are based on theoretical (four gas five of the property of Chinese materia medica Taste, ascending-aescending-floating-sinking, channel tropism enter internal organs) and efficacy of drugs cure mainly as principle composition of prescription, for upward, dissipated to export-oriented table Yang-energy to be reduced to master, based on heavy, based on receiving；In the part of the body cavity above the diaphragm housing the heart and lungs, internal heat, Pinggan Yang, respectful drop lung heat drop；Lower two burnt, the temperature in Tonifying spleen and stomach, temperature compensation nephrons tonify the liver and kidney to restrain to take the photograph and receive, and guiding fire to origin, both help extreme misery.
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after having read the content of the invention recorded, art technology Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited Fixed range.
A kind of Chinese medicine aromatotherapy composition for having effects that intelligence promoting and tranquilization and helping sleep of embodiment 1
Bulk pharmaceutical chemicals are taken according to parts by weight equivalent proportion: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus Flower, camellia, west safflower, finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower, cloves, agalloch eaglewood, villous amomum flower.
A kind of Chinese medicine aromatotherapy spray for having effects that intelligence promoting and tranquilization and helping sleep of embodiment 2
Bulk pharmaceutical chemicals are taken according to parts by weight equivalent proportion: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus Flower, camellia, west safflower, finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower, cloves, agalloch eaglewood, villous amomum flower.Tool is prepared according to conventional pharmaceutical method in each bulk pharmaceutical chemicals and spray auxiliary material There is intelligence development soothing nerves and assisting sleep to sleep the Chinese medicine aromatotherapy spray of effect.
A kind of Chinese medicine aromatotherapy paste for having effects that intelligence promoting and tranquilization and helping sleep of embodiment 3
Bulk pharmaceutical chemicals are taken according to parts by weight equivalent proportion: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus Flower, camellia, west safflower, finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower, cloves, agalloch eaglewood, villous amomum flower.Each bulk pharmaceutical chemicals, which are prepared with paste auxiliary material according to conventional pharmaceutical method, to be had Intelligence promoting and tranquilization helps the Chinese medicine aromatotherapy paste of sleep effect.
A kind of Chinese medicine aromatotherapy oral solution for having effects that intelligence promoting and tranquilization and helping sleep of embodiment 4
Bulk pharmaceutical chemicals are taken according to parts by weight equivalent proportion: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus Flower, camellia, west safflower, finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower, cloves, agalloch eaglewood, villous amomum flower.Tool is prepared according to conventional pharmaceutical method in each bulk pharmaceutical chemicals and oral solution auxiliary material There is intelligence development soothing nerves and assisting sleep to sleep the Chinese medicine aromatotherapy oral solution of effect.
5 zoopery of embodiment
1 experimental animal
Healthy ICR mouse, male, weight 18-22g, are randomly divided into 4 groups by weight by totally 32, and every group 8, weight between group It examines through t without significant difference (p < 0.05).Wherein one group be blank group, excess-three group be respectively high dose group (200ml/kg), Middle dose group (100ml/kg), low dose group (50ml/kg).
2 drugs
The oral solution that embodiment 4 is prepared.
3 experimental methods
Experiment carries out at night, carries out under 24 DEG C of -25 DEG C of quiet environments.
3.1 direct sleep experiments
Continuous gavage mouse 30d gives the given the test agent of 3 dosage, after control group gives 100ml/kg physiological saline, sees Examine the sleep incidence of each group mouse, if sleep phenomenon, sleep occur using righting reflex loss as index.When mouse is placed in back When clinostatism, can right immediately body position such as more than 30-60s cannot the person of righting, that is, righting reflex loss is thought, into sleep.It rights Reflection restores to be animal awakening, and righting reflex loss is the animal sleep time to this period is restored, and records blank control group With test sample group sleep number of animals and sleeping time.
3.2 extend the experiment of yellow Jackets sleeping time
First carry out preliminary experiment before doing formal experiment, determining makes animal 100% fall asleep, but do not make sleeping time it is too long penta Barbital sodium dosage (30-60mg/kg.bw), is formally tested with this dosage.
After animal last gives blank control and various concentration given the test agent 10-15min, to groups of animals intraperitoneal injection penta Barbital sodium, injection volume 0.2mL/20g, using righting reflex loss as index, can observation given the test agent extend amobarbital Sodium sleeping time.
3.3 yellow Jackets sub-threshold dose hypnosis experiment
Preliminary experiment is first carried out before formal experiment, determines pentobarbital sodium sub-threshold lull dosage (16-30mg/kg.bw).Animal After last gives blank control and various concentration given the test agent 10-15min, yellow Jackets maximum threshold is injected intraperitoneally in groups of animals Lower hypnotic dose records sleep number of animals (righting reflex loss up to 1 minute or more person) in 30min.
The experiment of 3.4 barbital sodium Sleep latencies
Preliminary experiment is first carried out before doing formal experiment, determining makes animal 100% fall asleep, but does not make sleeping time too long bar Than the dosage (200-300mg/kg) of appropriate sodium, formally tested with this dosage.
After animal last gives blank control and various concentration given the test agent 10-20min, groups of animals intraperitoneal injection bar is given Than appropriate sodium, injection volume 0.2mL/20g observes given the test agent to barbital sodium sleep latency using righting reflex loss as index The influence of phase.
4. carrying out one-way analysis of variance to experimental result with spss11.0 editions softwares, P < 0.05, P < 0.01 distinguish table Show with significant difference and extremely significant difference.
5. experimental data and result judgement
5.1 direct sleep experiments
Continuous gavage mouse 30d gives the given the test agent of 3 dosage, and after control group gives same volume distilled water, last is given After medicine, the activity condition of mouse in 60min is observed, without phenomenon of sleeping, mouse is living for sample sets and control group during this period It is dynamic normal, illustrate we without the function of direct hypnosis.
5.2 extend the experiment of yellow Jackets sleeping time
First carry out preliminary experiment before doing formal experiment, determining makes animal 100% fall asleep, but do not make sleeping time it is too long penta Barbital sodium dosage is 45mg/kg, is formally tested with this dosage.
After animal last gives blank control and various concentration given the test agent 10-15min, to groups of animals intraperitoneal injection penta Barbital sodium, using righting reflex loss as index, can observation given the test agent extend yellow Jackets sleeping time.As a result see The following table 1.
Table 1
Group Dosage (ml/kg.bw) Number of animals (only) Sleeping time (min) Rate elongation (%)
High dose group 200 8 77.36±8.25** 207
Middle dose group 100 8 75.26±12.36** 200
Low dose group 50 8 42.7±13.52* 70
Blank group 100 8 25.12±4.59 0
P < 0.01 * has highly significant difference compared to the blank group, and P < 0.05 * has significant difference compared to the blank group.
As can be seen from Table 1, the present composition compared to the blank group can significant Sleeping Time Prolong Ed (P < 0.01)；Sleeping time after low dose group makes mouse give yellow Jackets extends 0.7 times, and middle dosage makes mouse give penta bar Extend 2 times than the sleeping time after appropriate sodium, high dose and middle dose group are without significant difference.Show that the present composition compares penta bar Appropriate sodium has synergistic effect.
5.3 yellow Jackets sub-threshold dose hypnosis experiment
By preliminary experiment, determine that pentobarbital sodium sub-threshold lull dosage is 25mg/kg.bw.Animal last gives blank group And after various concentration given the test agent 10-15min, yellow Jackets maximum subthreshold hypnotic dosage, record is injected intraperitoneally in groups of animals Sleep number of animals in 30min (righting reflex loss up to 1 minute or more person).It the results are shown in Table 2.
Table 2
Group Dosage (ml/kg.bw) Number of animals (only) Sleep number (only) Sleep rate (%)
It is high 200 8 6 75
In 100 8 5 62.5
It is low 50 8 4 50
Blank group 100 8 2 25
The experiment of 5.4 barbital sodium Sleep latencies
By preliminary experiment, determining makes animal 100% fall asleep, but does not make the dosage of sleeping time too long barbital sodium 250mg/kg is formally tested with this dosage.After animal last gives blank control and various concentration given the test agent 10-20min, give Barbital sodium is injected intraperitoneally in groups of animals, and injection volume 0.2mL/20g observes given the test agent using righting reflex loss as index Influence to barbital sodium Sleep latency.It the results are shown in Table 3.
Table 3
Group Dosage (ml/kg.bw) Number of animals (only) Sleep latency (min)
It is high 200 8 16.63±1.14**
In 100 8 17.02±3.34**
It is low 50 8 19.89±3.26*
Blank group 100 8 25.36±4.12
P < 0.01 * has highly significant difference compared to the blank group, and P < 0.05 * has significant difference compared to the blank group.
Above-mentioned table 3 statistics indicate that, the present composition can shorten compared to the blank group mice sleep incubation period (P < 0.01), low dose group makes mice sleep incubation period averagely shorten 5.47min, and middle dose group makes mice sleep incubation period averagely contract Short 8.34min, high dose group make mice sleep incubation period averagely shorten 8.73min.High dose group and middle dose group are without conspicuousness Difference.
In conclusion the present composition is able to extend yellow Jackets sleeping time, in yellow Jackets sub-threshold dose With syngignoscism, barbital sodium Sleep latency can be shortened, the present composition is improving sleep function, treatment sleep disturbance Aspect significant effect.
We are directed to insomnia, and with syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of tri-jiao, the differentiation of channels and collaterals formulates principle of reatment, Aromatics Chinese herbal medicine is selected with property of Chinese materia medica theory, formulates the therapeutic scheme of aromatotherapy --- Chinese medicine aromatotherapy.Compatibility group Side is to be reduced to master, based on heavy, to receive as main advantage: based on the property of Chinese materia medica, theoretical (four natures and five flavors of drug, ascending-aescending-floating-sinking, channel tropism enter dirty Internal organs) and efficacy of drugs cure mainly as principle composition of prescription, for upward, the yang-energy dissipated to export-oriented table is to sink to be reduced to master It is main, based on receiving；In the part of the body cavity above the diaphragm housing the heart and lungs, internal heat, Pinggan Yang, respectful drop lung heat drop；Lower two burnt, warmly invigorating spleen and stomaches, temperature compensation nephrons, help liver in Kidney is received with restraining to take the photograph, guiding fire to origin, and both help extreme misery.Using pure natural aromatics flowers and aromatics plant as composition of prescription, no Contain any artificial synthetic ingredient.Using fragrant inhalation and fragrant Transdermal absorption method, it is suitable for that overwhelming majority crowd uses, improves The acceptance of patient, curative effect are good, have very strong practicability.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art Member, without departing from the principle of the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as Protection scope of the present invention.

Claims (9)

1. it is a kind of have effects that intelligence promoting and tranquilization help sleep Chinese medicine aromatotherapy composition, which is characterized in that the composition by The bulk pharmaceutical chemicals of such as the following parts by weight are made: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, west Safflower, finger citron flower, rose, armeniaca mume, dalbergia wood, Flos Magnoliae Officinalis, inular flower, Flos Albiziae, broad bean flower, cortex cinnamomi, Saussurea laniceps flower, fourth Perfume, agalloch eaglewood, villous amomum flower.
2. composition according to claim 1, which is characterized in that be prepared into clinic according to Chinese medicine conventional formulation preparation method Upper acceptable pharmaceutical preparation.
3. composition according to claim 2, which is characterized in that the pharmaceutical preparation be aerosol, spray, paste, Lotion, pulvis or oral solution.
4. composition described in claim 1 has effects that intelligence promoting and tranquilization helps in the Chinese medicine aromatotherapy drug of sleep in preparation Using.
5. a kind of Chinese medicine aromatotherapy drug for having effects that intelligence promoting and tranquilization and helping sleep, which is characterized in that the drug is by right It is required that composition described in 1 is made.
6. drug according to claim 5, which is characterized in that the drug the preparation method is as follows:
Dry bulk pharmaceutical chemicals, each bulk pharmaceutical chemicals are crushed and are mixed after the parts by weight such as taking described in claim 1 fresh or dehydration It extracts to obtain the drug by steam distillation or organic solvent extraction after conjunction.
7. drug according to claim 5, which is characterized in that the drug the preparation method is as follows:
(1) dry bulk pharmaceutical chemicals, each bulk pharmaceutical chemicals are crushed simultaneously after the parts by weight such as taking described in claim 1 fresh or dehydration It extracts to obtain plants essential oil by steam distillation or organic solvent extraction after mixing；
(2) plants essential oil for taking step (1) to obtain is dissolved as perfume ingredient, and to assign fragrant rate as the ratio uniform of 15-25% In the ethanol solution that concentration is 95%, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains drug.
8. drug according to claim 6, which is characterized in that the organic solvent extraction is selected from one of the following:
A. smashed bulk pharmaceutical chemicals are taken, organic solvent is added to medicinal material is just submerged, is then mentioned using water-bath reflow method It takes, extracts 3 times altogether, extract 1-3h every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution；
B. smashed each raw material mixing is taken, and organic solvent is added to medicinal material is just submerged, is then mentioned using cold-maceration It takes, extracts 3 times altogether, extract 5-7d every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution.
9. drug according to claim 6, which is characterized in that the organic solvent in the organic solvent extraction are as follows: stone Oily ether, n-hexane, chloroform, ether or ethyl acetate.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113288834A (en) * 2021-04-23 2021-08-24 花安堂生物科技集团有限公司 New application of Magnolia sieboldii extract
CN113730511A (en) * 2021-09-17 2021-12-03 吉首大学 Eucommia male flower formula composition capable of soothing nerves and helping sleep and application of eucommia male flower formula composition
CN114632036A (en) * 2020-12-16 2022-06-17 蔻诗曼嘉韩国股份公司 Pressure-relieving and mind-stabilizing extract water composition containing rose extract and camellia extract

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Publication number Priority date Publication date Assignee Title
CN109793870A (en) * 2019-04-04 2019-05-24 上海市同济医院 A kind of pure plant essence perfume with antidepression antianxiety

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793870A (en) * 2019-04-04 2019-05-24 上海市同济医院 A kind of pure plant essence perfume with antidepression antianxiety

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114632036A (en) * 2020-12-16 2022-06-17 蔻诗曼嘉韩国股份公司 Pressure-relieving and mind-stabilizing extract water composition containing rose extract and camellia extract
KR20240076766A (en) * 2020-12-16 2024-05-30 주식회사 코스메카코리아 Aromatic composition containing extract of rosa hybrid and extract of camellia japonica flower for psychological relaxation
KR102678013B1 (en) 2020-12-16 2024-06-26 주식회사 코스메카코리아 Aromatic composition containing extract of rosa hybrid and extract of camellia japonica flower for psychological relaxation
CN113288834A (en) * 2021-04-23 2021-08-24 花安堂生物科技集团有限公司 New application of Magnolia sieboldii extract
CN113730511A (en) * 2021-09-17 2021-12-03 吉首大学 Eucommia male flower formula composition capable of soothing nerves and helping sleep and application of eucommia male flower formula composition

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Application publication date: 20190816