CN110349645A - Application of the partial connection number in the analysis of disease treatment Stability - Google Patents
Application of the partial connection number in the analysis of disease treatment Stability Download PDFInfo
- Publication number
- CN110349645A CN110349645A CN201910640181.7A CN201910640181A CN110349645A CN 110349645 A CN110349645 A CN 110349645A CN 201910640181 A CN201910640181 A CN 201910640181A CN 110349645 A CN110349645 A CN 110349645A
- Authority
- CN
- China
- Prior art keywords
- connection number
- analysis
- curative effect
- disease
- partial connection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/20—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It include step S1, step S2, step S3, step S4, step S5 the present invention relates to application of the partial connection number in the analysis of disease treatment Stability；Step S1 selects disease and different therapeutic schemes, determines curative effect determinate standard, observe and record interim therapeutic effect；Step S2 calculates the cure rate, obvious effective rate and improvement rate of each therapeutic scheme；Step S3 constructs cure rate, obvious effective rate, improvement rate three-unit connection number；Step S4, according to three-unit connection number μ=a+bi+cj of each therapeutic scheme, each rank polarization connection number and each rank for calculating the calculating three-unit connection number corresponding to it bear connection number and the full partial connection number of second order partially；Step S5 carries out stability analysis to curative effect of disease according to full partial connection number size.Its advantage is shown: providing decision support for clear therapeutic scheme；The overall stability providing method for improving curative effect on different curative effect levels for disease is supported.
Description
Technical field
The present invention relates to partial connection number applied technical fields, specifically, being a kind of partial connection number in disease treatment curative effect
Application in stability analysis.
Background technique
Set Pair Analysis is taught by Chinese scholar Zhao Keqin and was proposed in 1989, is a kind of processing certainty and uncertain pass
The systematic mathematical of system is theoretical.Collect to a unit being combined by 2 collection is referred to, such as indicates to be made of set A and set B with H
Collection pair, Chang Jicheng H=(A, B).Connection number is the characteristic function of collection pair, gathers various relationships to 2 in H for indicating to collect
Contact status.Partial connection number is to reflect connection according to a kind of Copula for contacting component level characteristic in connection number and establishing
The things development trend that coefficient is portrayed.Assuming that set has N number of feature, wherein S is to collect the shared feature quantity of centering, and P is collection
The opposite feature quantity of centering, F are the collection uncertain feature quantity of centering, and S+P+F=N.Connection coefficient expressions can then be obtained
Are as follows:Wherein a is known as identical degree, and b is known as diversity factor, and c is known as opposition degree, and i ∈ [- 1,1], and j is normal
Take -1.Due to a=1, the coefficient i of the coefficient j=-1, b of c are between -1 and 1.Therefore, a, b, c are located at positive section, just
Negative transition section, between minus zone, to embody a kind of hierarchy.From the viewpoint of with development, it can be assumed that a positioned at positive section is
It is developed from the b for being located at positive and negative transition section, is originally also on the level of b, hair here can be depicted with a/ (a+b)
Exhibition degree；Similarly, it can be assumed that the b positioned at positive and negative transition section is developed from the c between minus zone, and c is originally also at
Level on, development degree here can be depicted with b/ (b+c)；And a/ (a+b) is with the connection of b/ (b+c) and then from entirety
On depict connection number μ=a+bi+cj be biased to positive direction development trend.Similarly, under the premise of negative sense develops hypothesis, can recognize
It is on the level of a for current b, is developed by a level negative sense originally, indicate the trend developed to negative sense with b/ (b+a),
And c/ (b+c) then indicates the trend that the c of current state develops from b level to negative sense.
Method of Set Pair Analysis is advantageous in terms of analysis and research object certainty with uncertain and its dependent interaction, therefore
It has been widely used in numerous areas.Set Pair Analysis tcm field application example such as: periodical " when treasure's traditional Chinese medical science traditional Chinese medicines "
The paper " application of the Wuying national forestry park in psoriasis vulgaris prescription law study " that 7th periodical in 2018 goes out passes through collection pair
The prescription rule that analysis Wuying national forestry park takes prescription treatment psoriasis vulgaris orally to 260 first Chinese medicines makees secondary analysis.By 260 head
Chinese medicine takes the prescription data of prescription treatment psoriasis vulgaris orally, is divided into " high frequency time (f > 100), higher frequency according to the medication frequency
Five layers of secondary (75 f≤100 <), the middle frequency (50 f≤75 <), the relatively low frequency (25 f≤75 <), low frequency time (1 f≤25 <) "
It is secondary, it wherein " high frequency time " medication will regard " routine administration " as, the kind number of routine administration is indicated with A；" the higher frequency " medication
Regard " inclined routine administration " as, the kind number of inclined routine administration is indicated with B；" the middle frequency " medication is regarded as and " is in conventional and anti-
Intermediate state medication between routine " indicates the kind number of intermediate state medication with C；" the relatively low frequency " medication is regarded as " partially anti-
Routine administration " indicates the kind number of inclined anti-convention medication with D；" low frequency " medication is regarded as " anti-convention medication ", is indicated with E
The kind number of anti-convention medication；Building Wuying national forestry park μ=a+bi+cj+dk+el simultaneously analyzes its situation.The result shows that the relatively low frequency
With 169 kinds of shared medicine of low frequency time, be preceding three classes medicine 12 times of totally 14 kinds.U=0.0385+0.0055i+0.0330j+
0.1099k+0.8132l belongs to 19 grades of anti-gesture (153 grades of total situation), prompts prescription trend to inclined anti-convention medication or abnormality
Rule medication direction is developed.Illustrate that the handle of psoriasis vulgaris Chinese traditional treatment types of medicines number possesses larger difficulty, may be good at " anti-
Conventional plus-minus medication " is proper, just has and obtains preferable clinical efficacy.Periodical " Chinese traditional Chinese medicine academic periodical " the 8th periodical in 2018 goes out
Paper " the psoriasis medication based on Set Pair Analysis curative effect curve and partial connection number is preferably inquired into ", pass through the quaternary of Set Pair Analysis
The drug of connection number curative effect curve and partial connection number progress psoriasis blood-heat syndrome selects excellent, further increases curative effect.Method: first with
Maximum correlation coefficient filters out psoriasis blood-heat syndrome conventional Chinese medicine, and " recovery from illness " " effective " for establishing single medicinal material " turns " engineering noise
Four-element connection number calculates four-element connection number curative effect area and full partial connection number, sorts from large to small according to numerical value.Set Pair Analysis
With the confidence level of different anti-system Comparison Method analysis two methods sequence, the drug of serial number same (with a high credibility) will be arranged according to curative effect
The sequence of area carries out minor sort again, determines that psoriasis blood-heat syndrome often uses the preferred agents in heat-clearing drug.As a result: in institute
Serial number is arranged in the preceding 14 kinds of psoriasis blood-heat syndrome conventional Chinese medicine filtered out with being mock-strawberry, schizonepeta, the fruit of summer cypress, wherein mock-strawberry,
The curative effect area sequence of schizonepeta is forward, is preferred agents, this is consistent with tcm clinical practice experience.Conclusion: can be in psoriasis blood-heat syndrome
Clinical application selects excellent middle application based on the curative effect curve and partial connection number of Set Pair Analysis four-element connection number, faces card to other diseases and uses
See also using such algorithm when medicine selects excellent.
Though Set Pair Analysis Theory has been applied to numerous areas, extensive not enough in the field application of traditional Chinese medicine, also need more
It is more, deeper into research and development.Secondly, many diseases have the characteristics that it is easy to recur, therefore treat stability seem especially
It is important.The superiority and inferiority of current clinically more same 2 kinds of therapeutic schemes of disease mostly uses the significance test in health statistics
Method, but the requirement that traditional test of significance approach has sample size to be not less than 30, partial connection number rule is without this requirement.By
It is varied in clinical treatment, thus which kind of therapeutic scheme is selected to obtain a more stable therapeutic effect, Chang Weilin
Bed doctor is hesitated.Therefore, the stability for how going to deduce curative effect from the interim therapeutic effect of patient is pendulum in clinician
A major issue in front.
In conclusion need it is a kind of curative effect of disease stability is analyzed based on partial connection number, filter out in curing psoriasis compared with
For stable therapeutic scheme, is controlled for psoriasis clinical syndrome differentiation opinion and effective prescription is selected to provide a kind of new scientific basis, in the hope of further
Improve the technical solution of curative effect.
Chinese patent literature: CN107564589A, publication date: 2018.01.09 is disclosed a kind of based on four-element connection number
Symptomatic medicine assessment prediction method and system, comprising: step S1 establishes disease item by way of " four methods of diagnosis " in Chinese medicine
Mesh；Step S2 carries out efficacy evaluation to the disease project in step S2；Step S3: the curative effect four of " four methods of diagnosis " project is obtained
Member connection number μ (gt)=at+bti+ctj+dtk (t=1,2 ... 16)；Step S4 calculates 3 ranks of curative effect four-element connection number μ (gt)
Full partial connection number and the sequence to the full partial connection number of 3 ranks from big to small；Step S5 makees the ratio between number η=" total invalidating "
Sequence from big to small；Step S6, the η value sequence number on same project with the full partial connection number of 3 ranks of the project from big to small
Sequence number compare.
Chinese patent literature: CN107491650A, publication date: 2017.12.19 is disclosed a kind of based on partial connection number method
Chinese medicine screening method and system.The Chinese medicine screening method only calculates directly reflection Current therapeutic and arranges to four-element connection number
Apply the variation tendency of lower curative effect of medication, and the full partial connection number of single order of more clinical meaning and according to its sequence in i ∈ [0.5,
1], to i, j value in j ∈ [0.5,0], so that the full partial connection number of single order is not entirely less than 0 (meeting clinical practice).The Chinese medicine
Screening system includes that characteristic function establishes module, for establishing the curative effect four-element connection number of different symptoms；Computing module, based on
Calculate the full partial connection number of single order；Correction module, for, in i ∈ [0.5,1], j ∈ [0.5,0] to be interior to i, and j value is made according to its sequence
Further adjustment, so that the full partial connection number of single order is not entirely less than 0.
But it yet there are no about a kind of application of the partial connection number of invention in the analysis of disease treatment Stability
Report.
Summary of the invention
It is an object of the present invention to provide a kind of application of partial connection number in the analysis of disease treatment Stability.
To achieve the above object, the technical solution adopted by the present invention is that:
A kind of application of partial connection number in the analysis of disease treatment Stability, the partial connection number is in disease treatment
Application in Stability analysis includes step S1, step S2, step S3, step S4, step S5；
The step S1 selects disease and different therapeutic schemes, determines curative effect determinate standard, observe and record stage and control
Therapeutic effect；
The step S2 calculates the cure rate, obvious effective rate and improvement rate of each therapeutic scheme；
The step S3 constructs cure rate, obvious effective rate, improvement rate three-unit connection number.If cure rate obtained in S2 is
Curative effect levels different in one scheme are indicated with connection number μ=a+bi+cj, are calculated each by a, obvious effective rate b, improvement rate c
The three-unit connection number of therapeutic scheme；
The step S4 is calculated corresponding to it according to three-unit connection number μ=a+bi+cj of each therapeutic scheme
Each rank polarization connection number and each rank for calculating three-unit connection number bear connection number and the full partial connection number of second order partially.Three-unit connection number μ
The single order polarization of=a+bi+cj contacts numberWhereinThe partially negative connection of single order
CoefficientWherein Its second order partial connection numberAre as follows:
Thus obtain each therapeutic scheme full partial connection number (polarization connection number with partially bear contact several algebraical sums) be
The step S5 carries out stability analysis to curative effect of disease according to full partial connection number size,Value get over
Illustrate that curative effect trend is more stable greatly.
The invention has the advantages that:
1, there are biggish uncertainties for different by herbs disease, are uniformly described not really using the connection number in Set Pair Analysis
Determine relationship, and Stability is analyzed according to partial connection number on this basis, provides decision branch for clear therapeutic scheme
It holds.
2, by examining patient's stage to treat the partial connection number of final result, stablize to recognize the curative effect of disease treatment scheme
Property, thinking is novel, and method is concise, and acquired results prove that the curative effect of traditional Chinese medicine treatment disease is more stable, and it is uneasy to recur, with clinic
It practices more consistent.
3, the overall stability providing method for improving curative effect on different curative effect levels for disease is supported.
Detailed description of the invention
Attached drawing 1 is a kind of flow chart of the application of partial connection number in the analysis of disease treatment Stability.
Attached drawing 2 is a kind for the treatment of results datagram of the application of partial connection number in the analysis of disease treatment Stability.
Specific embodiment
Below with reference to embodiment and referring to attached drawing, the invention will be further described.
Embodiment 1
Attached drawing 1 is please referred to, attached drawing 1 is a kind of partial connection number of the present embodiment in the analysis of disease treatment Stability
The flow chart of application.
Application of the partial connection number in the analysis of disease treatment Stability includes step S1, step S2, step
S3, step S4, step S5；
The step S1 selects disease and different therapeutic schemes, determines curative effect determinate standard, observe and record stage and control
Therapeutic effect；
The step S2 calculates the cure rate, obvious effective rate and improvement rate of each therapeutic scheme；
The step S3 constructs cure rate, obvious effective rate, improvement rate three-unit connection number.If cure rate obtained in S2 is
Curative effect levels different in one scheme are indicated with connection number μ=a+bi+cj, are calculated each by a, obvious effective rate b, improvement rate c
The three-unit connection number of therapeutic scheme；
The step S4 is calculated corresponding to it according to three-unit connection number μ=a+bi+cj of each therapeutic scheme
Each rank polarization connection number and each rank for calculating three-unit connection number bear connection number and the full partial connection number of second order partially.Three-unit connection number μ
The single order polarization of=a+bi+cj contacts numberWhereinThe partially negative connection of single order
CoefficientWherein Its second order partial connection numberAre as follows:
Thus obtain each therapeutic scheme full partial connection number (polarization connection number with partially bear contact several algebraical sums) be
The step S5 carries out stability analysis to curative effect of disease according to full partial connection number size,Value get over
Illustrate that curative effect trend is more stable greatly.
Embodiment 2
Attached drawing 2 is please referred to, attached drawing 2 is a kind of partial connection number of the present embodiment in the analysis of disease treatment Stability
The treatment results datagram of application.
The present embodiment is by taking curing psoriasis as an example:
1, clinical data
Data source in the paper that " Chinese Rural medicine " the 5th periodical in 1998 goes out, " control by 144 psoriasis combination of Chinese tradiational and Western medicine
The cognition for the treatment of ".144 psoriasis are out-patient per capita, wherein male 82, and women 62, the age is 17 years old minimum, maximum 71
Year, the course of disease is most 10 days short, longest 30 years, wherein 10 years or more person 57.According to clinical manifestation, using dialectical point of the combination of Chinese tradiational and Western medicine
Totally 122, type, blood-heat type is equivalent to acute stage psoriasis 84, and blood-dryness type is equivalent to resting stage 38 cases of Psoriasis, doctor trained in Western medicine control
Group 22 (this group of patient is past old patient, is taking the double woodss of second or ethyleneimine medicine always).According to clinical practice and this group
122 analyses, are substantially summarized as 2 types.
(1) blood-heat type: it is 84 this type of, it is equivalent to acute stage psoriasis, this phase, clinical typical skin lesion was red maculopapule, table
The silvery white scales of skin that peel off is covered in face, is gently scraped off the shinny film of the visible pale red of the surface scales of skin that peel off and blood dew phenomenon, be can be involved appointing for skin
What position, but stretched based on side with scalp and trunk, four limbs, skin lesion is in a point drop-wise, clear border, has in Chinese medical discrimination and accumulates
Heat, Yu Yuqi divide and rule the promoting blood circulation of suitable clearing heat and cooling blood, and side uses " dahsiao-ch'i side ", prescription: 15 grams of honeysuckle, public 15 grams of English, 15 grams of dahsiao-ch'i,
10 grams of Chinese violet, 15 grams of talcum, 15 grams of the fruit of summer cypress, 15 grams of rhizoma atractylodis ear, 10 grams of radix scutellariae, 10 grams of Cortex Phellodendri, 10 grams of kuh-seng, 6 grams of periostracum cicada, purple
10 grams, 10 grams of Radix Angelicae Sinensis of grass.
(2) blood-dryness type: totally 38, it is equivalent to resting stage psoriasis.This phase clinic skin lesion feature is gradually expanded for skin lesion, phase
Mutually fusion slabbing, irregular skin lesion, the surface scales of skin that peel off is thick, and substrate infiltration is plump, and the scales of skin that peel off adheres to tighter, skin lesion stripping group bottom
Bleeding is unobvious, and newborn fash is less, and the course of disease with the passing of time, aggravate, and Chinese medical discrimination is mostly course of disease day by summer disease amelioration, autumn and winter
Long, wind-heat dryness-transformation, dry impairment of yin blood, venation block, caused by failure of skin and muscle to be nourished.Suitable blood-nourishing skin-moisturizing is controlled, invigorating blood and dispelling wind cooperates externally applied drug
Cream, prescription: 30 grams of Radix Rehmanniae, 5 grams of Radix Salviae Miltiorrhizae, 10 grams of the root bark of tree peony, 10 grams of radix paeoniae rubra, 10 grams of Radix Angelicae Sinensis, 10 grams of kuh-seng, 10 grams of honeysuckle flower, folium isatidis
15 grams, 5 grams of trigone, 5 grams of curcuma zedoary, 15 grams of great burdock achene.
Doctor trained in Western medicine group 22, bis-morpholine is taken orally, oral dose 0.2g taken three times per day, and a month as a course for the treatment of, and routine of having a blood test
And blood liver function.
2, curative effect determinate standard
Clinical recovery: symptom and skin lesion all disappear, and only remain pigmentation spots or depigmentation spot, no newborn fash hair
It is raw.Be almost recovered: symptom disappears substantially with skin lesion, or the individual obstinate skin lesions of residual.Effective: treatment is two months full, and skin lesion is subsided
80% or more.Invalid: treatment is two months full, and skin lesion recession is less than 50%.
3, treatment results
As follows to Chinese medicine group and simple western medicine group treatment condition difference according to above-mentioned efficacy assessment standard: blood-heat type is controlled altogether
84 are treated, male 51, women 33, the age is 16 years old minimum, and it is 63 years old maximum, it is course of disease longest 12 years, most 3 months short, after medication
Cured person 40 account for 47.6%, and effective 26 account for 31%, improve 4 and account for 4.7%, invalid 14 account for 16.7%, and total effective rate is
83.3%, average curative day is 59.5 days.Blood-dryness type treats 38 altogether, and male 29, women 9, the age is 23 years old minimum, most
71 years old big, the course of disease is most 3 years short, and up to 20 years or more, recovery from illness 10 accounted for 26.3%, and effective 8 account for 21.1%, improves 13 and accounts for
34.2%, invalid 7 account for 18.4%, and total effective rate 81.6%, average curative day is 61 days.Western medicine group treats 22 altogether,
Male 16, women 6, minimal ages 29 years old, max age 57 years old, bis-morpholine is taken orally, oral dose 0.2g takes daily 3 times, and 1
A month as a treatment course, while chemically examining blood routine and liver function, takes medicine two months altogether, treatment results: recovery from illness 14 accounts for 65.9%, effective
5 account for 27.2%, improve 1 and account for 0.1%, and invalid 2 account for 6.8%, and total effective rate 93.3%, average curative day is 40
It.
To totally 64 patients of clinical cure carried out 3~12 months follow-up discovery have 12 in 3 months recidivists
It is Western medicine group patient, recidivist 21 in half a year, Chinese and Western medicine group 7, Chinese medicine group 14, wherein blood-dryness type 5, blood-heat type
9, in short, traditional Chinese medicine diagnosis and treatment, short term effect is good, and late result is also more satisfied than doctor trained in Western medicine, and recurrence rate is controlled compared with simple western medicine
It treats low.Adverse reaction: in the psoriatic of 122 tcm syndrome differentiation and treatments, not finding 1 adverse reaction, and in 22 doctors trained in Western medicine
Occur checking leukocyte count after leukocyte count is reduced to 5 × 109/L hereinafter, being discontinued 2 weeks after 2 four weeks after taking in the patient for the treatment of
Go up to normal range (NR).It is little that two groups of curative effects are statistically analyzed difference, X2=1.65, P > 0.05.Two groups for the treatment of recurrence rate warps
Statistical procedures difference highly significant, X2=21.14, P < 0.001.
4, Stability is analyzed with partial connection number
4.1 calculate three-unit connection number according to treatment results
Due on Present clinical determine be invalid curative effect be not present neighbour's moment reverse, to determine
Whether current clinical efficacy is stable, should be only for the inclined of the three-unit connection number being made of " recovery from illness " " effective " " improvement "
Coefficient calculates, therefore the curative effect three-unit connection number of " recovery from illness " " effective " " improvement " composition is as follows:
μ (u1)=0.476+0.310i+0.047j+0.167k
μ (u2)=0.263+0.211i+0.342j+0.184k
μ (u3)=0.410+0.279i+0.139j+0.172k
μ (u4)=0.636+0.227i+0.045j+0.090k
4.2 calculate each rank polarization connection number of three-unit connection number and the partially negative connection number of each rank and the full partial connection number of second order
Single order polarization contacts number are as follows:
The partially negative connection number of single order are as follows:
Second order polarization contacts number are as follows:
The negative connection number of Second Order Partial are as follows:
The full partial connection number of second order are as follows:
4.2 comparative analysis
Due to 0.1606 (u1) > 0.0817 (u4) >, 0.0201 (u3) > 0.0111 (u2), it is believed that Chinese medicine blood-head group
(u1) Stability be better than Western medicine group be better than Chinese medicine add up to group be better than dry group of Chinese medicine blood.This conclusion and institute's selection
It offers minimum, the most stable of conclusion of curative effect about Chinese medicine blood-head group recurrence rate to be consistent, also extends thinking for Stability analysis.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, without departing from the principle of the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (4)
1. a kind of application of partial connection number in the analysis of disease treatment Stability, which is characterized in that the partial connection number
Application in the analysis of disease treatment Stability includes step S1, step S2, step S3, step S4, step S5；
The step S1 selects disease and different therapeutic schemes, determines curative effect determinate standard, observes and records interim treatment effect
Fruit；
The step S2 calculates the cure rate, obvious effective rate and improvement rate of each therapeutic scheme；
The step S3 constructs cure rate, obvious effective rate, improvement rate three-unit connection number；
The step S4 calculates the calculating corresponding to it according to three-unit connection number μ=a+bi+cj of each therapeutic scheme
Each rank polarization connection number of three-unit connection number and the partially negative connection number of each rank and the full partial connection number of second order；
The step S5 carries out stability analysis to curative effect of disease according to full partial connection number size.
2. application of the partial connection number according to claim 1 in the analysis of disease treatment Stability, which is characterized in that
The step S3, if cure rate obtained in S2 is a, obvious effective rate b, improvement rate c, by curative effect layers different in a scheme
It is secondary to be indicated with connection number μ=a+bi+cj, calculate the three-unit connection number of each therapeutic scheme.
3. application of the partial connection number according to claim 1 in the analysis of disease treatment Stability, which is characterized in that
The single order polarization of the step S4, three-unit connection number μ=a+bi+cj contact numberWhereinThe partially negative connection number of single orderWhereinIts second order partial connection numberAre as follows: Thus obtain each therapeutic scheme full partial connection number (polarization contact number with it is partially negative
Contact the algebraical sum of number) be
4. application of the partial connection number according to claim 1 in the analysis of disease treatment Stability, which is characterized in that
The step S5,Value bigger illustrate that curative effect trend is more stable.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910640181.7A CN110349645A (en) | 2019-07-16 | 2019-07-16 | Application of the partial connection number in the analysis of disease treatment Stability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910640181.7A CN110349645A (en) | 2019-07-16 | 2019-07-16 | Application of the partial connection number in the analysis of disease treatment Stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110349645A true CN110349645A (en) | 2019-10-18 |
Family
ID=68176432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910640181.7A Pending CN110349645A (en) | 2019-07-16 | 2019-07-16 | Application of the partial connection number in the analysis of disease treatment Stability |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110349645A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110718283A (en) * | 2019-10-23 | 2020-01-21 | 上海中医药大学附属岳阳中西医结合医院 | Significance testing method for supplementary substitution |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107516013A (en) * | 2017-08-25 | 2017-12-26 | 上海中医药大学附属岳阳中西医结合医院 | It is a kind of that the preferable method and system of medicine are carried out by curative effect triangle |
| CN109192320A (en) * | 2018-09-17 | 2019-01-11 | 上海中医药大学附属岳阳中西医结合医院 | Application of the Set Pair Analysis in the representative prescription medicine law research of disease |
| CN109192263A (en) * | 2018-11-26 | 2019-01-11 | 上海中医药大学附属岳阳中西医结合医院 | Utilize the method and system of the equilibrium between yin and yang equation diagnosis and treatment chronic ulcer of skin based on Set Pair Analysis |
-
2019
- 2019-07-16 CN CN201910640181.7A patent/CN110349645A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107516013A (en) * | 2017-08-25 | 2017-12-26 | 上海中医药大学附属岳阳中西医结合医院 | It is a kind of that the preferable method and system of medicine are carried out by curative effect triangle |
| CN109192320A (en) * | 2018-09-17 | 2019-01-11 | 上海中医药大学附属岳阳中西医结合医院 | Application of the Set Pair Analysis in the representative prescription medicine law research of disease |
| CN109192263A (en) * | 2018-11-26 | 2019-01-11 | 上海中医药大学附属岳阳中西医结合医院 | Utilize the method and system of the equilibrium between yin and yang equation diagnosis and treatment chronic ulcer of skin based on Set Pair Analysis |
Non-Patent Citations (2)
| Title |
|---|
| 李斌 等: "基于四元联系数的中医四诊与银屑病疗效关系研究", 《辽宁中医杂志》 * |
| 许逊哲 等: "四元联系数在土槐菝葜汤治疗血热型银屑病疗效研究中的应用", 《中国中西医结合皮肤性病学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110718283A (en) * | 2019-10-23 | 2020-01-21 | 上海中医药大学附属岳阳中西医结合医院 | Significance testing method for supplementary substitution |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Srithi et al. | Medicinal plant knowledge and its erosion among the Mien (Yao) in northern Thailand | |
| CN101284121A (en) | Combination medicine for curing the hoary hair | |
| CN111643619B (en) | Medicated bath traditional Chinese medicine composition for treating psoriasis and application thereof | |
| Tsai et al. | Prescription pattern of Chinese herbal products for hypertension in Taiwan: a population-based study | |
| CN110349645A (en) | Application of the partial connection number in the analysis of disease treatment Stability | |
| CN109192263A (en) | Utilize the method and system of the equilibrium between yin and yang equation diagnosis and treatment chronic ulcer of skin based on Set Pair Analysis | |
| CN1112424A (en) | Toutongning-medicine for headache | |
| CN106421579A (en) | Traditional Chinese medicinal composition for treating fatigue and preparation method of traditional Chinese medicinal composition | |
| CN103933280A (en) | Traditional Chinese medicine composition for treating PCI (percutanecus coronary intervention) postoperative angina of phlegm-obstructing heart vessel type coronary heart disease and application thereof | |
| Zhu et al. | Efficacy and safety of Wuling San for treatment of breast-cancer-related upper extremity lymphoedema: study protocol for a pilot trial | |
| CN110706768A (en) | Method for summarizing traditional Chinese medicine insomnia diagnosis information and medication rule | |
| CN1060954C (en) | External use Chinese drug powder and its preparing method and medicinal pad | |
| CN1255147C (en) | Oral liquid for preserving one's longevity | |
| CN108671054A (en) | A kind of waist Chinese medicine composition and preparation method thereof admittedly | |
| CN104352669B (en) | A kind of application of Chinese medicine in weak sperm disease is treated | |
| CN107582952A (en) | A kind of medicine for treating cervical spondylopathy and preparation method thereof | |
| Liu et al. | Based on data mining to explore the medication rule of Professor Shao Zheng-bin in the treatment of coronary heart disease combined with type2 diabetes mellitus after PCI. | |
| CN103705664A (en) | Pharmaceutical composition used for treating psoriasis, and preparation method thereof | |
| CN1451415A (en) | Medicine for treating acne and preparing process thereof | |
| CN104888032B (en) | Diarrhea applies | |
| CN107007759A (en) | Treat rheumatism bone disease, Chinese medicine composition of traumatic injury and preparation method thereof | |
| Wei et al. | Analysis of professor Wang Yongyan's experience in treating hemorrhagic diseases based on traditional Chinese medicine inheritance support system | |
| CN105998843A (en) | Traditional Chinese medicine preparation for treating recurring type dental ulcers | |
| Yang et al. | Utilizing data mining techniques to analyze traditional Chinese medicine patterns in patients with acute cardiorenal syndrome | |
| Wang et al. | Discussion on the medication rule of Professor Ba Yuanming in the treatment of chronic glonerulonephritis based on data mining technology. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191018 |