CN109192320A - Application of the Set Pair Analysis in the representative prescription medicine law research of disease - Google Patents
Application of the Set Pair Analysis in the representative prescription medicine law research of disease Download PDFInfo
- Publication number
- CN109192320A CN109192320A CN201811082126.2A CN201811082126A CN109192320A CN 109192320 A CN109192320 A CN 109192320A CN 201811082126 A CN201811082126 A CN 201811082126A CN 109192320 A CN109192320 A CN 109192320A
- Authority
- CN
- China
- Prior art keywords
- curative effect
- prescription
- disease
- set pair
- perfect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Public Health (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to application of the Set Pair Analysis in the representative prescription medicine law research of disease, the application filters out the representative prescription that the disease is treated reported in document the following steps are included: step S1, selection disease name；Step S2, four-element connection number method: clinical efficacy " healing ", " effective ", " improvement ", the engineering noise of the representative prescription screened in step S1 are indicated with 4 yuan of connection number μ=a+bi+cj+dk in Set Pair Analysis；Step S3, it is calculated at a distance from perfect curative effect: calculating 4 yuan of connection number μ of curative effect of each first prescriptiont=at+bti+ctj+dtK is contacted at a distance from several μ=1+0i+0j+0k with ideal perfect 4 yuan of curative effect；Step S4, look for medicine law: investigate it is all represent system curative effect in prescription and come preceding 3 medicine laws, by medication frequency cluster；Step S5, discussion is compared.Its advantage is shown: being inquired into the general medicine law in different diagnosis and treatment prescriptions, while being carried out trap queuing to all curative effects for representing prescription by the calculating of total effective rate, to improve clinical efficacy.
Description
Technical field
The present invention relates to technical field of Chinese medicine, specifically, being representative prescription medicine law of the Set Pair Analysis in disease
Application in research.
Background technique
Set Pair Analysis is taught by Chinese scholar Zhao Keqin and was proposed in 1989, is a kind of processing certainty and uncertain pass
The systematic mathematical of system is theoretical.Collect to a unit being combined by 2 collection is referred to, such as indicates to be made of set A and set B with H
Collection pair, Chang Jicheng H=(A, B).Connection number is the characteristic function of collection pair, gathers various relationships to 2 in H for indicating to collect
Contact status.The characteristic function of collection pair is established by whole relationships of two set of analysis first -- connection number.By connection component
Number has binary to contact number (all relationships are divided into 2 classes: determining and uncertain), and (all relationships are divided into 3 classes to three-unit connection number: altogether
It is similar, phase foreign peoples, opposite class), four-element connection number (all relationships are divided into 4 classes: common class, different partially similar, different partially anti-class,
Counter opposition class), then make mathematical model using connection number, corresponding network analysis and Mathematical treatment, solution are carried out according to model
Question and answer topic.Answer result and other method acquired results are finally compared discussion, provide conclusion.
Method of Set Pair Analysis is advantageous in terms of analysis and research object certainty with uncertain and its dependent interaction, therefore
It has been widely used in numerous areas.Set Pair Analysis tcm field application example such as: " the Chinese combination of Chinese tradiational and Western medicine is miscellaneous for periodical
Will " paper " constructing the dialectical model of psoriasis vulgaris blood-heat syndrome using Set Pair Analysis Method " that 2012 years the 10th periodicals go out, pass through
Same, different, anti-quantifying is carried out to psoriasis vulgaris blood-heat syndrome clinical symptoms to portray, and establishes corresponding Set Pair Analysis mathematical modulo
Type improves the accuracy of clinical syndrome differentiation to instruct clinic.Method choice has complete data after treating using cool blood checking exuberance of yang method
202 psoriasis vulgaris blood-heat syndrome patients, system collects its clinical symptoms, sign etc..It, will by the method for Set Pair Analysis
Treat final result be recovery from illness and it is effective be classified as same portion, be effectively classified as different portion, be classified as anti-portion in vain, calculated according to formula every dialectical
The U value of the factor, the relevant connection factor of screening psoriasis vulgaris blood-heat syndrome Chinese medical discrimination, according to each dialectical factor connection number
Size constructs the dialectical model of psoriasis vulgaris blood-heat syndrome.Blood-heat syndrome >=0.75 U can determine that as blood-heat syndrome, using Chinese medicine cool blood
Treatment can obtain good curative effect；U blood-heat syndrome < 0.75, then patient on the basis of blood-heat syndrome with other card types, it is simple cool
Blood therapeutic effect is bad.The paper that " Chinese traditional Chinese medicine magazine " the 3rd periodical in 2018 goes out: " is based on Set Pair Analysis gesture value achievement
Psoriasis vulgaris blood-heat syndrome clinic is studied again ", it is managed by random controls (RCT) evaluation in clinical the past Set Pair Analysis gesture value
By the clinical efficacy of the Regimen Chemotherapy psoriasis blood-heat syndrome obtained.Method: the psoriasis vulgaris blood-heat syndrome that the standard of being included in meets
60,2 groups are randomly divided into using table of random number, tradition dialectical group 30 is added and subtracted for basic side with card with xijiao Dihuang Tang；
Set Pair Analysis gesture value achievement group 30, is looked back with seminar's case early period and the Chinese medicine of clinical observation passes through classical statistics sum aggregate pair
It is that basic side is added and subtracted with card that 15 kinds of Chinese medicines, which are obtained, in analysis gesture value achievement method.Observation 4 weeks, index include PASI point system and
Zung manifest anxiety scale (SAS) and Zung Depression Scale.As a result: clinical studies show, Set Pair Analysis gesture value achievement group effective percentage are
93.10%, cure-remarkable-effectiveness rate 58.62%.Dialectical group of effective percentage of tradition is 96.55%, cure-remarkable-effectiveness rate 41.38%, Set Pair Analysis gesture
It is worth achievement group and is better than traditional dialectical group (P < 0.05).Two groups can reduce psoriasis clinical symptoms PASI scoring (P < 0.01), collection
Traditional dialectical group (P < 0.01) is better than to analysis gesture value achievement group；Simultaneously two groups can reduce patient Zung index score (P <
0.01), dialectical group of effect of tradition is better than Set Pair Analysis gesture value achievement group (P < 0.01).Conclusion: it is based on Set Pair Analysis gesture value achievement
Prescription be clinical treatment psoriasis vulgaris blood-heat syndrome effective prescription, significantly improve patient clinical syndrome and improve life matter
Amount, is just worthy of further application substantially as treatment based on disease differentiation.The paper that " new Chinese medicine " the 10th periodical in 2017 goes out " is based on
The curative effect curve of Set Pair Analysis selects the application in excellent in psoriasis blood-heat syndrome drug ", it is put forward for the first time Set Pair Analysis curative effect curve, is visited
Rope selects the application in excellent in psoriasis blood-heat syndrome drug based on Set Pair Analysis four-element connection number curative effect curve, in the hope of further increasing
Curative effect.Method: filtering out psoriasis blood-heat syndrome conventional Chinese medicine first with maximum correlation coefficient, establish single medicinal material recovery from illness,
Effective, improvement, invalid four-element connection number estimate rectangular co-ordinate in curative effect quantitative measure and curative effect property further according to four-element connection number
Curative effect curve is drawn in system.By curative effect curve mapping into four-dimensional curative effect space, being calculated each curative effect curve and perfect curative effect
The Euclidean distance of curve, it is according to the superiority and inferiority of the psoriasis blood-heat syndrome conventional Chinese medicine that sorts out from small to large of Euclidean distance, this is excellent
Bad sequence determines optimal drug, suboptimum drug compared with by cure rate sequence from high to low.As a result: what is filtered out
In preceding 14 kinds of psoriasis blood-heat syndrome conventional Chinese medicine, mock-strawberry sequence the 1st, kuh-seng sequence the 2nd, Paris polyphylla sequence the 3rd, this and tcm clinical practice
Experience is consistent.Conclusion: excellent treatment of the middle application based on Set Pair Analysis four-element connection number can be selected in psoriasis blood-heat syndrome clinical application
Curve is imitated, other diseases are faced when card medication selects excellent see also using this curative effect curve and its algorithm.
Though Set Pair Analysis Theory has been applied to numerous areas, extensive not enough in the field application of traditional Chinese medicine, also need more
More research and developments.Secondly, the state of an illness based on psoriatic is that a dynamic changing process is former by taking curing psoriasis as an example
Reason, by clinical efficacy be divided into " healings ", " effective ", " improvement ", " in vain, it is assumed that recovery process of the patient after treating, by " nothing
Effect ", finally to " recovery from illness ", calculates with this and analyzes partial connection number, but the feelings of differentiation of tcm to " improvement ", " effective " development
Condition is more more complicated than the relationship that mathematical model is shown, the state of an illness of patient is changeable, is not limited to by vain to the performance of recovery from illness, quaternary
The method for establishing model for contacting number needs further research.Finally for the Set Pair Analysis curative effect curve having proposed do not show i, j,
The occurrence of k, and disregarding i when the value of j, k, directly uses distance between two points formula: more research and developments.Secondly, with
For curing psoriasis, the state of an illness based on psoriatic be a dynamic changing process principle, by clinical efficacy be divided into " healing ",
" effective ", " improvement ", " it is invalid, it is assumed that recovery process of the patient after treating, from engineering noise to " improvement ", " effective " development, most
Eventually to " recovery from illness ", partial connection number, but the relationship that the case where differentiation of tcm is shown than mathematical model are calculated and analyzed with this
More complicated, the state of an illness of patient is changeable, is not limited to by vain to the performance of recovery from illness, the method for establishing model needs of four-element connection number
Further research.Do not show the occurrence of i, j, k finally for the Set Pair Analysis curative effect curve having proposed, and disregards i, j, k
Value when, directly use distance between two points formula:
It is possible that the case where obscuring superiority and inferiority.
In conclusion needing a kind of weighting curative effect curve based on Set Pair Analysis Theory, the occurrence of i, j, k are provided, is visited
Application of the Set Pair Analysis in the representative prescription medicine law research of disease is begged for, in the hope of further increasing the technical solution of curative effect,
And it is had not been reported about this technical solution.
Summary of the invention
The purpose of the present invention is aiming at the shortcomings in the prior art, provide a kind of weighting curative effect based on Set Pair Analysis Theory
Curve provides the occurrence of i, j, k, inquires into application of the Set Pair Analysis in the representative prescription medicine law research of disease, in the hope of
Further increase curative effect.
To achieve the above object, the technical solution adopted by the present invention is that:
Set Pair Analysis disease representative prescription medicine law research in application, it is described application the following steps are included:
Step S1, disease name is selected, the representative prescription for treating the disease reported in document is filtered out；
Step S2, four-element connection number method: the clinical efficacy " healing " of the representative prescription screened in step S1, " effective ",
" improvement ", engineering noise indicate that wherein a indicates " cure rate " with 4 yuan of connection number μ=a+bi+cj+dk in Set Pair Analysis, and b is indicated
" obvious effective rate ", c indicate " improvement rate ", and d indicates " inefficiency "；
Step S3, it is calculated at a distance from perfect curative effect: using μ=1+0i+0j+0k of cure rate a=1 as ideal perfect
4 yuan of connection numbers of curative effect calculate 4 yuan of connection number μ of curative effect of each first prescriptiont=at+bti+ctj+dtK and ideal perfect curative effect 4
The distance of member connection number μ=1+0i+0j+0k, calculation formula:
ρtSmall prescription curative effect is better than ρtBig prescription curative effect；
Step S4, look for medicine law: investigate it is all represent system curative effect in prescription and come preceding 3 medicine laws, by using
Medicine frequency cluster；
Step S5, discussion is compared.
As a kind of perferred technical scheme, in the four-element connection number method in step S2, when it is invalid for taking k=0, i is taken
=0.666, j=0.333；When k=-1 is invalid and deteriorates, i=-0.333, i=-0.666 are taken.
As a kind of perferred technical scheme, in step S3 calculate perfect curative effect apart from when, also pass through setting control
The mode of group is compared, subtracted with idealized perfect curative effect at a distance from Chinese Herbs control group and idealized perfect curative effect away from
From further according to the difference sequence of the two distances.
As a kind of perferred technical scheme, in step S4 specifically includes the following steps:
Step S41, the representative prescription screened in step S1 by perfect curative effect apart from size sequence and by single cure rate
Size sequence compares；
Step S42, the representative prescription screened in step S1 by perfect curative effect apart from size sequence and by comprehensive evaluation value
Size sequence compares；
Step S42, it calculates every head and represents the curative effect of prescription and the increase rate of control group curative effect, be discharged and represent by range difference
The superiority and inferiority of prescription, and discuss.
As a kind of perferred technical scheme, the application applied in psoriasis.
The invention has the advantages that:
1, the weighting curative effect curve based on Set Pair Analysis Theory provides the occurrence of i, j, k, inquires into Set Pair Analysis in disease
Representative prescription medicine law research in application, further increase curative effect.
2, it by method of the invention, can be applicable in psoriasis, to filter out each autotherapy of the first prescription of curing psoriasis 9
Effect helps to improve psoriasis differential diagnosis in tcm opinion and controls clinical efficacy.
Detailed description of the invention
Attached drawing 1 is the process of the application of the invention based on Set Pair Analysis in the representative prescription medicine law research of disease
Block diagram.
Specific embodiment
It elaborates with reference to the accompanying drawing to specific embodiment provided by the invention.
Fig. 1 is please referred to, Fig. 1 is the answering in the representative prescription medicine law research of disease of the invention based on Set Pair Analysis
Flow diagram.
Set Pair Analysis disease representative prescription medicine law research in application, it is described application the following steps are included:
Step S1, disease name is selected, the representative prescription for treating the disease reported in document is filtered out；
Step S2, four-element connection number method: the clinical efficacy " healing " of the representative prescription screened in step S1, " effective ",
" improvement ", engineering noise indicate that wherein a indicates " cure rate " with 4 yuan of connection number μ=a+bi+cj+dk in Set Pair Analysis, and b is indicated
" obvious effective rate ", c indicate " improvement rate ", and d indicates " inefficiency "；
Step S3, it is calculated at a distance from perfect curative effect: using μ=1+0i+0j+0k of cure rate a=1 as ideal perfect
4 yuan of connection numbers of curative effect calculate 4 yuan of connection number μ of curative effect of each first prescriptiont=at+bti+ctj+dtK and ideal perfect curative effect 4
The distance of member connection number μ=1+0i+0j+0k, calculation formula:
ρtSmall prescription curative effect is better than ρtBig prescription curative effect；
Step S4, look for medicine law: investigate it is all represent system curative effect in prescription and come preceding 3 medicine laws, by using
Medicine frequency cluster；
Step S5, discussion is compared.
As example of the invention, 9 head of selection treatment psoriasis represent prescription.
Specific embodiment: by taking curing psoriasis as an example
Specific embodiment: by taking curing psoriasis as an example
1, data: data is controlled on 9 kinds of traditional Chinese medicine core periodicals such as " Chinese medicine journal " " Chinese combination of Chinese tradiational and Western medicine magazines "
Treat the document of psoriasis, 9 head represent prescription name and the Regional Distribution and clinical efficacy of place periodical and related author with compare
See Table 1 for details and table 2 for the data such as the curative effect of group.
19 head of table represents the drug composition and relevant information of prescription
The therapeutic effect of table 29 first Chinese medicinal formulae and its control group: number (%)
2 research methods
2.1 four-element connection number methods
4 in the clinical efficacy " healing " of 9 prescriptions in table 2, " effective ", " improvement ", engineering noise Set Pair Analysis
Member connection number μ=a+bi+cj+dk indicates that wherein a indicates " cure rate ", and b indicates " obvious effective rate ", and c indicates " improvement rate ", and d is indicated
" inefficiency " takes i=0.666, j=0.333 when taking k=0 (invalid)；When k=-1 (invalid and deterioration), i=- is taken
0.333, i=-0.666.
2.2 calculate at a distance from perfect curative effect
Using μ=1+0i+0j+0k of cure rate a=1 as 4 yuan of connection numbers of ideal perfect curative effect, each first prescription is calculated
4 yuan of curative effect connection number μ t=at+bti+ctj+dtk and ideal perfect 4 yuan of curative effect contact several μ=1+0i+0j+0k away from
From calculation formula:
ρtSmall prescription curative effect is better than ρtBig prescription curative effect.
2.3 look for medicine law
It investigates system curative effect in 9 first prescriptions and comes preceding 3 medicine laws, clustered by the medication frequency.
2.4 compare discussion
(1) 9 first prescriptions are sorted by perfect curative effect apart from size and is compared with by the sequence of single cure rate size.
(2) 9 first prescriptions are sorted by perfect curative effect apart from size and is compared with by the sequence of comprehensive evaluation value size.
(3) curative effect of every first prescription and the increase rate (respectively with the range difference of perfect curative effect) of control group curative effect are calculated,
The superiority and inferiority of 9 sides head is discharged by range difference, and discusses
3 results
3.19 head represent prescription clinical efficacy " healing ", " effective ", " improvement ", engineering noise 4 yuan of connection numbers and only press
The size ranking results of " cure rate " a are shown in Table 3.
3 nine head of table represents 4 yuan of connection numbers of curative effect and the cure rate sequence of prescription
4 yuan of connection number μ of curative effect in 3.2 pairs of tables 3t=at+bti+ctj+dtI in k takes i=0.666, j to take j=
0.333, k takes the sum of the integrated value after k=0 to be shown in Table 4
Table 4 takes effective coefficient i=0.75, and each prescription curative effect of improvement coefficient j=0.25, non-significant coefficients k=0 contact number
3.3 9 head represent 4 yuan of connection numbers of clinical efficacy of prescription and are taking i=-0.333, after j=-0.666, k=-1 with reason
The perfect curative effect connection number μ=1+0i+0j+0k thought apart from calculated result and its sequence, (distance value is small big prior to distance
) 4 right sides are shown in Table, as can be seen from Table 4, optimal curative effect prescription, suboptimum curative effect prescription, excellent curative effect prescription is successively native Chinese scholartree chinaroot greenbrier again
Soup, refreshing and detoxicating soup, LXHXT decoction.
3.4 9 head represent synthesis of the 4 yuan of connection numbers of clinical efficacy of prescription after i=0.666, j=0.333, k=0 and add
With value at+bti+ctJ is shown in Table 4 right sides, and by the big sequence small prior to comprehensive addition and value of comprehensive addition and value, coming the 1st is
Native Chinese scholartree chinaroot greenbrier soup, this is identical as by the result of idealized perfect curative effect distance-taxis, comes the 2nd, 3 removing pattogenic heat from the blood and toxic material from the body soup, cool blood
Blood activating decoction and other each side are identical with comprehensive virtual value ranking results in idealized perfect curative effect Furthest Neighbor, and with given in table 3
The size ranking results for only pressing cure rate out are also identical, show idealized perfect curative effect Furthest Neighbor discharge given herein
The priority of preceding 3 prescriptions is completely believable.
3.5 medicine law
In conjunction with table 1 as can be seen that without sharing in this 3 first prescription of native Chinese scholartree chinaroot greenbrier soup, refreshing and detoxicating soup, LXHXT decoction
Medicine, wherein the Chinese medicine (i.e. the medication frequency is 2) shared in wantonly two first prescriptions have Radix Rehmanniae, cortex dictamni, smilax, cortex moutan, sophora flower,
Radix paeoniae rubra, Radix Isatidis, Radix Angelicae Sinensis, Asian puccoon, madder, remaining chinaroot greenbrier, subprostrate sophora, the Cornu Saigae Tataricae powder medication frequency are all 1.
4 discuss
(1) compared with three prescriptions of ranking most end, the native Chinese scholartree chinaroot greenbrier soup being ranked first also increases chinaroot greenbrier, oldenlandia diffusa,
Polygonum cuspidate, Radix Salviae Miltiorrhizae etc., " product remittance essence is wanted ": " chinaroot greenbrier can dissipate pyogenic infections "；" Quanzhou book on Chinese herbal medicine ": " oldenlandia diffusa, main heat-clearing dissipate the stasis of blood, and disappear carbuncle
Removing toxic substances "；" Japan hanako materia medica ": " polygonum cuspidate, main sore malignant boil carbuncle poison, flutter and hurt hemostasis "；Three makes full side enhance clearing heat and detoxicating function, and medicine
Researches show that chinaroot greenbriers to contain flavones ingredient for reason, has apparent antitumor action and anti-immunity, anti-inflammatory cytokine effect, suppression
The secretion of TNF-α processed reduces infiltration of the inflammatory cell to tissue；Oldenlandia diffusa has the effects that anticancer, anti-inflammatory, and polygonum cuspidate has
The effects of improvement microcirculation, antitumor, adjusting are metabolized, Compendium of Material Medica cloud: " Radix Salviae Miltiorrhizae can break place blood, mend new blood, menstruation regulating arteries and veins "；Energy
Blood viscosity is reduced, improves microcirculation and hemorheology, so that skin lesion be promoted to subside.The refreshing and detoxicating soup of ranking the 2nd increases
Caulis Spatholobi, tripterygium wilfordii, the drug of the dredging collateral such as centipede, " pathogen usually intruding into collateral in protracted disease " " network is to lead to for use ", increasing rattan class drug can invigorate blood circulation also
Can dredging collateral, centipede is the tangible product of flesh and blood, has jump to attack the property of punching, and body yin is positive, tunnel network can be goed deep into, attack the phlegm-blood stasis for picking chronic knot,
The dynamic gas of rotation sun removes the agglomeration of hemostasis, and pharmacological research shows tripterygium wilfordii dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, has strength anti-inflammatory
Effect, and humoral immunity and cellular immunity can be inhibited, there is rapid and significant curative effect to certain allergic diseases.Centipede can
Blood vessel is expanded, blood viscosity is reduced, improves the high coagulation of local organization, it is more significant that all medicines play the benefits of making complete square stagnation resolvation altogether.
The LXHXT decoction of ranking the 3rd adds rheum officinale, antelope's horn, and antelope's horn energy is anti-inflammatory, antipyretic, enhancing is immune etc., and rheum officinale heat-clearing is cool
Blood, dispelling stasis of blood and stimulating the menstrual flow, Shennong's Herbal cloud: " lower hemostasis breaks accumulation, cleanses stomach, weeding through the old to new " has and adjusts stomach and intestine function
Can, it is antitumor, anti-inflammatory the effects of, demonstrate the reliability of Set Pair Analysis.Therefore, it is suggested that increasing on the basis of native Chinese scholartree chinaroot greenbrier soup
Caulis Spatholobi, tripterygium wilfordii, centipede, antelope's horn, rheum officinale, to obtain higher curative effect, this also needs further clinical verification.
(2) relationship of onset of psoriasis and local environment and life style and customs is considered, we also note that 9 first prescriptions
Region, therefore again using first prescription curative effect every in document compared with control group curative effect, calculate each control group curative effect and reason
The distance (being shown in Table 4) for the perfect curative effect thought, and further calculate the increase rate of Chinese medicinal formulae curative effect Yu control group curative effect, that is, it uses
Chinese Herbs subtract control group at a distance from idealized perfect curative effect at a distance from idealized perfect curative effect, further according to the two distances
Difference sequence, big small better than difference of difference, such calculated result is also listed in the right side of table 4.Increase rate is most as seen from Table 4
Excellent is still native Chinese scholartree chinaroot greenbrier soup, followed by refreshing and detoxicating soup, and the prescription is resonable to be thought also to come the 2nd in perfect curative effect ranking method,
Coming the 3rd is the anti-silver-colored soup of black snake, and the prescription is resonable to be thought to come the 7th in perfect curative effect Furthest Neighbor.
(3) " cure rate ", " obvious effective rate ", " improvement rate " and " nothing in psoriasis clinical efficacy are portrayed with 4 yuan of connection numbers
Efficiency " have systematicness and it is comprehensive, this be it is unquestionable, but 4 yuan connection numbers in i, how value is one by j, k
Stubborn problem.In the text, we are when calculating total virtual value, invalid k value is represented as k=0, so also just " controlling
More ", the definition space where " effective ", " improvement ", engineering noise is in [0,1] section, and [0, a 1] section is divided into [0,
0.333], (0.333,0.666), (0.666,1] three subintervals, i and j are two intermediate separations respectively, so taking i=
0.666, j=0.333, when clinical meaning is comparable to the weight of " healing " to regard " 1 " as, " effective " is equivalent to 0.666 power
" healing " of weight, " improvement " are equivalent to " healing " of 0.333 weight, and the total cure rate meter of each prescription curative effect is convenient in such setting
It calculates, it is consistent with determined by the other angles 9 first trap queuing results of entirety curative effect of prescription, illustrate that this setting is reasonable.
(4) concept of curative effect curve is put forward for the first time in the literature, but does not show i, j, the occurrence of k, and is disregarding i,
When the value of j, k, distance between two points formula is directly used:
It is possible that the case where obscuring superiority and inferiority, such as have 3 different prescription μ1、μ2、μ3, clinical efficacy connection number
It is μ respectively1=0.8+0.2i+0j+ok,
μ2=0.8+0i+0.2j+ok, μ3=0.8+0i+0j+0.2k, intuitively can be seen that μ1Better than μ2Better than μ3If not
Haggle over the value of i, j, k, μ1、μ2、μ3Number μ is contacted away from optimal curative effect0The distance of=1+0i+0j+0k presses formula:
Calculated result be it is identical, be allObviously unkind and irrigational, by giving herein
I, j, k value agreement out, takes i=-0.333, j=-0.666, k=-1, then has:
Namely μ1Away from idealized perfect curative effect μ0The distance of=1+0i+0j+0k is 0.2107, compares μ2Away from idealized perfect curative effect
Distance 0.2402 closer to perfect curative effect, similarly, because 0.2402 < 0.2828, knows μ2Compare μ3More excellent, this is kissed with actual conditions
It closes.
In fact, the value of i, j, k are in Set Pair Analysis meaning when the value of i, j, k are calculated with comprehensive virtual value herein
It is consistent.For example, i takes i=0.666 when comprehensive virtual value calculates, imply that and have in " effective " and 66.6% tend to " to cure " "+
1 " direction, then remaining 0.333 should be intended to " -1 " direction, that is, will back on " improvement " level, so this
In take i=-0.333；Similarly, j takes j=0.333 when comprehensive virtual value calculates, and implies that in " improvement " there was only 33.3% tendency
In " healing " "+1 " direction, then remaining 0.666 should be intended to " -1 " direction, so taking j=-0.666 here；Together
Reason, k take k=0 (being namely not counted in comprehensive virtual value) when comprehensive virtual value calculates, imply that in engineering noise and only have 0% to incline
To in " healing " "+1 " direction, remaining 100% tends to the opposite direction " -1 " in "+1 " direction so taking k=-1 here.
(5) therefore, the comprehensive therapeutic effect of 9 first prescriptions, other than experimental group and the sequence of control group increase rate, other
The integrated ordered ranking results all having the same of one angle, 3 prescription its comprehensive advantages of preceding 3 sequences thereby determined that
Be it is believable, therefore forming native Chinese scholartree chinaroot greenbrier soup, refreshing and detoxicating soup, LXHXT decoction this 3 drugs represented in prescription also has
The priority of clinical application.If the connection geometry of numbers attribute inspection this 3 proposed in document is recycled to represent the curative effect of prescription
Stability, there are geometrical stability (a=0.3953, b=0.3721, c=0.1395, a for the curative effect of discovery only refreshing and detoxicating soup
+ b > c, a+c > b, the b+c > validity of the prescription drug a) is prompted to be worth further research；Certainly, remaining 6 represent prescription
Therefore drug of choice cannot negate that, because being adapted to the psoriatic of different geographical, only general curative effect is to be improved without exception, because
For research shows that: even 9 first treatment psoriasis represent the best native Chinese scholartree chinaroot greenbrier soup of curative effect in prescription, cure rate also only has
51.43%, it can be seen that, the task that traditional Chinese medicine cures psoriasis completely is also very arduous, improves psoriasis differential diagnosis in tcm opinion and controls
There are also much rooms for clinical efficacy.
The solution have the advantages that: differentiation of tcm disease and prescriptions with disease plus-minus have it is many it is uncertain because
Element causes the representative prescription for treating certain disease to have very much, and curative effect is also had nothing in common with each other, it is therefore proposed that a kind of be based on Set Pair Analysis
The theory for weighting curative effect curve, inquires into the general medicine law in different diagnosis and treatment prescriptions, is one rich in scientific meaning
Problem, while trap queuing is carried out to all curative effects for representing prescription by the calculating of total effective rate, to improve clinical efficacy.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, under the premise of not departing from the method for the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (5)
1. Set Pair Analysis disease representative prescription medicine law research in application, which is characterized in that the application include with
Lower step:
Step S1, disease name is selected, the representative prescription for treating the disease reported in document is filtered out；
Step S2, four-element connection number method: the clinical efficacy " healing " of the representative prescription screened in step S1, " effective ", " good
Turn ", engineering noise indicated with 4 yuan of connection number μ=a+bi+cj+dk in Set Pair Analysis, wherein a indicate " cure rate ", b indicate " show
Efficiency ", c indicate " improvement rate ", and d indicates " inefficiency "；
Step S3, it is calculated at a distance from perfect curative effect: using μ=1+0i+0j+0k of cure rate a=1 as ideal perfect curative effect
4 yuan of connection numbers calculate 4 yuan of connection number μ of curative effect of each first prescriptiont=at+bti+ctj+dtK and ideal 4 yuan of connection of perfect curative effect
The distance of coefficient μ=1+0i+0j+0k, calculation formula:
ρtSmall prescription curative effect is better than ρtBig prescription curative effect；
Step S4, look for medicine law: investigate it is all represent system curative effect in prescription and come preceding 3 medicine laws, frequently by medication
Secondary cluster；
Step S5, discussion is compared.
2. application of the Set Pair Analysis according to claim 1 in the representative prescription medicine law research of disease, feature
It is, in the four-element connection number method in step S2, when it is invalid for taking k=0, takes i=0.666, j=0.333；When k=-1 without
When effect and deterioration, i=-0.333, i=-0.666 are taken.
3. application of the Set Pair Analysis according to claim 1 in the representative prescription medicine law research of disease, feature
Be, in step S3 calculate perfect curative effect apart from when, be also compared in such a way that control group is set, use Chinese Herbs
Control group is subtracted at a distance from idealized perfect curative effect at a distance from idealized perfect curative effect, is sorted further according to the difference of the two distances.
4. application of the Set Pair Analysis according to claim 1 in the representative prescription medicine law research of disease, feature
Be, in step S4 specifically includes the following steps:
Step S41, the representative prescription screened in step S1 by perfect curative effect apart from size sequence and by single cure rate size
Sequence compares；
Step S42, the representative prescription screened in step S1 by perfect curative effect apart from size sequence and by comprehensive evaluation value size
Sequence compares；
Step S42, it calculates every head and represents the curative effect of prescription and the increase rate of control group curative effect, represent prescription by range difference discharge
Superiority and inferiority, and discuss.
5. a kind of answering in the representative prescription medicine law research of disease using any one of the claim 1-4 Set Pair Analysis
With, which is characterized in that the application applied in psoriasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811082126.2A CN109192320A (en) | 2018-09-17 | 2018-09-17 | Application of the Set Pair Analysis in the representative prescription medicine law research of disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811082126.2A CN109192320A (en) | 2018-09-17 | 2018-09-17 | Application of the Set Pair Analysis in the representative prescription medicine law research of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109192320A true CN109192320A (en) | 2019-01-11 |
Family
ID=64911708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811082126.2A Pending CN109192320A (en) | 2018-09-17 | 2018-09-17 | Application of the Set Pair Analysis in the representative prescription medicine law research of disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109192320A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110349645A (en) * | 2019-07-16 | 2019-10-18 | 上海中医药大学附属岳阳中西医结合医院 | Application of the partial connection number in the analysis of disease treatment Stability |
| CN110782995A (en) * | 2019-10-23 | 2020-02-11 | 上海中医药大学附属岳阳中西医结合医院 | Set pair analysis partial relation coefficient based method for researching recurrence factor of psoriasis and preventing and treating psoriasis |
| CN111489809A (en) * | 2020-04-07 | 2020-08-04 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine diagnosis and treatment system based on set pair analysis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107463791A (en) * | 2017-08-25 | 2017-12-12 | 上海中医药大学附属岳阳中西医结合医院 | The effect of using based on Set Pair Analysis four-element connection number, dsm screen chose the method and system of medicine |
| CN107491650A (en) * | 2017-08-25 | 2017-12-19 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicine screening method and system based on partial connection number method |
| CN107516013A (en) * | 2017-08-25 | 2017-12-26 | 上海中医药大学附属岳阳中西医结合医院 | It is a kind of that the preferable method and system of medicine are carried out by curative effect triangle |
| CN107564589A (en) * | 2017-08-25 | 2018-01-09 | 上海中医药大学附属岳阳中西医结合医院 | One kind is based on four-element connection number Symptomatic medicine assessment prediction method and system |
-
2018
- 2018-09-17 CN CN201811082126.2A patent/CN109192320A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107463791A (en) * | 2017-08-25 | 2017-12-12 | 上海中医药大学附属岳阳中西医结合医院 | The effect of using based on Set Pair Analysis four-element connection number, dsm screen chose the method and system of medicine |
| CN107491650A (en) * | 2017-08-25 | 2017-12-19 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicine screening method and system based on partial connection number method |
| CN107516013A (en) * | 2017-08-25 | 2017-12-26 | 上海中医药大学附属岳阳中西医结合医院 | It is a kind of that the preferable method and system of medicine are carried out by curative effect triangle |
| CN107564589A (en) * | 2017-08-25 | 2018-01-09 | 上海中医药大学附属岳阳中西医结合医院 | One kind is based on four-element connection number Symptomatic medicine assessment prediction method and system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110349645A (en) * | 2019-07-16 | 2019-10-18 | 上海中医药大学附属岳阳中西医结合医院 | Application of the partial connection number in the analysis of disease treatment Stability |
| CN110782995A (en) * | 2019-10-23 | 2020-02-11 | 上海中医药大学附属岳阳中西医结合医院 | Set pair analysis partial relation coefficient based method for researching recurrence factor of psoriasis and preventing and treating psoriasis |
| CN111489809A (en) * | 2020-04-07 | 2020-08-04 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine diagnosis and treatment system based on set pair analysis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jiang | Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science | |
| CN109192320A (en) | Application of the Set Pair Analysis in the representative prescription medicine law research of disease | |
| CN104587090A (en) | Medicine for treating rheumatoid arthritis | |
| CN103610769B (en) | Diabetic peripheral neuropathy treatment traditional Chinese medicine composition | |
| CN112992378B (en) | Multi-dimensional traditional Chinese medicine prescription recommendation method and recommendation system | |
| CN102178800A (en) | Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof | |
| CN1150928C (en) | Medicine for curing cancers and its preparation method | |
| CN103055205B (en) | Heterophylla and astragalus mongholicus reinvigorating particle as well as preparation method and application thereof in preparation of medicament for treating acquired immune deficiency syndrome | |
| CN105796789A (en) | Traditional Chinese medicine preparation for treating coronary heart disease | |
| CN103800840A (en) | Oral traditional Chinese medicine solution for treating cervical spondylosis | |
| CN103830591A (en) | Traditional Chinese medicine formula for treating stroke and post-traumatic brain syndrome and preparation method of traditional Chinese medicine | |
| Wang et al. | Analysis on the medication rule of famous old tcm doctors in the treatment of cervical spondylosis based on data mining | |
| CN102614479B (en) | Traditional Chinese medicine lotion preparation method for curing kidney-yang deficiency ecthyma | |
| Hu et al. | Research on the modern clinical herbal administration rules in TCM treatment of ovarian cysts based on data mining | |
| CN103751671B (en) | A kind of Chinese herbal medicine formula for the treatment of hyperosteogeny and preparation method thereof | |
| Liu et al. | Based on data mining to explore the medication rule of Professor Shao Zheng-bin in the treatment of coronary heart disease combined with type2 diabetes mellitus after PCI. | |
| CN104258331A (en) | Traditional Chinese medicine for treating postpartum abdominal pain | |
| CN104586988A (en) | Traditional Chinese medicine used for treating irregular menstruation | |
| CN103211977A (en) | Traditional Chinese medicine preparation used for treating hyperthyroidism | |
| Huang | Thoughts on coronavirus disease 2019 based on JingFang medicine (classical chinese formula) solutions for COVID-19 | |
| CN103330811B (en) | Chinese herbal preparation for curing chronic pelvic inflammatory diseases | |
| Zhang et al. | Study on Professor Diangui Li's Medication Experience in Treating Atrophic Gastritis Concomitant with Helicobacter Pylori Infection Based on Data Mining | |
| CN102671111B (en) | Chinese medicinal composition for treating malignant soft tissue neoplasm | |
| Jiao-zhi et al. | Study on the Medication Law of Traditional Chinese medicine treating Lumbago based on TCM electronic medical record | |
| Duan et al. | Stability and compatibility of common traditional Chinese medicine injections matching with fructose injection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190111 |
|
| RJ01 | Rejection of invention patent application after publication |