CN110339203A - 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 - Google Patents
用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 Download PDFInfo
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
- 229960004276 zoledronic acid Drugs 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biochemistry (AREA)
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| US201361809575P | 2013-04-08 | 2013-04-08 | |
| US61/809575 | 2013-04-08 | ||
| CN201480032692.6A CN105338987A (zh) | 2013-04-08 | 2014-04-08 | 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 |
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| CN201480032692.6A Division CN105338987A (zh) | 2013-04-08 | 2014-04-08 | 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 |
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| CN110339203A true CN110339203A (zh) | 2019-10-18 |
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| CN201910445731.XA Pending CN110339203A (zh) | 2013-04-08 | 2014-04-08 | 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 |
| CN201480032692.6A Pending CN105338987A (zh) | 2013-04-08 | 2014-04-08 | 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201480032692.6A Pending CN105338987A (zh) | 2013-04-08 | 2014-04-08 | 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 |
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| JP (1) | JP6525956B2 (enExample) |
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| CN (2) | CN110339203A (enExample) |
| AU (1) | AU2014251093B2 (enExample) |
| BR (1) | BR112015025206A2 (enExample) |
| CA (1) | CA2907924C (enExample) |
| ES (1) | ES3038057T3 (enExample) |
| HK (1) | HK1219418A1 (enExample) |
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| RU (1) | RU2713555C2 (enExample) |
| SG (2) | SG11201508336TA (enExample) |
| WO (1) | WO2014168947A2 (enExample) |
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|---|---|---|---|---|
| WO2017165675A1 (en) * | 2016-03-24 | 2017-09-28 | The Board Of Regents Of The University Of Texas System | Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds |
| US20190298751A1 (en) * | 2016-05-27 | 2019-10-03 | The Board Of Regents Of The University Of Texas System | 6-thio-2'-deoxyguanosine (6-thio-dg) results in telomerase dependent telomere dysfunction and cell death in various models of therapy-resistant cancer cells |
| WO2019183482A1 (en) * | 2018-03-22 | 2019-09-26 | The Board Of Regents Of The University Of Texas System | USE OF 6-THIO-dG TO TREAT THERAPY-RESISTANT TELOMERASEPOSITIVE PEDIATRIC BRAIN TUMORS |
| AU2019208197B2 (en) | 2018-07-31 | 2025-05-29 | Howmedica Osteonics Corp. | Fixation devices and prostheses for soft tissue connection to the same |
| JP7576843B2 (ja) * | 2018-10-17 | 2024-11-01 | リャオ，シビン | ６－メルカプトプリンヌクレオシドアナログ |
| USD1046142S1 (en) | 2019-07-24 | 2024-10-08 | Howmedica Osteonics Corp. | Proximal tibial prosthesis |
| CN112898292A (zh) | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
| FI4117667T3 (fi) | 2020-03-13 | 2025-02-10 | Univ Texas | Syöpien jaksottainen hoito käyttäen 6-tio-dg- ja tarkistuspisteen inhibiittoreita |
| CN120981470A (zh) * | 2023-03-14 | 2025-11-18 | 浙江华海药业股份有限公司 | 一类核苷类似物及其应用 |
| CN121002041A (zh) * | 2023-03-14 | 2025-11-21 | 浙江华海药业股份有限公司 | 一类靶向端粒酶的核苷类似物及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20100323979A1 (en) * | 2009-06-16 | 2010-12-23 | Weis-Amon Angelika B | Methods and compositions for inhibiting proliferation of aneuploid cells |
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| JPS57209226A (en) * | 1981-06-18 | 1982-12-22 | Yamasa Shoyu Co Ltd | Antitumor activity intensifier |
| WO1992013561A1 (en) * | 1991-02-08 | 1992-08-20 | Pro-Neuron, Inc. | Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis |
| CA2606399A1 (en) | 2005-04-25 | 2006-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic | Use of compounds to enhance processivity of telomerase |
| CN101220071B (zh) * | 2008-01-17 | 2011-04-06 | 南京长澳医药科技有限公司 | 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物 |
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- 2014-04-08 MX MX2015014159A patent/MX387008B/es unknown
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100323979A1 (en) * | 2009-06-16 | 2010-12-23 | Weis-Amon Angelika B | Methods and compositions for inhibiting proliferation of aneuploid cells |
Non-Patent Citations (3)
| Title |
|---|
| G.A. LEPAGE: "Manipulation of DNA synthesis in normal and neoplastic tissues with drugs", 《ADVANCES IN ENZYME REGULATION》 * |
| SUSAN W. TENDIAN等: "Interaction of Deoxyguanosine Nucleotide Analogs with Human Telomerase", 《MOLECULAR PHARMACOLOGY》 * |
| V N VISWANADHAN等: "Analysis of the in Vitro Antitumor Activity of Novel Purine-6-sulfenamide,-sulfinamide, and -sulfonamide Nucleosides and Certain Related Compounds Using a Computer-Aided Receptor Modeling Procedure", 《JOURNAL OF MEDICINAL CHEMISTRY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201508336TA (en) | 2015-11-27 |
| JP6525956B2 (ja) | 2019-06-05 |
| MX387008B (es) | 2025-03-19 |
| SG10202002556QA (en) | 2020-04-29 |
| PL3682888T3 (pl) | 2025-09-22 |
| AU2014251093A1 (en) | 2015-10-15 |
| EP2983675A2 (en) | 2016-02-17 |
| CA2907924A1 (en) | 2014-10-16 |
| CA2907924C (en) | 2022-10-25 |
| WO2014168947A3 (en) | 2015-02-19 |
| NZ713498A (en) | 2017-07-28 |
| AU2014251093B2 (en) | 2017-06-15 |
| MX2015014159A (es) | 2016-06-21 |
| WO2014168947A2 (en) | 2014-10-16 |
| US20140303239A1 (en) | 2014-10-09 |
| KR20150143587A (ko) | 2015-12-23 |
| RU2713555C2 (ru) | 2020-02-05 |
| RU2015147555A (ru) | 2017-05-15 |
| HUE072426T2 (hu) | 2025-11-28 |
| HK1219418A1 (zh) | 2017-04-07 |
| CN105338987A (zh) | 2016-02-17 |
| BR112015025206A2 (pt) | 2017-07-18 |
| ES3038057T3 (en) | 2025-10-09 |
| WO2014168947A9 (en) | 2014-12-31 |
| NZ732228A (en) | 2020-11-27 |
| US10463685B2 (en) | 2019-11-05 |
| EP3682888A1 (en) | 2020-07-22 |
| EP3682888B1 (en) | 2025-06-11 |
| JP2016516773A (ja) | 2016-06-09 |
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