HUE072426T2 - Merkaptopurin-ribonukleozid analógok a telomeráz-mediált telomer módosítására - Google Patents
Merkaptopurin-ribonukleozid analógok a telomeráz-mediált telomer módosításáraInfo
- Publication number
- HUE072426T2 HUE072426T2 HUE20155920A HUE20155920A HUE072426T2 HU E072426 T2 HUE072426 T2 HU E072426T2 HU E20155920 A HUE20155920 A HU E20155920A HU E20155920 A HUE20155920 A HU E20155920A HU E072426 T2 HUE072426 T2 HU E072426T2
- Authority
- HU
- Hungary
- Prior art keywords
- ribonucleoside analogues
- mercaptopurine ribonucleoside
- altering
- mediated telomere
- telomerase mediated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biochemistry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809575P | 2013-04-08 | 2013-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE072426T2 true HUE072426T2 (hu) | 2025-11-28 |
Family
ID=50819958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE20155920A HUE072426T2 (hu) | 2013-04-08 | 2014-04-08 | Merkaptopurin-ribonukleozid analógok a telomeráz-mediált telomer módosítására |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10463685B2 (enExample) |
| EP (2) | EP2983675A2 (enExample) |
| JP (1) | JP6525956B2 (enExample) |
| KR (1) | KR20150143587A (enExample) |
| CN (2) | CN110339203A (enExample) |
| AU (1) | AU2014251093B2 (enExample) |
| BR (1) | BR112015025206A2 (enExample) |
| CA (1) | CA2907924C (enExample) |
| ES (1) | ES3038057T3 (enExample) |
| HK (1) | HK1219418A1 (enExample) |
| HU (1) | HUE072426T2 (enExample) |
| MX (1) | MX387008B (enExample) |
| NZ (1) | NZ713498A (enExample) |
| PL (1) | PL3682888T3 (enExample) |
| RU (1) | RU2713555C2 (enExample) |
| SG (2) | SG11201508336TA (enExample) |
| WO (1) | WO2014168947A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017165675A1 (en) * | 2016-03-24 | 2017-09-28 | The Board Of Regents Of The University Of Texas System | Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds |
| US20190298751A1 (en) * | 2016-05-27 | 2019-10-03 | The Board Of Regents Of The University Of Texas System | 6-thio-2'-deoxyguanosine (6-thio-dg) results in telomerase dependent telomere dysfunction and cell death in various models of therapy-resistant cancer cells |
| WO2019183482A1 (en) * | 2018-03-22 | 2019-09-26 | The Board Of Regents Of The University Of Texas System | USE OF 6-THIO-dG TO TREAT THERAPY-RESISTANT TELOMERASEPOSITIVE PEDIATRIC BRAIN TUMORS |
| AU2019208197B2 (en) | 2018-07-31 | 2025-05-29 | Howmedica Osteonics Corp. | Fixation devices and prostheses for soft tissue connection to the same |
| JP7576843B2 (ja) * | 2018-10-17 | 2024-11-01 | リャオ，シビン | ６－メルカプトプリンヌクレオシドアナログ |
| USD1046142S1 (en) | 2019-07-24 | 2024-10-08 | Howmedica Osteonics Corp. | Proximal tibial prosthesis |
| CN112898292A (zh) | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
| FI4117667T3 (fi) | 2020-03-13 | 2025-02-10 | Univ Texas | Syöpien jaksottainen hoito käyttäen 6-tio-dg- ja tarkistuspisteen inhibiittoreita |
| CN120981470A (zh) * | 2023-03-14 | 2025-11-18 | 浙江华海药业股份有限公司 | 一类核苷类似物及其应用 |
| CN121002041A (zh) * | 2023-03-14 | 2025-11-21 | 浙江华海药业股份有限公司 | 一类靶向端粒酶的核苷类似物及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57209226A (en) * | 1981-06-18 | 1982-12-22 | Yamasa Shoyu Co Ltd | Antitumor activity intensifier |
| WO1992013561A1 (en) * | 1991-02-08 | 1992-08-20 | Pro-Neuron, Inc. | Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis |
| CA2606399A1 (en) | 2005-04-25 | 2006-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic | Use of compounds to enhance processivity of telomerase |
| CN101220071B (zh) * | 2008-01-17 | 2011-04-06 | 南京长澳医药科技有限公司 | 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物 |
| WO2010147663A1 (en) * | 2009-06-16 | 2010-12-23 | Massechusetts Institute Of Technology | Methods and compositions for inhibiting proliferation of aneuploid cells |
-
2014
- 2014-04-08 JP JP2016507608A patent/JP6525956B2/ja active Active
- 2014-04-08 MX MX2015014159A patent/MX387008B/es unknown
- 2014-04-08 NZ NZ713498A patent/NZ713498A/en not_active IP Right Cessation
- 2014-04-08 CN CN201910445731.XA patent/CN110339203A/zh active Pending
- 2014-04-08 KR KR1020157031880A patent/KR20150143587A/ko not_active Ceased
- 2014-04-08 CA CA2907924A patent/CA2907924C/en active Active
- 2014-04-08 HK HK16107437.8A patent/HK1219418A1/zh unknown
- 2014-04-08 ES ES20155920T patent/ES3038057T3/es active Active
- 2014-04-08 CN CN201480032692.6A patent/CN105338987A/zh active Pending
- 2014-04-08 EP EP14726468.3A patent/EP2983675A2/en not_active Withdrawn
- 2014-04-08 SG SG11201508336TA patent/SG11201508336TA/en unknown
- 2014-04-08 RU RU2015147555A patent/RU2713555C2/ru active
- 2014-04-08 WO PCT/US2014/033330 patent/WO2014168947A2/en not_active Ceased
- 2014-04-08 AU AU2014251093A patent/AU2014251093B2/en not_active Ceased
- 2014-04-08 BR BR112015025206A patent/BR112015025206A2/pt not_active Application Discontinuation
- 2014-04-08 US US14/247,967 patent/US10463685B2/en active Active
- 2014-04-08 EP EP20155920.0A patent/EP3682888B1/en active Active
- 2014-04-08 PL PL20155920.0T patent/PL3682888T3/pl unknown
- 2014-04-08 SG SG10202002556QA patent/SG10202002556QA/en unknown
- 2014-04-08 HU HUE20155920A patent/HUE072426T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201508336TA (en) | 2015-11-27 |
| JP6525956B2 (ja) | 2019-06-05 |
| MX387008B (es) | 2025-03-19 |
| SG10202002556QA (en) | 2020-04-29 |
| PL3682888T3 (pl) | 2025-09-22 |
| AU2014251093A1 (en) | 2015-10-15 |
| EP2983675A2 (en) | 2016-02-17 |
| CA2907924A1 (en) | 2014-10-16 |
| CA2907924C (en) | 2022-10-25 |
| WO2014168947A3 (en) | 2015-02-19 |
| NZ713498A (en) | 2017-07-28 |
| AU2014251093B2 (en) | 2017-06-15 |
| MX2015014159A (es) | 2016-06-21 |
| WO2014168947A2 (en) | 2014-10-16 |
| US20140303239A1 (en) | 2014-10-09 |
| KR20150143587A (ko) | 2015-12-23 |
| RU2713555C2 (ru) | 2020-02-05 |
| RU2015147555A (ru) | 2017-05-15 |
| CN110339203A (zh) | 2019-10-18 |
| HK1219418A1 (zh) | 2017-04-07 |
| CN105338987A (zh) | 2016-02-17 |
| BR112015025206A2 (pt) | 2017-07-18 |
| ES3038057T3 (en) | 2025-10-09 |
| WO2014168947A9 (en) | 2014-12-31 |
| NZ732228A (en) | 2020-11-27 |
| US10463685B2 (en) | 2019-11-05 |
| EP3682888A1 (en) | 2020-07-22 |
| EP3682888B1 (en) | 2025-06-11 |
| JP2016516773A (ja) | 2016-06-09 |
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