HK1219418A1 - 用於改变端粒酶介导的端粒的化合物 - Google Patents

用於改变端粒酶介导的端粒的化合物 Download PDF

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Publication number
HK1219418A1
HK1219418A1 HK16107437.8A HK16107437A HK1219418A1 HK 1219418 A1 HK1219418 A1 HK 1219418A1 HK 16107437 A HK16107437 A HK 16107437A HK 1219418 A1 HK1219418 A1 HK 1219418A1
Authority
HK
Hong Kong
Prior art keywords
telomere
telomerase
mercaptopurine
analogues
ribonucleoside analogues
Prior art date
Application number
HK16107437.8A
Other languages
English (en)
Chinese (zh)
Inventor
Jerry W. Shay
Sergei M. Gryaznov
Original Assignee
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Texas System filed Critical The Board Of Regents Of The University Of Texas System
Publication of HK1219418A1 publication Critical patent/HK1219418A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biochemistry (AREA)
HK16107437.8A 2013-04-08 2014-04-08 用於改变端粒酶介导的端粒的化合物 HK1219418A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361809575P 2013-04-08 2013-04-08
US201361809575P 2013-04-08
PCT/US2014/033330 WO2014168947A2 (en) 2013-04-08 2014-04-08 Telomerase mediated telomere altering compounds

Publications (1)

Publication Number Publication Date
HK1219418A1 true HK1219418A1 (zh) 2017-04-07

Family

ID=50819958

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16107437.8A HK1219418A1 (zh) 2013-04-08 2014-04-08 用於改变端粒酶介导的端粒的化合物

Country Status (17)

Country Link
US (1) US10463685B2 (enExample)
EP (2) EP2983675A2 (enExample)
JP (1) JP6525956B2 (enExample)
KR (1) KR20150143587A (enExample)
CN (2) CN110339203A (enExample)
AU (1) AU2014251093B2 (enExample)
BR (1) BR112015025206A2 (enExample)
CA (1) CA2907924C (enExample)
ES (1) ES3038057T3 (enExample)
HK (1) HK1219418A1 (enExample)
HU (1) HUE072426T2 (enExample)
MX (1) MX387008B (enExample)
NZ (1) NZ713498A (enExample)
PL (1) PL3682888T3 (enExample)
RU (1) RU2713555C2 (enExample)
SG (2) SG11201508336TA (enExample)
WO (1) WO2014168947A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017165675A1 (en) * 2016-03-24 2017-09-28 The Board Of Regents Of The University Of Texas System Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds
US20190298751A1 (en) * 2016-05-27 2019-10-03 The Board Of Regents Of The University Of Texas System 6-thio-2'-deoxyguanosine (6-thio-dg) results in telomerase dependent telomere dysfunction and cell death in various models of therapy-resistant cancer cells
WO2019183482A1 (en) * 2018-03-22 2019-09-26 The Board Of Regents Of The University Of Texas System USE OF 6-THIO-dG TO TREAT THERAPY-RESISTANT TELOMERASEPOSITIVE PEDIATRIC BRAIN TUMORS
AU2019208197B2 (en) 2018-07-31 2025-05-29 Howmedica Osteonics Corp. Fixation devices and prostheses for soft tissue connection to the same
JP7576843B2 (ja) * 2018-10-17 2024-11-01 リャオ，シビン ６－メルカプトプリンヌクレオシドアナログ
USD1046142S1 (en) 2019-07-24 2024-10-08 Howmedica Osteonics Corp. Proximal tibial prosthesis
CN112898292A (zh) 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途
FI4117667T3 (fi) 2020-03-13 2025-02-10 Univ Texas Syöpien jaksottainen hoito käyttäen 6-tio-dg- ja tarkistuspisteen inhibiittoreita
CN120981470A (zh) * 2023-03-14 2025-11-18 浙江华海药业股份有限公司 一类核苷类似物及其应用
CN121002041A (zh) * 2023-03-14 2025-11-21 浙江华海药业股份有限公司 一类靶向端粒酶的核苷类似物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57209226A (en) * 1981-06-18 1982-12-22 Yamasa Shoyu Co Ltd Antitumor activity intensifier
WO1992013561A1 (en) * 1991-02-08 1992-08-20 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
CA2606399A1 (en) 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic Use of compounds to enhance processivity of telomerase
CN101220071B (zh) * 2008-01-17 2011-04-06 南京长澳医药科技有限公司 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物
WO2010147663A1 (en) * 2009-06-16 2010-12-23 Massechusetts Institute Of Technology Methods and compositions for inhibiting proliferation of aneuploid cells

Also Published As

Publication number Publication date
SG11201508336TA (en) 2015-11-27
JP6525956B2 (ja) 2019-06-05
MX387008B (es) 2025-03-19
SG10202002556QA (en) 2020-04-29
PL3682888T3 (pl) 2025-09-22
AU2014251093A1 (en) 2015-10-15
EP2983675A2 (en) 2016-02-17
CA2907924A1 (en) 2014-10-16
CA2907924C (en) 2022-10-25
WO2014168947A3 (en) 2015-02-19
NZ713498A (en) 2017-07-28
AU2014251093B2 (en) 2017-06-15
MX2015014159A (es) 2016-06-21
WO2014168947A2 (en) 2014-10-16
US20140303239A1 (en) 2014-10-09
KR20150143587A (ko) 2015-12-23
RU2713555C2 (ru) 2020-02-05
RU2015147555A (ru) 2017-05-15
HUE072426T2 (hu) 2025-11-28
CN110339203A (zh) 2019-10-18
CN105338987A (zh) 2016-02-17
BR112015025206A2 (pt) 2017-07-18
ES3038057T3 (en) 2025-10-09
WO2014168947A9 (en) 2014-12-31
NZ732228A (en) 2020-11-27
US10463685B2 (en) 2019-11-05
EP3682888A1 (en) 2020-07-22
EP3682888B1 (en) 2025-06-11
JP2016516773A (ja) 2016-06-09

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