CN110327387A - The Chinese medicinal plaster and preparation method thereof for treating tinnitus - Google Patents
The Chinese medicinal plaster and preparation method thereof for treating tinnitus Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/16—Otologicals
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Abstract
The present invention relates to the Chinese medicinal plasters and preparation method thereof for the treatment of tinnitus, it contains a Chinese medicinal plaster, and Chinese medicine is composed of the following raw materials in parts by weight in plaster: 65 ~ 75 parts of the rhizome of davallia, 40 ~ 50 parts of radix scutellariae, 20 ~ 30 parts of ginseng, 20 ~ 30 parts of Rhizoma Chuanxiong, 20 ~ 30 parts of Radix Angelicae Sinensis, 20 ~ 30 parts of radix bupleuri.Plaster made of Chinese medicine composition provided by the present invention is under the guidance of traditional Chinese medical theory, with percutaneous (Transdermal absorption) medication, by means of the function of prescription medicine overall coordination, play component drug nourishing kidney deficiency, life essence-filling, marrow-benefitting, lifting disease, soothing liver-qi stagnation, dispel hot purging intense heat the effect of, and i.e. fill blood again qi and blood circulation promotion, i.e. tonifying spleen and stomach transport again taste achieve the effect that treatment tinnitus.
Description
Technical field
The invention belongs to tcm fields, and in particular to treat Chinese medicinal plaster of tinnitus and preparation method thereof.
Background technique
Traditional Chinese medicine plaster is convenient administration dosage form, using the long history for having thousand.Plaster plays a role through skin, emplastrum
The effect of medication is one of common outer treating method of tcm clinical practice, it follows differentiation of tcm and Chinese medicine cures mainly and channel tropism
Principle, give full play to drug coordinate mutually for efficiency, composition multi-flavor drug compound, to play the good effect of drug
Fruit.Since plaster is directly applied to body surface, and the most smell of drug for making paste is denseer, adds Xin Xiang and walks to alter extremely strong draw
Through drug, by infiltrating through skin, the effects of interior transmission from one channel to another network, internal organs, it is wet to play regulating the qi flowing in the channels blood, degrading the channel, cold dispelling, pain of reducing swelling.Phase
Than operation with other drugs treat, while playing therapeutic effect, have it is simple to operate, low-cost, do not influence to suffer from
The advantages that person's daily work life.The ingredient altered often is walked containing fragrance in plaster, therefore pregnant woman will be used with caution, skin allergy person is not yet
Preferably paste use.
Tinnitus is both one of the common sympton of a variety of diseases, is also a kind of independent disease.Long-term tinnitus can be raw to patient
Bioplasm amount causes strong influence.The clinical treatment medication of tinnitus is mainly oral western medicine at present, there is local anesthetic, antidepression
Medicine and anxiolytic, anticonvulsive drug, expansion blood vessel and improve microcirculation medicine etc., treatment while will appear drowsiness, dizzy, skin
The side effects such as rash, behavior disorder, out of strength, and easily repeatedly, efficient low, drug cost is high.A small number of clinics are taken orally with Chinese medicine
Or the treatment such as external application acupuncture, but it is efficient low and easy to recur.
Summary of the invention
The first object of the present invention is to provide a kind of Chinese medicinal plaster for treating tinnitus, contains a plaster, institute
The drug stated in plaster is composed of the following raw materials in parts by weight: 65~75 parts of the rhizome of davallia, 40~50 parts of radix scutellariae, ginseng 20~30
Part, 20~30 parts of Rhizoma Chuanxiong, 20~30 parts of Radix Angelicae Sinensis, 20~30 parts of radix bupleuri.
As a further improvement of the present invention, the drug in the plaster is composed of the following raw materials in parts by weight: bone is broken
Mend 70 parts, 45 parts of radix scutellariae, 25 parts of ginseng, 25 parts of Rhizoma Chuanxiong, 25 parts of Radix Angelicae Sinensis, 25 parts of radix bupleuri.
Another object of the present invention is to provide the preparation methods of the Chinese medicinal plaster of above-mentioned treatment tinnitus, by Six-element Chinese medicine
Raw material crushes respectively and sieves with 100 mesh sieve to obtain each traditional Chinese medicine fine powder, takes each fine medicinal material powder by above-mentioned quality proportioning, is uniformly mixed, adds
Enter Auxiliary Liquid Material, reconciles uniformly into traditional Chinese medicinal ointment, take appropriate traditional Chinese medicinal ointment to be put into plaster sky patch, the Chinese medicinal plaster is made.
As a further improvement of the present invention, the Auxiliary Liquid Material is sesame oil；Further, Auxiliary Liquid Material additional amount is
140~180mL.
As a further improvement of the present invention, it takes 15~20 grams of ointment to be put into plaster sky patch, the traditional Chinese medicinal ointment is made
Drug paste.
Chinese medicinal plaster provided by the invention is under the guidance of traditional Chinese medical theory, with traditional percutaneous (Transdermal absorption)
Method administration, borrow prescription medicine entirety function, play component drug fill blood and qi and blood circulation promotion, i.e. tonifying spleen and stomach transport taste,
And nourishing kidney deficiency, life essence-filling, marrow-benefitting, lifting disease, soothing liver-qi stagnation, dispel hot purging intense heat the effect of, achieve the effect that treat tinnitus.Tool
Chinese medicinal plaster provided by the invention for body, be using the The strong bone of kidney tonifying of the rhizome of davallia, the hot purging intense heat of dispelling of radix scutellariae, ginseng big benefit
It vigour and reinforces the spleen to benefit the lung, the soothing liver-qi stagnation of the blood-activating and qi-promoting of the replenishing and activating blood of Radix Angelicae Sinensis, Rhizoma Chuanxiong, radix bupleuri and lifting disease overall efficacy
Obtain the effect for the treatment of tinnitus.Compared with prior art, treatment tinnitus Chinese medicinal plaster provided by the invention has following prominent
The utility model has the advantages that
(1) plaster is convenient administration dosage form in traditional Chinese medicine, there is long applicating history in thousand, can be used for activating blood circulation and dispersing blood clots,
Nourishing qi and blood, promoting menstruation walk network, strengthening the muscles and bones, relaxing tendons and activating collaterals etc., and application foundation is good and curative effect is extensive.Playing the same of therapeutic effect
When, have many advantages, such as simple to operate, relative low price, influence patient's daily work life.
(2) Chinese medicinal plaster prescription provided by the invention is that 2015 editions " Chinese Pharmacopoeias " (one) clinic for recording is common
Chinese medicine is nontoxic.Patient medication safely, trust.
(3) Chinese medicine based on tinnitus is fallen ill theory, mainly from kidney tonifying void, replenishing essence marrow, act yang-energy, fill blood, transport taste, rush down
Burning hot and soothing liver-qi stagnation, dredging the channel etc. are set about, prescription compatibility, achieve the effect that treat tinnitus.The plaster prescription
Advantage is not according to the simple prescription of morbidity theory, but during long-term clinical trials, in the guidance of traditional Chinese medical theory
The Chinese prescription compatibility of lower acquisition.The rhizome of davallia, ginseng, radix scutellariae, the kidney tonifying void of radix bupleuri, replenishing essence marrow, dispel showing tremendous enthusiasm, act yang-energy, solution liver
Strongly fragrant and other effects performance establish Radix Angelicae Sinensis, Rhizoma Chuanxiong blood-activating and qi-promoting effect basis on, Radix Angelicae Sinensis, Rhizoma Chuanxiong blood-activating and qi-promoting, enrich blood
The effect of promoting blood circulation ensure that other each group drug dispensings performance.Meanwhile the kidney tonifying of the rhizome of davallia, ginseng, radix scutellariae, radix bupleuri is empty, increases vigour, benefit
Spleen and lung, lift yang-energy, solution liver depression has cooperateed with Radix Angelicae Sinensis again, the function of the blood-activating and qi-promoting of Rhizoma Chuanxiong, replenishing and activating blood, promoting the circulation of qi helps to invigorate blood circulation, work
Blood is beneficial and fortune, gas energy promoting circulation of blood, blood again can carrier gas.Fat-soluble, the promotion skin absorption of added liquid auxiliary material sesame oil, finally
Reach the beneficial effect for the treatment of tinnitus by the synergistic effect between each component and Auxiliary Liquid Material.
Specific embodiment
Chinese medicinal plaster provided by the invention is made of Six-element Chinese medicine: the rhizome of davallia, radix scutellariae, ginseng, Rhizoma Chuanxiong, Radix Angelicae Sinensis, bavin
Recklessly, which is that 2015 editions " Chinese Pharmacopoeias " (one) records kind.
According to 2015 editions " Chinese Pharmacopoeias " (one), the meridian distribution of property and flavor and major function of Six-element Chinese medicine are as follows:
The rhizome of davallia (DRYNARIAE RHIZOMA): bitter, temperature.Return liver and kidney channel.It cures the wound analgesic, The strong bone of kidney tonifying；External application disappears wind
Nti-freckle.For falling winks frustrates, injured bone, lumbago due to the kidney deficiency, muscles and bones impotence, Hiccough and deaf, tooth mobility；Control outward alopecia areata, leucoderma
Wind.
Radix scutellariae (SCUTELLARIAE RADIX): it is bitter, it trembles with fear.Return lung, gallbladder, spleen, large intestine, small intestinl channel.Heat-clearing and damp-drying drug, purging intense heat solution
Poison, hemostasis, miscarriage prevention.For damp-warm syndrome, summer-heat and damp, chest tightness and emesis, damp and hot feeling of fullness, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head
Hematemesis, carbuncle sore tumefacting virus, threatened abortion.
Ginseng (GINSENG RADIX ET RHIZOMA): sweet, slight bitter, tepor.Returns spleen, lung, the heart, kidney channel.It reinforces vital energy,
Veins takes off admittedly reinforces the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.It to be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough,
Injury thirst, Heat Diabetes, deficiency of qi and blood, prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold.
Rhizoma Chuanxiong (CHUANXIONG RHIZOMA): acrid in flavour and warm in nature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For
Chest impediment and cardialgia, pricking pain in the chest, tumbling and swelling, irregular menstruation, amenorrhea and algomenorrhea , abdominal mass and abdominal pain, headache, rheumatic arthralgia.
Radix Angelicae Sinensis (ANGELICAE SINENSIS RADIX): sweet, acrid, warm.Return liver, the heart, the spleen channel.Replenishing and activating blood, menstruation regulating stop
Bitterly, relax bowel and defecation.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia falls and flutters damage
Wound, ulcer sores, dry constipation of intestines.
Radix bupleuri (BUPLEURI RADIX): it is pungent, bitter, it is slightly cold.Return liver, gallbladder, lung channel.Evacuation is brought down a fever, soothing liver-qi stagnation, is risen and is lifted sun
Gas.For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, rectal prolapse.
Embodiment 1
The drug of the present embodiment is composed of the following raw materials in parts by weight: rhizome of davallia 70g, radix scutellariae 45g, ginseng 25g, Rhizoma Chuanxiong
25g, Radix Angelicae Sinensis 25g, radix bupleuri 25g.
Embodiment 2
The drug of the present embodiment is composed of the following raw materials in parts by weight: rhizome of davallia 65g, radix scutellariae 40g, ginseng 20g, Rhizoma Chuanxiong
20g, Radix Angelicae Sinensis 20g, radix bupleuri 20g.
Embodiment 3
The drug of the present embodiment is composed of the following raw materials in parts by weight: rhizome of davallia 75g, radix scutellariae 50g, ginseng 30g, Rhizoma Chuanxiong
30g, Radix Angelicae Sinensis 30g, radix bupleuri 30g.
The preparation method of 4 Chinese medicinal plaster of embodiment
Enough Six-element Chinese medicine is crushed respectively and crosses No. six sieves as defined in 2015 editions " Chinese Pharmacopoeia " (one) note on the use
(100 mesh) obtains each traditional Chinese medicine fine powder, according to any one traditional Chinese medicinal ointment plaster formula of Examples 1 to 3 and quality proportioning, is uniformly mixed,
140~180mL sesame oil is added, reconciles uniformly into traditional Chinese medicinal ointment, takes 15~20g traditional Chinese medicinal ointment to be put into plaster sky patch, cream is made
Drug paste.
Embodiment 5 treats tinnitus clinical observation experiment
(1) general information
Selected case is from May, 2016 to the attached Jiangsu Province's combination of Chinese tradiational and Western medicine of in May, 2019 Nanjing University of Traditional Chinese Medicine
Hospital's ear-nose-throat department, patient amount to 210 people, wherein male 105, and women 105, the age was not between 25~68 years old
With the tinnitus of degree, other organic tinnitus are excluded on inspection.
(2) tinnitus treatment effect clinic compares grouping and medication
(3 are less than according to gender (male, female), age (20~35 years old, 36~50 years old, 51~70 years old), tinnitus length of time
Month, 3 months~12 months, 12 months~24 months, 24 months or more) it is randomly divided into 7 groups, every group of 30 people, group and administration feelings
Condition is shown in Table 1, and the random situation that is grouped is shown in Table 2.
Table 1 is a kind of to treat the experiment of tinnitus Chinese medicinal plaster clinical therapeutic efficacy and compares grouping and medication
| Group | Medication |
| Control group 1 (nimodipine tablet) | It is oral.One at a time, 3 times a day, it continuously takes 21 days |
| Control group 2 (Flunarizine piece) | It is oral.Once a grain, 2 times a day, it continuously takes 21 days |
| Control group 3 (Liuwei Dihuang Wan) | It is oral.8 balls are 3 times a day continuously taken 21 days |
| Control group 4 (antideaf otic pill) | It is oral.9g 2 times a day continuously takes 21 days |
| Treatment group 1 (embodiment 1) | It is affixed on MINGMEN acupoint, is pasted within one day 1, the application time is no less than 8 hours, and continuous 21 days |
| Treatment group 2 (embodiment 2) | It is affixed on MINGMEN acupoint, is pasted within one day 1, the application time is no less than 8 hours, and continuous 21 days |
| Treatment group 3 (embodiment 3) | It is affixed on MINGMEN acupoint, is pasted within one day 1, the application time is no less than 8 hours, and continuous 21 days |
Table 2 implements case and is grouped situation at random
(3) curative effect determinate standard
Tinnitus classification: referring to The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med's hals,Nasen und Ohrenheilkunde Liu Peng, tinnitus grading with
The discussion of efficacy assessment standard, 181-183 pages of the phase of Chinese Journal of Otorhinolaryngology of Integrated Traditional And Western Medicine 2004 volume 12 the 4th.By
It is mainly the severity for judge according to the subjective perception of patient tinnitus in tinnitus, the tinnitus classification founded has at home
There is wide influence power.
0 grade: without tinnitus；
1 grade: Tinnitus volume is slight, seemingly has like nothing；
2 grades: Tinnitus volume is slight, only occurs when peace and quiet, does not influence normal life and work；
3 grades: Tinnitus volume is relatively rung, and can be heard in general environment, but to normal life and work without significantly interfering with；
4 grades: tinnitus can be heard in any environment, influence to sleep, it is absent minded, to the slight interference of work；
5 grades: tinnitus is very loud, there is noisy feeling, seriously affects sleep and work, and start to occur slight agitation, anxiety,
The mental symptoms such as melancholy；
6 grades: tinnitus is extremely rung, and is perplexed all day by tinnitus, can not be slept, cannot work completely, and apparent agitation occurs not
The mental symptoms such as peace, anxiety, melancholy.
Therapeutic effect evaluation:
Effective: tinnitus degree reduces by 2 ranks or more (including 2 ranks)；
Effective: tinnitus degree reduces by 1 rank (including 1 rank)；
Invalid: tinnitus degree is without change.
(4) treatment results
See Table 3 for details to tinnitus patient treatment results for different groups, and interpretation of result is shown in Table 4.
The different groups of table 3 are to tinnitus patient therapeutic effect situation
Note: * represent it is effective, # represent effectively, -- represent without effective or effective.
The different groups of table 4 are to tinnitus patient treatment results
| Group | Case load | It is effective | Effectively | In vain | Efficient (%) |
| Control 1 | 30 | 2 | 9 | 19 | 36.67 |
| Control 2 | 30 | 1 | 11 | 18 | 40.00 |
| Control 3 | 30 | 2 | 12 | 16 | 46.67 |
| Control 4 | 30 | 2 | 14 | 14 | 53.33 |
| Treatment 1 | 30 | 26 | 4 | 0 | 100.00 |
| Treatment 2 | 30 | 24 | 5 | 1 | 96.67 |
| Treatment 3 | 30 | 27 | 3 | 0 | 100.00 |
6 typical case of embodiment
(1) Mr. Wang, male, 55 years old, left ear tinnitus more than 2 years, in the cicada cried sample, night was obvious, has a significant effect to sleep, repeatedly
Check prompt induction nervous tinnitus.There is hypertension history, oral drugs control is good.Through in MINGMEN acupoint docile embodiment every night
For 2 plasters after 1 week, tinnitus sees improvement, disappears substantially after 3 weeks.
(2) Mr. Wang, female, 35 years old, auris dextra tinnitus was more than half a year, drone sample cry, had auris dextra occlusion sense slightly.Repeatedly examined
It looks into, auris dextra is showed no obvious abnormalities.Take trophic nerve and equal Chinese patent drugs promoting blood circulation and removing obstruction in channels, no improvement.Without special disease history.Through
MINGMEN acupoint is every night described in docile embodiment 1 after plaster 1 week, and tinnitus is obviously improved, and after 3 weeks, tinnitus is completely disappeared.
(3) Feng, female 50 years old, ears tinnitus more than 2 years, are in drone sample sound, do not influence on sleep, but is consciously vexed
Discomfort, prompt ears Combination Hearing of going to a doctor is with tinnitus.Without hypertension and diabetes medical history.Through in MINGMEN acupoint docile every night
Described in embodiment 3 after plaster 1 week, tinnitus has improvement, and insults tinnitus disappears substantially within 3 weeks.
(4) Liu, female, 68 years old, ears tinnitus more than 10 years, in the cicada cried sample and machine, rumbling sample sound, daytime and night were equal
It can hear, influence daily life and sleep.There are hypertension and diabetes medical history.Through described in the MINGMEN acupoint every night docile embodiment 1
After plaster 2 weeks, tinnitus has improvement, and insults tinnitus improves obviously within 3 weeks, and patient has felt to feel quite pleased, it is desirable that continues to use plaster
Patch treatment.
Claims (7)
1. a kind of Chinese medicinal plaster for treating tinnitus, contain a plaster, which is characterized in that drug in the plaster by
The raw material composition of following parts by weight: 65 ~ 75 parts of the rhizome of davallia, 40 ~ 50 parts of radix scutellariae, 20 ~ 30 parts of ginseng, 20 ~ 30 parts of Rhizoma Chuanxiong, Radix Angelicae Sinensis 20
~ 30 parts, 20 ~ 30 parts of radix bupleuri.
2. Chinese medicinal plaster according to claim 1, which is characterized in that the drug in the plaster is by following parts by weight
Raw material composition: 70 parts of the rhizome of davallia, 45 parts of radix scutellariae, 25 parts of ginseng, 25 parts of Rhizoma Chuanxiong, 25 parts of Radix Angelicae Sinensis, 25 parts of radix bupleuri.
3. Chinese medicinal plaster according to claim 1 or 2, which is characterized in that the Chinese medicinal plaster is applied to MINGMEN acupoint
It uses.
4. the preparation method of Chinese medicinal plaster as claimed in claim 1 or 2, which is characterized in that crush Six-element raw material respectively and mistake
100 meshes obtain fine powder, are according to the proportion uniformly mixed fine powder, and Auxiliary Liquid Material is added, and reconcile uniformly at traditional Chinese medicinal ointment, take traditional Chinese medicinal ointment
It is put into plaster sky patch, the Chinese medicinal plaster is made.
5. the preparation method according to claim 4, which is characterized in that addition Auxiliary Liquid Material is sesame oil.
6. preparation method according to claim 4 or 5, which is characterized in that the additional amount of Auxiliary Liquid Material is 140 ~ 180mL.
7. the preparation method according to claim 4, which is characterized in that take 15 ~ 20 grams of traditional Chinese medicinal ointments to be put into plaster sky patch,
The Chinese medicinal plaster is made.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111494511A (en) * | 2020-05-25 | 2020-08-07 | 广西医科大学 | Traditional Chinese medicine plaster for treating sleep disorder after laparoscopic hepatoma resection and preparation method thereof |
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| CN107898980A (en) * | 2018-01-18 | 2018-04-13 | 河南中医药大学 | A kind of Chinese medicine for treating liver qi stagnation type tinnitus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494511A (en) * | 2020-05-25 | 2020-08-07 | 广西医科大学 | Traditional Chinese medicine plaster for treating sleep disorder after laparoscopic hepatoma resection and preparation method thereof |
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