CN111494511A - Traditional Chinese medicine plaster for treating sleep disorder after laparoscopic hepatoma resection and preparation method thereof - Google Patents
Traditional Chinese medicine plaster for treating sleep disorder after laparoscopic hepatoma resection and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection and a preparation method thereof, wherein the traditional Chinese medicine plaster comprises the following raw materials in parts by weight: 40 parts of uncaria root, 40 parts of Japanese climbing fern fruit, 30 parts of achyranthes root, 30 parts of Japanese polygala, 25 parts of akebia stem, 15 parts of caulis polygoni multiflori, 15 parts of climbing entada herb and 15 parts of bur leaf pepper. The plaster prepared from the traditional Chinese medicine composition provided by the invention is used for treating sleep disorder after laparoscopic liver cancer resection by a percutaneous (transdermal absorption) administration method under the guidance of the traditional Chinese medicine theory and by virtue of the integral synergistic effect of the medicines, the effects of tranquilizing and allaying excitement, clearing away heart-fire and relieving restlessness, and promoting blood circulation and removing obstruction in channels of the medicines are exerted.
Description
The technical field is as follows:
the invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection and a preparation method thereof.
Background art:
the traditional Chinese medicine plaster is a traditional administration form and has a long history of thousands of years of application. The plaster plays a role through skin, and the plaster therapy is one of the commonly used external treatment methods in the clinical traditional Chinese medicine, follows the principles of the treatment based on syndrome differentiation and the efficacy, the main treatment and the channel tropism of the traditional Chinese medicine, fully mobilizes the efficiency of the medicines which are mutually coordinated, forms a compound of a plurality of medicines and plays a good role of the medicines. Because the plaster is directly applied to the body surface, most of the medicines for preparing the plaster have strong smell, and the medicines with strong pungent flavor and strong fleeing property are added, so that the medicines penetrate into the skin and internally transmit channels and collaterals and viscera to play the roles of regulating qi and blood, dredging channels and collaterals, dispelling cold and dampness, eliminating swelling and pain and the like. The other medicines have the advantages of simple and convenient operation, low cost, no influence on the daily work and life of the patient and the like while playing a role in treatment.
The sleep disorder after the laparoscopic liver cancer resection refers to sleep disorder occurring on a patient subjected to the laparoscopic liver cancer resection, is a secondary sleep disorder, and has the main clinical manifestations of difficulty in falling asleep, light sleep and dreaminess, early awakening and easy waking, short sleep time, residual symptoms during the day, palpitation, fatigue, fear, amnesia, dysphoria with feverish sensation in the chest, dizziness, dysphoria and other symptoms. The pathogenesis of the insomnia is complex, the treatment means is relatively single, the modern medicine mainly adopts sedative and antipsychotic drugs for treating the insomnia, and although the short-term curative effect is good, the dependence, the drug resistance and the adverse reaction are easy to generate. The disease belongs to the categories of insomnia, sleeplessness and insomnia of traditional Chinese medicine, is positioned in the heart and is closely related to liver, spleen and kidney. The basic pathogenesis of the liver-fire-dispelling type traditional Chinese medicine is that yang is abundant and yin is weak, yin and yang are not crossed, the pathological properties are deficiency and excess, liver depression transforms into fire, phlegm heat disturbs heart, and uneasiness of heart and spirit is excess; deficiency of both heart and spleen, deficiency of both heart and gallbladder, disharmony between heart and kidney, and malnutrition of heart-mind; deficiency and excess mixed with chronic diseases can remove blood stasis and enter collaterals, blood stasis disturbs the mind, and then the insomnia symptom is aggravated, so the specific treatment methods of ' tranquilizing and allaying excitement ', ' clearing heart and relieving restlessness ', and promoting blood circulation and dredging collaterals ' can be taken as the basis of the treatment methods, and the treatment methods can be produced as required.
The invention content is as follows:
the invention provides a traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection, which comprises a plaster, wherein the medicine in the plaster comprises the following raw materials in parts by weight: 40 parts of uncaria root, 40 parts of Japanese climbing fern fruit, 30 parts of achyranthes root, 30 parts of Japanese polygala, 25 parts of akebia stem, 15 parts of caulis polygoni multiflori, 15 parts of climbing entada herb and 15 parts of bur leaf pepper.
The invention also aims to provide a preparation method of the traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection, which comprises the steps of respectively crushing the eight traditional Chinese medicine raw materials, sieving the crushed raw materials by a 100-mesh sieve to obtain fine powder of each traditional Chinese medicine, taking the fine powder of each medicinal material according to the mass ratio, uniformly mixing the fine powder of each medicinal material, adding liquid auxiliary materials, uniformly mixing to obtain a traditional Chinese medicine paste, taking a proper amount of the traditional Chinese medicine paste, and putting the traditional Chinese medicine paste into an empty plaster of the plaster to obtain the traditional Chinese medicine plaster.
As a further improvement of the invention, the liquid auxiliary material is sesame oil, and the addition amount of the liquid auxiliary material is 140-180 m L.
As a further improvement of the invention, 15-20 g of ointment is put into an empty plaster to prepare the traditional Chinese medicine plaster.
The pharmacology of the main traditional Chinese medicine raw materials used by the invention is as follows:
uncaria root: sweet and slightly cold. It enters liver meridian. Dispelling pathogenic wind, tranquilizing mind, lowering blood pressure, and relieving inflammation. Can be used for treating acute measles, sunstroke, infantile convulsion, metrorrhagia, puerperal rheumatism, dyspepsia, somnolence, hypertension, metrorrhagia, rheumatalgia, rheumatoid arthritis, and Congo-jiangshi (sciatica)
Climbing fern seed: sweet, bitter, pungent and cool. It enters kidney meridian. Dispel wind, activate collaterals, dispel cold, alleviate pain, and calm the mind. Can be used for treating lumbago, skelalgia, toothache, gastralgia, neurasthenia, spermatorrhea, premature ejaculation, and venomous snake bite.
The uncaria root and the Japanese climbing fern are combined to calm, and the medicine is the monarch medicine.
And (3) bovine earlap: sweet and warm; it enters liver and kidney meridians. Dispelling pathogenic wind, activating collaterals, tranquilizing mind, relieving spasm, relieving swelling and pain. Can be used for treating infantile paralysis and sequela of infantile paralysis, metrorrhagia, and obstruction of qi in the chest (rheumatalgia and rheumatoid arthritis).
Japanese milkwort herb: pungent, bitter and mild. It enters lung meridian. Dispel phlegm and stop cough, dredge meridian passage, activate blood and remove toxicity, relieve pain and soothe the nerves. Can be used for treating anger and hare (pneumonia), mouth cloth gourd ladle (canker sore), hire osteomyelitis, and throat distress (pharyngolaryngitis).
The uncaria root and the Japanese climbing fern seed are used together to calm the nerves and serve as ministers.
B, wood through: bitter and cold. It enters heart, small intestine and bladder meridians. Induce diuresis to treat stranguria, clear heart fire and relieve restlessness, dredge meridians and promote lactation. Can be used for treating stranguria, edema, vexation, dark urine, aphtha, amenorrhea, hypomenorrhea, and arthralgia due to damp-heat.
Akebia stem, radix Akebiae is used as adjuvant for clearing heart fire and relieving restlessness.
Six-square vine: pungent, slightly bitter and cool. It enters kidney meridian. Dispel wind and dampness, activate blood and dredge collaterals. Can be used for treating rheumatalgia, lumbar muscle strain, and traumatic injury.
Post crossing: astringent, slightly bitter and cool. Dispel wind and dampness, activate blood and dredge collaterals. Can be used for treating metrorrhagia, metrostaxis, rheumatalgia, rheumatoid arthritis, traumatic injury, flat metrorrhagia, apoplexy, hemiplegia, hemorrhoid hemorrhage, and dark sac due to venomous snake bite.
B, carrying out burley: pungent and warm. It enters liver, stomach and lung meridians. Warming channels and invigorating spleen, dispelling pathogenic wind and cold, promoting blood circulation and removing obstruction in collaterals, and relieving swelling and pain. Can be used for treating Hazhuang anger Ha (common cold with cough), haqiang (bronchitis), cassie distress (epigastric pain), metrorrhagia and stuffiness (rheumatalgia and rheumatoid arthritis), Confucianism and Jiangjiang distress (sciatica), Rongguwa pump distress (postpartum abdominal pain), pungent and tasty pair (irregular menstruation), leucorrhea disease (leukorrhagia), seeding and flushing (traumatic swelling and pain), dark sac (venomous snake bite) and centipede bite.
The combination of the six-flowered gloryvine, the climbing entada herb and the ramie leaf piper is used for promoting blood circulation and removing obstruction in channels, and is used as the guide.
The medicinal materials are from Yao medicine quality standard of autonomous region of Guangxi Zhuang nationality or Tujia medicine Zhi.
Compared with the prior art, the traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection has the following outstanding beneficial effects:
(1) the plaster is a traditional administration form in the traditional Chinese medicine, has a long application history for thousands of years, can be used for promoting blood circulation to remove blood stasis, tonifying qi and nourishing blood, clearing and activating channels and collaterals, strengthening tendons and bones, relaxing tendons and activating collaterals and the like, and has good application foundation and wide curative effect. The medicine has the advantages of simple and convenient operation, relatively low price, no influence on the daily work and life of the patient and the like while playing a role in treatment.
(2) The advantages of the plaster formula are not simple formula according to pathogenesis, but traditional Chinese medicine formula compatibility obtained under the guidance of traditional Chinese medicine theory in the long-term clinical test process, the traditional Chinese medicine plaster prepared by using uncaria rhynchophylla, Japanese ardisia seed, bovine eardrops, Japanese polygala root, akebia stem and other traditional Chinese medicines interact and influence with each other, has the effects of tranquilizing and allaying excitement, clearing away heart-fire and relieving restlessness, and promoting blood circulation and removing obstruction in channels, can effectively treat sleep disorder after laparoscopic liver cancer resection, and uses natural medicines as the raw medicines, so the plaster has the advantages of quick response, good curative effect and no toxic or side effect.
Detailed Description
The medicine of the embodiment is composed of the following raw materials in parts by weight: 40g of uncaria root, 40g of Japanese climbing fern fruit, 30g of achyranthes root, 30g of Japanese polygala, 25g of akebia stem, 15g of caulis spatholobi, 15g of climbing entada herb and 15g of burley leaf.
The preparation method of the traditional Chinese medicine plaster comprises the steps of respectively crushing sufficient eight traditional Chinese medicines, sieving the crushed traditional Chinese medicines through a six-mesh sieve (100 meshes) specified in general cases of 2015 edition of Chinese pharmacopoeia (one part), uniformly mixing the traditional Chinese medicine fine powder according to the traditional Chinese medicine plaster formula and the mass ratio, adding 140-180 m L sesame oil, uniformly mixing to obtain a traditional Chinese medicine plaster, taking 15-20 g of the traditional Chinese medicine plaster, and putting the traditional Chinese medicine plaster into an empty plaster to obtain the plaster.
The following is the clinical statistics of the traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection.
1. The subjects were planned to include 80 cases meeting the criteria, 46 women and 34 men. The age is 18-80 years. The samples were randomly divided into two groups of 40 cases. Control group: only the eszolam is taken orally. Treatment groups: administering a Chinese medicinal plaster.
2. The clinical symptoms comprise difficulty in falling asleep, light sleep and dreaminess, early awakening and easy waking, short sleep time and residual symptoms in the daytime, and are often accompanied by symptoms such as palpitation, fatigue, fear, amnesia, dysphoria, dizziness, dysphoria and the like.
3. The treatment method comprises applying onto YONGQUAN acupoint before sleep for at least 8 hr for 14 days, 1 day.
4. Observation index
PSQI total score (pittsburgh sleep quality index): before treatment (day 1 after operation), and after treatment (day 7 after operation) were evaluated once each day.
Integration of insomnia in traditional Chinese medicine: before and after treatment, the evaluation was performed once.
5. Evaluation of therapeutic Effect
Sleep quality assessment: PSQI Total score before and after treatment
The standard for judging the traditional Chinese medicine syndrome curative effect is that the integral of the traditional Chinese medicine insomnia is subtracted by fraction according to the guidance principle of clinical research of new traditional Chinese medicine, the curative effect is evaluated, and the subtracted fraction is (the integral of the traditional Chinese medicine insomnia before treatment-the integral of the traditional Chinese medicine insomnia after treatment)/the integral of the traditional Chinese medicine insomnia before treatment) × 100 percent
The clinical cure is as follows: the reduction rate is more than or equal to 75 percent;
the effect is shown: the reduction rate is more than or equal to 50% and less than 75%;
the method has the following advantages: the reduction ratio is more than or equal to 25% and less than 50%:
and (4) invalidation: the reduction rate is less than 25 percent
6. Statistical analysis
Data analysis software: statistical analysis and calculation were performed using the sps 13.0 statistical software.
The statistical method comprises the following steps: data were measured as mean ± standard deviationThe form of the method is shown in the specification, classification counting data is tested by chi-square, grade data is tested by rank sum, paired t test is adopted before and after treatment, non-parameter median rank sum test or independent sample t test is adopted for comparison of a treatment group and a control group, the difference is not statistically significant when P is more than 0.05, and the difference is statistically significant when P is less than 0.05.
7. Therapeutic results
Comparing the PSQI total score of the treatment group with that of the control group before and after treatment and the difference value: comparing the PSQI total score before treatment of the treatment group and the control group, and performing a normality test (Shapiro-Wilk) to ensure that the PSQI total score does not conform to normal distribution, so that the P is more than 0.05 by adopting a rank sum test and performing statistical analysis, and the difference of two groups of patients has no statistical significance; comparing the two groups of treated PSQI total scores, and performing normality test (Shapiro-Wilk) to obtain a result that the P is less than 0.05 by adopting rank sum test and performing statistical analysis, wherein the difference between the two groups of patients has statistical significance; the difference values before and after treatment of the two groups of PSQI total scores are compared, and the normal distribution is not met through a normality test (Shapiro-Wilk), so that the P is less than 0.05 through a statistical analysis by adopting a rank sum test, the difference of two groups of patients has statistical significance, and the PSQI total scores of a treatment group are obviously reduced compared with that of a control group. (see Table 1)
The PSQI total scores of the treatment group and the control group were compared before and after treatment: the PSQI total scores of the treatment group and the control group are compared before and after treatment, and are in accordance with normal distribution through a normality test (Shapiro-Wilk), so that P is less than 0.01 by adopting a pairing t test and through statistical analysis, and the difference has statistical significance. (see Table 1)
TABLE 1 comparison of total scores for PSQI
Group of | n | Before treatment | After treatment | Difference between front and rear |
Treatment group | 40 | 13.03±1.45 | 9.48±1.40 | 3.56±0.49 |
Control group | 40 | 13.04±1.29 | 11.08±1.20 | 1.96±0.29 |
Note: before treatment, Z is-0.091, P is 0.927; after treatment Z-4.677, P-0; the difference Z is-7.864, and P is 0; treatment t-45.654, P-0; control t is 41.594 and P is 0.
The curative effect of the treatment group is compared with that of the control group: after the treatment, the total effective rate of the treatment group is 92.5 percent, the total effective rate of the control group is 77.5 percent, the two groups of the treatment effect are distributed by adopting the rank sum test, the P is less than 0.05 by the statistical analysis, and the difference of two groups of patients has statistical significance. (see Table 2)
TABLE 2 comparison of therapeutic effect (percentage) between the treatment group and the control group
Group of | n | Clinical recovery | Show effect | Is effective | Invalidation | Total effective rate |
Treatment group | 40 | 14 | 16 | 7 | 3 | 92.5% |
Control group | 40 | 10 | 10 | 11 | 9 | 77.5% |
Note: z-2.052 and P0.04
The research result shows that: the total PSQI score of the treated group is lower than that of the control group; the PSQI total score of the treatment group and the control group is reduced compared with that before treatment, and the difference of the two groups is compared, so that the treatment group is obviously reduced; compared with the curative effect of the control group, the effective rate of the treatment group is 92.5 percent, and the effective rate of the control group is 77.5 percent. The differences are all statistically significant.
The clinical observation data show that the ointment patch has good treatment effect on sleep disorder after laparoscopic liver cancer resection.
Claims (6)
1. A traditional Chinese medicine plaster for treating sleep disorder after laparoscopic liver cancer resection comprises a plaster, wherein the medicine in the plaster comprises the following raw materials in parts by weight: 40 parts of uncaria root, 40 parts of Japanese climbing fern fruit, 30 parts of achyranthes root, 30 parts of Japanese polygala, 25 parts of akebia stem, 15 parts of caulis polygoni multiflori, 15 parts of climbing entada herb and 15 parts of bur leaf pepper.
2. The traditional Chinese medicine plaster of claim 1, wherein the traditional Chinese medicine plaster is applied to the Yongquan acupoint.
3. The method for preparing a traditional Chinese medicine plaster as claimed in claim 1, wherein the eight raw materials are respectively pulverized and sieved by a 100-mesh sieve to obtain fine powders, the fine powders are uniformly mixed according to the proportion, liquid auxiliary materials are added, the mixture is uniformly blended to form a traditional Chinese medicine plaster, and the traditional Chinese medicine plaster is put into an empty plaster to obtain the traditional Chinese medicine plaster.
4. The preparation method according to claim 3, wherein the liquid excipient added is sesame oil.
5. The preparation method according to claim 3 or 4, wherein the amount of the liquid excipient added is 140 to 180m L.
6. The preparation method according to claim 3, wherein the traditional Chinese medicine plaster is prepared by putting 15-20 g of traditional Chinese medicine plaster into an empty plaster.
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