CN110325636A - 稳定的蛋白酶变体 - Google Patents

稳定的蛋白酶变体 Download PDF

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Publication number
CN110325636A
CN110325636A CN201780087051.4A CN201780087051A CN110325636A CN 110325636 A CN110325636 A CN 110325636A CN 201780087051 A CN201780087051 A CN 201780087051A CN 110325636 A CN110325636 A CN 110325636A
Authority
CN
China
Prior art keywords
ala
gly
pro
kumamolisin
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780087051.4A
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English (en)
Chinese (zh)
Inventor
A·米歇尔斯
A·沙伊迪格
C·埃伦德
C·克拉普
T·霍恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EW Nutrition GmbH
Original Assignee
EW Nutrition GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EW Nutrition GmbH filed Critical EW Nutrition GmbH
Publication of CN110325636A publication Critical patent/CN110325636A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Fodder In General (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201780087051.4A 2016-12-22 2017-12-22 稳定的蛋白酶变体 Pending CN110325636A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16206367.1 2016-12-22
EP16206367 2016-12-22
PCT/EP2017/084452 WO2018115473A2 (en) 2016-12-22 2017-12-22 Stable protease variants

Publications (1)

Publication Number Publication Date
CN110325636A true CN110325636A (zh) 2019-10-11

Family

ID=57629395

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780087051.4A Pending CN110325636A (zh) 2016-12-22 2017-12-22 稳定的蛋白酶变体

Country Status (10)

Country Link
US (1) US11396648B2 (https=)
EP (2) EP3559225A2 (https=)
JP (2) JP7035079B2 (https=)
KR (2) KR102686572B1 (https=)
CN (1) CN110325636A (https=)
AU (2) AU2017380106B2 (https=)
BR (1) BR112019012980A2 (https=)
CA (1) CA3047868A1 (https=)
MX (2) MX2019007287A (https=)
WO (1) WO2018115473A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250064903A1 (en) * 2020-10-30 2025-02-27 University Of Washington Compositions and methods for treating celiac sprue disease
AU2023213894B2 (en) 2022-01-26 2025-04-10 Digestiva, Inc. Blood glucose stabilizing methods and compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050265932A1 (en) * 2004-05-24 2005-12-01 Oliver Kappler Collagenolytic active enzyme containing compositions, and their use in the dental field
CN105555300A (zh) * 2013-08-14 2016-05-04 华盛顿大学商业中心 用于治疗口炎性腹泻的组合物和方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6342802B2 (ja) 2011-08-10 2018-06-13 ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーションＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｗａｓｈｉｎｇｔｏｎ Ｔｈｒｏｕｇｈ Ｉｔｓ Ｃｅｎｔｅｒ Ｆｏｒ Ｃｏｍｍｅｒｃｉａｌｉｚａｔｉｏｎ セリアックスプルー病を治療するための組成物および方法
HK1245129A1 (zh) * 2015-06-08 2018-08-24 University Of Washington 治疗腹腔疾病的组合物及方法
EP3475420B1 (en) 2016-06-23 2025-07-16 EW Nutrition GmbH Feed composition comprising an acid protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050265932A1 (en) * 2004-05-24 2005-12-01 Oliver Kappler Collagenolytic active enzyme containing compositions, and their use in the dental field
CN105555300A (zh) * 2013-08-14 2016-05-04 华盛顿大学商业中心 用于治疗口炎性腹泻的组合物和方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLANCEY WOLF ET AL: "Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions", 《J AM CHEM SOC》 *
NAOKI TSURUOKA ET AL: "Collagenolytic serine-carboxyl proteinase from Alicyclobacillus sendaiensis strain NTAP-1: purification, characterization, gene cloning, and heterologous expression", 《APPL ENVIRON MICROBIOL》 *

Also Published As

Publication number Publication date
JP7344329B2 (ja) 2023-09-13
KR20190095361A (ko) 2019-08-14
WO2018115473A2 (en) 2018-06-28
JP2022081554A (ja) 2022-05-31
EP3559225A2 (en) 2019-10-30
JP2020505944A (ja) 2020-02-27
MX2019007287A (es) 2019-09-27
BR112019012980A2 (pt) 2020-05-26
EP4732675A2 (en) 2026-04-29
AU2017380106B2 (en) 2024-05-09
JP7035079B2 (ja) 2022-03-14
KR102686572B1 (ko) 2024-07-19
US11396648B2 (en) 2022-07-26
US20190322994A1 (en) 2019-10-24
CA3047868A1 (en) 2018-06-28
WO2018115473A3 (en) 2019-01-31
MX2024000078A (es) 2024-02-23
AU2024202526A1 (en) 2024-05-30
KR20230107898A (ko) 2023-07-18
AU2017380106A1 (en) 2019-07-04
KR102553627B1 (ko) 2023-07-07

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