CN1102931C - 具有免疫调解剂作用的酰化n－羟甲基酞胺哌啶酮－前药 - Google Patents

具有免疫调解剂作用的酰化n－羟甲基酞胺哌啶酮－前药 Download PDF

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Publication number
CN1102931C
CN1102931C CN97193682A CN97193682A CN1102931C CN 1102931 C CN1102931 C CN 1102931C CN 97193682 A CN97193682 A CN 97193682A CN 97193682 A CN97193682 A CN 97193682A CN 1102931 C CN1102931 C CN 1102931C
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CN
China
Prior art keywords
neurosedyn
prodrug
expression
acid
thalidomide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97193682A
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English (en)
Chinese (zh)
Other versions
CN1215397A (zh
Inventor
J·施纳特
W·温特
S·沃南特
K·兹温根伯格
K·艾格
M·艾克曼
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Gruenenthal GmbH
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Gruenenthal GmbH
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Publication date
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Publication of CN1215397A publication Critical patent/CN1215397A/zh
Application granted granted Critical
Publication of CN1102931C publication Critical patent/CN1102931C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
CN97193682A 1996-04-09 1997-03-22 具有免疫调解剂作用的酰化n－羟甲基酞胺哌啶酮－前药 Expired - Fee Related CN1102931C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19613976.7 1996-04-09
DE19613976A DE19613976C1 (de) 1996-04-09 1996-04-09 Thalidomid-Prodrugs mit immunmodulatorischer Wirkung

Publications (2)

Publication Number Publication Date
CN1215397A CN1215397A (zh) 1999-04-28
CN1102931C true CN1102931C (zh) 2003-03-12

Family

ID=7790778

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193682A Expired - Fee Related CN1102931C (zh) 1996-04-09 1997-03-22 具有免疫调解剂作用的酰化n－羟甲基酞胺哌啶酮－前药

Country Status (12)

Country Link
US (1) US6417197B1 (cg-RX-API-DMAC7.html)
EP (1) EP0892794B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000508298A (cg-RX-API-DMAC7.html)
CN (1) CN1102931C (cg-RX-API-DMAC7.html)
AT (1) ATE212989T1 (cg-RX-API-DMAC7.html)
AU (1) AU707144B2 (cg-RX-API-DMAC7.html)
DE (2) DE19613976C1 (cg-RX-API-DMAC7.html)
DK (1) DK0892794T3 (cg-RX-API-DMAC7.html)
ES (1) ES2171923T3 (cg-RX-API-DMAC7.html)
HU (1) HUP9902181A3 (cg-RX-API-DMAC7.html)
PT (1) PT892794E (cg-RX-API-DMAC7.html)
WO (1) WO1997037988A1 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
AU3224997A (en) * 1996-05-29 1998-01-05 Prototek, Inc Prodrugs of thalidomide and methods for using same as modulators of t-cell function
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
DE19743968C2 (de) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen
DE69834668T2 (de) * 1997-11-18 2007-01-11 Celgene Corp. Substituierte 2-(2,6-dioxo-3-fluoropiperidine-3-yl)-isoindoline und ihre Verwendung zum reduzieren des TNF-alpha spiegels
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
AU4515001A (en) * 1999-12-02 2001-06-18 Regents Of The University Of Michigan, The Compositions and methods for locally treating inflammatory diseases
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
EP1389203B8 (en) * 2001-02-27 2010-03-10 The Governement of the United States of America, represented by The Secretary Department of Health and Human services Analogs of thalidomide as angiogenesis inhibitors
CN100488959C (zh) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 水溶性的酞胺哌啶酮衍生物
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
CN100398534C (zh) * 2003-09-15 2008-07-02 天津和美生物技术有限公司 合成酞胺哌啶酮及其衍生物的方法
US7973057B2 (en) * 2003-09-17 2011-07-05 The United States Of America As Represented By The Department Of Health And Human Services Thalidomide analogs
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
US7423150B2 (en) * 2003-10-16 2008-09-09 Novartis Ag Substituted benzazoles and methods of their use as inhibitors of Raf kinase
ITMI20041113A1 (it) * 2004-06-01 2004-09-01 Antibioticos Spa Processo per la sintesi della talidomide
US20070155791A1 (en) * 2005-12-29 2007-07-05 Zeldis Jerome B Methods for treating cutaneous lupus using aminoisoindoline compounds
WO2007120669A1 (en) 2006-04-13 2007-10-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
EP3354646A1 (en) * 2008-10-29 2018-08-01 Celgene Corporation Isoindoline compounds for use in the treatment of cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
TWI782395B (zh) * 2016-01-08 2022-11-01 美商西建公司 抗增生化合物，及其醫藥組合物及用途
US20200199097A1 (en) * 2017-08-21 2020-06-25 Nanjing Noratech Pharmaceuticals Co., Ltd Pomalidomide derivative and preparation method therefor
CN111499610A (zh) * 2019-01-31 2020-08-07 南京诺瑞特医药科技有限公司 泊马度胺前体药物盐的多晶型物
EP3771711A1 (en) 2019-07-29 2021-02-03 Bayer Animal Health GmbH Pyrazole derivatives for controlling arthropods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018496A1 (de) * 1991-04-17 1992-10-29 Grünenthal GmbH Neue thalidomidderivate, ein verfahren zu deren herstellung sowie die verwendung derselben in arzneimitteln
US5385901A (en) * 1991-02-14 1995-01-31 The Rockefeller University Method of treating abnormal concentrations of TNF α

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385901A (en) * 1991-02-14 1995-01-31 The Rockefeller University Method of treating abnormal concentrations of TNF α
WO1992018496A1 (de) * 1991-04-17 1992-10-29 Grünenthal GmbH Neue thalidomidderivate, ein verfahren zu deren herstellung sowie die verwendung derselben in arzneimitteln

Also Published As

Publication number Publication date
US6417197B1 (en) 2002-07-09
HK1017350A1 (en) 1999-11-19
PT892794E (pt) 2002-07-31
WO1997037988A1 (de) 1997-10-16
AU2505297A (en) 1997-10-29
HUP9902181A3 (en) 2002-11-28
DK0892794T3 (da) 2002-04-15
AU707144B2 (en) 1999-07-01
ATE212989T1 (de) 2002-02-15
EP0892794A1 (de) 1999-01-27
JP2000508298A (ja) 2000-07-04
HUP9902181A2 (hu) 2000-04-28
DE19613976C1 (de) 1997-11-20
DE59706313D1 (de) 2002-03-21
EP0892794B1 (de) 2002-02-06
CN1215397A (zh) 1999-04-28
ES2171923T3 (es) 2002-09-16

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