CN110279669B - 延迟释放的药物制剂 - Google Patents

延迟释放的药物制剂 Download PDF

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Publication number
CN110279669B
CN110279669B CN201910246206.5A CN201910246206A CN110279669B CN 110279669 B CN110279669 B CN 110279669B CN 201910246206 A CN201910246206 A CN 201910246206A CN 110279669 B CN110279669 B CN 110279669B
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delayed release
drug
polymer
layer
polymeric material
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Chinese (zh)
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CN110279669A (zh
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F·J·O·瓦卢姆
R·C·布拉沃冈萨雷斯
T·布塞尔
A·W·巴斯特
A·C·弗雷尔
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Tillotts Pharma AG
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/606Salicylic acid; Derivatives thereof having amino groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005Coating of tablets or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201910246206.5A 2013-10-29 2013-10-29 延迟释放的药物制剂 Active CN110279669B (zh)

Priority Applications (1)

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CN201910246206.5A CN110279669B (zh) 2013-10-29 2013-10-29 延迟释放的药物制剂

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Application Number Priority Date Filing Date Title
CN201910246206.5A CN110279669B (zh) 2013-10-29 2013-10-29 延迟释放的药物制剂
CN201380079616.6A CN105555260B (zh) 2013-10-29 2013-10-29 延迟释放的药物制剂
PCT/EP2013/072648 WO2015062640A1 (en) 2013-10-29 2013-10-29 A delayed release drug formulation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380079616.6A Division CN105555260B (zh) 2013-10-29 2013-10-29 延迟释放的药物制剂

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CN110279669A CN110279669A (zh) 2019-09-27
CN110279669B true CN110279669B (zh) 2022-02-15

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US (1) US10799515B2 (OSRAM)
EP (2) EP3542791A1 (OSRAM)
JP (1) JP6273356B2 (OSRAM)
KR (2) KR102174942B1 (OSRAM)
CN (2) CN105555260B (OSRAM)
AU (2) AU2013404367B2 (OSRAM)
BR (2) BR122020013726B1 (OSRAM)
CA (1) CA2923063C (OSRAM)
CR (1) CR20160192A (OSRAM)
CU (1) CU20160055A7 (OSRAM)
EA (1) EA032504B1 (OSRAM)
HK (1) HK1222547A1 (OSRAM)
IL (2) IL244260B (OSRAM)
MA (1) MA38847B2 (OSRAM)
MX (2) MX388063B (OSRAM)
MY (1) MY189394A (OSRAM)
NZ (2) NZ747731A (OSRAM)
PH (2) PH12020551522A1 (OSRAM)
SA (2) SA116370660B1 (OSRAM)
SG (1) SG11201600501UA (OSRAM)
TN (1) TN2016000119A1 (OSRAM)
TW (3) TWI736031B (OSRAM)
UA (1) UA117260C2 (OSRAM)
WO (1) WO2015062640A1 (OSRAM)
ZA (1) ZA201600630B (OSRAM)

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JOP20200144A1 (ar) 2012-04-30 2017-06-16 Tillotts Pharma Ag تركيبة عقار ذو إطلاق متأخر
CN113061089A (zh) 2015-09-23 2021-07-02 凯瑞康宁生物工程(武汉)有限公司 γ-羟基丁酸的前药及其组合物和用途
EP3162362A1 (de) 2015-10-30 2017-05-03 Dr. Falk Pharma Gmbh Optimierte mesalazinhaltige hochdosistablette
EP3257501A1 (en) 2016-06-14 2017-12-20 Tillotts Pharma AG Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating
US20190193928A1 (en) * 2017-12-21 2019-06-27 Pepsico, Inc. Multi-ingredient ephemeral beverage pod for making a beverage
EP3662898A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Solid composition comprising mesalazine
EP3662902B1 (en) * 2018-12-07 2024-07-31 Tillotts Pharma AG Colonic drug delivery formulation
EP3662895A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG A process for manufacturing reducing sugar-free 5-asa tablet cores
EP3662901B1 (en) 2018-12-07 2025-01-01 Tillotts Pharma AG Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing
EP3662900A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Colonic drug delivery formulation
GB201906917D0 (en) * 2019-05-16 2019-07-03 Intract Pharma Ltd Novel compositions
JP7624444B2 (ja) * 2019-12-11 2025-01-30 エボニック オペレーションズ ゲーエムベーハー 病気の治療又は予防において使用するための剤形

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SA114360006B1 (ar) 2016-11-09
HK1222547A1 (zh) 2017-07-07
KR20160077040A (ko) 2016-07-01
BR112016004863A8 (pt) 2020-02-11
MX388063B (es) 2025-03-19
AU2013404367A1 (en) 2016-02-18
MX2016001840A (es) 2016-08-11
TN2016000119A1 (en) 2017-10-06
PH12016500307B1 (en) 2022-02-11
BR122020013726B1 (pt) 2022-11-01
TW202011945A (zh) 2020-04-01
NZ747731A (en) 2020-02-28
AU2013404367B2 (en) 2020-02-27
TWI680774B (zh) 2020-01-01
IL244260B (en) 2021-08-31
TW201542243A (zh) 2015-11-16
PH12020551522A1 (en) 2022-11-14
JP2016535030A (ja) 2016-11-10
EA032504B1 (ru) 2019-06-28
US20160250232A1 (en) 2016-09-01
CU20160055A7 (es) 2016-10-28
JP6273356B2 (ja) 2018-01-31
PH12016500307A1 (en) 2016-05-16
TW201944984A (zh) 2019-12-01
SA116370660B1 (ar) 2019-02-24
MA38847B2 (fr) 2021-02-26
AU2020201365B2 (en) 2021-09-16
NZ717159A (en) 2019-06-28
IL244260A0 (en) 2016-04-21
EP3062776A1 (en) 2016-09-07
CN105555260B (zh) 2021-04-23
MX382146B (es) 2025-03-13
BR112016004863B1 (pt) 2022-09-20
SG11201600501UA (en) 2016-02-26
TWI736031B (zh) 2021-08-11
ZA201600630B (en) 2017-05-31
KR102174942B1 (ko) 2020-11-06
IL265381B (en) 2022-05-01
MA38847A1 (fr) 2017-08-31
KR20200075041A (ko) 2020-06-25
MY189394A (en) 2022-02-09
CN105555260A (zh) 2016-05-04
CR20160192A (es) 2016-07-13
TWI725458B (zh) 2021-04-21
UA117260C2 (uk) 2018-07-10
AU2020201365A1 (en) 2020-03-12
EP3542791A1 (en) 2019-09-25
EA201690596A1 (ru) 2016-08-31
US10799515B2 (en) 2020-10-13
CA2923063A1 (en) 2015-05-07
MX2019002162A (es) 2019-06-17
IL265381A (en) 2019-05-30
CA2923063C (en) 2021-09-07
WO2015062640A1 (en) 2015-05-07
CN110279669A (zh) 2019-09-27
KR102237356B1 (ko) 2021-04-08

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