CN110279588B - Dental floss containing rare saponins of panax notoginseng and preparation method thereof - Google Patents
Dental floss containing rare saponins of panax notoginseng and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to the technical field of oral cleaning products, and particularly relates to dental floss containing rare notoginsenoside and a preparation method thereof. The dental floss containing rare saponins of panax notoginseng is mainly prepared from a wire rod, a treatment solution of rare saponins of panax notoginseng and a wax treatment solution; the rare panax notoginseng saponin treating fluid comprises rare panax notoginseng saponin pre-prepared milk, xylitol, pullulan and water; the waxy treatment fluid includes microcrystalline wax, white wax, and menthol. According to the invention, rare notoginsenoside is attached to the wire rod and sealed and protected by wax, so that the rare notoginsenoside is dissolved in saliva between gingiva during use, thereby helping to improve the conditions of gingival inflammation, redness and swelling, bleeding and the like, preventing oral problems such as gingivitis, periodontitis and the like, and enabling the oral environment to be healthier.
Description
Technical Field
The invention belongs to the technical field of oral cleaning products, and particularly relates to dental floss containing rare notoginsenoside and a preparation method thereof.
Background
Dental floss is an oral cleaning product, and can keep oral hygiene by removing food residues, dental plaque, soft dirt and the like between teeth. While conventional dental floss only provides a cleaning effect, in order to enrich the efficacy of the floss, various active ingredients have been introduced into the floss.
For example, patent document CN1784212 discloses an oral care product which exerts in the oral cavity an effect of inhibiting the release of pro-inflammatory cytokines, especially interleukin 8, from the cells of the oral tissue and reducing the damage caused by reactive oxygen species to the inflamed tissue by introducing a non-peptide polyamine chelating agent or a physiologically acceptable salt thereof into a binder (e.g. a wax or a polymer) and coating onto dental floss.
Also, for example, patent document CN101321513 discloses an oral care medium containing magnolia bark extract, which may be dental floss, wherein it is disclosed that the dental floss may be prepared by processing, specifically passing a suitable size of cotton filament through a solution containing magnolia bark extract and a surfactant, then drying the dental floss through a drying oven to remove moisture, and then coating the impregnated dental floss with paraffin, which may be convenient and stable before use, and further coating the dental floss with microcrystalline wax. The dental floss has certain effect in treating gingivitis and periodontal disease due to the introduction of cortex Magnolia officinalis extract.
Pseudo-ginseng, also known as pseudo-ginseng, is a root and stem of a perennial herb of panax of Araliaceae, is one of traditional rare Chinese medicinal materials, has the effects of removing blood stasis, relieving pain, activating blood and relieving pain, and has obvious curative effects on diseases such as hemorrhage, traumatic injury, blood stasis, swelling and pain, deficiency, injury, internal injury and the like. Modern researches have shown that the main active substance of Notoginseng radix is saponin component. To date, more than 70 saponin components have been isolated and identified by researchers from different parts of notoginseng. The saponin components are mostly dammarane type ginsenoside, mainly comprising 20(S) -protopanaxadiol type and 20(S) -protopanaxatriol type. In addition, radix Notoginseng also contains unique component different from ginsenoside, such as notoginsenoside R1、R2、R3、R4、R6、Fa、FcAnd FeAnd the like. Wherein, ginsenoside Rb1、Rb2、Rb3、Rc、Rd、ReAnd Rg1The content of the ginsenoside in the panax plants is higher, so the ginsenoside is called as common ginsenoside; some ginsenosides such as Rg2、Rh1、Rg3、Rg6、F4、Rk3、Rg5And Rk1Etc. are contained in ginseng plants at a very low level, and are therefore called rare ginsenosides. The pharmacological action of the saponin component in the notoginseng mainly includes the influence on cardiovascular and cerebrovascular diseases, central nervous system, blood and immune system, and the anti-tumor effect.
At present, people pay attention to the introduction of pseudo-ginseng into oral cleaning products to exert the oral health care effect of pseudo-ginseng. For example, patent documents CN107982084A, CN108056928A and CN108078871A, etc. prepare a pre-formulated emulsion of rare saponins of panax notoginseng, which is applied to toothpaste, oral gel and mouthwash respectively, and have the effect of effectively solving multiple oral problems such as excessive internal heat in the oral cavity, gingival swelling and pain, oral ulcer, etc. Through retrieval, the application of the rare saponins of panax notoginseng in dental floss is not found.
Disclosure of Invention
In order to enrich the effect of the dental floss and widen the application range of the rare saponins of panax notoginseng, the invention provides the dental floss containing the rare saponins of panax notoginseng, the dental floss is characterized in that the rare saponins of panax notoginseng are attached to a wire rod and are sealed and protected by wax, and the rare saponins of panax notoginseng are dissolved in saliva between gingiva during use, thereby helping to improve the conditions of inflammation, red swelling, bleeding and the like of gingiva, simultaneously preventing oral problems of gingivitis, periodontitis and the like and enabling the oral environment to be healthier.
The dental floss containing rare saponins of panax notoginseng provided by the invention is mainly prepared from a wire rod, a rare saponins of panax notoginseng treatment solution and a wax treatment solution;
the rare saponin treating fluid for panax notoginseng comprises the following raw materials in parts by weight: 25-40 parts of pseudo-ginseng rare saponin pre-prepared milk, 20-40 parts of xylitol, 2-8 parts of pullulan and 20-40 parts of water;
the waxy treatment fluid comprises the following raw materials in parts by weight: 15-20 parts of microcrystalline wax, 3-10 parts of white wax and 5-15 parts of menthol;
the wire rod firstly passes through the rare panax notoginseng saponin treatment solution, a rare panax notoginseng saponin layer is formed on the surface of the wire rod after drying, and then a wax layer is formed on the surface of the rare panax notoginseng saponin layer after the wire rod passes through the wax treatment solution and is cooled, so that the dental floss containing rare panax notoginseng saponin is obtained.
Further, the wire is one of a polyester wire, a bulked wire and a teflon wire.
Further, the preparation method of the pseudo-ginseng rare saponin pre-prepared milk comprises the following steps:
a1, grinding pseudo-ginseng to obtain pseudo-ginseng powder, adding petroleum ether into the pseudo-ginseng powder, stirring for 3-4 hours, standing for 1 hour, removing upper-layer liquid, repeating the operation until the upper-layer liquid is colorless, removing the upper-layer liquid, taking medicine residues, and drying to obtain degreased pseudo-ginseng powder;
a2, placing degreased pseudo-ginseng powder in a container, adding water, soaking for 2h, performing ultrasonic treatment at room temperature, then adding bromide ion liquid and tween-20, stirring uniformly, performing ultrasonic treatment at room temperature, performing suction filtration, adding dipotassium hydrogen phosphate into filtrate, stirring until the mixture is dissolved, centrifuging, taking upper-layer liquid, and performing low-temperature concentration to obtain the pseudo-ginseng rare saponin pre-prepared emulsion.
Furthermore, the weight of the petroleum ether is 3-4 times of that of the pseudo-ginseng.
Further, the added weight of the water is 6 times of the weight of the defatted pseudo-ginseng powder.
Further, the bromide ion liquid is brominated 1-butyl-3-methylimidazole, and the added weight of the bromide ion liquid is 1.2 times of the weight of the degreased pseudo-ginseng powder.
Further, the added weight of the tween-20 is 1/8 of the weight of the degreased pseudo-ginseng powder.
Further, the weight of the added dipotassium phosphate is 8 times of that of the degreased pseudo-ginseng powder.
Correspondingly, the invention also provides a preparation method of the dental floss containing the panax notoginseng rare saponin, which comprises the following steps:
s1, mixing xylitol, pullulan and water, heating to 40-60 ℃, uniformly stirring, adding pseudo-ginseng rare saponin pre-prepared emulsion, stirring for 15-20 min to obtain pseudo-ginseng rare saponin treatment liquid, and placing the pseudo-ginseng rare saponin treatment liquid in a first heating tank;
s2, placing the microcrystalline wax and the white wax in a second heating tank, heating to 70-90 ℃, adding the menthol after the microcrystalline wax and the white wax are completely melted, and stirring for 15-20 min to obtain a wax treatment solution;
s3, taking the wire, placing the wire on a dental floss holder, firstly passing through a hot oven, then passing through the rare panax notoginseng saponin treatment liquid in a first heating groove, then passing through a first refrigerating box for air drying, then passing through the waxy treatment liquid in a second heating groove, then passing through a second refrigerating box for cooling, and finally taking up the wire through a winding machine to obtain the dental floss containing the rare panax notoginseng saponin.
Furthermore, two extrusion bearings are respectively arranged at the middle upper ends of the first heating groove and the second heating groove, the dental floss penetrates through the middle of the two extrusion bearings, the extrusion pressure of the extrusion bearings is 0.2-0.7 MPa, the rotating speed is 50-100 m/min, and the adhesion amount of the rare notoginsenoside treatment liquid and the wax treatment liquid in the dental floss is controlled by controlling the extrusion pressure and the rotating speed of the two bearings.
The invention aims to provide a dental floss containing rare notoginsenoside, and therefore, an inventor firstly extracts and emulsifies notoginseng through bromide ion liquid to obtain rare notoginsenoside pre-prepared emulsion which has the effect of improving multiple oral problems such as oral cavity inflammation, gingival swelling and pain, oral ulcer and the like.
Therefore, in order to ensure the effect of pre-prepared milk of rare notoginsenoside, the invention designs a rare notoginsenoside layer obtained from rare notoginsenoside treatment liquid and a waxy layer coated on the surface of the rare notoginsenoside layer. Specifically, the panax notoginseng rare saponin treatment fluid takes xylitol and water as a diluting solvent, wherein the xylitol can improve the stability of the panax notoginseng rare saponin pre-prepared emulsion on one hand, and can cover the special smell of the panax notoginseng rare saponin pre-prepared emulsion as a sweetening agent on the other hand, meanwhile, pullulan is introduced into the panax notoginseng rare saponin treatment fluid, and the pullulan can cooperate with the xylitol to improve the stability of the panax notoginseng rare saponin pre-prepared emulsion on the one hand, and on the other hand, the good film forming property and the compact film structure of the panax notoginseng rare saponin treatment fluid can protect a panax notoginseng rare saponin layer, so that the panax notoginseng rare saponin layer is prevented from being dissolved when contacting high-temperature waxy treatment fluid, and the active ingredients in the panax notoginseng rare saponin layer are also prevented from being degraded at high. The wax treatment liquid is composed of microcrystalline wax, white wax and menthol, and the substances are compounded according to a certain proportion, so that the effective protection of a rare saponin layer of the panax notoginseng is realized, the shelf life of a dental floss product is prolonged, the use effect is ensured, and the active ingredients of the dental floss are quickly dissolved in saliva of an oral cavity, so that the dental floss treatment liquid has the effects of improving the conditions of inflammation, redness and swelling, bleeding and the like of the gum and preventing oral problems of gingivitis, periodontitis and the like, and the aim of the invention is fulfilled.
Therefore, compared with the prior art, the invention has the following advantages:
(1) the dental floss containing the rare saponins of panax notoginseng enriches the efficacy of the dental floss, widens the application range of the rare saponins of panax notoginseng, can improve the conditions of inflammation, swelling, bleeding and the like of gum, prevents oral problems of gingivitis, periodontitis and the like, makes the oral environment healthy, and has stable product quality, long shelf life and good market prospect.
(2) The dental floss containing rare saponins of panax notoginseng is safe, nontoxic, reliable to use, non-irritating to gum tissues, free of drug resistance and suitable for long-term use, and the preparation method is simple in process, easy to control conditions, capable of realizing industrial production and capable of being popularized and applied.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
In the preparation method of the dental floss containing the notoginsen rare saponins, the adopted equipment is a TAF60 type dental floss COATING machine (the English name is TAF 68COATING-BONDING MACHINE AC), and the manufacturer is MP s.r.l.
Example 1A pre-prepared milk of rare saponins of panax notoginseng and a preparation method thereof
A1, pulverizing radix Notoginseng, sieving with a 20-mesh sieve to obtain radix Notoginseng powder, adding petroleum ether into the radix Notoginseng powder, wherein the weight of the petroleum ether is 3 times of that of radix Notoginseng, stirring at 300r/min for 4h, standing for 1h, removing upper layer liquid, repeating the above operations until the upper layer liquid is colorless, removing upper layer liquid, collecting medicinal residues, and drying to obtain defatted radix Notoginseng powder;
a2, placing degreased pseudo-ginseng powder into a container, adding water, wherein the weight of the added water is 6 times of the weight of the degreased pseudo-ginseng powder, soaking for 2 hours, performing ultrasonic treatment for 5 minutes at room temperature, then adding 1-butyl-3-methylimidazole bromide, adding tween-20 and tween-20, the weight of the added tween-20 is 1/8 times of the weight of the degreased pseudo-ginseng powder, stirring uniformly, performing ultrasonic treatment for 5 minutes at room temperature, performing suction filtration, adding dipotassium hydrogen phosphate and the weight of the added dipotassium hydrogen phosphate is 8 times of the weight of the degreased pseudo-ginseng powder into filtrate, stirring until the mixture is dissolved, centrifuging, taking upper layer liquid, and performing low-temperature concentration at 25-30 ℃ to obtain the pseudo-ginseng rare saponin pre-prepared milk.
Example 2 dental floss containing rare saponins of panax notoginseng according to the present invention and method for preparing the same
The formula is as follows: is mainly prepared from a bulking thread, a rare saponin treatment liquid of panax notoginseng and a wax treatment liquid;
the rare saponin treating fluid for panax notoginseng comprises the following raw materials: 30kg of pseudo-ginseng rare saponin pre-prepared milk, 25kg of xylitol, 5kg of pullulan and 30kg of water in example 1;
the waxy treatment fluid comprises the following raw materials: 15kg of microcrystalline wax, 5kg of white wax and 10kg of menthol;
the preparation method comprises the following steps:
s1, mixing xylitol, pullulan and water, heating to 50 ℃, stirring uniformly, adding pseudo-ginseng rare saponin pre-prepared emulsion, stirring for 15min to obtain pseudo-ginseng rare saponin treatment liquid, and placing the pseudo-ginseng rare saponin treatment liquid in a first heating tank;
s2, placing the microcrystalline wax and the white wax in a second heating tank, heating to 80 ℃, adding the menthol after the microcrystalline wax and the white wax are completely melted, and stirring for 20min to obtain a wax treatment solution;
s3, taking 60kg of leavened threads, placing the leavened threads on a dental floss holder, firstly shrinking the threads on the threads through a hot oven, then passing through the rare panax notoginseng saponin treatment liquid in a first heating groove, then air-drying through a first refrigerating box, then passing through the waxy treatment liquid in a second heating groove, then cooling through a second refrigerating box, and finally taking up the threads through a winding machine to obtain the dental floss containing the rare panax notoginseng saponin.
The dental floss is characterized in that two extrusion bearings are respectively arranged at the middle upper ends of the first heating groove and the second heating groove, the dental floss penetrates through the middle of the two extrusion bearings, the extrusion pressure of the extrusion bearings is controlled to be 0.5MPa, and the rotating speed is controlled to be 80 m/min.
Example 3 dental floss containing rare saponins of panax notoginseng according to the present invention and method for preparing the same
The formula is as follows: is mainly prepared from a bulking thread, a rare saponin treatment liquid of panax notoginseng and a wax treatment liquid;
the rare saponin treating fluid for panax notoginseng comprises the following raw materials: 25kg of pseudo-ginseng rare saponin pre-prepared milk, 20kg of xylitol, 2kg of pullulan and 20kg of water in example 1;
the waxy treatment fluid comprises the following raw materials: 15kg of microcrystalline wax, 3kg of white wax and 5kg of menthol;
the preparation method comprises the following steps:
s1, mixing xylitol, pullulan and water, heating to 40 ℃, stirring uniformly, adding pseudo-ginseng rare saponin pre-prepared emulsion, stirring for 15min to obtain pseudo-ginseng rare saponin treatment liquid, and placing the pseudo-ginseng rare saponin treatment liquid in a first heating tank;
s2, placing the microcrystalline wax and the white wax in a second heating tank, heating to 70 ℃, adding the menthol after the microcrystalline wax and the white wax are completely melted, and stirring for 15min to obtain a wax treatment solution;
s3, taking 50kg of bulked thread, placing the bulked thread on a dental floss holder, firstly shrinking the thread hairs on the thread through a hot oven, then passing through the rare panax notoginseng saponin treatment liquid in a first heating groove, then air-drying through a first refrigerating box, then passing through the waxy treatment liquid in a second heating groove, then cooling through a second refrigerating box, and finally taking up the thread through a winding machine to obtain the dental floss containing the rare panax notoginseng saponin.
The dental floss is characterized in that two extrusion bearings are respectively arranged at the middle upper ends of the first heating groove and the second heating groove, the dental floss penetrates through the middle of the two extrusion bearings, the extrusion pressure of the extrusion bearings is controlled to be 0.2MPa, and the rotating speed is controlled to be 50 m/min.
Example 4 dental floss containing rare saponins of panax notoginseng according to the present invention and method of preparing the same
The formula is as follows: is mainly prepared from a bulking thread, a rare saponin treatment liquid of panax notoginseng and a wax treatment liquid;
the rare saponin treating fluid for panax notoginseng comprises the following raw materials: 40kg of pseudo-ginseng rare saponin pre-prepared milk, 40kg of xylitol, 8kg of pullulan and 40kg of water in example 1;
the waxy treatment fluid comprises the following raw materials: 20kg of microcrystalline wax, 10kg of white wax and 15kg of menthol;
the preparation method comprises the following steps:
s1, mixing xylitol, pullulan and water, heating to 60 ℃, stirring uniformly, adding pseudo-ginseng rare saponin pre-prepared emulsion, stirring for 20min to obtain pseudo-ginseng rare saponin treatment liquid, and placing the pseudo-ginseng rare saponin treatment liquid in a first heating tank;
s2, placing the microcrystalline wax and the white wax in a second heating tank, heating to 90 ℃, adding the menthol after the microcrystalline wax and the white wax are completely melted, and stirring for 20min to obtain a wax treatment solution;
s3, taking 80kg of bulked thread, placing the bulked thread on a dental floss holder, firstly shrinking the thread hairs on the thread through a hot oven, then passing through the rare panax notoginseng saponin treatment liquid in a first heating groove, then air-drying through a first refrigerating box, then passing through the waxy treatment liquid in a second heating groove, then cooling through a second refrigerating box, and finally taking up the thread through a winding machine to obtain the dental floss containing the rare panax notoginseng saponin.
The dental floss is characterized in that two extrusion bearings are respectively arranged at the middle upper ends of the first heating groove and the second heating groove, the dental floss penetrates through the middle of the two extrusion bearings, the extrusion pressure of the extrusion bearings is controlled to be 0.7MPa, and the rotating speed is controlled to be 100 m/min.
Example 5 dental floss containing rare saponins of panax notoginseng according to the present invention and method for preparing the same
The formula is as follows: is mainly prepared from a bulking thread, a rare saponin treatment liquid of panax notoginseng and a wax treatment liquid;
the rare saponin treating fluid for panax notoginseng comprises the following raw materials: 30kg of pseudo-ginseng rare saponin pre-prepared milk, 20kg of xylitol, 6kg of pullulan and 40kg of water in example 1;
the waxy treatment fluid comprises the following raw materials: 20kg of microcrystalline wax, 3kg of white wax and 5kg of menthol;
the preparation method comprises the following steps:
s1, mixing xylitol, pullulan and water, heating to 50 ℃, stirring uniformly, adding pseudo-ginseng rare saponin pre-prepared emulsion, stirring for 20min to obtain pseudo-ginseng rare saponin treatment liquid, and placing the pseudo-ginseng rare saponin treatment liquid in a first heating tank;
s2, placing the microcrystalline wax and the white wax in a second heating tank, heating to 90 ℃, adding the menthol after the microcrystalline wax and the white wax are completely melted, and stirring for 15min to obtain a wax treatment solution;
s3, taking 60kg of leavened threads, placing the leavened threads on a dental floss holder, firstly shrinking the threads on the threads through a hot oven, then passing through the rare panax notoginseng saponin treatment liquid in a first heating groove, then air-drying through a first refrigerating box, then passing through the waxy treatment liquid in a second heating groove, then cooling through a second refrigerating box, and finally taking up the threads through a winding machine to obtain the dental floss containing the rare panax notoginseng saponin.
The dental floss is characterized in that two extrusion bearings are respectively arranged at the middle upper ends of the first heating groove and the second heating groove, the dental floss penetrates through the middle of the two extrusion bearings, the extrusion pressure of the extrusion bearings is controlled to be 0.6MPa, and the rotating speed is controlled to be 60 m/min.
Comparative example 1
Compared with example 2, the comparative example only differs in that the rare arasaponin preformulation of example 1 is not added, and the contents of other raw materials are adjusted accordingly: 32kg of xylitol, 3kg of pullulan and 32kg of water.
Comparative example 2
Compared with example 2, the comparative example only differs in that xylitol is not added, and the contents of other raw materials are adjusted to 40kg of pseudo-ginseng rare saponin pre-prepared milk, 8kg of pullulan and 40kg of water correspondingly.
Comparative example 3
The comparative example differs from example 2 only in that no pullulan was added.
Test example I, the dental floss containing rare notoginsenoside of the invention is used for detecting the sanitation, sense and physical and chemical index performance
1. Test materials: examples 2 to 5 dental floss containing rare saponins of Panax notoginseng
2. The test method comprises the following steps: the health index, the sensory index and the physical property of the dental floss containing the rare notoginsenoside prepared in the embodiments 2-5 are detected by referring to the relevant standards of the light industry standard QB/T4748-.
3. And (3) test results: the results of the hygiene test are shown in Table 1 below, and the results of the sensory and physicochemical tests are shown in Table 2 below.
Table 1: the invention discloses a dental floss containing rare notoginsenosides and a result of hygiene index test
As can be seen from the above table 1, the hygiene index test results of the dental floss containing rare saponins of panax notoginseng prepared in the embodiments 2 to 5 of the present invention all meet the relevant standards of QB/T4748-.
Table 2: the dental floss containing rare notoginsenosides of the invention has the test results of sensory index and physical property
As can be seen from the above table 2, the sensory index and physical property test results of the dental floss containing rare saponins of panax notoginseng prepared in the embodiments 2-5 of the present invention both meet the relevant standards of QB/T4748-. Therefore, the dental floss containing the notoginsenoside rare earth saponin prepared in the embodiments 2-5 of the invention is safe and reliable, and can be used for a long time.
Test example II, efficacy test of dental floss containing rare saponins of panax notoginseng according to the present invention
1. Test materials: dental floss prepared in examples 2-5 and comparative examples 1-2.
2. Test subjects: 70 SD rats with complete dentition, no dental caries and periodontal disease at 5 weeks age are selected, each of which has half of a female and a male, and the body weight of 200 +/-20 g.
3. Animal molding: randomly selecting 62 rats, cutting and stripping gingiva around teeth at two sides with ophthalmology curved scissors, repeating cutting once after 2d, and feeding soft feed soaked with 10% white sugar water and white sugar water every day. At 3 weeks, the rat was observed to have gingival tissues swollen and dark red, periodontal pockets formed and food residues, bleeding was easy to occur by touch, and the rat curls little and moves, loses weight, loosens fur and does not have appetite, indicating that the molding is successful. The remaining 8 rats were in the normal group and were not treated.
4. The test method comprises the following steps: the 56 rats successfully molded were randomly divided into 7 groups, i.e., example 2 group, example 3 group, example 4 group, example 5 group, comparative example 1 group, comparative example 2 group and comparative example 3 group, each of which was 8 rats and was male and female. In the experiment, the floss containing rare saponins of panax notoginseng was fed normally while the floss of examples 2, 3, 4 and 5 and the solutions prepared by flossing comparative examples 1, 2 and 3 were administered twice daily, respectively. Specifically, the dental floss was taken 20cm each, and placed in 10 ml of artificial saliva, and stirred for 5min to obtain a solution of example 2, a solution of example 3, a solution of example 4, a solution of example 5, a solution of comparative example 1, a solution of comparative example 2, and a solution of comparative example 3.
At the end of the trial on day 8, each group of rats was observed for gingival bleeding index, plaque index, depth of visit and rate of gingival recovery. Wherein, the swelling degree of the gum is divided into 4 grades and scored: there is no swelling in 0 point, slight swelling in 1 point, obvious swelling in 2 points and very swelling in 3 points. The gingival swelling degree was scored and the recovery rate of the gingiva was calculated for each group of rats. The gingival recovery rate calculation formula is as follows: the recovery rate was (1-total of daily observation scores/total of pre-dose observation scores) × 100%.
5. And (3) test results: as shown in table 3 below.
Table 3: index observations of groups of test rats
| Group of | Gingival bleeding index | Index of bacterial plaque | Depth of visit | Rate of recovery of gum |
| Normal group | 0 | 0.20±0.1 | 0 | - |
| EXAMPLE 2 group | 0.80±0.28 | 1.01±0.12 | 0.62±0.12 | 79.17％ |
| EXAMPLE 3 group | 0.89±0.25 | 1.22±0.10 | 0.70±0.20 | 75.0％ |
| EXAMPLE 4 group | 1.10±0.31 | 1.30±0.14 | 0.81±0.15 | 66.67％ |
| EXAMPLE 5 group | 1.03±0.36 | 1.33±0.15 | 0.76±0.13 | 70.83％ |
| Comparative example 1 group | 2.09±0.40 | 1.70±0.12 | 1.25±0.16 | 33.33％ |
| Comparative example 2 group | 1.61±0.38 | 1.60±0.16 | 1.07±0.14 | 50.0％ |
| Comparative example 3 group | 1.50±0.40 | 1.58±0.15 | 1.01±0.17 | 45.83％ |
From table 3 above, it can be seen that:
(1) compared with the group of the comparative example 1, the dental floss of the group of the invention 2-5 rats have obviously reduced gingival bleeding index, plaque index and probing depth and obvious gingival recovery effect, and the dental floss containing the rare notoginsenoside has the effects of improving gingival bleeding, swelling, inflammation and the like and can be used as a daily oral cleaning health care product. Among them, the best index of recovery of rats in the group of example 2 is used, so that the dental floss containing notoginsenoside and the preparation method thereof in example 2 are the best examples of the present invention.
(2) The comparative example 2 does not contain xylitol, the comparative example 3 does not contain pullulan, the dental floss solution has no obvious improvement effect on bleeding, swelling, inflammation and the like of the gum of a rat, and the stability of the rare saponin of panax notoginseng in the dental floss can be effectively improved by the xylitol and the pullulan, so that the effect of the rare saponin of panax notoginseng in the dental floss can be ensured.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.
Claims (9)
1. A dental floss containing rare saponins of panax notoginseng is characterized by being mainly prepared from a wire rod, a rare saponins of panax notoginseng treatment fluid and a wax treatment fluid;
the rare saponin treating fluid for panax notoginseng comprises the following raw materials in parts by weight: 25-40 parts of pseudo-ginseng rare saponin pre-prepared milk, 20-40 parts of xylitol, 2-8 parts of pullulan and 20-40 parts of water;
the waxy treatment fluid comprises the following raw materials in parts by weight: 15-20 parts of microcrystalline wax, 3-10 parts of white wax and 5-15 parts of menthol;
the preparation method of the pseudo-ginseng rare saponin pre-prepared milk comprises the following steps:
a1, grinding pseudo-ginseng to obtain pseudo-ginseng powder, adding petroleum ether into the pseudo-ginseng powder, stirring for 3-4 hours, standing for 1 hour, removing upper-layer liquid, repeating the operation until the upper-layer liquid is colorless, removing the upper-layer liquid, taking medicine residues, and drying to obtain degreased pseudo-ginseng powder;
a2, placing degreased pseudo-ginseng powder into a container, adding water, soaking for 2 hours, performing ultrasonic treatment at room temperature, then adding bromide ion liquid and tween-20, stirring uniformly, performing ultrasonic treatment at room temperature, performing suction filtration, adding dipotassium hydrogen phosphate into filtrate, stirring until the mixture is dissolved, centrifuging, taking upper-layer liquid, and performing low-temperature concentration at 25-30 ℃ to obtain pseudo-ginseng rare saponin pre-prepared milk.
2. The dental floss containing notoginsenoside as set forth in claim 1, wherein the wire is one of dacron wire, bulking wire and teflon wire.
3. The dental floss containing notoginsenoside rare earth saponins of claim 1, wherein the weight of the petroleum ether added is 3-4 times of the weight of the notoginsenosides.
4. The dental floss containing rare saponins of panax notoginseng according to claim 1, wherein the added weight of water is 6 times the weight of the defatted panax notoginseng powder.
5. The dental floss containing notoginsenoside rare earth saponins of claim 1, wherein the bromide ion liquid is 1-butyl-3-methylimidazole bromide, which is added in an amount of 1.2 times the weight of the defatted notoginseng powder.
6. The dental floss containing notoginsenoside rare earth saponins of claim 1, wherein the added weight of tween-20 is 1/8 of the weight of the defatted panax notoginseng powder.
7. The dental floss containing rare saponins of panax notoginseng according to claim 1, wherein the weight of added dipotassium phosphate is 8 times of the weight of the defatted panax notoginseng powder.
8. A method of preparing a dental floss containing rare saponins of panax notoginseng according to claim 1, comprising the steps of:
s1, mixing xylitol, pullulan and water, heating to 40-60 ℃, uniformly stirring, adding pseudo-ginseng rare saponin pre-prepared emulsion, stirring for 15-20 min to obtain pseudo-ginseng rare saponin treatment liquid, and placing the pseudo-ginseng rare saponin treatment liquid in a first heating tank;
s2, placing the microcrystalline wax and the white wax in a second heating tank, heating to 70-90 ℃, adding the menthol after the microcrystalline wax and the white wax are completely melted, and stirring for 15-20 min to obtain a wax treatment solution;
s3, taking the wire, placing the wire on a dental floss holder, firstly passing through a hot oven, then passing through the rare panax notoginseng saponin treatment liquid in a first heating groove, then passing through a first refrigerating box for air drying, then passing through the waxy treatment liquid in a second heating groove, then passing through a second refrigerating box for cooling, and finally taking up the wire through a winding machine to obtain the dental floss containing the rare panax notoginseng saponin.
9. The method for preparing dental floss containing notoginsenoside rare earths according to claim 8, wherein two extrusion bearings are respectively arranged at the middle upper ends of the first heating tank and the second heating tank, the extrusion pressure of the extrusion bearings is 0.2-0.7 MPa, and the rotating speed is 50-100 m/min.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1482888A (en) * | 2000-12-29 | 2004-03-17 | 金伯利-克拉克环球有限公司 | Hemostat coated dental floss and hemostat coated dental tape |
| CN101321513A (en) * | 2005-12-02 | 2008-12-10 | Gic创新公司 | Vehicles for oral care with magnolia bark extract |
| CN107982084A (en) * | 2018-01-30 | 2018-05-04 | 三椒口腔健康股份有限公司 | A kind of toothpaste of the rare saponin(e containing pseudo-ginseng and preparation method thereof |
| CN108056928A (en) * | 2018-02-06 | 2018-05-22 | 三椒口腔健康股份有限公司 | A kind of buccal cavity gel of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
| CN108078871A (en) * | 2018-02-06 | 2018-05-29 | 三椒口腔健康股份有限公司 | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
-
2019
- 2019-06-12 CN CN201910508142.1A patent/CN110279588B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1482888A (en) * | 2000-12-29 | 2004-03-17 | 金伯利-克拉克环球有限公司 | Hemostat coated dental floss and hemostat coated dental tape |
| CN101321513A (en) * | 2005-12-02 | 2008-12-10 | Gic创新公司 | Vehicles for oral care with magnolia bark extract |
| CN107982084A (en) * | 2018-01-30 | 2018-05-04 | 三椒口腔健康股份有限公司 | A kind of toothpaste of the rare saponin(e containing pseudo-ginseng and preparation method thereof |
| CN108056928A (en) * | 2018-02-06 | 2018-05-22 | 三椒口腔健康股份有限公司 | A kind of buccal cavity gel of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
| CN108078871A (en) * | 2018-02-06 | 2018-05-29 | 三椒口腔健康股份有限公司 | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
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