CN110269810A - A kind of composition and oral care product of the effective component containing thyme - Google Patents
A kind of composition and oral care product of the effective component containing thyme Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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Abstract
The present invention relates to the compositions and oral care product of a kind of effective component containing thyme, belong to oral care product technical field.To solve the problems, such as that gluconic acid chlorhexidine excessive concentration easily causes tooth staining and mucosal irritation in existing sterile products, the present invention provides the compositions and oral care product of a kind of effective component containing thyme, are 1~25:1~25:1~10:1~10 gluconic acid chlorhexidine, thyme linaloe oil, oleanolic acid and ursolic acid including mass ratio.Gluconic acid chlorhexidine in the present invention under thyme effective component complex role can in the oral cavity slow release and maintain effective low strength range always, the frequency of use that gluconic acid chlorhexidine can be reduced while playing bacteriostasis, the malaise symptoms such as dyeing caused by avoiding high concentration glucose acid chlorhexidine from being used for a long time, mucosal irritation, numb tongue.Thyme effective component also acts as simultaneously cooperates with antibacterial, promotion ulcer healing, effect that is anti-inflammatory and alleviating swelling and aching of gum.
Description
Technical field
The invention belongs to the composition of oral care product technical field more particularly to a kind of effective component containing thyme and
Oral care product.
Background technique
Chlorhexidine gluconate is a kind of cationic biguanide compound, is had obviously to Gram-negative bacteria and positive bacteria
Inhibitory effect, be a kind of generally acknowledged broad spectrum antimicrobial agent, thimerosal starting applied to the end of the sixties in last century in the oral cavity.
Some researches show that the thimerosal containing 0.5% chlorhexidine gluconate continues the antibacterial time at 48 hours or so, contains 2% grape
The thimerosal of saccharic acid Chlorhexidine continues the antibacterial time at 192 hours or so.But the chlorhexidine gluconate of high concentration is for sticking
Membrane tissue may result in stimulation or mucosa injury, cause tooth, dummy or back dyeing, and generate numb feeling in the tongue.
Currently, the chlorhexidine gluconate sterile products used on the market mainly have 0.03%, 0.12%, 0.2% and 2%
Several concentration, usual Chlorhexidine concentration is used for a long time 0.12% or more will appear tooth staining, and concentration is in 0.5% or more meeting
Cause mucosa irritation.
Summary of the invention
Tooth staining and mucosal irritation are easily caused to solve gluconic acid chlorhexidine excessive concentration in existing sterile products
The problem of, the present invention provides the compositions and oral care product of a kind of effective component containing thyme.
Technical solution of the present invention:
A kind of composition of the effective component containing thyme is 1~25:1~25:1~10:1~10 Portugal including mass ratio
Grape saccharic acid chlorhexidine, thyme linaloe oil, oleanolic acid and ursolic acid, wherein thyme linaloe oil contain 45~75% Thymol, 10
~20% carvacrol and 15~35% linalool, the material purity of ursolic acid and oleanolic acid is >=98%.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surplus are pure water；The preparation side of the oral care product
Method are as follows: by solubilizer, gluconic acid chlorhexidine and appropriate pure water be mixed and stirred for uniformly, be added thyme linaloe oil, oleanolic acid and
Ursolic acid stirs evenly, and remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surplus is pure water；The oral care product the preparation method comprises the following steps: sweetener is dissolved in appropriate pure water, solubilizer, grape is added
Saccharic acid chlorhexidine and appropriate pure water stir evenly, and thyme linaloe oil, oleanolic acid and ursolic acid is added and stirs evenly, aromatic is added
It stirs evenly, remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, surplus are pure water；
The oral care product the preparation method comprises the following steps: solubilizer, gluconic acid chlorhexidine and appropriate pure water are mixed and stirred for by (1)
It is even, clear transparent solutions I are obtained, surfactant is heated to 50 DEG C by (2), and thyme linaloe oil, oleanolic acid, ursolic acid stirring is added
At least 5~10min makes to be uniformly mixed, and the solution that gained is uniformly mixed is added in solution I and stirs evenly by (3), is added remaining pure
Water stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, ethyl alcohol 0.01~1%, surplus are pure water；Oral cavity shield
Manage product the preparation method comprises the following steps: solubilizer, gluconic acid chlorhexidine and appropriate pure water are mixed and stirred for uniformly, to clarify by (1)
Thyme linaloe oil, oleanolic acid, ursolic acid are dissolved in ethyl alcohol by clear solution I, (2), are added in solution I and are stirred while stirring
It mixes uniformly, remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, ethyl alcohol 0.01~
1%, surplus is pure water；The oral care product the preparation method comprises the following steps: (1) by solubilizer, gluconic acid chlorhexidine and appropriate pure
Water is mixed and stirred for uniformly, obtaining clear transparent solutions I, and thyme linaloe oil, oleanolic acid, ursolic acid are dissolved in ethyl alcohol by (2), on one side
Stirring is added in solution I on one side and stirs evenly to obtain clear transparent solutions II, (3) by surfactant be heated to 50 DEG C and by its
It is added in solution II and stirs evenly, remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1) sweetener is dissolved in it is suitable
It measures in pure water, solubilizer is added and gluconic acid chlorhexidine is mixed and stirred for uniformly, obtaining clear transparent solutions I, (2) are living by surface
Property agent be heated to 50 DEG C, thyme linaloe oil, oleanolic acid, ursolic acid and aromatic stirring at least 5~10min, which is added, keeps mixing equal
Even, the solution that gained is uniformly mixed is added in solution I and stirs evenly by (3), and remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Ethyl alcohol 0.01~1%, surplus are pure water；The oral care product the preparation method comprises the following steps: sweetener is dissolved in appropriate pure water by (1)
In, solubilizer and gluconic acid chlorhexidine is added and is mixed and stirred for uniformly, obtaining clear transparent solutions I, (2) by thyme linaloe oil, together
Pier tartaric acid, ursolic acid are dissolved in ethyl alcohol, are added in solution I while stirring and are stirred evenly to obtain clear transparent solutions II, (3)
Aromatic is added to stir evenly, remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, ethyl alcohol 0.01~1%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1)
Sweetener is dissolved in appropriate pure water, (2) solubilizer is added and gluconic acid chlorhexidine is mixed and stirred for uniformly, obtaining clear
Thyme linaloe oil, oleanolic acid, ursolic acid are dissolved in ethyl alcohol by solution I, (3), are added in solution I and are stirred while stirring
It is even that surfactant is heated to 50 DEG C by clear transparent solutions II, (4), aromatic is added, stirring at least 5~10min makes to mix
It closes uniformly, is then added into solution II and stirs evenly, remaining pure water is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, gelling agent 0.01~10%, surplus are pure water；The mouth
Chamber care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), be uniformly mixing to obtain transparent gel-type vehicle, (2) to
Solubilizer is added in gel-type vehicle and gluconic acid chlorhexidine stirs evenly, thyme linaloe oil, oleanolic acid and ursolic acid is added and stirs
It mixes uniformly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1),
It is uniformly mixing to obtain transparent gel-type vehicle, (2) solubilizer is added into gel-type vehicle and gluconic acid chlorhexidine stirs evenly,
Thyme linaloe oil, oleanolic acid and ursolic acid is added to stir evenly, sweetener is added and aromatic stirs evenly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, gelling agent 0.01
~10%, surplus is pure water；The oral care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), stir evenly
To transparent gel-type vehicle, (2) solubilizer is added into gel-type vehicle and gluconic acid chlorhexidine stirs evenly, and thyme is added
Oil, oleanolic acid and ursolic acid stir evenly, and surfactant is added and stirs evenly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps:
(1) gelling agent is dissolved in pure water, is uniformly mixing to obtain transparent gel-type vehicle, (2) into gel-type vehicle be added solubilizer and
Gluconic acid chlorhexidine stirs evenly, and thyme linaloe oil, oleanolic acid and ursolic acid is added and stirs evenly, and surfactant is added and stirs
It mixes uniformly, sweetener is added and aromatic stirs evenly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, ethyl alcohol 0.01~1%, gelling agent 0.01~10%, remaining
Amount is pure water；The oral care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), be uniformly mixing to obtain transparent
Gel-type vehicle, (2) solubilizer is added into gel-type vehicle and gluconic acid chlorhexidine stirs evenly to obtain viscous fluid I, and (3) are by hundred li
Sesame oil, oleanolic acid and ursolic acid, which are dissolved in ethyl alcohol, to stir evenly, and obtains solution I, and (3) solution I is added in viscous fluid I, stirring
Uniformly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, ethyl alcohol 0.01~
1%, gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1) gelling agent is dissolved in it is pure
In water, it is uniformly mixing to obtain transparent gel-type vehicle, (2) solubilizer and the stirring of gluconic acid chlorhexidine are added into gel-type vehicle
Uniformly, (3) are added surfactant and stir evenly, and obtain viscous fluid I, and (4) are by thyme linaloe oil, oleanolic acid and black bearberry acid solution second
It is stirred evenly in alcohol, obtains solution I, (5) solution I is added in viscous fluid I, stirs evenly.
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Ethyl alcohol 0.01~1%, gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1) will coagulate
Jelly is dissolved in pure water, is uniformly mixing to obtain transparent gel-type vehicle, and (2) solubilizer and gluconic acid are added into gel-type vehicle
Chlorhexidine stirs evenly, and obtains viscous fluid I, and thyme linaloe oil, oleanolic acid and ursolic acid are dissolved in ethyl alcohol by (3) to stir evenly, and obtains
Solution I is added in viscous fluid I, adds sweetener and aromatic stirs evenly by solution I, (4).
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, ethyl alcohol 0.01~1%, gelling agent 0.01~10%, surplus are pure water；The oral care produces
Product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), be uniformly mixing to obtain transparent gel-type vehicle, (2) are to gel-type vehicle
Middle addition solubilizer and gluconic acid chlorhexidine stir evenly, and surfactant is added and stirs evenly, obtains viscous fluid I, (3) are by hundred
In sesame oil, oleanolic acid and ursolic acid be added in ethyl alcohol and stir evenly, obtain solution I, (4) solution I is added in viscous fluid I, stirs
It mixes uniformly, sweetener is added and aromatic stirs evenly.
Further, the present invention in solubilizer be one or both of glycerol or propylene glycol combination.
Further, the present invention in sweetener be D-sorbite, xylitol, sucrose, tri-chloro galactose type sugar, saccharin sodium, Ah
The combination of one or more of this Ba Tian or acesulfame potassium.
Further, aromatic is green lemon Mint Essence, Chinese ilex Mint Essence, Green tea essence, milk perfume in the present invention
The combination of one or more of essence, flavoring apple essence or strawberry essence.
Further, surfactant is in PEG60- rilanit special, Tween-80 or Arlacel-20 in the present invention
One or more of combinations.
Further, gelling agent is sodium carboxymethylcellulose, carbomer, polyvinyl alcohol, hypromellose in the present invention
The combination of one or more of element, ethyl cellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, carragheen or xanthan gum.
The raw material that the present invention uses is commercially available finished product, and wherein the manufacturer of thyme linaloe oil is that the prosperous essence of state, Shenzhen is fragrant
Expect Co., Ltd, the manufacturer of ursolic acid is Nanjing Dao Sifu Biotechnology Co., Ltd, and the manufacturer of oleanolic acid is
Xieli Pharmaceutical Co., Ltd., Sichuan.
Beneficial effects of the present invention:
The composition of the effective component provided by the invention containing thyme is by gluconic acid chlorhexidine and thyme linaloe oil, olive
Acid, ursolic acid mutually compound, and gluconic acid chlorhexidine penetrates into dentine and cementum and shape with thyme diffusion of active ingredient
It at crystallization, and is slowly dissolved under the action of saliva and releases gluconic acid chlorhexidine, make intraoral gluconic acid chlorhexidine
Always effective low strength range is maintained, persistently antibacterial effect is played, thus by reducing the oral cavity of chlorhexidine containing gluconic acid shield
The frequency of use for managing product, dyeing caused by avoiding high concentration glucose acid chlorhexidine from being used for a long time, stimulation mucous membrane and numb tongue etc.
Malaise symptoms improve the compliance of the oral care product of chlorhexidine containing gluconic acid.Thyme in the present composition is effective
Ingredient also acts as simultaneously cooperates with antibacterial, promotion ulcer healing, effect that is anti-inflammatory and alleviating swelling and aching of gum.
The present invention also provides the oral care products of the effective component containing thyme, anti-including the effective component containing thyme
The oral antimicrobial gel of bacterium gargle and the effective component containing thyme.Antibacterial gargle or oral antimicrobial gel are able to extend containing hundred
In fragrant effective component composition residence time in the oral cavity so that the effective component in composition has time enough diffusion
It penetrates into dentine and cementum and forms crystallization, after removing antibacterial gargle or oral antimicrobial gel, in oral cavity still
There is the gluconic acid chlorhexidine of sustained release to play antibacterial action.
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention, and however, it is not limited to this, all right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be contained
Lid is within the protection scope of the present invention.
Embodiment 1
A kind of composition of the effective component containing thyme is 1~25:1~25:1~10:1~10 Portugal including mass ratio
Grape saccharic acid chlorhexidine, thyme linaloe oil, oleanolic acid and ursolic acid, wherein in thyme linaloe oil raw material containing 45~75% thyme
The material purity of phenol, 10~20% carvacrol and 15~35% linalool, ursolic acid and oleanolic acid is >=98%.
Embodiment 2
A kind of composition of the effective component containing thyme, including gluconic acid chlorhexidine that mass ratio is 1:1:1:1, in hundred
Sesame oil, oleanolic acid and ursolic acid wherein contain 75% Thymol, 10% carvacrol and 15% in thyme linaloe oil raw material
Linalool, the material purity of ursolic acid and oleanolic acid is >=98%.
Embodiment 3
A kind of composition of the effective component containing thyme, including gluconic acid chlorhexidine that mass ratio is 5:5:2:2, in hundred
Sesame oil, oleanolic acid and ursolic acid wherein contain 45% Thymol, 20% carvacrol and 35% in thyme linaloe oil raw material
Linalool, the material purity of ursolic acid and oleanolic acid is >=98%.
Embodiment 4
A kind of composition of the effective component containing thyme, including mass ratio be 5:20:5:5 gluconic acid chlorhexidine, hundred
In sesame oil, oleanolic acid and ursolic acid, wherein in thyme linaloe oil raw material containing 60% Thymol, 15% carvacrol and
The material purity of 25% linalool, ursolic acid and oleanolic acid is >=98%.
In the composition that embodiment 1-4 is provided, gluconic acid chlorhexidine penetrates into tooth with thyme diffusion of active ingredient
Essence and cementum simultaneously form crystallization, and gluconic acid chlorhexidine slow release can make intraoral grape under the action of saliva
Saccharic acid chlorhexidine maintains effective low strength range always, i.e., on its minimum inhibitory concentration 0.02%, effectively extends gluconic acid
Chlorhexidine plays persistently antibacterial effect in the residence time of site of action.
Since the gluconic acid chlorhexidine in composition has slow release effect, use can be reduced and contain gluconic acid
The frequency of chlorhexidine oral care product, avoid high concentration glucose acid chlorhexidine be used for a long time caused by dyeing, stimulation mucous membrane,
The malaise symptoms such as numb tongue improve the compliance of the oral care product of chlorhexidine containing gluconic acid.
The metabolism that thyme linaloe oil passes through interference bacterial cell DNA in thyme effective component used in the present embodiment
Journey, promotes cell death, and chlorhexidine gluconate causes the rupture of cell membrane to damage by the permeability of change bacterial cell membrane
Wound, leaks out cellular content, bacterium is killed, the two acts on the different parts of bacterium, collaboration bacteriostasis is played, into one
Step improves the bacteriostasis of composition.
In addition, thyme linaloe oil can promote canker sore to heal, by directly acting on intraoral anaerobic bacteria, improvement group
Interior anaerobic condition is knitted, inhibits bacterial growth, control and prevention mouth infection, reduces the secretion of ulcer surface, improve canker sore
The blood circulation of part plays a role.Thyme linaloe oil plays anti-inflammatory effect, olive by improving the phagocytic function of macrophage
Acid, ursolic acid play anti-inflammatory effect by immunologic specificity inflammatory reaction, and swelling and aching of gum can be effectively relieved in the two collaboration.
Embodiment 5
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surplus are pure water；The preparation side of the oral care product
Method are as follows: solubilizer and gluconic acid chlorhexidine are added in suitable quantity of water and are mixed and stirred for uniformly, thyme linaloe oil, oleanolic acid being added
It is stirred evenly with ursolic acid, remaining pure water is added and stirs evenly.
Embodiment 6
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02%, thyme linaloe oil 0.02%, oleanolic acid 0.02%, black bearberry
Acid 0.02%, glycerol 1%, surplus are pure water.
Embodiment 7
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.5%, thyme linaloe oil 0.5%, oleanolic acid 0.2%, ursolic acid
0.2%, propylene glycol 50%, surplus are pure water.
Embodiment 8
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.05%, thyme linaloe oil 0.15%, oleanolic acid 0.03%, black bearberry
Acid 0.03%, glycerol 10%, propylene glycol 10%, surplus are pure water.
Embodiment 9
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surplus is pure water；The oral care product the preparation method comprises the following steps: sweetener is dissolved in suitable quantity of water, solubilizer and glucose is added
Sour chlorhexidine stirs evenly, and thyme linaloe oil, oleanolic acid and ursolic acid is added and stirs evenly, and aromatic is added and stirs evenly, adds
Remaining pure water stirs evenly.
Embodiment 10
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.08%, thyme linaloe oil 0.16%, oleanolic acid 0.04%, black bearberry
Acid 0.04%, glycerol 5%, D-sorbite 1%, green lemon Mint Essence 0.01%, surplus are pure water.
Embodiment 11
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.10%, thyme linaloe oil 0.18%, oleanolic acid 0.06%, black bearberry
Acid 0.06%, propylene glycol 5%, xylitol 10%, Chinese ilex Mint Essence 0.5%, surplus are pure water.
Embodiment 12
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, surplus are pure water；
The oral care product the preparation method comprises the following steps: (1) solubilizer and gluconic acid chlorhexidine are added in suitable quantity of water is mixed and stirred for
Uniformly, clear transparent solutions I are obtained, surfactant is heated to 50 DEG C by (2), and thyme linaloe oil, oleanolic acid, ursolic acid is added and stirs
Mixing at least 5~10min makes to be uniformly mixed, and the solution that gained is uniformly mixed is added in solution I and stirs evenly by (3), is added remaining
Pure water stirs evenly.
Embodiment 13
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.12%, thyme linaloe oil 0.20%, oleanolic acid 0.07%, black bearberry
Acid 0.07%, glycerol 10%, PEG60- rilanit special 0.01%, surplus are pure water.
Embodiment 14
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.15%, thyme linaloe oil 0.23%, oleanolic acid 0.08%, black bearberry
Acid 0.08%, propylene glycol 10%, PEG60- rilanit special 0.5%, surplus are pure water.
Embodiment 15
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, ethyl alcohol 0.01~1%, surplus are pure water；Oral cavity shield
Reason product the preparation method comprises the following steps: (1) solubilizer and gluconic acid chlorhexidine are added in suitable quantity of water is mixed and stirred for uniformly, obtaining clear
Clear clear solution I, thyme linaloe oil, oleanolic acid, ursolic acid are dissolved in ethyl alcohol, are added in solution I while stirring simultaneously by (2)
It stirs evenly, remaining pure water is added and stirs evenly.
Embodiment 16
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.17%, thyme linaloe oil 0.25%, oleanolic acid 0.09%, black bearberry
Acid 0.09%, glycerol 15%, ethyl alcohol 0.01%, surplus are pure water.
Embodiment 17
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.20%, thyme linaloe oil 0.28%, oleanolic acid 0.10%, black bearberry
Acid 0.10%, propylene glycol 15%, ethyl alcohol 1%, surplus are pure water.
Embodiment 18
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, ethyl alcohol 0.01~
1%, surplus is pure water；The oral care product the preparation method comprises the following steps: (1) solubilizer and gluconic acid chlorhexidine are added it is appropriate
It being mixed and stirred for uniformly, obtaining clear transparent solutions I in water, thyme linaloe oil, oleanolic acid, ursolic acid are dissolved in ethyl alcohol by (2), and one
The clear transparent solutions II in solution I and stirred evenly are added in side stirring on one side, and surfactant is added in solution II and stirs by (3)
It mixes uniformly, remaining pure water is added and stirs evenly.
Embodiment 19
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.23%, thyme linaloe oil 0.3%, oleanolic acid 0.11%, ursolic acid
0.11%, glycerol 20%, Tween-80 0.05%, ethyl alcohol 0.05%, surplus are pure water.
Embodiment 20
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.25%, thyme linaloe oil 0.35%, oleanolic acid 0.12%, black bearberry
Acid 0.12%, propylene glycol 20%, Tween-80 0.07%, ethyl alcohol 0.06%, surplus are pure water.
Embodiment 21
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1) sweetener is dissolved in it is suitable
It measures in pure water, solubilizer and gluconic acid chlorhexidine is added and stirs evenly, obtain clear transparent solutions I, (2) are by surfactant
50 DEG C are heated to, thyme linaloe oil, oleanolic acid, ursolic acid and aromatic stirring at least 5~10min, which is added, to be made to be uniformly mixed, (3)
The solution that gained is uniformly mixed is added in solution I and is stirred evenly, remaining pure water is added to stir evenly.
Embodiment 22
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.28%, thyme linaloe oil 0.34%, oleanolic acid 0.13%, black bearberry
Acid 0.13%, glycerol 25%, sucrose 2%, milk flavour 0.03%, Arlacel-20 0.03%, surplus are pure water.
Embodiment 23
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.30%, thyme linaloe oil 0.36%, oleanolic acid 0.14%, black bearberry
Acid 0.14%, propylene glycol 25%, tri-chloro galactose type sugar 3%, flavoring apple essence 0.06%, Arlacel-20 0.06%, surplus are pure water.
Embodiment 24
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Ethyl alcohol 0.01~1%, surplus are pure water；The oral care product the preparation method comprises the following steps: sweetener is dissolved in appropriate pure water by (1)
In, solubilizer and gluconic acid chlorhexidine is added and stirs evenly, obtains clear transparent solutions I, (2) are by thyme linaloe oil, olive
Acid, ursolic acid are dissolved in ethyl alcohol, and the clear transparent solutions II in solution I and stirred evenly are added while stirring, and (3) are added
Aromatic stirs evenly, and remaining pure water is added to stir evenly.
Embodiment 25
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.03%, thyme linaloe oil 0.05%, oleanolic acid 0.05%, black bearberry
It is acid 0.05%, glycerol 5%, D-sorbite 4%, tri-chloro galactose type sugar 0.05%, green lemon Mint Essence 0.3%, ethyl alcohol 0.5%, remaining
Amount is pure water.
Embodiment 26
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.12%, thyme linaloe oil 0.05%, oleanolic acid 0.05%, black bearberry
It is acid 0.05%, glycerol 5%, D-sorbite 4%, tri-chloro galactose type sugar 0.05%, green lemon Mint Essence 0.3%, ethyl alcohol 0.5%, remaining
Amount is pure water.
Embodiment 27
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, ethyl alcohol 0.01~1%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1)
Sweetener is dissolved in appropriate pure water, (2) solubilizer is added and gluconic acid chlorhexidine is mixed and stirred for uniformly, obtaining clear
Thyme linaloe oil, oleanolic acid, ursolic acid are dissolved in ethyl alcohol by solution I, (3), are added in solution I and are stirred while stirring
Surfactant is heated to 50 DEG C by even clear transparent solutions II, (4), and aromatic is added, and stirring at least 5~10min makes to mix
It closes uniformly, is then added into solution II and stirs evenly, remaining pure water is added to stir evenly.
Embodiment 28
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.34%, thyme linaloe oil 0.38%, oleanolic acid 0.15%, black bearberry
Acid 0.15%, glycerol 30%, saccharin sodium 4%, flavoring apple essence 0.08%, PEG60- rilanit special 0.01%, ethyl alcohol 0.07%,
Surplus is pure water.
Embodiment 29
A kind of oral care product of the effective component containing thyme, which is antibacterial gargle, containing such as
The component of lower mass percentage: gluconic acid chlorhexidine 0.36%, thyme linaloe oil 0.4%, oleanolic acid 0.16%, ursolic acid
0.16%, propylene glycol 30%, Aspartame 5%, strawberry essence 0.10%, PEG60- rilanit special 0.01%, ethyl alcohol
0.08%, surplus is pure water.
Embodiment 30
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, gelling agent 0.01~10%, surplus are pure water；The mouth
Chamber care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), be uniformly mixing to obtain transparent gel-type vehicle, (2) to
Solubilizer is added in gel-type vehicle and gluconic acid chlorhexidine stirs evenly, thyme linaloe oil, oleanolic acid and ursolic acid is added and stirs
It mixes uniformly.
Embodiment 31
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.1%, thyme linaloe oil 0.03%, oleanolic acid 0.03%, black bearberry
Acid 0.03%, glycerol 8%, sodium carboxymethylcellulose 0.01%, surplus are pure water.
Embodiment 32
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.11%, thyme linaloe oil 0.04%, oleanolic acid 0.04%, bear
Tartaric acid 0.04%, glycerol 12%, carbomer 10%, surplus are pure water.
Embodiment 33
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.12%, thyme linaloe oil 0.05%, oleanolic acid 0.05%, bear
Tartaric acid 0.05%, hydroxypropyl methylcellulose 2%, propylene glycol 40%, surplus are pure water.
Embodiment 34
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1),
It is uniformly mixing to obtain transparent gel-type vehicle, (2) solubilizer is added into gel-type vehicle and gluconic acid chlorhexidine stirs evenly,
Thyme linaloe oil, oleanolic acid and ursolic acid is added to stir evenly, sweetener is added and aromatic stirs evenly.
Embodiment 35
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.14%, thyme linaloe oil 0.06%, oleanolic acid 0.06%, bear
Tartaric acid 0.06%, glycerol 14%, acesulfame potassium 6%, green lemon Mint Essence 0.15%, polyvinyl alcohol 0.5%, surplus are pure water.
Embodiment 36
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.16%, thyme linaloe oil 0.07%, oleanolic acid 0.07%, bear
Tartaric acid 0.07%, propylene glycol 16%, D-sorbite 4%, xylitol 3%, Chinese ilex Mint Essence 0.20%, ethyl cellulose
1.0%, surplus is pure water.
Embodiment 37
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, gelling agent 0.01
~10%, surplus is pure water；The oral care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), stir evenly
To transparent gel-type vehicle, (2) solubilizer is added into gel-type vehicle and gluconic acid chlorhexidine stirs evenly, and thyme is added
Oil, oleanolic acid and ursolic acid stir evenly, and surfactant is added and stirs evenly.
Embodiment 38
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.18%, thyme linaloe oil 0.10%, oleanolic acid 0.8%, black bearberry
Acid 0.8%, propylene glycol 24%, Tween-80 0.01~0.5%, hydroxypropyl cellulose 1.5%, surplus are pure water.
Embodiment 39
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.22%, thyme linaloe oil 0.14%, oleanolic acid 0.09%, bear
Tartaric acid 0.09%, glycerol 26%, Arlacel-20 0.01~0.5%, polyvinylpyrrolidone 2.5%, surplus are pure water.
Embodiment 40
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps:
(1) gelling agent is dissolved in pure water, is uniformly mixing to obtain transparent gel-type vehicle, (2) into gel-type vehicle be added solubilizer and
Gluconic acid chlorhexidine stirs evenly, and thyme linaloe oil, oleanolic acid and ursolic acid is added and stirs evenly, and surfactant is added and stirs
It mixes uniformly, sweetener is added and aromatic stirs evenly.
Embodiment 41
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.24%, thyme linaloe oil 0.16%, oleanolic acid 0.1%, black bearberry
Acid 0.1%, glycerol 30%, sucrose 4%, tri-chloro galactose type sugar 4%, milk flavour 0.35%, PEG60- rilanit special 0.01~
0.5%, carragheen 3.0%, surplus are pure water.
Embodiment 42
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.26%, thyme linaloe oil 0.18%, oleanolic acid 0.11%, bear
Tartaric acid 0.11%, propylene glycol 32%, saccharin sodium 4%, Aspartame 5%, flavoring apple essence 0.4%, PEG60- rilanit special
0.01~0.5%, xanthan gum 3.5%, surplus are pure water.
Embodiment 43
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, ethyl alcohol 0.01~1%, gelling agent 0.01~10%, remaining
Amount is pure water；The oral care product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), be uniformly mixing to obtain transparent
Solubilizer and gluconic acid chlorhexidine are added into gel-type vehicle and stirs evenly for gel-type vehicle, (2), and (3) are by thyme linaloe oil, Qi Dun
Tartaric acid and ursolic acid are dissolved in ethyl alcohol, are stirred evenly.
Embodiment 44
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.32%, thyme linaloe oil 0.21%, oleanolic acid 0.12%, bear
Tartaric acid 0.12%, glycerol 35%, ethyl alcohol 0.01~1%, sodium carboxymethylcellulose 2.0%, carbomer 2.0%, surplus are pure water.
Embodiment 45
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.35%, thyme linaloe oil 0.23%, oleanolic acid 0.13%, bear
Tartaric acid 0.13%, propylene glycol 38%, ethyl alcohol 0.01~1%, polyvinyl alcohol 3%, hydroxypropyl methylcellulose 1.5%, surplus are pure water.
Embodiment 46
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, surfactant 0.01~0.5%, ethyl alcohol 0.01~
1%, gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1) gelling agent is dissolved in it is pure
In water, it is uniformly mixing to obtain transparent gel-type vehicle, (2) solubilizer and the stirring of gluconic acid chlorhexidine are added into gel-type vehicle
Uniformly, surfactant is added to stir evenly, thyme linaloe oil, oleanolic acid and ursolic acid are dissolved in ethyl alcohol by (3), are stirred evenly
?.
Embodiment 47
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.37%, thyme linaloe oil 0.27%, oleanolic acid 0.14%, bear
Tartaric acid 0.14%, glycerol 40%, PEG60- rilanit special 0.01~0.5%, ethyl alcohol 0.5%, ethyl cellulose 2%, hydroxypropyl
Base cellulose 3%, surplus are pure water.
Embodiment 48
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.42%, thyme linaloe oil 0.30%, oleanolic acid 0.15%, bear
Tartaric acid 0.15%, propylene glycol 42%, PEG60- rilanit special 0.01~0.5%, ethyl alcohol 0.55%, polyvinylpyrrolidone
2%, carragheen 3.5%, surplus are pure water.
Embodiment 49
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Ethyl alcohol 0.01~1%, gelling agent 0.01~10%, surplus are pure water；The oral care product the preparation method comprises the following steps: (1) will coagulate
Jelly is dissolved in pure water, is uniformly mixing to obtain transparent gel-type vehicle, and (2) solubilizer and gluconic acid are added into gel-type vehicle
Chlorhexidine stirs evenly, and obtains viscous fluid I, and thyme linaloe oil, oleanolic acid and ursolic acid are dissolved in ethyl alcohol and stirred evenly by (3), obtains molten
Solution I is added in viscous fluid I for liquid I, (4), and sweetener is added and aromatic stirs evenly.
Embodiment 50
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.43%, thyme linaloe oil 0.33%, oleanolic acid 0.16%, bear
Tartaric acid 0.16%, propylene glycol 45%, acesulfame potassium 5%, D-sorbite 5%, strawberry essence 0.45%, ethyl alcohol 0.01~1%, xanthan
Glue 2%, sodium carboxymethylcellulose 2%, carbomer 2%, surplus are pure water.
Embodiment 51
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.45%, thyme linaloe oil 0.36%, oleanolic acid 0.17%, bear
Tartaric acid 0.17%, glycerol 47%, xylitol 3%, tri-chloro galactose type sugar 3%, Aspartame 3%, green lemon Mint Essence 0.5%, second
Alcohol 0.01~1%, polyvinyl alcohol 1.5%, hydroxypropyl methylcellulose 2%, ethyl cellulose 3%, surplus are pure water.
Embodiment 52
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid
0.02~0.2%, ursolic acid 0.02~0.2%, solubilizer 1~50%, sweetener 1~10%, aromatic 0.01~0.5%,
Surfactant 0.01~0.5%, ethyl alcohol 0.01~1%, gelling agent 0.01~10%, surplus are pure water；The oral care produces
Product the preparation method comprises the following steps: gelling agent is dissolved in pure water by (1), be uniformly mixing to obtain transparent gel-type vehicle, (2) are to gel-type vehicle
Middle addition solubilizer and gluconic acid chlorhexidine stir evenly, and surfactant is added and stirs evenly to obtain viscous fluid I, and (3) are by hundred
In sesame oil, oleanolic acid and ursolic acid be dissolved in ethyl alcohol and stirring evenly, obtain solution I (4) and solution I be added in viscous fluid I, be added
Sweetener and aromatic stir evenly.
Embodiment 53
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.47%, thyme linaloe oil 0.42%, oleanolic acid 0.18%, bear
Tartaric acid 0.18%, glycerol 48%, saccharin sodium 2%, acesulfame potassium 2%, D-sorbite 2%, Chinese ilex Mint Essence 0.26%, PEG60-
Rilanit special 0.01~0.5%, ethyl alcohol 0.01~1%, polyvinylpyrrolidone 2%, carragheen 3%, carboxymethyl cellulose
Sodium 3%, surplus are pure water.
Embodiment 54
A kind of oral care product of the effective component containing thyme, the oral care product are oral antimicrobial gel, are contained
The component of following mass percentage: gluconic acid chlorhexidine 0.48%, thyme linaloe oil 0.46%, oleanolic acid 0.19%, bear
Tartaric acid 0.19%, propylene glycol 49%, Aspartame 1%, sucrose 1%, tri-chloro galactose type sugar 1%, Green tea essence 0.37%, PEG60-
Rilanit special 0.01~0.5%, ethyl alcohol 0.01~1%, carbomer 2%, polyvinyl alcohol 2%, carragheen 2%, xanthan gum
2%, surplus is pure water.
Comparative example 1
This comparative example provides a kind of antibacterial gargle that thyme effective component is not added, and contains following mass percentage
Component: chlorhexidine gluconate 0.03%, glycerol 5%, D-sorbite 4%, tri-chloro galactose type sugar 0.05%, green lemon Mint Essence
0.3%, ethyl alcohol 0.5%, surplus are pure water.The antibacterial gargle the preparation method comprises the following steps: D-sorbite and tri-chloro galactose type sugar is molten
In suitable quantity of water, addition glycerol, chlorhexidine gluconate are stirred evenly, and add green lemon Mint Essence and ethyl alcohol stirs evenly,
Pure water is added to stir evenly.
Comparative example 2
This comparative example provides a kind of antibacterial gargle for only adding thyme linaloe oil, the group containing following mass percentage
Point: chlorhexidine gluconate 0.03%, thyme linaloe oil 0.05%, glycerol 5%, D-sorbite 4%, tri-chloro galactose type sugar 0.05%,
Green lemon Mint Essence 0.3%, ethyl alcohol 0.5%, surplus be pure water.The antibacterial gargle the preparation method comprises the following steps: by D-sorbite and
Tri-chloro galactose type sugar is dissolved in suitable quantity of water, and glycerol, chlorhexidine gluconate, thyme linaloe oil is added and stirs evenly, it is thin to add green lemon
Lotus essence and ethyl alcohol stir evenly, and remaining pure water is added to stir evenly.
Comparative example 3
This comparative example provides a kind of antibacterial gargle for only adding oleanolic acid, the group containing following mass percentage
Point: chlorhexidine gluconate 0.03%, oleanolic acid 0.05%, glycerol 5%, D-sorbite 4%, tri-chloro galactose type sugar 0.05%,
Green lemon Mint Essence 0.3%, ethyl alcohol 0.5%, surplus are pure water.The antibacterial gargle the preparation method comprises the following steps: by D-sorbite and
Tri-chloro galactose type sugar is dissolved in suitable quantity of water, and glycerol, chlorhexidine gluconate, oleanolic acid is added and stirs evenly, it is thin to add green lemon
Lotus essence and ethyl alcohol stir evenly, and remaining pure water is added to stir evenly.
Comparative example 4
This comparative example provides a kind of antibacterial gargle for only adding ursolic acid, the component containing following mass percentage:
Chlorhexidine gluconate 0.03%, ursolic acid 0.05%, glycerol 5%, D-sorbite 4%, tri-chloro galactose type sugar 0.05%, green lemon are thin
Lotus essence 0.3%, ethyl alcohol 0.5%, surplus are pure water.The antibacterial gargle the preparation method comprises the following steps: by D-sorbite and trichlorine half
Lactose is dissolved in suitable quantity of water, glycerol is added, chlorhexidine gluconate, ursolic acid stir evenly, add green lemon Mint Essence and
Ethyl alcohol stirs evenly, and remaining pure water is added to stir evenly.
Comparative example 5
This comparative example provides a kind of oral antimicrobial gel that thyme effective component is not added, and contains containing following quality percentage
The component of amount: chlorhexidine gluconate 0.12%, hydroxypropyl methylcellulose 2%, propylene glycol 40%, green lemon Mint Essence 0.3%, remaining
Amount is pure water.The oral antimicrobial gel the preparation method comprises the following steps: hydroxypropyl methylcellulose is dissolved in pure water, stir evenly；It is added third
Glycol stirs evenly；Chlorhexidine gluconate is added, is stirred evenly；It is eventually adding green lemon Mint Essence, is stirred evenly i.e.
It can.
Comparative example 6
This comparative example provides a kind of oral antimicrobial gel for only adding thyme linaloe oil, the group containing following mass percentage
Point: chlorhexidine gluconate 0.12%, thyme linaloe oil 0.05%, hydroxypropyl methylcellulose 2%, propylene glycol 40%, green lemon minty note
Essence 0.3%, surplus are pure water.The oral antimicrobial gel the preparation method comprises the following steps: hydroxypropyl methylcellulose is dissolved in pure water, stirring is equal
It is even；Propylene glycol is added, stirs evenly；Chlorhexidine gluconate and thyme linaloe oil are added, is stirred evenly；It is thin to be eventually adding green lemon
Lotus essence, stirs evenly.
Comparative example 7
This comparative example provides a kind of oral antimicrobial gel for only adding oleanolic acid, the group containing following mass percentage
Point: chlorhexidine gluconate 0.12%, oleanolic acid 0.05%, hydroxypropyl methylcellulose 2%, propylene glycol 40%, green lemon minty note
Essence 0.3%, surplus are pure water.The oral antimicrobial gel the preparation method comprises the following steps: hydroxypropyl methylcellulose is dissolved in pure water, stirring is equal
It is even；Propylene glycol is added, stirs evenly；Chlorhexidine gluconate and oleanolic acid are added, is stirred evenly；It is thin to be eventually adding green lemon
Lotus essence, stirs evenly.
Comparative example 8
This comparative example provides a kind of oral antimicrobial gel for only adding ursolic acid, the group containing following mass percentage
Point: chlorhexidine gluconate 0.12%, ursolic acid 0.05%, hydroxypropyl methylcellulose 2%, propylene glycol 40%, green lemon Mint Essence
0.3%, surplus is pure water.The oral antimicrobial gel the preparation method comprises the following steps: hydroxypropyl methylcellulose is dissolved in pure water, stirring is equal
It is even；Propylene glycol is added, stirs evenly；Chlorhexidine gluconate and ursolic acid are added, is stirred evenly；It is eventually adding green lemon peppermint
Essence stirs evenly.
Fungistatic effect examines experiment:
(1) the lasting fungistatic effect of observation embodiment 25 and the antibacterial gargle of comparative example 1-4 preparation in vitro.
50 20~40 years old healthy volunteers are selected, are divided into 5 groups, every group of 10 people, every group uses embodiment 25, right respectively
The antibacterial gargle of ratio 1-4 preparation, containing 20mL antibacterial gargle is gargled, spue gargle after 30s.Using preceding and use respectively
Afterwards 30min, 12h, for 24 hours, 36h, 48h, 72h and 96h respectively sample 1 time, acquire Oral Health Suryey sample with sampling swab, carry out thin
Bacterium culture, the results are shown in Table 1:
Table 1
As can be known from Table 1, after using 36 hours, bacterial population starts to rebound 25 antibacterial gargle of embodiment, shows it
Continuing the antibacterial time can reach 36 hours, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 the antibacterial time that continues be 12
Hour；That is under conditions of gluconic acid chlorhexidine concentration is 0.03% in antibacterial gargle, embodiment 25 and hundred
In sesame oil, oleanolic acid and ursolic acid compounding gargle the antibacterial duration be substantially better than without thyme effective component,
Or contain only the gargle of single active ingredient preparation.This absolutely proves gluconic acid chlorhexidine, thyme linaloe oil, oleanolic acid and bear
Tartaric acid can significantly extend the antibacterial time of gluconic acid chlorhexidine after mutually compounding, so as to reduce gluconic acid chlorhexidine
Frequency of use reduces the uncomfortable reaction that gluconic acid chlorhexidine generates.
(2) the lasting fungistatic effect of observation embodiment 33 and the oral antimicrobial gel of comparative example 5-8 preparation in vitro.
50 20~40 years old healthy volunteers are selected, are divided into 5 groups, every group of 10 people, every group uses embodiment 33, right respectively
The oral antimicrobial gel of ratio 5-8 preparation, takes oral antimicrobial gel 0.5ml to be applied on mucous membrane of mouth, should not drink water in 30min
And feed.Respectively using it is preceding and using rear 30min, 12h, for 24 hours, 36h, 48h, 72h and 96h respectively sample 1 time, use sampling swab
Oral Health Suryey sample is acquired, Bacteria Culture is carried out, the results are shown in Table 2；
Table 2
As can be known from Table 2, after using 72 hours, bacterial population starts to rebound 33 oral antimicrobial gel of embodiment, shows
Its lasting antibacterial time can reach 72 hours, and the antibacterial time that continues of the oral antimicrobial gel of comparative example 5-8 preparation is 12 hours.
That is under conditions of gluconic acid chlorhexidine concentration is 0.12% in oral antimicrobial gel, embodiment 33 and thyme
The antibacterial duration of the gargle of oil, oleanolic acid and ursolic acid compounding is substantially better than without thyme effective component or only
The oral antimicrobial gel of the preparation containing single active ingredient.This absolutely prove gluconic acid chlorhexidine, thyme linaloe oil, oleanolic acid and
Ursolic acid can significantly extend the antibacterial time of gluconic acid chlorhexidine after mutually compounding, so as to reduce gluconic acid chlorhexidine
Frequency of use, reduce the uncomfortable reaction that gluconic acid chlorhexidine generates.
(3) the antibacterial gargle of embodiment 25 and comparative example 1-4 preparation is observed to escherichia coli and Staphylococcus aureus
The deactivation of bacterium.
Test strain: escherichia coli (ATCC 25922), staphylococcus aureus (ATCC 6538)；Referring to " disinfection skill
Art specification " (version in 2002) 2.1.11.3.1 tested, 5min and 10min are acted on respectively with gargle stoste 1ml, as a result such as
Shown in table 3；
Table 3
By the data comparison of table 3 it is found that the gargle that embodiment 25 is compounded with thyme linaloe oil, oleanolic acid and ursolic acid
Fungistatic effect is significantly better than the gargle that comparative example 1-4 is free of thyme effective component or contains only single active ingredient preparation.This
It is since thyme linaloe oil promotes cell death, grape by the metabolic process of interference bacterial cell DNA in thyme effective component
Saccharic acid Chlorhexidine causes the fracture damage of cell membrane, leaks out cellular content by the permeability of change bacterial cell membrane, will
Bacterium kills, and the two acts on the different parts of bacterium, plays collaboration bacteriostasis, further improves the suppression of antibacterial gargle
Bacterium ability.
(4) antibacterial gel of embodiment 33 and comparative example 5-8 preparation is observed to escherichia coli and staphylococcus aureus
Deactivation.
Test strain: escherichia coli (ATCC 25922), staphylococcus aureus (ATCC 6538)；Referring to " disinfection skill
Art specification " (version in 2002) 2.1.11.3.1 tested, 5min and 10min result such as table 4 is acted on respectively with gel stoste 1g
It is shown；
Table 4
By the data comparison of table 4 it is found that the oral antimicrobial that embodiment 33 is compounded with thyme linaloe oil, oleanolic acid and ursolic acid
The fungistatic effect of gel is significantly better than the mouth that comparative example 1-4 is free of thyme effective component or contains only single active ingredient preparation
Chamber antibacterial gel.This is because thyme linaloe oil is promoted by the metabolic process of interference bacterial cell DNA in thyme effective component
Cell death, chlorhexidine gluconate cause the fracture damage of cell membrane, make cell by the permeability of change bacterial cell membrane
Content leaks out, and bacterium is killed, the two acts on the different parts of bacterium, plays collaboration bacteriostasis, further improves
The bacteriostasis of oral antimicrobial gel.
(5) antiphlogistic effects of the antibacterial oral care product of embodiment 25, embodiment 33 and comparative example 1-8 preparation are observed.
Test method: male mice 20,20 ± 3g of weight, 30 μ l of dimethylbenzene is applied to mouse right ear exterior feature, and will implement
Example 25,33 and the antibacterial oral care product of comparative example 1-8 preparation are applied to mouse bilateral auricle, and left auricle, which is used as, to be compareed, after 2h
Auricle is cut, auricle is removed with diameter 9mm punch, weighs, the intensity of inflammatory reaction is indicated with binauricular weight difference, as a result
As shown in table 5；
Table 5
| Group | Auricle weight difference/mg* | Inhibiting rate |
| 25 product of embodiment | 9.6±3.4 | 51.0% |
| 1 product of comparative example | 19.6±4.4 | - |
| 2 product of comparative example | 15.1±4.2 | 23.0% |
| 3 product of comparative example | 13.8±3.8 | 29.6% |
| 4 product of comparative example | 14.7±3.7 | 25.0% |
| 33 product of embodiment | 9.2±4.0 | 52.3% |
| 5 product of comparative example | 19.3±3.6 | - |
| 6 product of comparative example | 14.8±3.8 | 23.3% |
| 7 product of comparative example | 13.8±3.4 | 28.5% |
| 8 product of comparative example | 14.3±3.5 | 26.0% |
N=10, *P < 0.05
By the data comparison of table 5 it is found that antibacterial of the embodiment 25 relative to comparative example 1 without thyme effective component is containing gargling
The inflammation inhibiting rate of liquid is 51%, oral antimicrobial gel of the embodiment 33 relative to comparative example 5 without thyme effective component
Inflammation inhibiting rate is 52.3%, the oral cavity shield that gluconic acid chlorhexidine is compounded with thyme linaloe oil, oleanolic acid and ursolic acid
The antiphlogistic effects of reason product are significantly better than the oral care product that gluconic acid chlorhexidine is only compounded with single active ingredient, this is
Since thyme linaloe oil plays anti-inflammatory effect by improving the phagocytic function of macrophage, oleanolic acid, ursolic acid pass through immune spy
Anti-inflammatory effect is played in anisotropic inflammatory reaction, and three's compounding, which plays, cooperates with anti-inflammatory effect, further improves oral care product
Fungistatic effect, while also improving its antiphlogistic effects.
Claims (10)
1. a kind of composition of effective component containing thyme, which is characterized in that including mass ratio be 1~25:1~25:1~10:1
~10 gluconic acid chlorhexidine, thyme linaloe oil, oleanolic acid and ursolic acid.
2. a kind of oral care product of effective component containing thyme, which is characterized in that the group containing following mass percentage
Point: gluconic acid chlorhexidine 0.02~0.5%, thyme linaloe oil 0.02~0.5%, oleanolic acid 0.02~0.2%, ursolic acid
0.02~0.2%, solubilizer 1~50%, surplus are pure water.
3. the oral care product of a kind of effective component containing thyme according to claim 2, which is characterized in that also containing such as
The component of lower mass percentage: sweetener 1~10% and aromatic 0.01~0.5%.
4. the oral care product of a kind of effective component containing thyme according to claim 2, which is characterized in that also containing such as
The component of lower mass percentage: surfactant 0.01~0.5%.
5. according to a kind of oral care product of the effective component containing thyme of claim 2 or 4, which is characterized in that also contain
There is the component of following mass percentage: ethyl alcohol 0.01~1%.
6. the oral care product of a kind of effective component containing thyme according to claim 3, which is characterized in that also containing such as
The component of lower mass percentage: surfactant 0.01~0.5%.
7. according to a kind of oral care product of the effective component containing thyme of claim 3 or 6, which is characterized in that also contain
There is the component of following mass percentage: ethyl alcohol 0.01~1%.
8. according to claim 2,3,4 or a kind of 6 oral care products of the effective component containing thyme, which is characterized in that
Also contain the component of following mass percentage: gelling agent 0.01~10%.
9. the oral care product of a kind of effective component containing thyme according to claim 5, which is characterized in that also containing such as
The component of lower mass percentage: gelling agent 0.01~10%.
10. the oral care product of a kind of effective component containing thyme according to claim 7, which is characterized in that also contain
The component of following mass percentage: gelling agent 0.01~10%.
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| EP3097905A1 (en) * | 2015-05-28 | 2016-11-30 | Symrise AG | Cosmetic compositions |
| CN105997792A (en) * | 2016-06-21 | 2016-10-12 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicine mothproofing and tooth-protecting gargle and preparation method thereof |
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Application publication date: 20190924 |