CN110227175A - It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof - Google Patents
It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof Download PDFInfo
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- CN110227175A CN110227175A CN201910391916.7A CN201910391916A CN110227175A CN 110227175 A CN110227175 A CN 110227175A CN 201910391916 A CN201910391916 A CN 201910391916A CN 110227175 A CN110227175 A CN 110227175A
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- solution
- medical dressing
- wound healing
- antibacterial
- fibroin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Artificial Filaments (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof, and the sodium alginate soln that compound concentration is 2.0%~4.0% obtains spinning solution；20~50g silkworm raw silk is taken to be put into the Na2CO3 solution that 1~3L boils, heating is boiled, and is washed with deionized water, and obtains the complete fibroin fiber of degumming, its garnetting is dried for standby；5g is taken to dry fibroin fiber, with bath raio 1:(6~12) it is put into heating water bath in ternary solution and stirs, fibroin mixed solution is obtained, fresh silk fibroin solution is obtained with centrifugation after deionized water dialysis after cooling, obtains solidification liquid；Spinning solution is passed through into spinning nozzle, composite fibre is formed with solidification liquid, then composite fibre is formed into acupuncture cotton by needling process, forms medical dressing through moulding process.Product of the invention is soft, can be close to the surface of a wound, and air permeable humidity retaining is good, and sodium alginate has the function of the growth that the growth of epidermal tissue can be promoted to be beneficial to cambium, promotes Wound healing, mitigates patient's pain.
Description
Technical field
The present invention relates to medical dressing technical fields, and in particular to one kind has antibacterial, high-selenium corn and can promote wound and be cured
Medical dressing of conjunction and preparation method thereof.
Background technique
Sodium alginate is the by-product after extracting iodine and mannitol in the kelp or sargassum of brown algae.Its molecule by
Beta-D-mannuronic acid and α-L- guluronic acid are keyed by (1 → 4), are a kind of natural polysaccharides, have pharmaceutical preparation
Stability needed for auxiliary material, dissolubility, viscosity and safety.
Fibroin albumen and human body have good generation compatibility, occur mostly in the form of fibroin membrane as medical material." in
Magnificent plastic burn surgery " 14 interim reports treated fibroin membrane on without infection and the sterile surface of a wound 1998 years；" weaving is learned
Report " 5 phases in 2005 in " fibroin blend film " text, elaborate fibroin/chitosan mixed film physicochemical property, and point out silk
Element/chitosan semi-interpenetrating network type film has the possibility as " artificial tendon ".But fibroin protein film and its compound are due to its suppression
Bacterium function is poor, and it is ventilative, moisture retention is not strong, and cost of manufacture is higher, affects its application.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of with antibacterial, can promote wound healing
Medical dressing and preparation method thereof.
The technical solution adopted by the present invention to solve the technical problems is:
It is a kind of with antibacterial, can promote the medical dressing of wound healing, it is characterised in that: compound concentration is 2.0%~
4.0% sodium alginate soln, obtains spinning solution；The silk fibroin solution that ternary solution is dissolved into is as solidification liquid；By spinning
Solution enters after the spinning nozzle of spinning machine squeezes out forms the calcium alginate compounded fiber of fibroin in solidification liquid, then by fibroin seaweed
Sour calcium composite fibre forms acupuncture cotton by needling process, forms medical dressing through moulding process.
Wherein, the ternary solution is formulated by CaCl2:C2H5OH:H2O by 1:2:8.
The present invention also provides a kind of with antibacterial, the preparation method for the medical dressing that can promote wound healing, wherein should
The preparation step of solidification liquid in method is as follows:
(1) 20~50g silkworm raw silk is taken to be put into the Na2CO3 solution that 1~3L boils, 30min is boiled in heating, then uses
Deionized water cleans up, and obtains the complete fibroin fiber of degumming；
(2) it by clean fibroin fiber garnetting, is dried for standby in 45 DEG C~70 DEG C of baking oven；
(3) the domestic silkworm silk fibroin fiber after taking 5g to dry, with bath raio 1:(6~12) it is put into ternary solution heating water bath simultaneously
Stirring obtains domestic silkworm silk fibroin mixed solution；
(4) it is packed into bag filter after solution to be mixed is cooling, with fresh 68~80h of deionized water dialysis, after dialysis
Solution obtains fresh silk fibroin solution by centrifugation.
Wherein, the spinning solution is certain density sodium alginate soln, by the way that sodium alginate soln is dissolved in water
It is prepared.
As an improvement, the concentration of the Na2CO3 solution in the preparation step (1) of the solidification liquid is 0.4 ‰~0.8 ‰, it is excellent
It is selected as 0.6 ‰.
As an improvement, silkworm raw silk is put into the Na2CO3 solution boiled and is heated in the step of solidification liquid (1)
Temperature be 100 ± 2 DEG C.
Pass through repeatedly as an improvement, cleaning up needs with deionized water in the step of solidification liquid (1), preferably 3
It is secondary.
As an improvement, stirring 1h under the conditions of water bath heating temperature is 72 ± 2 DEG C in the step of solidification liquid (3).
As an improvement, in the step of solidification liquid (4) by the solution after dialysis by supercentrifuge 6500~
It is centrifuged 8~15min under 8000r/min revolving speed, obtains fresh silk fibroin solution.
Compared with the background technology, the present invention, it has the beneficial effect that medical dressing product of the invention is soft, can be close to
The surface of a wound, air permeable humidity retaining is good, is suitable for wound of various shapes, particularly suitable for the wound of difficult fixed position, has bonding skin
Skin and the double effects for absorbing wound fluid, sodium alginate have the function of that the growth of epidermal tissue can be promoted to be beneficial to newborn
The growth of tissue promotes Wound healing, mitigates patient's pain.
Specific embodiment
Embodiment 1
Step 1: configuration solidification liquid
(1) 20g silkworm raw silk is taken to be put into the Na2CO3 solution that concentration that 1.3L boils is 0.7 ‰, at 100 ± 2 DEG C
Under the conditions of continue heating boil 30min, then cleaned up with deionized water, obtain the complete fibroin fiber of degumming；
(2) by clean fibroin fiber garnetting, it is put into baking oven, is dried for standby at 70 DEG C；
(3) the domestic silkworm silk fibroin fiber after taking 5g to dry, be put into ternary solution with bath raio 1:6 (CaCl2:C2H5OH:
H2O is formulated with molar ratio 1:2:8), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, and it is molten to obtain the mixing of domestic silkworm silk fibroin
Liquid；
(4) it is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 75h, by the solution after dialysis
By being centrifuged 10min under supercentrifuge 7500r/min revolving speed, fresh silk fibroin solution is obtained.
Step 2: medical dressing is prepared
The sodium alginate soln that concentration is 2.0% is passed through into spinning nozzle, forms compound fibre with the solidification liquid of step 1 configuration
Dimension, then composite fibre is formed into acupuncture cotton by needling process, medical dressing is formed through moulding process.
Embodiment 2
Step 1: configuration solidification liquid
(1) 30g silkworm raw silk is taken to be put into the Na2CO3 solution that concentration that 1.7L boils is 0.4 ‰, at 100 ± 2 DEG C
Under the conditions of continue heating boil 30min, then cleaned up with deionized water, obtain the complete fibroin fiber of degumming；
(2) by clean fibroin fiber garnetting, it is put into baking oven, is dried for standby at 65 DEG C；
(3) the domestic silkworm silk fibroin fiber after taking 5g to dry, be put into ternary solution with bath raio 1:8 (CaCl2:C2H5OH:
H2O is formulated with molar ratio 1:2:8), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, and it is molten to obtain the mixing of domestic silkworm silk fibroin
Liquid；
(4) it is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 80h, by the solution after dialysis
By being centrifuged 10min under supercentrifuge 7500r/min revolving speed, fresh silk fibroin solution is obtained.
Step 2: medical dressing is prepared
The sodium alginate soln that concentration is 4% is passed through into spinning nozzle, forms composite fibre with the solidification liquid of step 1 configuration,
Composite fibre is formed into acupuncture cotton by needling process again, forms medical dressing through moulding process.
Embodiment 3
Step 1: configuration solidification liquid
(1) 40g silkworm raw silk is taken to be put into the Na2CO3 solution that concentration that 2L boils is 0.6 ‰, in 100 ± 2 DEG C of item
Continue heating under part and boil 30min, then cleaned up with deionized water, obtains the complete fibroin fiber of degumming；
(2) by clean fibroin fiber garnetting, it is put into baking oven, is dried for standby at 60 DEG C；
(3) the domestic silkworm silk fibroin fiber after taking 5g to dry, be put into ternary solution with bath raio 1:10 (CaCl2:C2H5OH:
H2O is formulated with molar ratio 1:2:8), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, and it is molten to obtain the mixing of domestic silkworm silk fibroin
Liquid；
(4) it is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 72h, by the solution after dialysis
By being centrifuged 10min under supercentrifuge 7500r/min revolving speed, fresh silk fibroin solution is obtained.
Step 2: medical dressing is prepared
The sodium alginate soln that concentration is 3.0% is passed through into spinning nozzle, forms compound fibre with the solidification liquid of step 1 configuration
Dimension, then composite fibre is formed into acupuncture cotton by needling process, medical dressing is formed through moulding process.
Embodiment 4
Step 1: configuration solidification liquid
(1) 50g silkworm raw silk is taken to be put into the Na2CO3 solution that concentration that 3L boils is 0.8 ‰, in 100 ± 2 DEG C of item
Continue heating under part and boil 30min, then cleaned up with deionized water, obtains the complete fibroin fiber of degumming；
(2) by clean fibroin fiber garnetting, it is put into baking oven, is dried for standby at 50 DEG C；
(3) the domestic silkworm silk fibroin fiber after taking 5g to dry, be put into ternary solution with bath raio 1:12 (CaCl2:C2H5OH:
H2O is formulated with molar ratio 1:2:8), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, and it is molten to obtain the mixing of domestic silkworm silk fibroin
Liquid；
(4) it is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 68h, by the solution after dialysis
By being centrifuged 10min under supercentrifuge 7500r/min revolving speed, fresh silk fibroin solution is obtained.
Step 2: medical dressing is prepared
The sodium alginate soln that concentration is 2.5% is passed through into spinning nozzle, forms compound fibre with the solidification liquid of step 1 configuration
Dimension, then composite fibre is formed into acupuncture cotton by needling process, medical dressing is formed through moulding process.
Above-mentioned specific embodiment is used to illustrate the present invention, rather than limits the invention, of the invention
In spirit and scope of protection of the claims, to any modifications and changes that the present invention makes, protection model of the invention is both fallen within
It encloses.
Claims (9)
1. it is a kind of with antibacterial, can promote the medical dressing of wound healing, it is characterised in that: compound concentration is 2.0%~4.0%
Sodium alginate soln, obtain spinning solution；The silk fibroin solution that ternary solution is dissolved into is as solidification liquid；Spinning solution is passed through
Enter the formation calcium alginate compounded fiber of fibroin in solidification liquid after crossing the spinning nozzle extrusion of spinning machine, then fibroin calcium alginate is answered
Condensating fiber forms acupuncture cotton by needling process, forms medical dressing through moulding process.
2. it is according to claim 1 it is a kind of with antibacterial, can promote the medical dressing of wound healing, it is characterised in that: institute
It states ternary solution and is formulated by CaCl2:C2H5OH:H2O by 1:2:8.
3. it is described in claim 1 it is a kind of with antibacterial, can promote the preparation method of wound healing medical dressing, feature exists
In: the preparation step of the solidification liquid in this method is as follows:
(1) 20~50g silkworm raw silk is taken to be put into the Na2CO3 solution that 1~3L boils, heating boil 30min, then spend from
Sub- water cleans up, and obtains the complete fibroin fiber of degumming；
(2) it by clean fibroin fiber garnetting, is dried for standby in 45 DEG C~70 DEG C of baking oven；
(3) the domestic silkworm silk fibroin fiber after taking 5g to dry, with bath raio 1:(6~12) it is put into heating water bath in ternary solution and stirs
It mixes, obtains domestic silkworm silk fibroin mixed solution；
(4) it is packed into bag filter after solution to be mixed is cooling, with fresh 68~80h of deionized water dialysis, by the solution after dialysis
By centrifugation, fresh silk fibroin solution is obtained.
4. it is according to claim 1 it is a kind of with antibacterial, can promote the medical dressing of wound healing, it is characterised in that: institute
Sodium alginate soln is stated to be prepared by the way that sodium alginate soln is dissolved in water.
5. the preparation method according to claim 3 for having antibacterial, can promote wound healing medical dressing, feature exist
In: the concentration of the Na2CO3 solution in the preparation step (1) of the solidification liquid is 0.4 ‰~0.8 ‰, preferably 0.6 ‰.
6. the preparation method according to claim 1 for having antibacterial, can promote wound healing medical dressing, feature exist
It is 100 ± 2 that silkworm raw silk, which is put into the temperature heated in the Na2CO3 solution boiled, in (1) in: the solidification liquid the step of
℃。
7. the preparation method according to claim 3 for having antibacterial, can promote wound healing medical dressing, feature exist
Needs are cleaned up by repeatedly with deionized water in (1) in: the solidification liquid the step of, preferably 3 times.
8. the preparation method according to claim 3 for having antibacterial, can promote wound healing medical dressing, feature exist
1h is stirred under the conditions of water bath heating temperature is 72 ± 2 DEG C in (3) in: the solidification liquid the step of.
9. the preparation method according to claim 3 for having antibacterial, can promote wound healing medical dressing, feature exist
In: the solidification liquid the step of in (4) by the solution after dialysis by being centrifuged under 6500~8000r/min of supercentrifuge revolving speed
8~15min obtains fresh silk fibroin solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910391916.7A CN110227175A (en) | 2019-05-13 | 2019-05-13 | It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910391916.7A CN110227175A (en) | 2019-05-13 | 2019-05-13 | It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof |
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| CN110227175A true CN110227175A (en) | 2019-09-13 |
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| CN201910391916.7A Pending CN110227175A (en) | 2019-05-13 | 2019-05-13 | It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917384A (en) * | 2019-12-14 | 2020-03-27 | 浙江惠龙医疗科技股份有限公司 | Medical dressing with antibacterial and high absorption functions and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1940153A (en) * | 2006-09-21 | 2007-04-04 | 青岛大学 | Chitose graft alginate fibre, its production and use |
| CN101049515A (en) * | 2007-05-15 | 2007-10-10 | 浙江理工大学 | Method for preparing medical use dressing of non-woven fabrics in wet-process cross blent from chitosan and silk fibrino |
| KR20130006834A (en) * | 2011-06-24 | 2013-01-18 | 주식회사 바이오알파 | Method for producing silk film for the protection of skins and wounds |
| CN103806123A (en) * | 2014-03-03 | 2014-05-21 | 武汉理工大学 | Silk fibroin/sodium alginate composite fiber and preparation method thereof |
| CN106267309A (en) * | 2016-08-19 | 2017-01-04 | 广东泰宝医疗科技股份有限公司 | A kind of alginate compound antiseptic dressing and preparation method thereof |
-
2019
- 2019-05-13 CN CN201910391916.7A patent/CN110227175A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1940153A (en) * | 2006-09-21 | 2007-04-04 | 青岛大学 | Chitose graft alginate fibre, its production and use |
| CN101049515A (en) * | 2007-05-15 | 2007-10-10 | 浙江理工大学 | Method for preparing medical use dressing of non-woven fabrics in wet-process cross blent from chitosan and silk fibrino |
| KR20130006834A (en) * | 2011-06-24 | 2013-01-18 | 주식회사 바이오알파 | Method for producing silk film for the protection of skins and wounds |
| CN103806123A (en) * | 2014-03-03 | 2014-05-21 | 武汉理工大学 | Silk fibroin/sodium alginate composite fiber and preparation method thereof |
| CN106267309A (en) * | 2016-08-19 | 2017-01-04 | 广东泰宝医疗科技股份有限公司 | A kind of alginate compound antiseptic dressing and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917384A (en) * | 2019-12-14 | 2020-03-27 | 浙江惠龙医疗科技股份有限公司 | Medical dressing with antibacterial and high absorption functions and preparation method thereof |
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