CN102389584B - Preparation method of konjac sponge medical dressing - Google Patents
Preparation method of konjac sponge medical dressing Download PDFInfo
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Abstract
The invention discloses a Konjac sponge medical dressing and a preparation method thereof and belongs to the technical field of medicines. The preparation method comprises the following steps: making an aqueous solution of Konjac refined powder containing 50% to 90% of Konjac glucomannan and having a molecular weight of 100000 to 500000, forming Konjac sponge, curing the Konjac sponge, cutting the Konjac sponge, packaging, and sterilizing to obtain the Konjac sponge medical dressing with liquid absorption capacity of 100 to 300 g/g and air permeability of 80% to 90%. The Konjac sponge medical dressing has a smooth and crack-free surface; is excellent in flexibility, elasticity, air permeability, barrier property, wear resistance, water absorptivity, biocompatibility, degradability and removability; can be used for treating different types of skin wounds, such as surgical wounds and burn wounds; and achieves the effects of preventing bacterial infection, accelerating tissue repair and promoting wound healing.
Description
Technical field
The present invention relates to a kind of konjac sponge medical dressing and preparation method thereof, belong to medical technical field.
Background technology
Skin has the invasion of the outer pathogenetic bacteria of opposed body, and excretion human body waste prevents that body water evaporation scatters and disappears, and mediator's temperature is experienced the important function such as stimulation of pressure, cold, temperature.Because of wound, scratch, burn and fester etc. while causing skin damage, be easy to bacterial infection, or fluid loss occur and cause various complication, while therefore treating, need to protect wound surface and promote wound healing with medical dressing.Traditional medical dressing (gauze) only plays flap coverage, along with social development and scientific and technological progress, particularly developing rapidly of modern medicine, biology and polymer material science, there is basic variation in the concept of modern dressing.Modern medical dressing should possess: the spreadability that (1) is excellent, can stop the breeding on wound of bacterial invasion and restricting bacterial; (2) good moisture pick-up properties and blocking performance, can absorbing wound exudate, hinders the dipping of transudate to health tissues simultaneously; (3) good elasticity, pliability, breathability and hemostatic function; (4) good biocompatibility, life-time service can not cause the ill symptomses such as wound site skin sensitivity or anaphylaxis; (5) provide moist healing environment, the healing of accelerated in wounds; (6) stable on wound surface, easily to remove, application is convenient with storage; (7) biodegradable, its garbage can not cause environmental pollution.The sponge material that adopts natural macromolecular material to process, there is excellent biocompatibility and degradability, and sponge material has very strong water absorbing capacity because having special loose structure, when contacting with moist wound, the wound fluids such as pus and blood are absorbed among sponge by pore, and shifted to inside and the rear back side of sponge by contact surface, thereby played the effect that pus and blood is removed from wound surface.Meanwhile, be adsorbed on transudate in sponge material not volatile, the wet environment that provides wound healing to need, accelerates the growth of wound surface granulation tissue, is therefore suitable for very much making medical dressing.
Rhizoma amorphophalli is NANTIANXING section Amorphophallus herbaceos perennial, wherein contains 40%～60% glucomannoglycan (KGM), is the only plant that can obtain in a large number glucomannoglycan of nature of finding so far.Rhizoma amorphophalli glucomannan structure uniqueness, the ratio by glucose, mannose in 1: 1.6, main chain is connected by 1-4 glycosidic bond, the heteropolysaccharide of the relative molecular weight narrow distribution that short-chain branch connects with 1-3 glycosidic bond.The sweet polysaccharide of Rhizoma amorphophalli has high viscosity, high expansion and high resiliency and good foaming capacity, and biocompatibility and degradability excellence, can be used for preparing sponge material.China Patent Publication No. is CN 1184180 A, open day is on June 10th, 1998, denomination of invention is the processing technology of Rhizoma amorphophalli foam, this application case adds konjaku powder in boiling water, after expansion, add alkali liquor to obtain compound, then injection molding, gas steam, freezing, except alkali, kill enzyme, decolouring, color fixative, natural drying, packing and spongy Rhizoma amorphophalli product.China Patent Publication No. is CN 1197676 A, open day is on November 4th, 1998, denomination of invention is health dressing and the method for making thereof made from Rhizoma amorphophalli, it is 8～12 that this application case regulates pH value by the hydrothermal solution of glucomannan with alkali liquor, then vigorous stirring forms a large amount of foams, freezing and hyperthermia drying and obtain spongy Rhizoma amorphophalli product.China Patent Publication No. is CN1249313 A, open day is on April 5th, 2000, denomination of invention is the manufacture method of Rhizoma amorphophalli beautifying face, preserving moisture and protecting skin sponge, this application case adds konjaku powder in boiling water, to form thick liquid, add after alkali injection molding high temperature steaming and obtain just base of colloid, then after freezing, lixiviating, decolouring, color fixative, moisturizing, pack packaging bag into, vacuum nitrogen filling gas, after sealing, high temperature sterilize gets product.China Patent Publication No. is CN 1583838 A, open day is on February 3rd, 2005, denomination of invention is a kind of preparation method of macroporous konjaku gel, this application case discloses take konjaku powder as raw material, inorganic base is flocculating agent, by pyroreaction, form gel, then, by freezing, room temperature thawing, multigelation, lyophilizing obtains macroporous konjaku gel.China Patent Publication No. is CN 101011163A, open day is on August 8th, 2007, denomination of invention is the Villiform edible keep-fit massage towel made from Rhizoma amorphophalli, grain, this application case is mixed with Grain Powder after Rhizoma amorphophalli powder is added to water gelatinizing, and add ferment-fermented and coagulant to solidify, then partial material is ground into powder, through mixing, injection molding, ripening, freezing, thaw, dewater, final oven dry form.China Patent Publication No. is CN 101147658 A, open day is on March 26th, 2008, denomination of invention is the konjak towel with skin-protecting function, this application case is mixed with Grain Powder after Rhizoma amorphophalli powder is added to water gelatinizing, and add ferment-fermented and coagulant to solidify, then injection molding, ripening, freezing, thaw, dewater, soak skin protection vegetable slurries, vacuum drying forms.China Patent Publication No. is CN 101423613 A, open day is on May 6th, 2009, denomination of invention is method for preparing glucomanna sponge through environment-friendly method, this application case discloses take calcium hydroxide as flocculating agent, does not produce the environmental friendliness preparation method of glucomannan sponge for the shower of the anhydrous and decolouring sewage of alkalescence in production technology.China Patent Publication No. is CN 102178484 A, within open day, be JIUYUE in 2011 14 days, denomination of invention is Rhizoma amorphophalli face-cloth having bathing and massage functions and preparation method thereof, this application case discloses Konjak dietary fiber powder is added and adds flocculating agent after water gelatinizing again and prepare compound, and then the method for konjac sponge face-cloth is prepared in freezing and the dehydration of thawing, bleaching, desulfurization, sterilization and lyophilization repeatedly for injection molding, steaming and decocting, low temperature.
The method of preparing konjac sponge material of bibliographical information is freeze-thaw method at present, the compact structure of this class konjac sponge, and water suction multiple is little, rate of water absorption is slow, and this product hardens during drying regime, rough surface, easy breed bacteria when moistening, the short time will degrade, and stores difficulty.Therefore, such konjac sponge only can be used for making the products such as towel, face wiping and powder puff, cannot meet the instructions for use of medical dressing.
Summary of the invention
For the problem of above-mentioned existence, the object of the present invention is to provide a kind of take konjaku powder as raw material, simple konjac sponge medical dressing of production technology and preparation method thereof, and the excellent combination properties such as the hygroscopicity of this konjac sponge medical dressing, breathability, pliability, toughness, elasticity and intensity, can be used in various types of skin traumas such as treatment surgical wound, empyrosis wound surface, to achieve these goals, its technical solution is:
A kind of konjac sponge medical dressing, konjac sponge medical dressing is take glucomannoglycan content as 50%～90%, molecular weight is that 100000～500000 konjaku powder is raw material, distilled water is solvent, adopt high-speed stirred and high-temperature digestion to prepare solution, by low temperature pre-freeze and vacuum drying technique, be shaped, then adopt sodium hydroxide alcoholic solution cured, and form through cutting, subpackage, sterilizing, the liquid absorption of wherein said konjac sponge medical dressing is 100～300g/g, and air penetrability is 80%～90%.
A preparation method for konjac sponge medical dressing, the preparation method of konjac sponge medical dressing comprises the steps:
The preparation of a konjaku powder aqueous solution
The ratio that is 1: 0.01～0.05 with konjaku powder according to mass ratio by distilled water is mixed, then high-speed stirred is dissolved, the rotating speed of homogenizer is 5000～10000r/min, solution temperature is 30～60 ℃, dissolution time is 2～6h, the konjaku powder aqueous solution that obtains being uniformly dissolved, wherein in konjaku powder, glucomannoglycan content is 50%～90%, molecular weight is 100000～500000;
The shaping of b konjac sponge
The konjaku powder aqueous solution making through step a is divided to install to and in mould, carry out pre-freeze, pre-freeze temperature is-26～-16 ℃, the pre-freeze time is 5～12h, then mould is placed in to vacuum drying oven and carries out vacuum drying, vacuum≤100Pa, baking temperature is 30～50 ℃, and be 4～12h drying time, and the dry rear demoulding obtains the konjac sponge being shaped;
The cured of c konjac sponge
The ratio that is 1: 0.01～0.05 with sodium hydroxide according to mass ratio by ethanol is mixed, then be stirred to and be uniformly dissolved, obtain the coagulating bath of konjac sponge, the konjac sponge obtaining through step b is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 40～60 ℃, be 2～8h hardening time, then the konjac sponge after solidifying is placed in to ethanol and carries out rinsing, and bath raio is 1: 100, wash time is 3～5min/ time, wash 2～5 times, after taking out, naturally dry, obtain solidifying konjac sponge;
The preparation of d konjac sponge dressing
By the curing konjac sponge cutting, the packing that obtain through step c, then through Co
60irradiation sterilization, obtaining liquid absorption is 100～300g/g, the konjac sponge medical dressing that air penetrability is 80%～90%.
Owing to having adopted technique scheme, the useful technique effect of a kind of konjac sponge medical dressing of the present invention and preparation method thereof is:
The preparation of 1 konjac sponge medical dressing of the present invention is take glucomannoglycan content as 50%～90%, molecular weight is that 100000～500000 konjaku powder is raw material, by the adjusting of the purity of konjaku powder and the control of molecular weight and konjaku powder concentration of aqueous solution, obtain dissolving the solution of abundant and modest viscosity, thereby it is reasonable to obtain space structure, the excellent combination properties such as elasticity, toughness and intensity, liquid absorption reaches 100～300g/g, and air penetrability reaches 80%～90% konjac sponge medical dressing.
The preparation of 2 konjac sponge medical dressings of the present invention adopts low temperature pre-freeze and vacuum drying technique to be shaped, by the crystallization of water and the mode of distillation, obtain hygroscopicity and breathability excellence, bio-compatible and biodegradable, the konjac sponge material of fine and smooth smooth and the flawless and easy removal in surface, this konjac sponge material can be used as medical dressing and is used for the treatment of surgical wound, various types of skin traumas such as empyrosis wound surface, make up existing konjac sponge and only can be used for making towel, the defect of the products such as face wiping and powder puff, expanded the range of application of Rhizoma amorphophalli, for the comprehensive development and utilization of agricultural byproducts provides an effective way.
The preparation of 3 konjac sponge medical dressings of the present invention adopts the alcoholic solution of sodium hydroxide to be cured, and clean take ethanol as cleaning mixture, can effectively prevent the coarse of the subsiding of sponge pore space structure, adhesion and sealing and sponge surface and harden, without adding softening agent, just can obtain flexibility excellence, liquid absorption reaches 100～300g/g, and air penetrability reaches 80%～90% konjac sponge medical dressing.
The preparation method of 4 konjac sponges of the present invention adopts general refrigerator pre-freeze and vacuum drying oven vacuum drying, and adopt the technology of natural air drying to prepare konjac sponge medical dressing, production equipment and technique are simple and energy consumption is low, reduced production cost, it is convenient to store, and is conducive to promoting the use of of konjac sponge medical dressing.
The specific embodiment
A kind of konjac sponge medical dressing, konjac sponge medical dressing is take glucomannoglycan content as 50%～90%, molecular weight is that 100000～500000 konjaku powder is raw material, by low temperature pre-freeze and vacuum drying technique, be shaped, then adopt sodium hydroxide alcoholic solution cured, and form through cutting, subpackage, sterilizing, the liquid absorption of wherein said konjac sponge medical dressing is 100～300g/g, air penetrability is 80%～90%.
A preparation method for konjac sponge medical dressing, the preparation method of konjac sponge medical dressing comprises the steps:
The preparation of a konjaku powder aqueous solution
The ratio that is 1: 0.01～0.05 with konjaku powder according to mass ratio by distilled water is mixed, then high-speed stirred is dissolved, the rotating speed of homogenizer is 5000～10000r/min, solution temperature is 30～60 ℃, dissolution time is 2～6h, the konjaku powder aqueous solution that obtains being uniformly dissolved, wherein in konjaku powder, glucomannoglycan content is 50%～90%, molecular weight is 100000～500000.
Because its molecular weight of konjaku powder is higher, viscosity is large and purity is lower, dissolves more difficultly, and the present invention adopts the way of high-speed stirred and high-temperature digestion, has realized the dissolving of konjaku powder in distilled water, has shortened dissolution time.
The shaping of b konjac sponge
The konjaku powder aqueous solution making through step a is divided and installed in mould, then be placed in refrigerator and carry out pre-freeze, pre-freeze temperature is-26～-16 ℃, the pre-freeze time is 5～12h, then mould is placed in to vacuum drying oven and carries out vacuum drying, vacuum≤100Pa, baking temperature is 30～50 ℃, be 4～12h drying time, and the dry rear demoulding obtains the konjac sponge being shaped.
Existing technique is to adopt freeze-thaw method to prepare konjac sponge material, by pinprick (thorn) by the thawing water discharge in konjak gel, thereby obtain the spongy Rhizoma amorphophalli material of porous.Because the density of gelinite volume large and thawing water is larger, so the sponge making is hardened after coarse and dry, cannot meet the instructions for use of medical dressing.Preparation method of the present invention adopts low temperature pre-freeze and high-temperature vacuum dry technology to be shaped, in pre-freeze process, konjaku powder aqueous solution freezes, the tiny water of crystallization crystal grain of inner formation, water of crystallization crystal grain distillation when high-temperature vacuum is dry, leave fine and closely woven hole, thereby obtain fine and smooth softness, elasticity and tenacity excellent, and the exsertile spongy Rhizoma amorphophalli material of breathability and water absorption, meets the instructions for use of medical dressing.In addition, existing Vacuum Freezing & Drying Technology need to adopt freezer dryer, this equipment cost is high and energy consumption is high, the present invention has realized the preparation of konjac sponge by domestic refrigerator (or freezer) and common vacuum drying oven, reduced equipment cost, and the baking temperature of vacuum drying oven is higher, shortened drying time, save the energy, reduced the cost of product, be conducive to promoting the use of of this product.
The cured of c konjac sponge
The ratio that is 1: 0.01～0.05 with sodium hydroxide according to mass ratio by ethanol is mixed, then be stirred to and be uniformly dissolved, obtain the coagulating bath of konjac sponge, the konjac sponge obtaining through step b is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 40～60 ℃, be 2～8h hardening time, then the konjac sponge after solidifying is placed in to ethanol and enters rinsing, bath raio is 1: 100, wash time is 3～5min/ time, wash 2～5 times, in order to save wash time and to strengthen clean result, the present invention also can carry out ultrasonic washing to konjac sponge, hyperacoustic power is 1200W, temperature is 50 ℃, after taking out, naturally dry, obtain solidifying konjac sponge, described ethanol is 100% analytical pure.
Konjac sponge after lyophilization is shaped is water-soluble, therefore needs to be cured and processes to improve its water absorption, meets the instructions for use of medical dressing.In existing technique, the flocculation of Rhizoma amorphophalli is bathed and is adopted the aqueous solution of sodium hydroxide, because konjac sponge is water-soluble, in process of setting the part pore space structure of sponge cave in, adhesion and sealing, make compact structure, hard, the embrittlement of sponge and lack flexibility.Preparation method of the present invention is the coagulating bath as konjac sponge with the alcoholic solution of sodium hydroxide, and adopt ethanol as cleaning mixture, utilize konjac sponge to be insoluble to the characteristic of ethanol, effectively avoided the problems referred to above, thereby obtain pliability and all good konjac sponges of elasticity.In addition, because ethanol is easy to volatilization, do not need to be shaped and hyperthermia drying processing through secondary freeze drying, air-dryly under natural conditions just can obtain dry konjac sponge, saved the energy, reduced cost.
The preparation of d konjac sponge dressing
By the curing konjac sponge cutting, the packing that obtain through step c, then through Co
60irradiation sterilization, obtaining liquid absorption is 100～300g/g, the konjac sponge medical dressing that air penetrability is 80%～90%.
Preparation method of the present invention is by purity and the molecular weight control of konjaku powder raw material, and the adjusting of konjaku powder concentration of aqueous solution, and by high-speed stirred and high-temperature digestion, obtain dissolving the solution of abundant and modest viscosity, adopt low temperature pre-freeze and high-temperature vacuum dry technology to obtain flexible spongy Rhizoma amorphophalli material, and using the alcoholic solution of sodium hydroxide as the coagulating bath of konjac sponge and ethanol as cleaning mixture, improved the water absorption of konjac sponge, effectively avoid the pore space structure of konjac sponge to cave in simultaneously, adhesion and sealing, thereby it is reasonable to obtain space structure, surface is fine and smooth smooth and flawless, and pliability, elasticity, the excellent combination property such as toughness and intensity, liquid absorption reaches 100～300g/g, air penetrability reaches 80%～90%, bio-compatible and biodegradable konjac sponge medical dressing, this konjac sponge material can be used as medical dressing and is used for the treatment of surgical wound, various types of skin traumas such as empyrosis wound surface, make up existing konjac sponge and only can be used for making towel, the defect of the products such as face wiping and powder puff, expanded the range of application of Rhizoma amorphophalli, for the comprehensive development and utilization of agricultural byproducts provides an effective way.
Below in conjunction with specific embodiment, a kind of konjac sponge medical dressing of the present invention and preparation method thereof is described in further detail:
Specific embodiment
Embodiment 1
Take successively 100 grams of distilled water, 5 grams of glucomannoglycan content and be 50% and the molecular weight konjaku powder that is 100000, while stirring the konjaku powder taking is added in the distilled water of 60 ℃, high-speed stirred is dissolved, the rotating speed of homogenizer is 5000r/min, dissolution time is 6h, the konjaku powder aqueous solution that obtains being uniformly dissolved; Konjaku powder aqueous solution is divided and installed in mould, and the refrigerator that mould is placed in to-26 ℃ carries out pre-freeze, and the pre-freeze time is 5h, then the vacuum drying oven that is placed in 50 ℃ carries out vacuum drying, vacuum is 60Pa, and be 4h drying time, and then the demoulding obtains the konjac sponge being shaped; Take successively the ethanol of 100 grams, the sodium hydroxide of 5 grams, sodium hydroxide is added in ethanol and stirred, obtain the coagulating bath of konjac sponge, the konjac sponge of shaping is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 60 ℃, be 2h hardening time, then konjac sponge is placed in to ethanol rinsing, wash time is 3min/ time, washs 5 times, washed and naturally dried afterwards, obtained solidifying konjac sponge; By konjac sponge cutting, packing after solidifying, then through Co
60it is 100g/g that irradiation sterilization obtains liquid absorption, the konjac sponge medical dressing that air penetrability is 90%.
Embodiment 2
Take successively 100 grams of distilled water, 1 gram of glucomannoglycan content and be 90% and the molecular weight konjaku powder that is 500000, while stirring the konjaku powder taking is added in the distilled water of 30 ℃, high-speed stirred is dissolved, the rotating speed of homogenizer is 10000r/min, dissolution time is 2h, the konjaku powder aqueous solution that obtains being uniformly dissolved; Konjaku powder aqueous solution is divided and installed in mould, and the refrigerator that mould is placed in to-16 ℃ carries out pre-freeze, and the pre-freeze time is 12h, then the vacuum drying oven that is placed in 30 ℃ carries out vacuum drying, vacuum is 100Pa, and be 12h drying time, and then the demoulding obtains the konjac sponge being shaped; Take successively the ethanol of 100 grams, the sodium hydroxide of 1 gram, sodium hydroxide is added in ethanol and stirred, obtain the coagulating bath of konjac sponge, the konjac sponge of shaping is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 40 ℃, be 8h hardening time, then konjac sponge is placed in to ethanol rinsing, wash time is 5min/ time, washs 2 times, washed and naturally dried afterwards, obtained solidifying konjac sponge; By konjac sponge cutting, packing after solidifying, then through Co
60it is 300g/g that irradiation sterilization obtains liquid absorption, the konjac sponge medical dressing that air penetrability is 80%.
Embodiment 3
Take successively 100 grams of distilled water, 4 grams of glucomannoglycan content and be 60% and the molecular weight konjaku powder that is 180000, while stirring the konjaku powder taking is added in the distilled water of 50 ℃, high-speed stirred is dissolved, the rotating speed of homogenizer is 6000r/min, dissolution time is 5h, the konjaku powder aqueous solution that obtains being uniformly dissolved; Konjaku powder aqueous solution is divided and installed in mould, and the refrigerator that mould is placed in to-18 ℃ carries out pre-freeze, and the pre-freeze time is 8h, then the vacuum drying oven that is placed in 35 ℃ carries out vacuum drying, vacuum is 90Pa, and be 10h drying time, and then the demoulding obtains the konjac sponge being shaped; Take successively the ethanol of 100 grams, the sodium hydroxide of 4 grams, sodium hydroxide is added in ethanol and stirred, obtain the coagulating bath of konjac sponge, the konjac sponge of shaping is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 50 ℃, and be 4h hardening time, then konjac sponge is placed in to ethanol and carries out ultrasonic cleaning, the power of ultrasonic echography ripple is 1200W, temperature is 50 ℃, and wash time is 3min/ time, washs 3 times, washed and naturally dried afterwards, obtained solidifying konjac sponge; By konjac sponge cutting, packing after solidifying, then through Co
60it is 250g/g that irradiation sterilization obtains liquid absorption, the konjac sponge medical dressing that air penetrability is 85%.
Embodiment 4
Take successively 100 grams of distilled water, 3 grams of glucomannoglycan content and be 70% and the molecular weight konjaku powder that is 220000, while stirring the konjaku powder taking is added in the distilled water of 40 ℃, high-speed stirred is dissolved, the rotating speed of homogenizer is 7000r/min, dissolution time is 4h, the konjaku powder aqueous solution that obtains being uniformly dissolved; Konjaku powder aqueous solution is divided and installed in mould, and the refrigerator that mould is placed in to-20 ℃ carries out pre-freeze, and the pre-freeze time is 10h, then the vacuum drying oven that is placed in 30 ℃ carries out vacuum drying, vacuum is 80Pa, and be 8h drying time, and then the demoulding obtains the konjac sponge being shaped; Take successively the ethanol of 100 grams, the sodium hydroxide of 3 grams, sodium hydroxide is added in ethanol and stirred, obtain the coagulating bath of konjac sponge, the konjac sponge of shaping is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 40 ℃, and be 5h hardening time, then konjac sponge is placed in to ethanol ultrasonic cleaning, the power of ultrasonic echography ripple is 1200W, temperature is 50 ℃, and wash time is 5min, washs 1 time, washed and naturally dried afterwards, obtained solidifying konjac sponge; By konjac sponge cutting, packing after solidifying, then through Co
60it is 200g/g that irradiation sterilization obtains liquid absorption, the konjac sponge medical dressing that air penetrability is 90%.
Embodiment 5
Take successively 100 grams of distilled water, 2 grams of glucomannoglycan content and be 80% and the molecular weight konjaku powder that is 310000, while stirring the konjaku powder taking is added in the distilled water of 60 ℃, high-speed stirred is dissolved, the rotating speed of homogenizer is 6000r/min, dissolution time is 3h, the konjaku powder aqueous solution that obtains being uniformly dissolved; Konjaku powder aqueous solution is divided and installed in mould, and the refrigerator that mould is placed in to-22 ℃ carries out pre-freeze, and the pre-freeze time is 12h, then the vacuum drying oven that is placed in 30 ℃ carries out vacuum drying, vacuum is 80Pa, and be 6h drying time, and then the demoulding obtains the konjac sponge being shaped; Take successively the ethanol of 100 grams, the sodium hydroxide of 2 grams, sodium hydroxide is added in ethanol and stirred, obtain the coagulating bath of konjac sponge, the konjac sponge of shaping is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 50 ℃, be 6h hardening time, then konjac sponge is placed in to ethanol rinsing, wash time is 5min/ time, washs 2 times, washed and naturally dried afterwards, obtained solidifying konjac sponge; By konjac sponge cutting, packing after solidifying, then through Co
60it is 180g/g that irradiation sterilization obtains liquid absorption, the konjac sponge medical dressing that air penetrability is 85%.
Claims (1)
1. a preparation method for konjac sponge medical dressing, is characterized in that: the preparation method of konjac sponge medical dressing comprises the steps,
The preparation of a konjaku powder aqueous solution
The ratio that is 1:0.01～0.05 with konjaku powder according to mass ratio by distilled water is mixed, then high-speed stirred is dissolved, the rotating speed of homogenizer is 5000～10000r/min, solution temperature is 30～60 ℃, dissolution time is 2～6h, the konjaku powder aqueous solution that obtains being uniformly dissolved, wherein in konjaku powder, glucomannoglycan content is 50%～90%, molecular weight is 100000～500000;
The shaping of b konjac sponge
The konjaku powder aqueous solution making through step a is divided to install to and in mould, carry out pre-freeze, pre-freeze temperature is-26～-16 ℃, the pre-freeze time is 5～12h, then mould is placed in to vacuum drying oven and carries out vacuum drying, vacuum≤100Pa, baking temperature is 30～50 ℃, and be 4～12h drying time, and the dry rear demoulding obtains the konjac sponge being shaped;
The cured of c konjac sponge
The ratio that is 1:0.01～0.05 with sodium hydroxide according to mass ratio by ethanol is mixed, then be stirred to and be uniformly dissolved, obtain the coagulating bath of konjac sponge, the konjac sponge obtaining through step b is immersed in above-mentioned coagulating bath and is cured, solidification temperature is 40～60 ℃, be 2～8h hardening time, then the konjac sponge after solidifying is placed in to ethanol and carries out rinsing, and bath raio is 1:100, wash time is 3～5min/ time, wash 2～5 times, after taking out, naturally dry, obtain solidifying konjac sponge;
The preparation of d konjac sponge dressing
By the curing konjac sponge cutting, the packing that obtain through step c, then through Co
60irradiation sterilization, obtaining liquid absorption is 100～300g/g, the konjac sponge medical dressing that air penetrability is 80%～90%.
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| CN103418020B (en) * | 2013-08-31 | 2015-01-07 | 西南大学 | Devilstongue gulcomannan hemostatic sponge and preparation method thereof |
| CN105949496A (en) * | 2016-06-20 | 2016-09-21 | 福建农林大学 | Konjac glucomannan oil-absorbing material and preparation method thereof |
| CN107185026B (en) * | 2017-05-15 | 2020-07-07 | 陕西科技大学 | Preparation method of medical konjac glucomannan antibacterial dressing |
| CN113974214A (en) * | 2021-12-17 | 2022-01-28 | 云南杰商科技有限公司 | Food-grade degradable environment-friendly filter tip and preparation method thereof |
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| CN102389584A (en) | 2012-03-28 |
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