CN110947022A - Preparation method of chitosan-based composite antibacterial dressing - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
The invention discloses a preparation method of a chitosan-based composite antibacterial dressing, which comprises the following operation steps: (1) carrying out oxidation reaction on konjac glucomannan and hemp fiber powder by adopting an oxidant sodium periodate to obtain powder A; (2) mixing carboxymethyl chitosan, seaweed extract and mint extract, adding the mixture into water, continuously mixing and stirring until a uniformly mixed dispersion system appears, adding a plastic agent, adding a powder A solution, injecting the solution into a polytetrafluoroethylene culture dish, sealing the culture dish by using a preservative film, standing for crosslinking reaction, placing the culture dish into a refrigerator for pre-freezing, transferring the culture dish to an environment with the temperature of 35 ℃ below zero to 38 ℃ below zero, and finally freezing and drying to prepare the chitosan-based composite antibacterial dressing. The chitosan-based composite antibacterial dressing prepared by the invention has excellent penetrating fluid absorption effect and antibacterial effect, has excellent biocompatibility, and can effectively promote the proliferation of epidermal fibroblasts and accelerate the speed of wound healing.
Description
Technical Field
The invention belongs to the technical field of medical antibacterial dressing preparation, and particularly relates to a preparation method of a chitosan-based composite antibacterial dressing.
Background
In the past 20 years, chitosan and some natural polymer materials are widely applied to the fields of biological materials and medical dressings, such as wound sutures, drug sustained-release carriers, tissue engineering scaffolds and the like. In the research of various natural polymer materials, chitosan has long been in the hot tide of research in various fields due to its various advantages and unique properties. Chitosan is a product formed by performing phthalidyl removal on chitin, namely phthalidyl-removed chitin, namely chitin and chitin, which are the only natural polymer materials which are in the nature, have cations and can be biodegraded. The chitosan is widely present in shells of shrimps, crabs and arthropods and in cell walls of some lower plants, and is a very abundant natural resource. Besides good biocompatibility and degradability, chitosan also has some excellent characteristics, such as improvement of body immunological activity, antibacterial and bacteriostatic ability, anti-tumor, procoagulant action, promotion of wound healing and the like. The excellent properties enable the chitosan to be used as an excellent biological material, thereby promoting the development of the fields of tissue engineering, biomedicine, drug carriers and medical dressings. In recent 30 years, due to the fact that many advantages of chitosan are well known, the chitosan is very colorful in the fields of clinical medicine, biological materials, drug carriers and the like, and is widely researched and applied.
Wound healing is a complex and delicate process, and is the result of the interaction of a series of different types of cells, protein kinases, growth factors, etc., which coordinate with each other to collectively complete wound repair. The moist wound healing theory provides that the moist wound can be kept moist, the formation of knots can be avoided, the wound recovery can be promoted, the moist environment can promote the wound healing in the aspects of increasing the epithelial regeneration, improving the activities of macrophages and fibroblasts, keeping the wound clean, relieving pain, reducing dressing change and the like. In order to achieve the effect of wet healing, dressings made of various emerging materials are inoculated. Among them, chitosan materials have been widely studied in the biological field due to their biocompatibility, biodegradability, nontoxicity and immunogenicity, and have been applied in the tissue engineering fields of vascular stents, wound repair, etc. In the field of wound repair, chitosan hemostatic plugging dressings and chitosan wound dressings are approved to be used in China.
However, the medical dressing prepared in the prior art cannot effectively prevent the wound of a patient from deteriorating, and cannot effectively promote the proliferation and growth of epidermal fibroblasts.
Disclosure of Invention
In order to solve the existing problems, the invention provides a preparation method of a chitosan-based composite antibacterial dressing.
The invention is realized by the following technical scheme.
A preparation method of chitosan-based composite antibacterial dressing comprises the following operation steps:
(1) adding konjac glucomannan and hemp fiber powder into deionized water according to the mass ratio of 18-22:1, continuously stirring until uniform dispersion liquid is obtained, adding sodium periodate serving as an oxidant into the dispersion liquid, performing oxidation reaction, performing rotary evaporation and concentration on a reaction product to one third of the volume, performing centrifugation after dialysis, collecting centrifugal supernatant, performing rotary evaporation and concentration, drying at constant temperature, and grinding into powder to obtain powder A;
(2) mixing 15-25 parts by weight of carboxymethyl chitosan, 1-3 parts by weight of seaweed extract and 2-5 parts by weight of mint extract, adding the mixture into 320 parts by weight of 280-one water, and continuously mixing and stirring until uniform mixing occurs
After the dispersion system is dispersed, adding a plasticizer, continuing stirring for 10-15min, adding 120-150 parts of powder A solution with the mass fraction of 10%, continuously stirring until the powder A is uniform, injecting the dispersion solution into a polytetrafluoroethylene culture dish, sealing the culture dish by using a preservative film, standing for crosslinking reaction, placing the culture dish into a refrigerator with the temperature of 1-3 ℃ for pre-freezing for 150min, transferring the culture dish to the environment with the temperature of minus 35 ℃ to minus 38 ℃ for treatment for 15-20h, and finally freezing and drying to prepare the chitosan-based composite antibacterial dressing.
Specifically, in the step (1), the hemp fiber powder has the thickness of 10-15 μm and the length of 0.03-0.06 mm.
Specifically, in the step (1), the adding amount of the sodium periodate is 65-70% of the mass of the konjac glucomannan.
Specifically, after the oxidation reaction in the step (1), adding ethylene glycol with the volume of 10-15% of that of deionized water to remove unreacted sodium periodate.
Specifically, in the step (1), the powder A is ground to have an average particle size of 600-800 mesh.
Specifically, in the step (2), the plasticizer is glycerol, and the addition amount of the plasticizer is 1-3% of the volume of water.
Specifically, in the step (2), the time for the standing crosslinking reaction is 50-60 min.
According to the technical scheme, the beneficial effects of the invention are as follows:
the chitosan-based composite antibacterial dressing prepared by the invention has excellent penetrating fluid absorption effect and antibacterial effect, has excellent biocompatibility, and can effectively promote the proliferation of epidermal fibroblasts and accelerate the speed of wound healing. According to the invention, after the konjac glucomannan and the hemp fiber powder are subjected to oxidation treatment, the konjac glucomannan and the hemp fiber powder have more excellent biocompatibility and water solubility, and are more stable in chemical and physical properties in the dressing, and aldehyde groups formed after the konjac glucomannan and the hemp fiber are subjected to oxidation treatment can also be used as a cross-linking agent, so that the finally prepared composite sponge has more excellent porosity and air permeability, and the gas exchange at the wound is effectively ensured, thereby being beneficial to the healing of the wound; the bioactive substances in the seaweed extract and the mint extract can effectively promote the proliferation of epidermal fibroblasts and accelerate the healing speed of wounds.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the following detailed description of the embodiments of the present invention is provided. However, it will be appreciated by those of ordinary skill in the art that numerous technical details are set forth in order to provide a better understanding of the present invention in its various embodiments. However, the technical solution claimed in the present invention can be implemented without these technical details and various changes and modifications based on the following embodiments.
Example 1
A preparation method of chitosan-based composite antibacterial dressing comprises the following operation steps:
(1) adding konjac glucomannan and hemp fiber powder with the thickness of 10-15 mu m and the length of 0.03-0.06mm into deionized water according to the mass ratio of 18:1, continuously stirring until uniform dispersion liquid is obtained, adding 65 percent of oxidant sodium periodate of the mass of the konjac glucomannan, after oxidation reaction, adding glycol with the volume of 10 percent of the deionized water to remove the sodium periodate which does not participate in the reaction, performing rotary evaporation and concentration on reaction products to one third of the volume, performing centrifugal collection after dialysis, performing rotary evaporation and concentration, drying at constant temperature, grinding into powder with the average particle size of 600 meshes to obtain powder A,
(2) mixing 15 parts by weight of carboxymethyl chitosan, 1 part by weight of seaweed extract and 2 parts by weight of mint extract, adding the mixture into 280 parts by weight of water, continuously mixing and stirring until a uniformly mixed dispersion system appears, adding 1% of plasticizer glycerol in water volume, continuously stirring for 10min, adding 120 parts by weight of powder A solution with the mass fraction of 10%, continuously stirring until the powder A is uniform, injecting the powder A solution into a polytetrafluoroethylene culture dish, sealing the powder A solution with a preservative film, standing for 50min for crosslinking reaction, pre-freezing the powder A solution in a refrigerator at the temperature of 1 ℃ for 120min, transferring the powder A solution to the environment at the temperature of 35 ℃ below zero to 38 ℃ for 15h, and finally freezing and drying the powder A solution to obtain the chitosan-based composite antibacterial dressing.
Example 2
A preparation method of chitosan-based composite antibacterial dressing comprises the following operation steps:
(1) adding konjac glucomannan and hemp fiber powder with the thickness of 10-15 mu m and the length of 0.03-0.06mm into deionized water according to the mass ratio of 20:1, continuously stirring until uniform dispersion liquid is obtained, adding 68% of oxidant sodium periodate of the mass of the konjac glucomannan, after oxidation reaction, adding ethylene glycol with the volume of 13% of the deionized water to remove the sodium periodate which does not participate in the reaction, performing rotary evaporation and concentration on the reaction product to one third of the volume, performing centrifugal collection after dialysis, performing rotary evaporation and concentration, drying at constant temperature, grinding into powder with the average particle size of 700 meshes to obtain powder A,
(2) mixing 20 parts by weight of carboxymethyl chitosan, 2 parts by weight of seaweed extract and 3 parts by weight of mint extract, adding the mixture into 300 parts by weight of water, continuously mixing and stirring until a uniformly mixed dispersion system appears, adding 2% of plasticizer glycerol in water volume, continuously stirring for 13min, adding 130 parts by weight of powder A solution with the mass fraction of 10%, continuously stirring until the powder A is uniform, injecting the powder A solution into a polytetrafluoroethylene culture dish, sealing the powder A solution by using a preservative film, standing for crosslinking reaction for 55min, pre-freezing for 130min in a refrigerator with the temperature of 2 ℃, transferring to the environment with the temperature of 35 ℃ below zero to 38 ℃ for 18h, and finally freezing and drying to prepare the chitosan-based composite antibacterial dressing.
Example 3
A preparation method of chitosan-based composite antibacterial dressing comprises the following operation steps:
(1) adding konjac glucomannan and hemp fiber powder with the thickness of 10-15 mu m and the length of 0.03-0.06mm into deionized water according to the mass ratio of 22:1, continuously stirring until uniform dispersion liquid is obtained, adding 70 percent of oxidant sodium periodate of the mass of the konjac glucomannan, after oxidation reaction, adding ethylene glycol with the volume of 15 percent of the deionized water to remove the sodium periodate which does not participate in the reaction, performing rotary evaporation and concentration on the reaction product to one third of the volume, performing centrifugal collection after dialysis, performing rotary evaporation and concentration, drying at constant temperature, grinding into powder with the average particle size of 800 meshes to obtain powder A,
(2) mixing 25 parts by weight of carboxymethyl chitosan, 3 parts by weight of seaweed extract and 5 parts by weight of mint extract, adding the mixture into 320 parts by weight of water, continuously mixing and stirring until a uniformly mixed dispersion system appears, adding 1-3% of plasticizer glycerol in water volume, continuously stirring for 15min, adding 150 parts by weight of powder A solution with the mass fraction of 10%, continuously stirring until the powder A is uniformly dispersed, injecting the powder A solution into a polytetrafluoroethylene culture dish, sealing the powder A solution with a preservative film, standing for crosslinking reaction for 60min, pre-freezing the powder A solution in a refrigerator at the temperature of 3 ℃ for 150min, transferring the powder A solution to the environment at the temperature of 35 ℃ below zero to 38 ℃ below zero, treating the powder A solution for 20h, and finally freezing and drying the treated powder to obtain the chitosan-based composite antibacterial dressing.
Comparative example 1
The hemp fiber powder is not added in the step (1), and the rest of the operation steps are completely the same as the example 1.
Comparative example 2
The procedure of step (2) was the same as that of example 2 except that the seaweed extract and the mint extract were not added.
The chitosan-based composite antibiotic dressing was prepared by the methods of the examples and comparative examples, respectively, and then the porosity and water vapor transmission rate thereof were measured, and the cell proliferation test was performed by the CCK-8 method, and the test results are shown in table 1:
TABLE 1 Chitosan-based composite antibacterial dressing effect verification test
| Item | Porosity% | Water vapor transmission rate, g/(cm)3×h) | Cell proliferation rate% |
| Example 1 | 98.6 | 8.6×103 | 98 |
| Comparative example 1 | 94.0 | 2.5×103 | 83 |
| Example 2 | 98.8 | 9.0×103 | 99 |
| Comparative example 2 | 97.3 | 8.8×103 | 71 |
| Example 3 | 98.9 | 9.2×103 | 99 |
As can be seen from table 1, the chitosan-based composite antibacterial dressing prepared in this embodiment has excellent porosity and air permeability, and can effectively promote proliferation of epidermal fibroblasts and accelerate wound healing.
It is to be understood that the above description is not intended to limit the present invention, and the present invention is not limited to the above examples, and those skilled in the art should understand that they can make various changes, modifications, additions and substitutions within the spirit and scope of the present invention.
Claims (7)
1. A preparation method of a chitosan-based composite antibacterial dressing is characterized by comprising the following operation steps:
(1) adding konjac glucomannan and hemp fiber powder into deionized water according to the mass ratio of 18-22:1, continuously stirring until uniform dispersion liquid is obtained, adding sodium periodate serving as an oxidant into the dispersion liquid, performing oxidation reaction, performing rotary evaporation and concentration on a reaction product to one third of the volume, performing centrifugation after dialysis, collecting centrifugal supernatant, performing rotary evaporation and concentration, drying at constant temperature, and grinding into powder to obtain powder A;
(2) mixing 15-25 parts by weight of carboxymethyl chitosan, 1-3 parts by weight of seaweed extract and 2-5 parts by weight of mint extract, adding the mixture into 320 parts by weight of 280-one water, and continuously mixing and stirring until uniform mixing occurs
After the dispersion system is dispersed, adding a plasticizer, continuing stirring for 10-15min, adding 120-150 parts of powder A solution with the mass fraction of 10%, continuously stirring until the powder A is uniform, injecting the dispersion solution into a polytetrafluoroethylene culture dish, sealing the culture dish by using a preservative film, standing for crosslinking reaction, placing the culture dish into a refrigerator with the temperature of 1-3 ℃ for pre-freezing for 150min, transferring the culture dish to the environment with the temperature of minus 35 ℃ to minus 38 ℃ for treatment for 15-20h, and finally freezing and drying to prepare the chitosan-based composite antibacterial dressing.
2. A method for preparing a chitosan-based composite antibacterial dressing according to claim 1, wherein in the step (1), the hemp fiber powder has a thickness of 10-15 μm and a length of 0.03-0.06 mm.
3. A method for preparing a chitosan-based composite antibacterial dressing according to claim 1, wherein in the step (1), the amount of sodium periodate added is 65-70% of the mass of konjac glucomannan.
4. A method for preparing a chitosan-based composite antibacterial dressing according to claim 1, wherein after the oxidation reaction in the step (1), ethylene glycol with a volume of 10-15% of deionized water is added to remove unreacted sodium periodate.
5. A method for preparing a chitosan-based composite antibacterial dressing according to claim 1, wherein in the step (1), the powder a is ground to have an average particle size of 600-800 mesh.
6. A method for preparing a chitosan-based composite antibacterial dressing according to claim 1, wherein in the step (2), the plasticizer is glycerol, and the addition amount is 1-3% of the water volume.
7. A method for preparing a chitosan-based composite antibacterial dressing according to claim 1, wherein in the step (2), the time of the standing crosslinking reaction is 50-60 min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112706477A (en) * | 2020-12-28 | 2021-04-27 | 河南亚都实业有限公司 | Dandelion wool-based antibacterial hemostatic dressing |
| CN113117134A (en) * | 2021-04-21 | 2021-07-16 | 石家庄亿生堂医用品有限公司 | Crosslinked chitosan hemostatic powder and preparation method thereof |
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Cited By (2)
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| CN112706477A (en) * | 2020-12-28 | 2021-04-27 | 河南亚都实业有限公司 | Dandelion wool-based antibacterial hemostatic dressing |
| CN113117134A (en) * | 2021-04-21 | 2021-07-16 | 石家庄亿生堂医用品有限公司 | Crosslinked chitosan hemostatic powder and preparation method thereof |
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Application publication date: 20200403 |