CN101049515A - Method for preparing medical use dressing of non-woven fabrics in wet-process cross blent from chitosan and silk fibrino - Google Patents
Method for preparing medical use dressing of non-woven fabrics in wet-process cross blent from chitosan and silk fibrino Download PDFInfo
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- CN101049515A CN101049515A CN 200710068650 CN200710068650A CN101049515A CN 101049515 A CN101049515 A CN 101049515A CN 200710068650 CN200710068650 CN 200710068650 CN 200710068650 A CN200710068650 A CN 200710068650A CN 101049515 A CN101049515 A CN 101049515A
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Abstract
A medical dressing material for stopping hemorrhage, preventing infection of wound and promoting healing is proportionally prepared from chitin fibers and silk protein fibers through mixing, adding deionized water, stirring to become pulp, adding water- soluble high-molecular material, fluffing, homogenizing, wet shaping, and baking.
Description
Technical field
The present invention relates to the preparation method of a kind of chitin and fibroin fiber blend wet nonwoven fabrics medical dressing.
Background technology
Chitin is as a kind of natural macromolecular material, without any side effects to human body, also having broad-spectrum antiseptic, infection and anastalsis and promote wound to heal again, strengthen physiological activities such as body immunity, is the suitable functional natural macromolecular material of safety and sucrose.
In developed country such as American-European-Japanese, chitin material and derivant thereof are widely used in the medical sanitary field.As the operation suture thread that du pont company is produced, need not remove after the recovery; U.S. Pat 6197322 is used non-weaving cloth the solution coatings that contains chitin/chitosan, non-weaving cloth after the coating is through containing the solution-treated of alkali, the chitosan that is present in the non-weaving cloth can slowly be absorbed by bioengineered tissue, thereby promotes the cell growth.
Domestic have chitin is prepared into aqueous solution or saliva stream film forming, or preparation becomes powder, gel or spun-laced nonwoven fabric etc. and is used for medical wound.But certain weak point is all arranged, the use inconvenience that has, the effective component content that has is lower, what have is soft inadequately, can not be close to wound surface, also have ventilative, moisture retention is not enough etc., has influenced result of use.
Fibroin albumen and human body have the good generation compatibility, occur as the many forms with fibroin membrane of medical material." Chinese shaping burns unit " 14 interim reports in 1998 are treated fibroin membrane on nothing infection and aseptic wound surface." textile journal " calendar year 2001 3 is interim makes the medicine fibroin membrane with antibacterials and fibroin albumen, and uses on Infected Burn Wound Surface." textile journal " 2005 5 phases have been set forth the physicochemical property of fibroin/chitosan mixed film in " fibroin blend film " literary composition, and point out that fibroin/chitosan semi-intercrossing network type film has the possibility as " artificial tendon ".But fibroin protein film and complex thereof be because its bacteria resistance function is relatively poor, and ventilative, moisture retention is not strong, and cost of manufacture is higher, has influenced its application.
Summary of the invention
At the deficiency of existing chitin and fibroin albumen medical material, the object of the present invention is to provide the preparation method of a kind of chitin and fibroin fiber blend wet nonwoven fabrics medical dressing.
The technical solution adopted for the present invention to solve the technical problems is:
Carry out proportioning for 2~10 parts with 10~20 parts of chitin fibers and fibroin fiber, add 200~1000 parts of deionized waters, fiber is pulled an oar after blend, add 0.01~1 part of water-soluble high-molecular material again, continue to discongest, homogenate, in the wet-web former online molding of manufacturing paper with pulp, oven dry is prepared into the lamellar non-woven fabric medical dressing.
Described water soluble polymer is sodium alginate, carboxymethyl cellulose, polyacrylic acid, polyacrylamide, Polyethylene Glycol, polyvinyl alcohol, gelatin, xanthan gum, quaternary polyamines or polyethylene glycol oxide.
The technology that described employing wet-laying method prepares non-woven fabrics is 10~20 meters/minute of the speed of a motor vehicle of manufacturing paper with pulp.
The present invention arrive the product of moisture content<10%.Section, packing, cobalt-60 radiosterilization.
The present invention compares with background technology, the beneficial effect that has is: product softness of the present invention, can be close to wound surface, air permeable humidity retaining is good, has the ability of stronger hemostasis and absorptive tissue transudate, can control wound infection effectively, promote wound healing, few with the wound surface adhesion, alleviate the misery of changing dressings, and reduced the generation of medical waste.Product processes is simple and easy, quick, has reduced production cost, and product is easy to use.
The specific embodiment
Embodiment 1:
Get 12 parts of chitin fibers and 8 parts of fibroin fibers, add 200 parts of deionized waters, pulled an oar 30 minutes, add gelatin 0.04, continue to discongest, homogenate is manufactured paper with pulp with 20 meters/minute speed of a motor vehicle and to be gone up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 30 gram/square metre product.
Embodiment 2:
Get 18 parts of chitin fibers and 2 parts of fibroin fibers, add 300 parts of deionized waters, pulled an oar 30 minutes, add xanthan gum 0.01 and continue to discongest, homogenate is manufactured paper with pulp with 10 meters/minute speed of a motor vehicle and to be gone up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 40 gram/square metre product.
Embodiment 3:
Get 10 parts of chitin fibers and 10 parts of fibroin fibers, add 400 parts of deionized waters, pulled an oar 30 minutes, add polyacrylamide 0.1, continue to discongest, homogenate is manufactured paper with pulp with 20 meters/minute speed of a motor vehicle and to be gone up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 50 gram/square metre product.
Embodiment 4:
Get 16 parts of chitin fibers and 4 parts of fibroin fibers, add 800 parts of deionized waters, pulled an oar 30 minutes, add 0.4 part of carboxymethyl cellulose, continue to discongest homogenate, manufacture paper with pulp with 10 meters/minute speed of a motor vehicle and to go up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 30~40 grams/square metre product.
Embodiment 5:
Get 10 parts of chitin fibers and 10 parts of fibroin fibers, add 1000 parts of deionized waters, pulled an oar 30 minutes, add 0.6 part of polyvinyl alcohol, continue to discongest, homogenate is manufactured paper with pulp with 20 meters/minute speed of a motor vehicle and to be gone up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 40~50 grams/square metre product.
Embodiment 6:
Get 16 parts of chitin fibers and 4 parts of fibroin fibers, add 800 parts of deionized waters, pulled an oar 30 minutes, add 1 part of Polyethylene Glycol, continue to discongest, homogenate is manufactured paper with pulp with 20 meters/minute speed of a motor vehicle and to be gone up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 30~40 grams/square metre product.
Embodiment 7:
Get 20 parts of chitin fibers and 4 parts of fibroin fibers, add 800 parts of deionized waters, pulled an oar 30 minutes, add 0.5 part of Polyethylene Glycol, continue to discongest, homogenate is manufactured paper with pulp with 20 meters/minute speed of a motor vehicle and to be gone up net forming, advance the oven dry of 60 ℃ of multistage drying tunnels, moisture content<10%, 30~40 grams/square metre product.
The above-mentioned specific embodiment is used for the present invention that explains, rather than limits the invention, and in the protection domain of spirit of the present invention and claim, any modification and change to the present invention makes all fall into protection scope of the present invention.
Claims (3)
1. the preparation method of chitin and fibroin fiber blend wet nonwoven fabrics medical dressing, it is characterized in that: carry out proportioning for 2~10 parts with 10~20 parts of chitin fibers and fibroin fiber, add 200~1000 parts of deionized waters, fiber is pulled an oar after blend, add 0.01~1 part of water-soluble high-molecular material again, continue to discongest, homogenate, in the wet-web former online molding of manufacturing paper with pulp, oven dry is prepared into the lamellar non-woven fabric medical dressing.
The preparation method of 2 a kind of chitins according to claim 1 and fibroin fiber blend wet nonwoven fabrics medical dressing is characterized in that: described water soluble polymer is sodium alginate, carboxymethyl cellulose, polyacrylic acid, polyacrylamide, Polyethylene Glycol, polyvinyl alcohol, gelatin, xanthan gum, quaternary polyamines or polyethylene glycol oxide.
3. the preparation method of a kind of chitin according to claim 1 and fibroin fiber blend wet nonwoven fabrics medical dressing is characterized in that: the technology that described employing wet-laying method prepares non-woven fabrics is 10~20 meters/minute of the speed of a motor vehicle of manufacturing paper with pulp.
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CN200710068650XA CN101049515B (en) | 2007-05-15 | 2007-05-15 | Method for preparing medical dressing of non-woven fabrics by wet-process blending chitosan and silk fibrino |
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CN200710068650XA CN101049515B (en) | 2007-05-15 | 2007-05-15 | Method for preparing medical dressing of non-woven fabrics by wet-process blending chitosan and silk fibrino |
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CN101049515B CN101049515B (en) | 2010-10-13 |
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Cited By (11)
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CN102319448A (en) * | 2011-09-16 | 2012-01-18 | 华中科技大学 | Antibacterial aquagel material for preparing medical wound dressing and preparation method thereof |
CN103374852A (en) * | 2012-04-19 | 2013-10-30 | 广东省造纸研究所 | Manufacture method of sisal fiber wet nonwoven fabric |
CN106215223A (en) * | 2016-07-28 | 2016-12-14 | 湖南帝星智能科技有限公司 | A kind of chitosan and bamboo fibre are blended the preparation method of wet nonwoven fabrics medical dressing |
CN106344953A (en) * | 2016-08-25 | 2017-01-25 | 杭州新华集团有限公司 | Method for preparing medical dressing by using chitin |
CN107028250A (en) * | 2017-04-25 | 2017-08-11 | 漯河医学高等专科学校 | Antibacterial mask filter disc |
CN108014363A (en) * | 2017-12-07 | 2018-05-11 | 中国纺织科学研究院 | Dressing, dressing film layer and preparation method thereof |
CN108096642A (en) * | 2017-12-07 | 2018-06-01 | 中国纺织科学研究院 | Absorbable film layer, adsorbable hemostatic agents and preparation method thereof |
CN108686266A (en) * | 2018-06-06 | 2018-10-23 | 重庆科技学院 | A kind of preparation method of three-dimensional porous micro rack module units |
CN110152048A (en) * | 2019-05-13 | 2019-08-23 | 浙江惠龙医疗科技股份有限公司 | One kind having anti-scar regeneration function medical dressing and preparation method thereof |
CN110227175A (en) * | 2019-05-13 | 2019-09-13 | 浙江惠龙医疗科技股份有限公司 | It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof |
CN111775519A (en) * | 2020-05-22 | 2020-10-16 | 沈百荣 | Super gentle medical treatment non-woven fabrics |
Family Cites Families (4)
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EP0513803A2 (en) * | 1991-05-17 | 1992-11-19 | Japan Vilene Company, Ltd. | Carrier for immobilization of animal cells, process for manufacture thereof, and methods for cultivation |
CN1515323A (en) * | 2003-01-09 | 2004-07-28 | 成都博联医疗信息产业有限责任公司 | Preparation method of flexible absorbable medical film material |
CN1332081C (en) * | 2005-04-27 | 2007-08-15 | 武汉大学 | Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof |
CN100482189C (en) * | 2005-09-07 | 2009-04-29 | 浙江大学 | Biological dressing and its preparing method |
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2007
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Cited By (13)
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CN102319448A (en) * | 2011-09-16 | 2012-01-18 | 华中科技大学 | Antibacterial aquagel material for preparing medical wound dressing and preparation method thereof |
CN103374852A (en) * | 2012-04-19 | 2013-10-30 | 广东省造纸研究所 | Manufacture method of sisal fiber wet nonwoven fabric |
CN103374852B (en) * | 2012-04-19 | 2017-06-06 | 广东省造纸研究所 | A kind of manufacture method of sisal fiber wet nonwoven fabrics |
CN106215223A (en) * | 2016-07-28 | 2016-12-14 | 湖南帝星智能科技有限公司 | A kind of chitosan and bamboo fibre are blended the preparation method of wet nonwoven fabrics medical dressing |
CN106344953A (en) * | 2016-08-25 | 2017-01-25 | 杭州新华集团有限公司 | Method for preparing medical dressing by using chitin |
CN107028250A (en) * | 2017-04-25 | 2017-08-11 | 漯河医学高等专科学校 | Antibacterial mask filter disc |
CN108014363A (en) * | 2017-12-07 | 2018-05-11 | 中国纺织科学研究院 | Dressing, dressing film layer and preparation method thereof |
CN108096642A (en) * | 2017-12-07 | 2018-06-01 | 中国纺织科学研究院 | Absorbable film layer, adsorbable hemostatic agents and preparation method thereof |
CN108014363B (en) * | 2017-12-07 | 2021-05-11 | 中国纺织科学研究院有限公司 | Dressing, dressing film layer and preparation method thereof |
CN108686266A (en) * | 2018-06-06 | 2018-10-23 | 重庆科技学院 | A kind of preparation method of three-dimensional porous micro rack module units |
CN110152048A (en) * | 2019-05-13 | 2019-08-23 | 浙江惠龙医疗科技股份有限公司 | One kind having anti-scar regeneration function medical dressing and preparation method thereof |
CN110227175A (en) * | 2019-05-13 | 2019-09-13 | 浙江惠龙医疗科技股份有限公司 | It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof |
CN111775519A (en) * | 2020-05-22 | 2020-10-16 | 沈百荣 | Super gentle medical treatment non-woven fabrics |
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