CN110152048A - One kind having anti-scar regeneration function medical dressing and preparation method thereof - Google Patents
One kind having anti-scar regeneration function medical dressing and preparation method thereof Download PDFInfo
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- CN110152048A CN110152048A CN201910391915.2A CN201910391915A CN110152048A CN 110152048 A CN110152048 A CN 110152048A CN 201910391915 A CN201910391915 A CN 201910391915A CN 110152048 A CN110152048 A CN 110152048A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
Abstract
The invention discloses kinds to have anti-scar regeneration function medical dressing and preparation method thereof, and the sodium alginate soln that compound concentration is 1.5%~5.0 obtains spinning solution；15~40g silkworm raw silk is taken to be put into the Na2CO3 solution that 1~2.5L boils, heating is boiled, and is washed with deionized water, and obtains the complete fibroin fiber of degumming, its garnetting is dried for standby；1~15g drying fibroin fiber is taken to mix with 15~20g chitin fiber, with bath raio 1:(6~12) it is put into heating water bath in the ternary solution of the calcium alginate crystallite and fibroin albumen containing loading nano silvery and stirs, obtain fibroin mixed solution, fresh silk fibroin solution is obtained with centrifugation after deionized water dialysis after cooling, obtains solidification liquid；Spinning solution is passed through into spinning nozzle, composite fibre is formed with solidification liquid, then composite fibre is formed into acupuncture cotton by needling process, forms medical dressing through moulding process.The advantages that product of the invention is soft, can be close to the surface of a wound, and air permeable humidity retaining is good, sterilization, sterilizing, promotes cytothesis long.
Description
Technical field
The present invention relates to medical dressing technical fields, and in particular to one kind have anti-scar regeneration function medical dressing and its
Preparation method.
Background technique
The agglutination of wound is a continuous dynamic process, be cell and cell, cell and cellular matrix and with
The process to interact between soluble mediators.From the point of view of the development of medical dressing, as " wet process therapy " theory and practice obtains
Universal, moist dressing obtains pay attention to day by day in world's medicine and hygiene fields.And the application of " wet process therapy " can make wound be in one
A warm and moist environment, in such a case bacterium wound breeding quickly, make wound become lesion in cross-infection
An important sources.In addition, negative pressure wound therapy instrument (also referred to as vacuum assisted closure therapeutic equipment) is by suction device and spy
After different wound dressing connection, wound is made to be maintained at negative pressure state, since Wound healing rate, promotion cell tissue can be improved in it
Growth, reduce bacteria planting and breeding, can will be dropped at least with the number of change dressings, wound is made to reach the purpose that quickly heals.
Therefore, medical dressing is during use, it is necessary to have following several big functions:
1, moisture-keeping functions are carried out to wound；
2, while carrying out moisturizing to wound, has the function of antibacterial, sterilization to the bacterium of wound；
3, growth is promoted to the cell of wound, improves the function of wound healing.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide one kind to have anti-scar regeneration function medical dressing
And preparation method thereof.
The technical solution adopted by the present invention to solve the technical problems is:
One kind having anti-scar regeneration function medical dressing, it is characterised in that: mixes sodium alginate with deionized water and matches
The sodium alginate soln that concentration processed is 1.5%~5.0%, obtains spinning solution；It will be made of fibroin fiber and chitin fiber
Mixture, through the lysigenous fibroin mixed solution of ternary solution as solidification liquid；Spinneret by spinning solution through spinning machine
Mouth enters after squeezing out forms the calcium alginate compounded fiber of fibroin in solidification liquid, then the calcium alginate compounded fiber of fibroin is pierced by needle
Technique forms acupuncture cotton, forms medical dressing through moulding process, wherein contain the seaweed of loading nano silvery in the ternary solution
Sour calcium crystallite and fibroin albumen.
Wherein, the ternary solution is formulated by CaCl2:C2H5OH:H2O by 1:2:8.
Further, the mass percent that the calcium alginate crystallite of the loading nano silvery accounts in the ternary solution is
6wt%~10wt%, the calcium alginate crystallite of loading nano silvery the preparation method is as follows:
By bentonite solution high-speed stirred, sodium chloride powder is added at whirlpool, after mixing evenly, seaweed sodium and chlorine is added dropwise
Change calcium, constant temperature stationary culture obtains the bentonite gel of the crystal of calcium alginate containing micron；The calcium alginate containing micron of preparation is brilliant
The bentonite gel of body is added in ethyl alcohol, and after quickly stirring dissipates, filtering, centrifuge washing has obtained micron calcium alginate crystal；It will
The micron calcium alginate crystal of preparation immerses in silver nitrate solution, after room temperature constant temperature 1h, crosses and removes extra silver ion, be added to
Sodium borohydride solution reduction reaction obtains the calcium alginate crystallite of loading nano silvery.
Wherein, it is 2wt%~4wt%, fibroin albumen that the fibroin albumen, which accounts for the mass percent in the ternary solution,
The preparation method is as follows:
Using the molten enzymolysis process of salt, waste and old cocoon shell or husks are successively impregnated through ethers, alcohol organic solvent to remove
Then waxy substance, carbohydrate and ash impurities therein are boiled by boiling and carry out that degumming, salt is molten, dialysis, protease hydrolyzed
Afterwards, being concentrated, being freeze-dried is to obtain nanoscale silk fibroin powder, having a size of 50~200nm.
The present invention also provides a kind of preparation methods with anti-scar regeneration function medical dressing, wherein in this method
The preparation step of solidification liquid is as follows:
Step 1: 15~40g silkworm raw silk is taken to be put into the Na2CO3 solution that 1~2.5L boils, heated at 100 ± 2 DEG C
30min is boiled, is then cleaned multiple times with deionized water, the complete fibroin fiber of degumming is obtained；
Step 2: clean fibroin fiber garnetting is dried for standby in 45 DEG C~70 DEG C of baking oven；
It is mixed Step 3: the chitin fiber of fibroin fiber and 15~25g after taking 2~15g to dry is mixed to form cellulose
After closing object, with bath raio 1:(6~12) it is put into the ternary solution of the calcium alginate crystallite and fibroin albumen containing loading nano silvery
Heating water bath simultaneously stirs, and obtains fibroin mixed solution；
Step 4: being packed into bag filter after solution to be mixed is cooling, with fresh 65~82h of deionized water dialysis, will dialyse
Solution afterwards obtains fresh silk fibroin solution by centrifugation.
As an improvement, the concentration of the Na2CO3 solution in the preparation step one of the solidification liquid is 0.5 ‰~0.9 ‰, it is excellent
0.6 ‰ are selected as, volume is preferably 2L, is preferably 3 times with deionized water wash number.
As an improvement, drying temperature is preferably 60 DEG C in baking oven in the step of solidification liquid two.
As an improvement, the mixed proportion of fibroin fiber and the chitin fiber is preferably in the step of solidification liquid three
1:5。
As an improvement, stirring 1h, fiber under the conditions of water bath heating temperature is 72 ± 2 DEG C in the step of solidification liquid three
The bath raio of plain mixture and ternary solution is preferably 1:10.
As an improvement, in the step of solidification liquid four the deionized water dialysis time be preferably 72h, by the solution after dialysis
By being centrifuged 10min under supercentrifuge 7500r/min revolving speed, fresh silk fibroin solution is obtained.
Compared with the background technology, the present invention, it has the beneficial effect that
(1) present invention is added to chitin fiber, and medical dressing product is soft, can be close to the surface of a wound, and air permeable humidity retaining is good, fits
For wound of various shapes, particularly suitable for the wound of difficult fixed position, there is bonding skin and absorb wound fluid
Double effects, it is long-term, effective that wound is kept to be in wet environment；
(2) present invention is added to the excellent nano wire fibroin of performance of keeping humidity, and biocompatibility is good, safe and non-toxic,
Itself has certain biocidal property, and the nutriment for being easy to be degraded into amino acid needed by human body is absorbed by the body utilization, improves
Dressing moisturizing and antibacterial effect；
(3) present invention has very strong hemostasis to the silver nano-grain calcium alginate crystallite containing attachment, calcium alginate is added to
Calcium alginate is made micron order and is scattered in medical dressing by effect, strong adsorption, and calcium alginate crystallite is more advantageous to wound
Absorption, and do not allow to easily cause and have stimulation excessively, prevent wound from forming keloid, in addition, containing attachment in calcium alginate crystallite
Silver nano-grain, it is ensured that the anti-microbial property of wound.
Specific embodiment
Embodiment 1
Step A: configuration solidification liquid
Step 1 takes 15g silkworm raw silk to be put into the Na2CO3 solution that concentration that 1L boils is 0.5 ‰, at 100 ± 2 DEG C
Under conditions of continue heating boil 30min, then cleaned up with deionized water, obtain the complete fibroin fiber of degumming；
Clean fibroin fiber garnetting is put into baking oven, is dried for standby at 45 DEG C by step 2；
Step 3 is taken 2g to mix with the domestic silkworm silk fibroin fiber after drying with 25g chitin fiber, is put into bath raio 1:6
(CaCl2:C2H5OH:H2O is formulated with molar ratio 1:2:8, the calcium alginate crystallite quality of loading nano silvery in ternary solution
Percentage is 6wt%, and the mass percent of fibroin albumen is 2wt%), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, is obtained
Fibroin mixed solution；
Step 4 is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 65h, after dialysis
Solution, which passes through under supercentrifuge 7500r/min revolving speed, is centrifuged 10min, obtains fresh silk fibroin solution.
Step B: medical dressing is prepared
The sodium alginate soln that concentration is 1.50% is passed through into spinning nozzle, forms compound fibre with the solidification liquid of step A configuration
Dimension, then composite fibre is formed into acupuncture cotton by needling process, medical dressing is formed through moulding process.
Embodiment 2
Step A: configuration solidification liquid
Step 1 takes 40g silkworm raw silk to be put into the Na2CO3 solution that concentration that 2L boils is 0.6 ‰, at 100 ± 2 DEG C
Under conditions of continue heating boil 30min, then cleaned up with deionized water, obtain the complete fibroin fiber of degumming；
Clean fibroin fiber garnetting is put into baking oven, is dried for standby at 70 DEG C by step 2；
Step 3 is taken 4g to mix with the domestic silkworm silk fibroin fiber after drying with 20g chitin fiber, is put into bath raio 1:10
(CaCl2:C2H5OH:H2O is formulated with molar ratio 1:2:8, the calcium alginate crystallite quality of loading nano silvery in ternary solution
Percentage is 8t%, and the mass percent of fibroin albumen is 3wt%), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, is obtained
Fibroin mixed solution；
Step 4 is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 72h, after dialysis
Solution, which passes through under supercentrifuge 7500r/min revolving speed, is centrifuged 10min, obtains fresh silk fibroin solution.
Step B: medical dressing is prepared
The sodium alginate soln that concentration is 3% is passed through into spinning nozzle, forms composite fibre with the solidification liquid of step A configuration,
Composite fibre is formed into acupuncture cotton by needling process again, forms medical dressing through moulding process.
Embodiment 3
Step A: configuration solidification liquid
Step 1 takes 30g silkworm raw silk to be put into the Na2CO3 solution that concentration that 2L boils is 0.6 ‰, at 100 ± 2 DEG C
Under conditions of continue heating boil 30min, then cleaned up with deionized water, obtain the complete fibroin fiber of degumming；
Clean fibroin fiber garnetting is put into baking oven, is dried for standby at 70 DEG C by step 2；
Step 3 is taken 8g to mix with the domestic silkworm silk fibroin fiber after drying with 18g chitin fiber, is put into bath raio 1:10
(CaCl2:C2H5OH:H2O is formulated with molar ratio 1:2:8, the calcium alginate crystallite quality of loading nano silvery in ternary solution
Percentage is 8wt%, and the mass percent of fibroin albumen is 3wt%), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C, is obtained
Fibroin mixed solution；
Step 4 is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 72h, after dialysis
Solution, which passes through under supercentrifuge 7500r/min revolving speed, is centrifuged 10min, obtains fresh silk fibroin solution.
Step B: medical dressing is prepared
The sodium alginate soln that concentration is 3% is passed through into spinning nozzle, forms composite fibre with the solidification liquid of step A configuration,
Composite fibre is formed into acupuncture cotton by needling process again, forms medical dressing through moulding process.
Embodiment 4
Step A: configuration solidification liquid
Step 1 takes 40g silkworm raw silk to be put into the Na2CO3 solution that concentration that 2.5L boils is 0.9 ‰, 100 ± 2
Continue heating under conditions of DEG C and boil 30min, then cleaned up with deionized water, obtains the complete fibroin fiber of degumming；
Clean fibroin fiber garnetting is put into baking oven, is dried for standby at 70 DEG C by step 2；
Step 3 is taken 15g to mix with the domestic silkworm silk fibroin fiber after drying with 20g chitin fiber, is put with bath raio 1:12
Enter in ternary solution that (CaCl2:C2H5OH:H2O is formulated with molar ratio 1:2:8, the calcium alginate microcrystalline of loading nano silvery
Amount percentage is 10wt%, and the mass percent of fibroin albumen is 4wt%), heating water bath and 1h is stirred under the conditions of 72 ± 2 DEG C,
Obtain fibroin mixed solution；
Step 4 is packed into bag filter after solution to be mixed is cooling, with fresh deionized water dialysis 82h, after dialysis
Solution, which passes through under supercentrifuge 7500r/min revolving speed, is centrifuged 10min, obtains fresh silk fibroin solution.
Step B: medical dressing is prepared
The sodium alginate soln that concentration is 5% is passed through into spinning nozzle, forms composite fibre with the solidification liquid of step A configuration,
Composite fibre is formed into acupuncture cotton by needling process again, forms medical dressing through moulding process.
Above-mentioned specific embodiment is used to illustrate the present invention, rather than limits the invention, of the invention
In spirit and scope of protection of the claims, to any modifications and changes that the present invention makes, protection model of the invention is both fallen within
It encloses.
Claims (10)
1. one kind has anti-scar regeneration function medical dressing, it is characterised in that: by sodium alginate and deionized water mixed preparing
The sodium alginate soln that concentration is 1.5%~5.0%, obtains spinning solution；By what is be made of fibroin fiber and chitin fiber
Mixture, through the lysigenous fibroin mixed solution of ternary solution as solidification liquid；Spinning nozzle by spinning solution through spinning machine
Enter after extrusion and form the calcium alginate compounded fiber of fibroin in solidification liquid, then the calcium alginate compounded fiber of fibroin is pierced into work by needle
Skill forms acupuncture cotton, forms medical dressing through moulding process, wherein contain the alginic acid of loading nano silvery in the ternary solution
Calcium crystallite and fibroin albumen.
2. according to claim 1 a kind of with anti-scar regeneration function medical dressing, it is characterised in that: the ternary is molten
Liquid is formulated by CaCl2:C2H5OH:H2O by 1.5:2:7.5.
3. according to claim 1 a kind of with anti-scar regeneration function medical dressing, it is characterised in that: the load is received
It is 6wt%~10wt% that the calcium alginate crystallite of meter Yin, which accounts for the mass percent in the ternary solution,.
4. according to claim 1 a kind of with anti-scar regeneration function medical dressing, it is characterised in that: the fibroin egg
The white mass percent accounted in the ternary solution is 2wt%~4wt%.
5. a kind of preparation method with anti-scar regeneration function medical dressing described in claim 1, it is characterised in that: the party
The preparation step of solidification liquid in method is as follows:
Step 1: 15~40g silkworm raw silk is taken to be put into the Na2CO3 solution that 1~2.5L boils, boiled in 100 ± 2 DEG C of heating
Then 30min is cleaned multiple times with deionized water, obtain the complete fibroin fiber of degumming；
Step 2: clean fibroin fiber garnetting is dried for standby in 45 DEG C~70 DEG C of baking oven；
Step 3: the chitin fiber of fibroin fiber and 15~25g after taking 2~15g to dry is mixed to form cellulose mixtures
Afterwards, with bath raio 1:(6~12) it is put into water-bath in the ternary solution of the calcium alginate crystallite and fibroin albumen containing loading nano silvery
It heats and stirs, obtain fibroin mixed solution；
Step 4: be packed into bag filter after solution to be mixed is cooling, with fresh 65~82h of deionized water dialysis, after dialysis
Solution obtains fresh silk fibroin solution by centrifugation.
6. the preparation method according to claim 5 with anti-scar regeneration function medical dressing, it is characterised in that: described
The concentration of Na2CO3 solution in the preparation step one of solidification liquid is 0.5 ‰~0.9 ‰, preferably 0.6 ‰, and volume is preferably
2L is preferably 3 times with deionized water wash number.
7. the preparation method according to claim 5 with anti-scar regeneration function medical dressing, it is characterised in that: described
Drying temperature is preferably 60 DEG C in baking oven in the step of solidification liquid two.
8. the preparation method according to claim 5 with anti-scar regeneration function medical dressing, it is characterised in that: described
The mixed proportion of fibroin fiber and the chitin fiber is preferably 1:5 in the step of solidification liquid three.
9. the preparation method according to claim 5 with anti-scar regeneration function medical dressing, it is characterised in that: described
1h is stirred under the conditions of water bath heating temperature is 72 ± 2 DEG C in the step of solidification liquid three, cellulose mixtures and ternary solution
Bath raio is preferably 1:10.
10. the preparation method according to claim 5 with anti-scar regeneration function medical dressing, it is characterised in that: institute
The deionized water dialysis time is preferably 72h in the step of stating solidification liquid four, and the solution after dialysis is passed through supercentrifuge
It is centrifuged 10min under 7500r/min revolving speed, obtains fresh silk fibroin solution.
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2019
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|---|---|---|---|---|
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| CN101049515A (en) * | 2007-05-15 | 2007-10-10 | 浙江理工大学 | Method for preparing medical use dressing of non-woven fabrics in wet-process cross blent from chitosan and silk fibrino |
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| CN103806123A (en) * | 2014-03-03 | 2014-05-21 | 武汉理工大学 | Silk fibroin/sodium alginate composite fiber and preparation method thereof |
| CN107447297A (en) * | 2017-07-26 | 2017-12-08 | 青岛海赛尔新材料科技有限公司 | A kind of hydrogel alginate fibre and preparation method thereof |
| CN108969790A (en) * | 2018-07-08 | 2018-12-11 | 东莞市联洲知识产权运营管理有限公司 | A kind of porous medical dressing of absorbable type and preparation method thereof with anti-scar regeneration function |
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Application publication date: 20190823 |