CN110226931A - A kind of breath analysis device and application method - Google Patents
A kind of breath analysis device and application method Download PDFInfo
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- CN110226931A CN110226931A CN201910614899.9A CN201910614899A CN110226931A CN 110226931 A CN110226931 A CN 110226931A CN 201910614899 A CN201910614899 A CN 201910614899A CN 110226931 A CN110226931 A CN 110226931A
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- 238000000034 method Methods 0.000 title claims abstract description 15
- 238000001514 detection method Methods 0.000 claims abstract description 39
- 210000004027 cell Anatomy 0.000 claims description 14
- 210000003743 erythrocyte Anatomy 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 9
- 102000001554 Hemoglobins Human genes 0.000 claims description 5
- 108010054147 Hemoglobins Proteins 0.000 claims description 5
- 230000000241 respiratory effect Effects 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000009736 wetting Methods 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 65
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010017740 Gas poisoning Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011173 large scale experimental method Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a kind of breath analysis devices, are disposed with the CO2 detection unit by pipeline connection, three-way valve along gas travel path;The three-way valve is communicated with the atmosphere all the way, and another way is connected with gas storage units, and the gas storage units are connected separately with gas exhaust piping, balance pipeline and signal piping, are provided with the first valve on the gas exhaust piping;The balance pipe road is provided with the second valve and filter element;Pressure pump and gas detection cell are provided on the signal piping.The beneficial effect of breath analysis device provided by the invention and application method is: by introducing CO2 detection unit, expiration phase, and the expiration that the state collection by coordinating each valve needs can be judged according to expiration waveform, it is easy to use, as a result accurate, there is good promotion prospect.
Description
Technical field
The present invention relates to expiration composition detection technical field, specially a kind of breath analysis device and application method.
Background technique
Diagnosis patient's illnesses can be assisted by the measurement of characteristics of contaminated respiratory droplets gas componant and its concentration, monitor disease
Diseased state and observation therapeutic effect etc., such as expiration nitric oxide survey asthma, and expiration carbon monoxide surveys gas poisoning.
Each tissue of the mammal by red blood cell to animal body conveys oxygen, and the CO concentration of alveolar air can extrapolate people
Body red blood cell life span, and whether sample gas derives from alveolar air and is affected to result.According to the result of study of Strocchi etc.,
When body red blood cell be in formation speed be equal to breakdown speed stable state when, in other words hemoglobin be in aggregate velocity be equal to divide
It, can be by detecting the endogenous CO concentration and peripheral blood hemoglobin concentration Hb of exhaled gas, and according to following public affairs when solving speed
Formula calculates horizontal (g/L) × 1.38/ endogenous CO concentration (ppm) of RBCS:RBCS (d)=peripheral blood Hb.
Be mostly at present large-scale experiment room equipment by the equipment that breath analysis calculates red blood cell life span, measuring method with set
Standby directly to measure endogenous CO concentration in alveolar air, the test equipment of existing expiratory air CO needs the finger in operator
The lower controlled expiration of progress is led, this cannot be used for lacking cognition or linking up the tester having some setbacks.
Summary of the invention
Expiration source can be judged automatically the purpose of the present invention is to provide one kind and is collected the breath analysis of detection
Device and the method for using the device.
To achieve the above object, the invention provides the following technical scheme:
A kind of breath analysis device is disposed with the CO connected by pipeline along gas travel path2Detection unit, three
Port valve door;The three-way valve is communicated with the atmosphere all the way, and another way is connected with gas storage units, the gas storage units point
It is not connected with gas exhaust piping, balance pipeline and signal piping, is provided with the first valve on the gas exhaust piping;The balance pipeline
On be provided with the second valve and filter element;Pressure pump and gas detection cell are provided on the signal piping.
Preferably, the CO2It is additionally provided with flow control device between detection unit and three-way valve and first flow passes
Sensor.
Preferably, wetting balance mechanism is additionally provided with before pressure pump on the signal piping.
Preferably, second flow sensor is additionally provided on the pressure pump.
Preferably, the gas detection cell is one of CO, NO, H2S, H2, CH4 chemical sensor or several chemistry
The combination of sensor.
Preferably, the filter element adsorbs or reacts away gas to be detected.
Preferably, the CO2The inlet end of detection unit is connected with the gas nozzle exhaled for user by pipeline
Present invention also provides the methods for using the breath analysis device to calculate red blood cell life span, comprising the following steps:
Step 1: mouth and gas nozzle cooperation are carried out normal exhalation by user, allow expiration to fully enter breath analysis by mouth expiration
Device;
Step 2:CO2Detection unit detects respiratory waveform, if current state is not end of breath, three-way valve and atmosphere
Connection, if being currently at end of breath, three-way valve be connected to gas storage units, the first valve opening, the second valve with
Pressure pump is closed, and the t that holds time of end of breath is recorded1And the expiratory gas flow F of flow sensor record, user keep exhaling
It inhales, until Σ Ft1=2V, V are the volumes of gas storage units, and triple valve is communicated with the atmosphere, and the first valve is closed, and stop adopting
Sample;
Step 3: opening the second valve and pressure pump, the gas in gas storage units is pumped by gas inspection with firm discharge
It surveys in unit, recording responses signal X1, when gas detection cell can't detect under test gas, recording responses signal X2;
Step 4: calculating red blood cell life span.
Preferably, the gas detection mechanism includes at least CO chemical sensor, and the filter mechanism is the work of CO absorption
Property charcoal;At this point, the method for calculating red blood cell life span RBCS described in step 4 are as follows:
Wherein, Hb is hemoglobin concentration, and C is end of breath CO concentration;
Wherein, K is the constant of gas detection cell.
The beneficial effect of breath analysis device provided by the invention and application method is: by introducing CO2Detection unit, energy
It is enough that expiration phase, and the expiration that the state collection by coordinating each valve needs are judged according to expiration waveform, it is easy to use, as a result
Accurately, there is good promotion prospect.
Detailed description of the invention
Fig. 1 is a kind of schematic diagram of breath analysis device provided by the embodiment of the present invention;
Fig. 2 is expiration waveform diagram.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
As shown in Figure 1, present embodiments providing a kind of breath analysis device, including set gradually simultaneously along gas travelling route
The CO2 detection unit 1 and three-way valve 2 connected by pipeline;2 one tunnel of three-way valve is directly connected to atmosphere, another way
Gas storage units 3 are connected with, the gas storage units 3 are connected separately with gas exhaust piping 31, balance pipeline 32 and detection pipe
Road 33;It is provided with the first valve 311 on the gas exhaust piping 31, balances and is provided with the second valve 321 and filtering list on pipeline 32
Member 322 is provided with pressure pump 331 and gas detection cell 332 on the signal piping 33.
In preferred embodiment, the CO2Flow control device 4 and are additionally provided between detection unit 1 and three-way valve 2
One flow sensor 5 adjusts different resistances, example to exhaled air flow by flow control device 4 for different detection gas
Expiratory resistance such as is adjusted to 5~20cmH to NO2O, expiratory gas flow are adjusted to 40~200ml/min.
Wetting balance mechanism 333 is additionally provided on the signal piping 33 before pressure pump 331, gas is flat by humidity
Weighing apparatus mechanism 333 increases or decreases humidity, reaches the requirement of gas detection cell 332.
It is additionally provided with second flow sensor 334 on the pressure pump 331, is supervised in real time by second flow sensor 334
The flow velocity of measuring pressure pump 331, and the parameter to control pressure pump 331 meets preset requirement with the flow velocity for ensuring pressure pump 331.
The gas detection cell can be determined according to the type of gas to be detected, generally in CO, NO, H2S, H2, CH4
A kind of chemical sensor, naturally it is also possible to using the tandem compound of a variety of chemical sensors;The filter element 322 needs basis
The type of gas to be detected determines that it acts as the under test gas adsorbed or reacted away in air.
Analytical equipment provided in this embodiment also needs to connect gas nozzle 6 when in use, in order to keep health preferably can be more
The disposable gas nozzle changed, and be connected to by pipeline with the inlet end of the CO2 detection unit 1.
The method that breath analysis device described in the use that the present embodiment also provides calculates red blood cell life span, including following step
It is rapid:
Step 1: mouth and gas nozzle cooperation are carried out normal exhalation by user, allow expiration to fully enter breath analysis by mouth expiration
Device;
Step 2: referring to expiration waveform shown in Fig. 2, calculating red blood cell life span needs to detect the CO concentration of alveolar air, therefore
It needs to acquire the expiration waveform latter stage i.e. expiratory air of phase III, utilizes CO2Detection unit 1 detects respiratory waveform, if current shape
State is not end of breath, then three-way valve 2 is communicated with the atmosphere, and exhaled gas is expelled directly out;If being currently at end of breath,
Three-way valve 2 is connected to gas storage units 3, and the first valve 331 is opened, and the second valve 321 and pressure pump 331 are closed, exhalation
Air-flow enters gas storage units 3 and original gas in gas storage units 3 is discharged from exhaust pipe 31, records end-tidal
The t that holds time of phase1And the expiratory gas flow F that first flow sensor 5 records, user keeps breathing, until Σ Ft1=2V, V
The volume of gas storage units 3, i.e., must air inflow reach twice of 3 volume of gas storage units, gas storage at this time is single
Original substantially all discharge of air in member 3, it is believed that the gas in gas storage units 3 is entirely the exhalation of end of breath
Gas;Three-way valve 2 is communicated with the atmosphere, the first valve 311 is closed, and sampling is stopped;
Wherein CO2It is state of the art that detection unit 1, which detects respiratory waveform, and details are not described herein again.
Step 3: opening the second valve 321 and pressure pump 331, taken out the gas in gas storage units 3 with firm discharge
Enter in gas detection cell 332, records its response signal X1, while outside air enters gas storage list by balance pipeline 32
Equilibrium air pressure in member 3, and will be into the gas to be detected in the air of the gas storage units 3 of device by filter element 322
It removes, when gas detection cell 332 can't detect under test gas, i.e. the air of equilibrium air pressure enters gas detection cell 332
Afterwards, recording responses signal X2;
Step 4: red blood cell life span RBCS is calculated,
Wherein, Hb is hemoglobin concentration, can be measured in advance by other approach in the prior art, C is end of breath
CO concentration;
Wherein, K is the constant of gas detection cell, can be demarcated and be obtained by standard substance.
Standard substance calibration process: the CO calibrating gas of configuration 100ppm concentration is passed through breath analysis device, records its sound
Answer information Y1, record passes through the gas response Y after filter element again2, calculate the constant K=(Y of the gas detection cell1-
Y2)/100。
Claims (9)
1. a kind of breath analysis device, it is characterised in that: be disposed with the CO connected by pipeline along gas travel path2Inspection
Survey unit, three-way valve;The three-way valve is communicated with the atmosphere all the way, and another way is connected with gas storage units, the gas
Storage unit is connected separately with gas exhaust piping, balance pipeline and signal piping, is provided with the first valve on the gas exhaust piping;Institute
It states balance pipe road and is provided with the second valve and filter element;Pressure pump and gas detection list are provided on the signal piping
Member.
2. a kind of breath analysis device according to claim 1, it is characterised in that: the CO2Detection unit and three-way valve
Between be additionally provided with flow control device and first flow sensor.
3. a kind of breath analysis device according to claim 2, it is characterised in that: on the signal piping pressure pump it
Before be additionally provided with wetting balance mechanism.
4. a kind of breath analysis device according to claim 1, it is characterised in that: be additionally provided with second on the pressure pump
Flow sensor.
5. a kind of breath analysis device according to claim 1, it is characterised in that: the gas detection cell be CO, NO,
The combination of one of H2S, H2, CH4 chemical sensor or several chemical sensors.
6. a kind of breath analysis device according to claim 5, it is characterised in that: the filter element absorption reacts away
Gas to be detected.
7. a kind of breath analysis device according to claim 1, it is characterised in that: the CO2The inlet end of detection unit is logical
Piping is connected with the gas nozzle exhaled for user.
8. the method for calculating red blood cell life span using the described in any item breath analysis devices of claim 1-7, it is characterised in that:
The following steps are included:
Step 1: mouth and gas nozzle cooperation are carried out normal exhalation by user, allow expiration to fully enter breath analysis dress by mouth expiration
It sets;
Step 2:CO2Detection unit detects respiratory waveform, if current state is not end of breath, three-way valve is communicated with the atmosphere,
If being currently at end of breath, three-way valve is connected to gas storage units, and the first valve is opened, the second valve and pressure pump
It closes, records the t that holds time of end of breath1And the expiratory gas flow F of flow sensor record, user keep breathing, until
ΣFt1=2V, V are the volumes of gas storage units, and triple valve is communicated with the atmosphere, and the first valve is closed, and stop sampling;
Step 3: opening the second valve and pressure pump, the gas in gas storage units is pumped by gas detection list with firm discharge
In member, recording responses signal X1, when gas detection cell can't detect under test gas, recording responses signal X2;
Step 4: calculating red blood cell life span.
9. the method that a kind of breath analysis device according to claim 8 calculates red blood cell life span, it is characterised in that: described
Gas detection mechanism includes at least CO chemical sensor, and the filter mechanism is the active carbon of CO absorption;At this point, described in step 4
Calculating red blood cell life span RBCS method are as follows:
Wherein, Hb is hemoglobin concentration, and C is end of breath CO concentration;
Wherein, K is the constant of gas detection cell.
Priority Applications (1)
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CN201910614899.9A CN110226931B (en) | 2019-07-09 | 2019-07-09 | Expiration analysis device and use method |
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CN201910614899.9A CN110226931B (en) | 2019-07-09 | 2019-07-09 | Expiration analysis device and use method |
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CN110226931B CN110226931B (en) | 2024-08-23 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111671472A (en) * | 2020-07-01 | 2020-09-18 | 深圳市步锐生物科技有限公司 | Handheld expired air collecting device |
CN111781303A (en) * | 2020-07-01 | 2020-10-16 | 深圳市步锐生物科技有限公司 | Handheld exhaled air collection multi-parameter classification collection mechanism |
CN113069102A (en) * | 2020-01-06 | 2021-07-06 | 深圳市先亚生物科技有限公司 | Breath collection system and method |
CN113777243A (en) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | Alveolar gas concentration detection device and method |
CN114200087A (en) * | 2021-12-15 | 2022-03-18 | 杭州汇健科技有限公司 | Expiration tester and using method thereof |
WO2023046165A1 (en) * | 2021-09-27 | 2023-03-30 | 惠雨恩科技(深圳)有限公司 | End-tidal gas collection apparatus having separate air channels |
CN117347610A (en) * | 2023-12-04 | 2024-01-05 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit system and expiration sampling detection equipment |
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CN113777243A (en) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | Alveolar gas concentration detection device and method |
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CN114200087A (en) * | 2021-12-15 | 2022-03-18 | 杭州汇健科技有限公司 | Expiration tester and using method thereof |
CN117347610A (en) * | 2023-12-04 | 2024-01-05 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit system and expiration sampling detection equipment |
CN117347610B (en) * | 2023-12-04 | 2024-03-26 | 深圳市瑞利医疗科技有限责任公司 | Detection gas circuit system and expiration sampling detection equipment |
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