CN110226931A - A kind of breath analysis device and application method - Google Patents

A kind of breath analysis device and application method Download PDF

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Publication number
CN110226931A
CN110226931A CN201910614899.9A CN201910614899A CN110226931A CN 110226931 A CN110226931 A CN 110226931A CN 201910614899 A CN201910614899 A CN 201910614899A CN 110226931 A CN110226931 A CN 110226931A
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gas
valve
breath analysis
breath
analysis device
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CN110226931B (en
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叶曼
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Hefei Miaokelai Biotechnology Co Ltd
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Hefei Miaokelai Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/082Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention discloses a kind of breath analysis devices, are disposed with the CO2 detection unit by pipeline connection, three-way valve along gas travel path;The three-way valve is communicated with the atmosphere all the way, and another way is connected with gas storage units, and the gas storage units are connected separately with gas exhaust piping, balance pipeline and signal piping, are provided with the first valve on the gas exhaust piping;The balance pipe road is provided with the second valve and filter element;Pressure pump and gas detection cell are provided on the signal piping.The beneficial effect of breath analysis device provided by the invention and application method is: by introducing CO2 detection unit, expiration phase, and the expiration that the state collection by coordinating each valve needs can be judged according to expiration waveform, it is easy to use, as a result accurate, there is good promotion prospect.

Description

A kind of breath analysis device and application method
Technical field
The present invention relates to expiration composition detection technical field, specially a kind of breath analysis device and application method.
Background technique
Diagnosis patient's illnesses can be assisted by the measurement of characteristics of contaminated respiratory droplets gas componant and its concentration, monitor disease Diseased state and observation therapeutic effect etc., such as expiration nitric oxide survey asthma, and expiration carbon monoxide surveys gas poisoning.
Each tissue of the mammal by red blood cell to animal body conveys oxygen, and the CO concentration of alveolar air can extrapolate people Body red blood cell life span, and whether sample gas derives from alveolar air and is affected to result.According to the result of study of Strocchi etc., When body red blood cell be in formation speed be equal to breakdown speed stable state when, in other words hemoglobin be in aggregate velocity be equal to divide It, can be by detecting the endogenous CO concentration and peripheral blood hemoglobin concentration Hb of exhaled gas, and according to following public affairs when solving speed Formula calculates horizontal (g/L) × 1.38/ endogenous CO concentration (ppm) of RBCS:RBCS (d)=peripheral blood Hb.
Be mostly at present large-scale experiment room equipment by the equipment that breath analysis calculates red blood cell life span, measuring method with set Standby directly to measure endogenous CO concentration in alveolar air, the test equipment of existing expiratory air CO needs the finger in operator The lower controlled expiration of progress is led, this cannot be used for lacking cognition or linking up the tester having some setbacks.
Summary of the invention
Expiration source can be judged automatically the purpose of the present invention is to provide one kind and is collected the breath analysis of detection Device and the method for using the device.
To achieve the above object, the invention provides the following technical scheme:
A kind of breath analysis device is disposed with the CO connected by pipeline along gas travel path2Detection unit, three Port valve door;The three-way valve is communicated with the atmosphere all the way, and another way is connected with gas storage units, the gas storage units point It is not connected with gas exhaust piping, balance pipeline and signal piping, is provided with the first valve on the gas exhaust piping;The balance pipeline On be provided with the second valve and filter element;Pressure pump and gas detection cell are provided on the signal piping.
Preferably, the CO2It is additionally provided with flow control device between detection unit and three-way valve and first flow passes Sensor.
Preferably, wetting balance mechanism is additionally provided with before pressure pump on the signal piping.
Preferably, second flow sensor is additionally provided on the pressure pump.
Preferably, the gas detection cell is one of CO, NO, H2S, H2, CH4 chemical sensor or several chemistry The combination of sensor.
Preferably, the filter element adsorbs or reacts away gas to be detected.
Preferably, the CO2The inlet end of detection unit is connected with the gas nozzle exhaled for user by pipeline
Present invention also provides the methods for using the breath analysis device to calculate red blood cell life span, comprising the following steps:
Step 1: mouth and gas nozzle cooperation are carried out normal exhalation by user, allow expiration to fully enter breath analysis by mouth expiration Device;
Step 2:CO2Detection unit detects respiratory waveform, if current state is not end of breath, three-way valve and atmosphere Connection, if being currently at end of breath, three-way valve be connected to gas storage units, the first valve opening, the second valve with Pressure pump is closed, and the t that holds time of end of breath is recorded1And the expiratory gas flow F of flow sensor record, user keep exhaling It inhales, until Σ Ft1=2V, V are the volumes of gas storage units, and triple valve is communicated with the atmosphere, and the first valve is closed, and stop adopting Sample;
Step 3: opening the second valve and pressure pump, the gas in gas storage units is pumped by gas inspection with firm discharge It surveys in unit, recording responses signal X1, when gas detection cell can't detect under test gas, recording responses signal X2
Step 4: calculating red blood cell life span.
Preferably, the gas detection mechanism includes at least CO chemical sensor, and the filter mechanism is the work of CO absorption Property charcoal;At this point, the method for calculating red blood cell life span RBCS described in step 4 are as follows:
Wherein, Hb is hemoglobin concentration, and C is end of breath CO concentration;
Wherein, K is the constant of gas detection cell.
The beneficial effect of breath analysis device provided by the invention and application method is: by introducing CO2Detection unit, energy It is enough that expiration phase, and the expiration that the state collection by coordinating each valve needs are judged according to expiration waveform, it is easy to use, as a result Accurately, there is good promotion prospect.
Detailed description of the invention
Fig. 1 is a kind of schematic diagram of breath analysis device provided by the embodiment of the present invention;
Fig. 2 is expiration waveform diagram.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
As shown in Figure 1, present embodiments providing a kind of breath analysis device, including set gradually simultaneously along gas travelling route The CO2 detection unit 1 and three-way valve 2 connected by pipeline;2 one tunnel of three-way valve is directly connected to atmosphere, another way Gas storage units 3 are connected with, the gas storage units 3 are connected separately with gas exhaust piping 31, balance pipeline 32 and detection pipe Road 33;It is provided with the first valve 311 on the gas exhaust piping 31, balances and is provided with the second valve 321 and filtering list on pipeline 32 Member 322 is provided with pressure pump 331 and gas detection cell 332 on the signal piping 33.
In preferred embodiment, the CO2Flow control device 4 and are additionally provided between detection unit 1 and three-way valve 2 One flow sensor 5 adjusts different resistances, example to exhaled air flow by flow control device 4 for different detection gas Expiratory resistance such as is adjusted to 5~20cmH to NO2O, expiratory gas flow are adjusted to 40~200ml/min.
Wetting balance mechanism 333 is additionally provided on the signal piping 33 before pressure pump 331, gas is flat by humidity Weighing apparatus mechanism 333 increases or decreases humidity, reaches the requirement of gas detection cell 332.
It is additionally provided with second flow sensor 334 on the pressure pump 331, is supervised in real time by second flow sensor 334 The flow velocity of measuring pressure pump 331, and the parameter to control pressure pump 331 meets preset requirement with the flow velocity for ensuring pressure pump 331.
The gas detection cell can be determined according to the type of gas to be detected, generally in CO, NO, H2S, H2, CH4 A kind of chemical sensor, naturally it is also possible to using the tandem compound of a variety of chemical sensors;The filter element 322 needs basis The type of gas to be detected determines that it acts as the under test gas adsorbed or reacted away in air.
Analytical equipment provided in this embodiment also needs to connect gas nozzle 6 when in use, in order to keep health preferably can be more The disposable gas nozzle changed, and be connected to by pipeline with the inlet end of the CO2 detection unit 1.
The method that breath analysis device described in the use that the present embodiment also provides calculates red blood cell life span, including following step It is rapid:
Step 1: mouth and gas nozzle cooperation are carried out normal exhalation by user, allow expiration to fully enter breath analysis by mouth expiration Device;
Step 2: referring to expiration waveform shown in Fig. 2, calculating red blood cell life span needs to detect the CO concentration of alveolar air, therefore It needs to acquire the expiration waveform latter stage i.e. expiratory air of phase III, utilizes CO2Detection unit 1 detects respiratory waveform, if current shape State is not end of breath, then three-way valve 2 is communicated with the atmosphere, and exhaled gas is expelled directly out;If being currently at end of breath, Three-way valve 2 is connected to gas storage units 3, and the first valve 331 is opened, and the second valve 321 and pressure pump 331 are closed, exhalation Air-flow enters gas storage units 3 and original gas in gas storage units 3 is discharged from exhaust pipe 31, records end-tidal The t that holds time of phase1And the expiratory gas flow F that first flow sensor 5 records, user keeps breathing, until Σ Ft1=2V, V The volume of gas storage units 3, i.e., must air inflow reach twice of 3 volume of gas storage units, gas storage at this time is single Original substantially all discharge of air in member 3, it is believed that the gas in gas storage units 3 is entirely the exhalation of end of breath Gas;Three-way valve 2 is communicated with the atmosphere, the first valve 311 is closed, and sampling is stopped;
Wherein CO2It is state of the art that detection unit 1, which detects respiratory waveform, and details are not described herein again.
Step 3: opening the second valve 321 and pressure pump 331, taken out the gas in gas storage units 3 with firm discharge Enter in gas detection cell 332, records its response signal X1, while outside air enters gas storage list by balance pipeline 32 Equilibrium air pressure in member 3, and will be into the gas to be detected in the air of the gas storage units 3 of device by filter element 322 It removes, when gas detection cell 332 can't detect under test gas, i.e. the air of equilibrium air pressure enters gas detection cell 332 Afterwards, recording responses signal X2
Step 4: red blood cell life span RBCS is calculated,
Wherein, Hb is hemoglobin concentration, can be measured in advance by other approach in the prior art, C is end of breath CO concentration;
Wherein, K is the constant of gas detection cell, can be demarcated and be obtained by standard substance.
Standard substance calibration process: the CO calibrating gas of configuration 100ppm concentration is passed through breath analysis device, records its sound Answer information Y1, record passes through the gas response Y after filter element again2, calculate the constant K=(Y of the gas detection cell1- Y2)/100。

Claims (9)

1. a kind of breath analysis device, it is characterised in that: be disposed with the CO connected by pipeline along gas travel path2Inspection Survey unit, three-way valve;The three-way valve is communicated with the atmosphere all the way, and another way is connected with gas storage units, the gas Storage unit is connected separately with gas exhaust piping, balance pipeline and signal piping, is provided with the first valve on the gas exhaust piping;Institute It states balance pipe road and is provided with the second valve and filter element;Pressure pump and gas detection list are provided on the signal piping Member.
2. a kind of breath analysis device according to claim 1, it is characterised in that: the CO2Detection unit and three-way valve Between be additionally provided with flow control device and first flow sensor.
3. a kind of breath analysis device according to claim 2, it is characterised in that: on the signal piping pressure pump it Before be additionally provided with wetting balance mechanism.
4. a kind of breath analysis device according to claim 1, it is characterised in that: be additionally provided with second on the pressure pump Flow sensor.
5. a kind of breath analysis device according to claim 1, it is characterised in that: the gas detection cell be CO, NO, The combination of one of H2S, H2, CH4 chemical sensor or several chemical sensors.
6. a kind of breath analysis device according to claim 5, it is characterised in that: the filter element absorption reacts away Gas to be detected.
7. a kind of breath analysis device according to claim 1, it is characterised in that: the CO2The inlet end of detection unit is logical Piping is connected with the gas nozzle exhaled for user.
8. the method for calculating red blood cell life span using the described in any item breath analysis devices of claim 1-7, it is characterised in that: The following steps are included:
Step 1: mouth and gas nozzle cooperation are carried out normal exhalation by user, allow expiration to fully enter breath analysis dress by mouth expiration It sets;
Step 2:CO2Detection unit detects respiratory waveform, if current state is not end of breath, three-way valve is communicated with the atmosphere, If being currently at end of breath, three-way valve is connected to gas storage units, and the first valve is opened, the second valve and pressure pump It closes, records the t that holds time of end of breath1And the expiratory gas flow F of flow sensor record, user keep breathing, until ΣFt1=2V, V are the volumes of gas storage units, and triple valve is communicated with the atmosphere, and the first valve is closed, and stop sampling;
Step 3: opening the second valve and pressure pump, the gas in gas storage units is pumped by gas detection list with firm discharge In member, recording responses signal X1, when gas detection cell can't detect under test gas, recording responses signal X2
Step 4: calculating red blood cell life span.
9. the method that a kind of breath analysis device according to claim 8 calculates red blood cell life span, it is characterised in that: described Gas detection mechanism includes at least CO chemical sensor, and the filter mechanism is the active carbon of CO absorption;At this point, described in step 4 Calculating red blood cell life span RBCS method are as follows:
Wherein, Hb is hemoglobin concentration, and C is end of breath CO concentration;
Wherein, K is the constant of gas detection cell.
CN201910614899.9A 2019-07-09 2019-07-09 Expiration analysis device and use method Active CN110226931B (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111671472A (en) * 2020-07-01 2020-09-18 深圳市步锐生物科技有限公司 Handheld expired air collecting device
CN111781303A (en) * 2020-07-01 2020-10-16 深圳市步锐生物科技有限公司 Handheld exhaled air collection multi-parameter classification collection mechanism
CN113069102A (en) * 2020-01-06 2021-07-06 深圳市先亚生物科技有限公司 Breath collection system and method
CN113777243A (en) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 Alveolar gas concentration detection device and method
CN114200087A (en) * 2021-12-15 2022-03-18 杭州汇健科技有限公司 Expiration tester and using method thereof
WO2023046165A1 (en) * 2021-09-27 2023-03-30 惠雨恩科技(深圳)有限公司 End-tidal gas collection apparatus having separate air channels
CN117347610A (en) * 2023-12-04 2024-01-05 深圳市瑞利医疗科技有限责任公司 Detection gas circuit system and expiration sampling detection equipment

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103747730A (en) * 2011-06-28 2014-04-23 弗雷德哈钦森癌症研究中心 End-tidal gas monitoring apparatus
CN104284699A (en) * 2011-12-21 2015-01-14 卡普尼亚公司 Collection and analysis of a volume of exhaled gas with compensation for the frequency of breathing parameter
CN106163394A (en) * 2014-03-07 2016-11-23 斯皮罗梅特里克斯公司 Respiratory monitor
CN108663503A (en) * 2017-03-30 2018-10-16 福建省先亚药业有限公司 A kind of method and system of intelligent measurement red blood cell life span
CN109602420A (en) * 2018-11-23 2019-04-12 深圳市美好创亿医疗科技有限公司 Exhaled gas detection device and detection method
CN210673313U (en) * 2019-07-09 2020-06-05 合肥妙可莱生物科技有限公司 Expiration analysis device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103747730A (en) * 2011-06-28 2014-04-23 弗雷德哈钦森癌症研究中心 End-tidal gas monitoring apparatus
CN104284699A (en) * 2011-12-21 2015-01-14 卡普尼亚公司 Collection and analysis of a volume of exhaled gas with compensation for the frequency of breathing parameter
CN106163394A (en) * 2014-03-07 2016-11-23 斯皮罗梅特里克斯公司 Respiratory monitor
CN108663503A (en) * 2017-03-30 2018-10-16 福建省先亚药业有限公司 A kind of method and system of intelligent measurement red blood cell life span
CN109602420A (en) * 2018-11-23 2019-04-12 深圳市美好创亿医疗科技有限公司 Exhaled gas detection device and detection method
CN210673313U (en) * 2019-07-09 2020-06-05 合肥妙可莱生物科技有限公司 Expiration analysis device

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113069102A (en) * 2020-01-06 2021-07-06 深圳市先亚生物科技有限公司 Breath collection system and method
CN111671472A (en) * 2020-07-01 2020-09-18 深圳市步锐生物科技有限公司 Handheld expired air collecting device
CN111781303A (en) * 2020-07-01 2020-10-16 深圳市步锐生物科技有限公司 Handheld exhaled air collection multi-parameter classification collection mechanism
CN111781303B (en) * 2020-07-01 2023-02-10 深圳市步锐生物科技有限公司 Handheld exhaled air collection multi-parameter classification collection mechanism
CN113777243A (en) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 Alveolar gas concentration detection device and method
WO2023046165A1 (en) * 2021-09-27 2023-03-30 惠雨恩科技(深圳)有限公司 End-tidal gas collection apparatus having separate air channels
CN114200087A (en) * 2021-12-15 2022-03-18 杭州汇健科技有限公司 Expiration tester and using method thereof
CN117347610A (en) * 2023-12-04 2024-01-05 深圳市瑞利医疗科技有限责任公司 Detection gas circuit system and expiration sampling detection equipment
CN117347610B (en) * 2023-12-04 2024-03-26 深圳市瑞利医疗科技有限责任公司 Detection gas circuit system and expiration sampling detection equipment

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